• Computers and Concrete
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• v.29 no.6
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• pp.375-391
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• 2022

This paper examined the impact of the cross-sectional structure on the structural results under different loading conditions of reinforced concrete (RC) members' management limited in Carbon Fiber Reinforced Polymers (CFRP). The mechanical properties of CFRC was investigated, then, totally 32 samples were examined. Test parameters included the cross-sectional shape as square, rectangular and circular with two various aspect rates and loading statues. The loading involved concentrated loading, eccentric loading with a ratio of 0.46 to 0.6 and pure bending. The results of the test revealed that the CFRP increased ductility and load during concentrated processing. A cross sectional shape from 23 to 44 percent was increased in load capacity and from 250 to 350 percent increase in axial deformation in rectangular and circular sections respectively, affecting greatly the accomplishment of load capacity and ductility of the concentrated members. Two Artificial Intelligence Models as Extreme Learning Machine (ELM) and Particle Swarm Optimization (PSO) were used to estimating the tensile and flexural strength of specimen. On the basis of the performance from RMSE and RSQR, C-Shape CFRC was greater tensile and flexural strength than any other FRP composite design. Because of the mechanical anchorage into the matrix, C-shaped CFRCC was noted to have greater fiber-matrix interfacial adhesive strength. However, with the increase of the aspect ratio and fiber volume fraction, the compressive strength of CFRCC was reduced. This possibly was due to the fact that during the blending of each fiber, the volume of air input was increased. In addition, by adding silica fumed to composites, the tensile and flexural strength of CFRCC is greatly improved.

• Journal of the Korean Society of Hazard Mitigation
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• v.5 no.1 s.16
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• pp.69-76
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• 2005

The pull-out capacity of expansion anchor(heavy duty anchor and wedge anchor) was studied experimentally in this paper. Loading conditions included tension, shear, and combined tension and shear. The heavy duty anchor and wedge anchor were manufactured in domestic and installed In plain concrete. The failure mode of steel and concrete were studied carefully for the analytical formula of the anchorage design and the experimental data were compared with different models for the interaction of tension and shear capacities. Based on the research, the following conclusion may be drawn : The interaction of forces is well-described by an elliptical interaction relationship.

• BMB Reports
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• v.57 no.6
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• pp.273-280
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• 2024

Cancer cells metastasize to distant organs by altering their characteristics within the tumor microenvironment (TME) to effectively overcome challenges during the multistep tumorigenesis. Plasticity endows cancer cell with the capacity to shift between different morphological states to invade, disseminate, and seed metastasis. The epithelial-to-mesenchymal transition (EMT) is a theory derived from tissue biopsy, which explains the acquisition of EMT transcription factors (TFs) that convey mesenchymal features during cancer migration and invasion. On the other hand, adherent-to-suspension transition (AST) is an emerging theory derived from liquid biopsy, which describes the acquisition of hematopoietic features by AST-TFs that reprograms anchorage dependency during the dissemination of circulating tumor cells (CTCs). The induction and plasticity of EMT and AST dynamically reprogram cell-cell interaction and cell-matrix interaction during cancer dissemination and colonization. Here, we review the mechanisms governing cellular plasticity of AST and EMT during the metastatic cascade and discuss therapeutic challenges posed by these two morphological adaptations to provide insights for establishing new therapeutic interventions.

• Journal of Korean Society of Steel Construction
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• v.15 no.6 s.67
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• pp.649-660
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• 2003

The paper presents an evaluation of the tensile strength of the expansion anchor that can cause failure in the concrete based on the design of the anchorage. Tests of the heavy-duty anchor and the wedge anchor that are domestically manufactured and installed in plain concrete members are conducted to probe the effects of the embedded depth, concrete strength, and anchors spacing. The design of post-installed steel anchors is presented using the Concrete Capacity Design (CCD) approach. The CCD method is applied to predict the concrete failure load of the expansion anchor in plain concrete under monotonic loading for important applications. The concrete tension capacity of the fastenings with heavy-duty anchors and wedge anchors in plain concrete predicted using the CCD method is compared with the test results. For the CCD method, a normalization coefficient of 9.94 is appropriale for the nominal concrete breakout strength of an anchor or a group of wedge anchors in tension. On the other hand, a normalization coefficient of 11.50 is appropriate for the nominal concrete breakout strength of an anchor or a group of heavy-duty anchors in tension.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.11a
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• pp.49-52
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• 2004

In this studies, Dapped End Beams(DEB) having disturbed regions were designed by using strut tie model, and the main purpose of this paper is that whether T-headed bars and Steel fibers will be present or not. The ability of DEB with T-headed bars have a superior performance rather than others, such as improved ductility, larger energy adsorption and enhanced post-peak load carrying capability. The capacity of DEB with steel fibers also show increase of ductility, shear strength, fatigue strength and crack. Each DEB with both headed bars and steel fibers, headed bars, and steel fibers as a substitute reinforced steel in the disturbed regions and a DEB with only stirrup and tie reinforced steel were comparable. In contrast, the headed bar stirrups, the tie headed bars and the reinforced steel fibers did not lose their anchorage and hence were able to develop strain hardening and also served to delay buckling of the flexural compression steel. Excellent load-deflection predictions were obtained by increasing the tension stiffening effect to account for high load effects.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.333-336
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• 2008

CFRP tendons have been attempted in concrete structures as a substitute for steel tendons considering their many advantages such as the corrosion-resistance, light weight etc. However, the elastic behavior up to failure is likely to result in ductility problems. To overcome such problems, prestress concrete beams with partially bonded tendons have been developed and suggested. In this new system, the un-bonded part near the mid-span contributes to the improvement of ductility. And the bonded parts at both ends play a role as a safe anchorage. According to the previous research on the static behavior, the suggested method has demonstrated enough ductility and strength. However it is essential to verify the long-term safety for repetitive fatigue loads under service states. For this purpose, flexural fatigue loading tests were carried out in this research. This paper includes an experimental investigation on the static load-carrying capacities of the beams with or without fatigue tests. The results showed that the beams prestressed with partially bonded CFRP tendons possessed good fatigue capacity under the constant cyclic loads.

• Journal of the Korea institute for structural maintenance and inspection
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• v.15 no.3
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• pp.186-194
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• 2011

The reinforced concrete beam-column connections are in lack of constructability and are likely to show anchorage failure because of the complex details of joint regions. Under seismic loads, a destruction of the column or the beam-column joint leads to collapse of the whole structures. For this reason, the safety of structures has to be guaranteed by following procedures which are based on the strong column-weak beam design concept: 1) failure of beam by generating plastic hinge in the beam maintained a certain distance from the surface of column, 2) failure of column or beam-column joint. In this study, headed bars were used as longitudinal reinforcements of beam and joint reinforcements in order to improve the strength and constructability of joint and to relocate plastic hinge. The finite element analyses (FEAs) were performed to the reinforced concrete beam-column joints utilizing headed bar reinforcements. To verify the availability of the analysis models, the FEAs for experimental tests performed by previous researchers were conducted and compared with the experimental results. Additional variables are also considered to confirm the excellence of headed bars. Analysis results indicate that the constructability of beam-column connections can be improved by using headed bars for the full anchorage of longitudinal reinforcements of beam under similar structural performance. In addition, the plastic hinge was relocated to the intended place by using headed bars as joint reinforcements. Under cyclic displacement loading, the energy dissipation capacity and ultimate stress were increased and the decrease in stiffness was minimized.

• Journal of the Korea Concrete Institute
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• v.19 no.6
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• pp.717-726
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• 2007

If conventional reinforcements are used for high-strength concrete (HSC) structures, a large amount of the reinforcement must be required to compensate for the brittleness of HSC and make the best use of HSC. This raises some structural problems such as steel congestion and an increase in self-weight. Therefore, alternative reinforcing materials and methods for HSC structures are needed. In this study, four full-scale beam specimens constructed with HSC (100 MPa) were tested to investigate the effect of the different shear reinforcements on the shear behavior. These four specimens were reinforced for shear stirrups with normal and high strength steels, headed bars, and carbon fiber-reinforced polymer (CFRP) bars, respectively. In addition, steel fibers were added to the HSC in the two of the specimens to observe their beneficial effects. The use of high strength steels resulted in the improvement of the shear capacity since the shear resistance provided by the shear reinforcements and the bond strength were increased. The specimen reinforced with headed bars also showed a superior performance to the conventional steel reinforced specimen due to the considerably high anchorage strength of headed bar. CFRP bars used in this research, however, seemed to be inadequate for shear reinforcement because of the inferior bond capacity. The presence of the steel fibers in concrete led to remarkable improvement in the ductility of the specimens as well as in the overall cracks control capability.

• Journal of Korean Society of Steel Construction
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• v.23 no.6
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• pp.747-761
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• 2011

This paper presents an investigation on the change in the statical behavior and the ultimate capacity of steel cable-stayed bridges after cable failure. Cable failure can occur due to fire, direct vehicle clash accidents, cable or anchorage fatigue, and so on. Moreover, the cable may be temporarily disconnected during cable replacement work. When cable failure occurs, the load, that was supported by the broken cable is first transferred to another cable. Then the structural state changes due to the interaction between the girder, mast, and cables. Moreover, it can be predicted that the ultimate capacity will decrease after cable failure, because of the loss of the support system. In this study, the analysis method is suggested to find the new equilibrium state after cable failure based on the theory of nonlinear finite element analysis. Moreover, the ultimate analysis method is also suggested to analyze the ultimate behavior of live loads after cable failure. For a more rational analysis, a three-step analysis procedure is suggested and used, which consisted of initial shape analysis, cable failure analysis, and live load analysis. Using this analysis method, an analytical study was performed to investigate the changes in the structural state and ultimate behavior of steel cable-stayed bridges.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.1
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• pp.21-30
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• 2024

The challenging clinical outcomes associated with advanced cervical cancer underscore the need for a novel therapeutic approach. Monensin, a polyether antibiotic, has recently emerged as a promising candidate with anti-cancer properties. In line with these ongoing efforts, our study presents compelling evidence of monensin's potent efficacy in cervical cancer. Monensin exerts a pronounced inhibitory impact on proliferation and anchorage-independent growth. Additionally, monensin significantly inhibited cervical cancer growth in vivo without causing any discernible toxicity in mice. Mechanism studies show that monensin's anti-cervical cancer activity can be attributed to its capacity to inhibit the Wnt/β-catenin pathway, rather than inducing oxidative stress. Monensin effectively reduces both the levels and activity of β-catenin, and we identify Akt, rather than CK1, as the key player involved in monensin-mediated Wnt/β-catenin inhibition. Rescue studies using Wnt activator and β-catenin-overexpressing cells confirmed that β-catenin inhibition is the mechanism of monensin's action. As expected, cervical cancer cells exhibiting heightened Wnt/β-catenin activity display increased sensitivity to monensin treatment. In conclusion, our findings provide pre-clinical evidence that supports further exploration of monensin's potential for repurposing in cervical cancer therapy, particularly for patients exhibiting aberrant Wnt/β-catenin activation.