• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8923-8929
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• 2014

Background: Increasing evidence suggests that stromal monocarboxylate transporter 4 (MCT4) and carbonic anhydrase IX (CA IX) may play key roles in tumor development. However, their clinical value remains largely unexplored in gastric cancer (GC). The present study aimed to determine clinicopathological significance and prognostic values of stromal MCT4 and CA IX in GC. Materials and Methods: Specimens from 143 GC patients were immunohistochemically stained using polyclonal anti-MCT4 and anti-CA IX antibodies. Expression was correlated with patient clinicopathologic characteristics and survival data. Results: High stromal MCT4 expression was detected in 72 of 143 (50.3%) GCs and high CA IX in 74 (51.7%). Both high stromal MCT4 and CA IX were correlated with advanced TNM stage (p=0.000; p=0.000). High CA IX expression was positively related to depth of invasion (p=0.022) and positive lymph nodes (p=0.002) as well. Survival analysis indicated high expression of stromal MCT4 to be an independent factor in predicting poor overall survival (OS) (HR and 95%CI=1.962, 1.032-3.729, p=0.040) and disease free survival (DFS) (HR and 95%CI=2.081, 1.158-3.741, p=0.014) of GC patients. However, high CA IX expression exhibited no significant predictive value. Conclusions: These findings suggest that high expression of stromal MCT4 and CA IX proteins is significantly correlated with GC progression. High stromal MCT4 heralds worse outcome of GC patient, suggesting a novel candidate prognostic marker and therapeutic target.

• Journal of Internet of Things and Convergence
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• v.6 no.3
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• pp.39-44
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• 2020

In this paper, we propose a SDN-based fog computing service mobility support scheme. Fog computing architecture has been attracted because it enables task offloading services to IoT(Internet of Things) devices which has limited computing and power resources. However, since static as well as mobile IoT devices are candidate service targets for the fog computing service, the efficient task offloading scheme considering the mobility should be required. Especially for the IoT services which need low-latency response, the new connection and task offloading delay with the new fog computing node after handover can occur QoS(Quality of Service) degradation. Therefore, this paper proposes an efficient service mobility support scheme which considers both task migration and flow rule pre-installations. Task migration allows for the service connectivity when the fog computing node needs to be changed. In addition, the flow rule pre-installations into the forwarding nodes along the path after handover enables to reduce the connection delay and service interruption time.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.4C
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• pp.388-396
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• 2009

This paper proposes a new fire-smoke detection method by using extracted features from camera images and pattern recognition technique. First, moving regions are detected by analyzing the frame difference between two consecutive images and generate candidate smoke regions by applying smoke color model. A smoke region generally has a few characteristics such as similar color, simple texture and upward motion. From these characteristics, we extract brightness, wavelet high frequency and motion vector as features. Also probability density functions of three features are generated using training data. Probabilistic models of smoke region are then applied to observation nodes of our proposed Dynamic Bayesian Networks (DBN) for considering time continuity. The proposed algorithm was successfully applied to various fire-smoke tasks not only forest smokes but also real-world smokes and showed better detection performance than previous method.

• Journal of KIISE:Information Networking
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• v.32 no.2
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• pp.215-219
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• 2005

Generally, the mobile nodes in MANET have the limited power capacity available for actual communications. Thus, the power management is very important for packet routing or forwarding. Although MTPR, MBCR and MMBCR are proposed to treat the problem of power consumption, there have been few researches resolving the link breakdown that is occurred by the power exhaustion during transmission. In this sense, the reliable scheme should be required to ensure the routing connectivity. In this paper, we propose three schemes to enforce the routing connectivity. If the signal strength is dropped below a signal threshold, the candidate route is previously selected to prepare the link breakdown. Also, on multi-channel, we propose the lifetime increment scheme of a node that it manage its available power to the needed power of a new link. The simulation results show the enforcement of the link connectivity and the performance improvements of the delay time through the effective connection management.

• Journal of the Korean Operations Research and Management Science Society
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• v.29 no.1
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• pp.57-70
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• 2004

Given a tree network on which each node has its own demand and also stands for a candidate location of a potential facility. such as plant or warehouse, the f-median problem on the network (PMPOT) is to select less than or equal to P number of facility locations so that the whole demand on a node is satisfied from only one facility and the total demand occurred on the network can be satisfied from those facilities with the minimum total cost, where the total cost Is the sum of transportation costs and the fixed costs of establishing facilities. Tamir(1996) developed an O(p n$^2$) algorithm for PMPOT which is known to be the best algorithm In terms of the time complexity, where n is the number of nodes in the network, but he didn't make any comments or explanation about implementation details for finding the optimal solution. In contrast to Tamir's work, Kariv and Hakimi(1979) developed O(p$^2$n$^2$) algorithm for PMPOT and presented O(n$^2$) algorithm for finding the optimal solution in detail. In this paper, we not only develop another O(p n$^2$) dynamic programming algorithm for PMPOT that is competitive to Tamir's algorithm in terms of the time complexity, but also present O(n) algorithm that is more efficient than kariv and Hakimi's algorithm in finding the optimal solution. finally, we implement our algorithm on a set of randomly generated problems and report the computational results.

• Korean Journal of Clinical Laboratory Science
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• v.40 no.1
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• pp.41-47
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• 2008

Colorectal carcinoma is occurred frequently to Korean and so ranked the fourth from various cancers. Due to western dietary life, this cancer has been increased continually. Therefore, the study will be needed to find a candidate gene involved in the development and progression of colorectal carcinoma and to diagnose and treatment helpfully. The striking feature from cancer suppressor genes is known for LOH (loss of heterozygosity), which is the method to find allele genetic loss or mutation of cancer cell. The purpose of this study was designed to find a carcinogenic gene from colon cancer using microsatellite marker on 17th and 18th chromosome from 30 subjects. The LOH was investigated in order of D18S59 57% (17/30), TP53CA 50% (15/30), D18S68 47% (14/30), D18S69 43% (13/30). The genetic mutation depends on loci of colorectal carcinoma was shown higher with 2.44 from colon cancer than with 1.25 from right colorectal carcinoma (p<0.032). The genetic mutation with lymph nodes was investigated higher with 2.69 at mutated group than with 1.14 at non-mutated group (p<0.003). At genetic mutated pattern depends on disease stage, there was higher significant difference at III-IV stage 2.50 than that of I-II stage 1.17, respectively (p=0.015). There was no difference at comparison between histological classification and serological CEA increase. The loss on 18q21 found in this study is highly recurrence loci and was observed 43% for Korean with high recurrence. Therefore, LOH is a very useful tool to detect 18q21 loci in clinical application, prior to the treatment of colorectal carcinoma. After the operation of colorectol carcinoma, the efficient application using LOH at operated part tissue which is designed to protect the recurrence as well as its cure will be needed.

• Biomolecules & Therapeutics
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• v.20 no.1
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• pp.104-112
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• 2012

The fruit of Terminalia chebula Retzius has been used as a panacea in India and Southeast Asia but its biological activities have not been fully elucidated. Here we report anti-arthritic and analgesic effect of NDI10218, a standardized ethanol extract of Terminalia chebula, on collagen-induced arthritis and acetic acid-induced writhing model, respectively. Arthritis was induced in DBA/1J mice by immunizing bovine type II collagen and mice were treated with NDI10218 daily for 5 weeks after the onset of the disease. NDI10218 reduced the arthritis index and blocked the synovial hyperplasia in a dose-dependent manner. The serum levels of pro-inflammatory cytokines TNF-${\alpha}$, IL-6, and IL-$1{\beta}$ were significantly reduced in mice treated with NDI10218. Production of the inflammatory IL-17, but not immunosuppressive IL-10, was also inhibited in splenocytes isolated from NDI10218-treated arthritis mice. Administration of NDI10218 markedly decreased the number of T cell subpopulations in the regional lymph nodes of the arthritis mice. Finally, NDI10218 reduced the number of abdominal contractions in acetic acid-induced writhing model, suggesting an analgesic effect of this extract. Taken together, these results suggest that NDI10218 can be a new therapeutic candidate for the treatment of rheumatoid arthritis.

• Korean Journal of Veterinary Service
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• v.33 no.1
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• pp.29-35
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• 2010

This study was performed to test the hypothesis that Brucella abortus strain RB51 (SRB51) might protect Korean indigenous mongrel dog against challenge with either virulent B. abortus biotype 1 or B. canis. A total of 12 Korean mongrel dogs were divided into four groups (Group A, B, C and D). Dogs belonging to Group A and C were inoculated subcutaneously with $1{\times}10^9$ CFU of SRB51 in 1ml of sterile phosphate buffered saline (PBS). Dogs of Group B and D were inoculated subcutaneously with 1ml of sterile PBS as control. At 12 weeks post vaccination, dogs of Group A and B were challenged by oral inoculation of virulent strain of B. canis ($5.0{\times}10^9$ CFU) and dogs of Group C and D were challenged by oral inoculation of virulent strain of B. abortus biotype 1 ($4.4{\times}10^{10}$ CFU). The serum antibodies titers in all dogs were monitored at regular interval for eight weeks after challenge (AC) by standard tube agglutination test, plate agglutination test, rose bengal test, 2-mercaptoethanol rapid slide agglutination test and 2-mercaptoethanol tube agglutination test. No antibody titers in Group A and C was detected. Also, the challenge strains were not found from blood of all dogs of Group A and C from 1 week AC till the end of the experiment by culture and modified AMOS-PCR, whereas B. canis and B. abortus challenge strains were detected from blood of Group B and D, respectively. In addition, neither of two challenge bacteria was recovered from liver, spleen, kidneys, lymph nodes and reproductive tracts of Group A and C dogs after postmortem. However, B. canis and B. abortus challenge strains were isolated from these tissues of Group B and D, respectively. These data suggest that SRB51 could be a promising vaccine candidate for immunizing dogs to control canine brucellosis caused by B. canis or B. abortus.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2010.03a
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• pp.7-7
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• 2010

Energy harvesting from the environment has been of great interest as a standalone power source of wireless sensor nodes for Ubiquitous Sensor Networks(USN). In particular, the piezoelectric energy harvesting from ambient vibration sources has intensively researched because it has a relatively high power density comparing with other energy scavenging methods. Through recent advances in low power consumption RF transmitters and sensors, it is possible to adopt a micro-power energy harvesting system realized by MEMS technology for the system-on-chip. However, the MEMS energy harvesting system has some drawbacks such as a high natural frequency over 300 Hz and a small power generation due to a small dimension. To overcome these limitations, we devised a novel power generator with a spiral spring structure as shown in the figure. The natural frequency of a cantilever could be decreased to the usable frequency region (under 300 Hz) because the natural frequency depends on the length of a cantilever. In this study, the natural frequency of the energy harvester was a lower than a normal cantilever structure and sufficiently controllable in 50 - 200 Hz frequency region as adjusting weight of a proof mass. Moreover, the MEMS energy harvester had a high energy conversion efficiency using a shear mode ($d_{15}$) is much larger than a 33 mode ($d_{33}$) and the energy conversion efficiency is proportional to the piezoelectric constant (d). We expect the spiral type MEMS power generator would be a good candidate for a standalone power generator for USN.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.6B
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• pp.338-348
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• 2005

Currently, IEEE 802.11 Wireless LAN (WLAN) is rising as the most popular means for the broadband wireless access network. In this thesis, we propose a QoS(Quality of Service)-Oriented mechanism using handshaking method of scanning phase in IEEE 802.11 handoff. In conventional process for handoff, the major criterion to select the best AP(Access Point) among candidates is normally based on the RSS(Received Signal Strength), which does not always make the selected network guarantee the maximum achievable performance. Even though the link quality with a neighboring AP is excellent, the AP may not be a good candidate to handoff to simply because MAC(Medium Access Control) protocol of IEEE 802.11 standard is contention-based such as CSMA/CA. Therefore, if we apply network level information to AP selection criteria, we can achieve better handoff efficiency rather than before. The analysis and simulation results applied to our new mechanism show clearly better performance than AP selection based on traditional handoff method.