• 대한핵의학회지
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• 제18권2호
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• pp.77-85
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• 1984

Monoclonal antibodies have become widely investigated in the Nuclear Oncology, especially in the radioimmunosassay of tumor markers and in vivo radioimmunoimaging of cancer. However, there are numerous factors as to whether radioimmunoimaging will ultimately successful. For imaging of tumors, metallic radionuclides such as In-111, Ga-67, Tc-99m have favorable nuclear properties than widely used I-131. These radioistopes have characteristics of the useful radiation for imaging, convenient short half-lives and the simple and rapid radiolabeling of monoclonal antibodies by using bifunctional chelaing agents. The obtained chelate-tagged antibodies are quite stable both in vitro and in vivo, without interfering antibody activities and animal experiments provided a good basis for its clinical applicability for the radioimmunoimaging of cancer. Much attention has also been given to the possibility, only beginning to be exploited, of the specific treatment of malignant neoplasms with these agents. Although specific antibody has not been developed that is uniquely specific for cancer alone and there are still many questions to be answered and problems to be overcome before radioimmunoimaging can be successfully used in ptients with cancer, these methods can be applied to the coupling of monoclonal antibodies with anti-neoplastic drugs or radionuclides suitable for internal radiation therapy of cancer.

• Investigative Magnetic Resonance Imaging
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• 제26권1호
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• pp.32-42
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• 2022

Purpose: To evaluate the clinical benefit of 2D contrast-enhanced T2 fluid-attenuated inversion recovery (CE-T2 FLAIR) image for detecting leptomeningeal metastasis (LM) in the brain metastasis work-up for lung cancer. Materials and Methods: From June 2017 to July 2019, we collected all consecutive patients with lung cancer who underwent brain magnetic resonance image (MRI), including contrast-enhanced 3D fast spin echo T1 black-blood image (CE-T1WI) and CE-T2 FLAIR; we recruited clinico-radiologically suspected LM cases. Two independent readers analyzed the images for LM in three sessions: CE-T1WI, CE-T2 FLAIR, and their combination. Results: We recruited 526 patients with suspected lung cancer who underwent brain MRI; of these, we excluded 77 (insufficient image protocol, unclear pathology, different contrast media, poor image quality). Of the 449 patients, 34 were clinico-radiologically suspected to have LM; among them, 23 were diagnosed with true LM. The calculated detection performance of CE-T1WI, CE-T2 FLAIR, and combined analysis obtained from the 34 suspected LM were highest in the combined analysis (AUC: 0.80, 0.82, and 0.89, respectively). The inter-observer agreement was also the highest in the combined analysis (0.68, 0.72, and 0.86, respectively). In quantitative analyses, CNR of CE-T2 FLAIR was significantly higher than that of CE-T1WI (Wilcoxon signed rank test, P < 0.05). Conclusion: Adding CE-T2 FLAIR might provide better detection for LM in the brain-metastasis screening for lung cancer.

• 대한영상의학회지
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• 제84권3호
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• pp.550-564
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• 2023

자기공명영상은 현재 선행보조치료 후 직장암을 평가할 수 있는 가장 우수한 영상검사이다. 선행보조치료 후 시행하는 직장 자기공명영상의 목적은 직장암의 절제가능성을 평가하고 임상적으로 완전관해로 생각되는 환자들에서 장기 보존 전략을 적용할 수 있게 하는 것이다. 이번 종설에서는 선행보조치료 후 자기공명영상에서 평가해야 할 중요한 소견들을 체계적으로 평가하는 방법을 다루고자 한다. 먼저 원발 종양의 치료 반응을 평가하고, 완전관해를 시사하는 영상 소견에 대해 고찰하고자 한다. 또한 선행보조치료 후 원발 종양과 주변 구조물과의 관계, 임파절, extramural venous invasion, tumor deposit의 소견을 다루고자 한다. 이러한 영상 소견 및 임상적 중요성에 대한 지식은 정확하고 임상적으로 의미 있는 판독을 제공하는데 기여할 것이다.

• Korean Journal of Radiology
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• 제21권1호
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• pp.77-87
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• 2020

Objective: To assess the feasibility of simultaneous multislice-accelerated diffusion-weighted imaging (SMS-DWI) of the rectum in comparison with conventional DWI (C-DWI) in rectal cancer patients. Materials and Methods: This study included 65 patients with initially-diagnosed rectal cancer. All patients underwent C-DWI and SMS-DWI with acceleration factors of 2 and 3 (SMS2-DWI and SMS3-DWI, respectively) using a 3T scanner. Acquisition times of the three DWI sequences were measured. Image quality in the three DWI sequences was reviewed by two independent radiologists using a 4-point Likert scale and subsequently compared using the Friedman test. Apparent diffusion coefficient (ADC) values for rectal cancer and the normal rectal wall were compared among the three sequences using repeated measures analysis of variance. Results: Acquisition times using C-DWI, SMS2-DWI, and SMS3-DWI were 173 seconds, 107 seconds, (38.2% shorter than C-DWI), and 77 seconds (55.5% shorter than C-DWI), respectively. For all image quality parameters other than distortion (margin sharpness, artifact, lesion conspicuity, and overall image quality), C-DWI and SMS2-DWI yielded better results than did SMS3-DWI (Ps < 0.001), with no significant differences observed between C-DWI and SMS2-DWI (Ps ≥ 0.054). ADC values of rectal cancer (p = 0.943) and normal rectal wall (p = 0.360) were not significantly different among C-DWI, SMS2-DWI, and SMS3-DWI. Conclusion: SMS-DWI using an acceleration factor of 2 is feasible for rectal MRI resulting in substantial reductions in acquisition time while maintaining diagnostic image quality and similar ADC values to those of C-DWI.

• Journal of Gastric Cancer
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• 제18권2호
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• pp.161-171
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• 2018

Purpose: This study assessed the feasibility of near-infrared (NIR) imaging with indocyanine green (ICG) in investigating the completeness of laparoscopic lymph node (LN) dissection for gastric cancer. Materials and Methods: Patients scheduled for laparoscopic gastrectomy for treating gastric cancer were enrolled in the study. After intraoperative submucosal ICG injection (0.05 mg/mL), LN dissection was performed under conventional laparoscopic light. After dissection, the LN stations of interest were examined under the NIR mode to locate any extra ICG-stained (E) tissues, which were excised and sent for pathologic confirmation. This technique was tested in 2 steps: infra-pyloric LN dissection (step 1) and review of all stations after proper radical node dissection (step 2). Results: In step 1, 15 patients who underwent laparoscopic pylorus-preserving gastrectomy (LPPG) and 15 patients who underwent laparoscopic distal gastrectomy (LDG) were examined. Seven and 2 E-tissues were obtained during LPPG and LDG, respectively. From the retrieved E-tissues, 1 and 0 tissue obtained during LPPG and LDG, respectively, was confirmed as LN. In step 2, 20 patients were enrolled (13 D1+ dissection and 7 D2 dissection). Six E-tissues were retrieved from 5 patients, and 1 tissue was confirmed as LN in the pathologic review. Overall, 15 E-tissues were detected and removed, and 2 tissues were confirmed as LNs in the pathologic review. Both nodes were from LN station #6, with 1 case each in the LDG and LPPG groups. Conclusions: NIR imaging may provide additional node detection during laparoscopic LN dissection for gastric cancer, especially in the infra-pyloric area.

• ETRI Journal
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• 제32권6호
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• pp.901-910
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• 2010

As a supplement to X-ray mammography, microwave imaging is a new and promising technique for breast cancer detection. Through solving the nonlinear inverse scattering problem, microwave tomography (MT) creates images from measured signals using antennas. In this paper, we describe a developed MT system and an iterative Gauss-Newton algorithm. At each iteration, this algorithm determines the updated values by solving the set of normal equations using Tikhonov regularization. Some examples of successful image reconstruction are presented.

• 한국방사선학회논문지
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• 제6권1호
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• pp.63-71
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• 2012

본 연구는 유방영상검사의 최고의 관심영역인 DR 방식의 유방영상에서 유방암 진단의 정확도를 평가하고, 유방암 환자들의 특성을 알아보고자 DR 방식으로 유방영상검사를 실시한 유방암 환자 57명을 대상으로 2010년 5월부터 2011년 6월까지 조사되었다. 유방암 환자들의 평균 나이는 50.8세이었고, 유방암의 발생 부위는 상외측(UOQ)이 전체의 33.3%로 가장 많은 것으로 조사되었다. 연령에 따른 유방암 발생은 40-49세에서 42.1%로 모든 연령대에서 가장 높게 나타났다. 유방암 환자들의 유방조직 밀도는 지방형 유방이 31.6%(18/57), 치밀유방이 68.4%(39/57)로 나타나, 70%에 가까운 유방암 환자들이 치밀유방의 형태를 띠고 있었다. 유방영상에서 방사선학적 병변 중 종괴와 미세석회화가 함께 동반된 경우 (45.3%)가 유방암 발견율이 가장 높은 것으로 조사되었고, 치밀유방에서 미세석회화를 동반하지 않는 종괴의 경우 지방형 유방에서보다 유방암의 발견율이 더 낮은 것으로 조사되었으며, 이러한 종괴는 치밀유방에서 위음성율을 높이는 원인이 되고 있다. Digital mammography의 위음성률은 7.0%이었고, 민감도는 93.0%인 것으로 조사되었다. 치밀유방의 위음성율은 12.8%, 민감도는 87.2%로 조사되었는데 이는 이전에 보고된 screen film mammography의 치밀유방에서 보다 유방암에 대한 민감도가 더 높은 것으로 조사되었다.

• Investigative Magnetic Resonance Imaging
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• 제14권2호
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• pp.121-125
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• 2010

목적 : 본 연구는 유방암 진단 후 추가적으로 유방암을 발견하는 데 있어 3 테슬러 유방자기공명 영상의 진단적 정확성을 알아보고자 하였다. 대상 및 방법 : 2009년 3월부터 6월까지, 새롭게 유방암을 진단 받은 101명의 환자가 유방 자기공명 영상을 촬영하고 수술을 받았다. 자기공명영상에서는 종양의 범위와 다초점, 다중심, 반대측 유방암이 의심되는 소견에 대해 분석하였다. 자기공명영상으로 발견된 유방암은 조직검사나 위치결정술 후 수술로 진단되었다. 결과 : 34명 환자에서 37예의 암이 의심되는 소견이 추가적으로 자기공명영상에서 보였다. 16예의 다초점 유방암, 11예의 다중심 유방암 그리고 2예의 반대측 유방암을 포함하여 29예가 진양성이었다(29/37, 78.4%); 13 (44.8%)예는 관내상피암 그리고 16 (55.1%)예는 침윤성 암이었다. 6예의 양성 병변, 2예의 고위험병변을 포함하여 8예가 위양성이었다(8/37, 21.6%). 결론 : 3 테슬러 자기공명영상에서 최근에 유방암이 진단된 환자의 33.7%에서 추가적으로 암이 의심되는 소견이 보였다. 추가적으로 유방암을 발견하는 3 테슬러 자기공명영상의 민감도와 특이도는 각각 100%, 89.3% 였다

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2007년도 학술대회
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• pp.73-73
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• 2007

• Korean Journal of Radiology
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• 제24권1호
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• pp.1-5
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• 2023