• 전자공학회논문지SC
• /
• 제48권1호
• /
• pp.1-8
• /
• 2011

MR 센서에 의해 지구자기장의 세기를 측정하여 방위각을 결정하는 전자 Compass의 정밀도는 MR센서 및 OP-Amp.의 온도 Drift, DC Offset등 소자에 의한 오차, 측정주변 자성체에 의한 자기장의 왜곡, 및 Compass Tilt에 의한 오차 등의 영향을 받는다. 본 연구에서는 Set/Reset Pulse 방법에 의해 MR 센서 및 OP-Amp의 온도 Drift 및 DC Offset에 의한 오차를 해결하였고, 주변 자성체에 의한 자기장의 왜곡에 의한 오차를 Hard-Iron Calibration 루틴 수행에 의해 보상하였으며, Compass Tilt에 의한 오차를 Euler Rotational Equation에 의해 보상할 수 있는 3축 MR 센서 및 3축 Accelerometer를 기반으로 하는 전자 Compass 를 설계하였다. 특히 이와 샅이 설계한 전자 Compass를 가지고 3측 MR 센서의 서로 다른 Sensitivity와 OP-Amp.의 서로 다른 Gain등을 규준화하기 위한 Sensitivity Calibration 루틴 수행 시 Tilt의 발생으로 야기되는 오차를 정량적으로 분석하였으며, 이를 바탕으로 $1^{\circ}$정도(精度) Compass를 설계할 수 있었다.

• 약학회지
• /
• 제46권5호
• /
• pp.324-330
• /
• 2002

This experiment was carried out to determine non-destructively the hydrogen peroxide concentration of 3％ antiseptic hydrogen peroxide solutions by portable near-infrared (NIR) system. Hydrogen peroxide standards were prepared ranging from 0 to 25.6 w/w％ and the NIR spectra of hydrogen peroxide standard solutions were collected by using a quartz cell in 1 mm pathlength. We found the variation of absorbance band due to OH vibration of hydrogen peroxide depending on the concentration around 1400 nm in the second derivatives spectra. Partial least square regression (PLSR) and multilinear regression (MLR) were explored to develop a calibration model over the spectral range 1100-1720 nm. The model using PLSR was better than that using MLR. The calibration showed good results with a standard error of prediction (SEP) of 0.16％. In order to validate the developed calibration model, routine analyses were performed using commercial antiseptic hydrogen peroxide solutions. The hydrogen peroxide values from the NIR calibration model were compared with the values from a redox titration method. The NIR routine analyses results showed good correlation with those of the redox titration method. This study showed that the rapid and non-destructive determination of hydrogen peroxide in the antiseptic solution was successfully performed by portable NIR system without very harmful solvents.

• 약학회지
• /
• 제47권5호
• /
• pp.261-265
• /
• 2003

Near-infrared (NIR) system was used to determine rapidly and simply indomethacin in buffer solution for a dissolution test of tablets and capsules. Indomethacin standards were prepared ranging from 10 to 50 ppm using the mixture of phosphate buffer (pH 7.2) and water (1 : 4). The near-infrared (NIR) transmittance spectra of indomethacin standard solutions were collected by using a quartz cell in 1 mm and 2 mm pathlength. Partial least square regression (PLSR) was explored to develop calibration models over the spectral range 1100∼1700 nm. The model using 1 mm quartz cell was better than that using 2 mm quartz cell. The PLSR models developed gave standard error of prediction (SEP) of 0.858 ppm. In order to validate the developed calibration model, routine analysis was performed using another standard solutions. The NIR routine analysis showed good correlation with actual values. Standard error of prediction (SEP) is 1.414 ppm for 7 indomethacin samples in routine analysis and its error was permeable in the regulation of Korean Pharmacopoeia (VII). These results show the potential use of the real time monitoring for indomethacin during a dissolution test.

• 센서학회지
• /
• 제6권4호
• /
• pp.307-315
• /
• 1997

본 논문에서는 센서교환이 용이하고 소량의 샘플을 요구하는 ISFET 센서용 전해질 분석기의 샘플챔버(sample chamber)를 설계하였으며, 이를 이용한 2점 교정방식의 4채널 전해질 분석기를 구현하였다. 샘플과 교정용액들의 사용을 최소화하기 위한 샘플의 로딩상태 감지회로를 제안하였으며 이를 실현하였다. 구현된 전해질 분석기는 제어계통과 액류흐름계통으로 구성되어 있으며 전해질 분석기의 효과적인 제어를 위하여 측정루틴, 교정루틴 및 세척루틴의 시스템 소프트웨어를 각각 개발하였다.

• 대한원격탐사학회지
• /
• 제27권3호
• /
• pp.369-377
• /
• 2011

Since well-calibrated satellite data is critical for their applications, calibration and validation of COMS science data was one of the key activities during the IOT. COMS MI radiometric calibration process was divided into two phases according to the out-gassing of the sensor: calibrations of the visible (VI) and infrared (IR) channels. Different from the VIS calibration, the calibration steps for the IR channels followed additional processes to secure their radiometric performances. Primary calibration steps of the IR were scan mirror emissivity correction, midnight effect compensation, slope averaging and 1/f noise compensation after a nominal calibration. First, the scan mirror emissivity correction was conducted to compensate the variability of the scan mirror emissivity driven by the coating material on the scan mirror. Second, the midnight effect correction was performed to remove unreasonable high spikes of the slope values caused by the excessive radiative sources during the local midnight. After these steps, the residual (difference between the previous slope and the given slope) was filtered by a smoothing routine to eliminate the remnant random noises. The 1/f noise compensation was also carried out to filter out the lower frequency noises caused from the electronics in the Imager. With through calibration processes during the entire IOT period, the calibrated IR data showed excellent performances.

• 한국근적외분광분석학회:학술대회논문집
• /
• 한국근적외분광분석학회 2001년도 NIR-2001
• /
• pp.1154-1154
• /
• 2001

Near infra-red (NIR) spectroscopy has been used for the non-invasive assessment of intact fruit for eating quality attributes such as total soluble solids (TSS) content. However, little information is available in the literature with respect to the robustness of such calibration models validated against independent populations (however, see Peiris et al. 1998 and Guthrie et al. 1998). Many studies report ‘prediction’ statistics in which the calibration and prediction sets are subsets of the same population (e. g. a three year calibration validated against a set from the same population, Peiris et al. 1998; calibration and validation subsets of the same initial population, Guthrie and Walsh 1997 and McGlone and Kawano 1998). In this study, a calibration was developed across 84 melon fruit (R$^2$= 0.86$^{\circ}$Brix, SECV = 0.38$^{\circ}$Brix), which predicted well on fruit excluded from the calibration set but taken from the same population (n = 24, SEP = 0.38$^{\circ}$Brix with 0.1$^{\circ}$Brix bias), relative to an independent group (same variety and farm but different harvest date) (n = 24, SEP= 0.66$^{\circ}$ Brix with 0.1$^{\circ}$Brix bias). Prediction on a different variety, different growing district and time was worse (n = 24, SEP = 1.2$^{\circ}$Brix with 0.9$^{\circ}$Brix bias). Using an ‘in-line’ unit based on a silicon diode array spectrometer, as described in Walsh et al. (2000), we collected spectra from fruit populations covering different varieties, growing districts and time. The calibration procedure was optimized in terms of spectral window, derivative function and scatter correction. Performance of a calibration across new populations of fruit (different varieties, growing districts and harvest date) is reported. Various calibration sample selection techniques (primarily based on Mahalanobis distances), were trialled to structure the calibration population to improve robustness of prediction on independent sets. Optimization of calibration population structure (using the ISI protocols of neighbourhood and global distances) resulted in the elimination of over 50% of the initial data set. The use of the ISI Local Calibration routine was also investigated.

• 대한전자공학회:학술대회논문집
• /
• 대한전자공학회 2001년도 하계종합학술대회 논문집(5)
• /
• pp.195-198
• /
• 2001

We developed the portable blood analysis system, which can be measured pH of the blood. This system is composed to electronic circuit, mechanism, and system software. Electronic circuit is composed to the sensor, pre-amp part, temperature regulation part, fluid sensing part, A/D(analog to digital) conversion part, main and peripheral device processing part. And the mechanism is composed to the flow cell and the liquid flow part. The liquid flow part is consisted of blood and washing control system under the control of the 6-channel solenoid valve and syringe rump. The system software is composed to measurement program, calibration program, washing and diagnostic program. The program of each routine is designed as sequential process for an efficiency. And the portable pH analysis system used two-point calibration method using the two types of corrective liquid. As a result, we obtained the calibration curve and calculated the value of pH. For verifying the system, we confirmed the output voltage of the sensor, and estimated reappearance of system using the standard liquid.

• 분석과학
• /
• 제16권2호
• /
• pp.95-101
• /
• 2003

본 연구에서는 근적외선 분광분석법 (NIR)을 이용하여 메탄올과 에탄올 혼합액 중의 물의 함량을 비파괴적으로 측정하였다. Photo-diode array 방식의 휴대용 NIR system과 scanning 방식의 NIR spectrometer를 이용하여 두 기기 사이의 calibration 결과를 비교하였다. 알코올 혼합액 중의 물의 함량을 정량분석 하기 위해 부분최소자승회귀분석법 (PLSR : partial least squares regression)을 사용하였다. 그 결과 SEP (standard error of prediction)가 photo-diode array 방식을 사용하였을 때는 0.10%, scanning 방식을 사용하였을 때는 0.12%였다. Calibration 모델의 안정성을 확인하기 위하여 6일 동안 2%의 메탄올을 함유하고 있는 에탄올 용액 중의 물의 함량이 3%, 5% 및 7% 되도록 시료를 조제하여 측정하였다. 두 가지 방식의 NIR 모두 3%이내의 변동계수 (CV : coefficient of variation)로 좋은 결과를 나타내었다. 이번 연구를 통해서 메탄올과 에탄올 혼합액 중의 물의 함량 측정이 근적외선 분광분석법을 이용하여 성공적으로 수행되었고 photo-diode array 방식의 휴대용 NIR 시스템을 이용해서 scanning 방식의 NIR spectrometer를 이용한 결과와 유사한 결과를 얻을 수 있었다.

• 한국의학물리학회지:의학물리
• /
• 제19권1호
• /
• pp.49-55
• /
• 2008

본 연구는 MDCT에서 선량을 측정하는데 사용되는 ionization chamber의 calibration 전과 후의 calibration factor에 따른 선량과 촬영실의 온도, 기압의 보정(correction factor) 적용 유무에 따른 $CTDI_w$를 비교 분석하는데 있다. 2007년 3월 21일에 교정된 Model 2026C electormeter (RADICAL 2026C, USA)를 이용한 MDCT (GE light speed plus 4 slice, USA)와 head and body CT dosimetry phantom을 사용하여 측정된 값을 비교 분석하였다. 결과는 calibration factor와 주변 온도, 압력의 correction factor를 보정 해 준 $CTDI_w$ 값이 보정을 하지 않고 계산된 값보다 $0.479{\sim}3.162mGy$의 범위만큼 더 많은 선량 값이 계산되었고 실제 병원에서 사용하는 복부 일반 CT (abdomen routine CT) 조건에서의 환자선량을 측정한 결과 factor적용 전과 후의 유효선량 차는 최고 0.7 mSv의 차이가 남을 확인 할 수 있었다. 이러한 결과는 ionization chamber의 calibration과 촬영실 주변 온도와 압력이 환자선량의 측정과 계산에 중요한 요소임을 알 수 있다. 따라서 정확한 환자 선량 측정을 위해서는 촬영실 주변 온도와 압력뿐만 아니라 습도 및 recombination factor, x-ray beam quality 특성, 촬영조건(exposure conditions), 측정부위(scan region) 등에 대한 보정 factor들의 정확한 정보를 알아야 한다.

• 약학회지
• /
• 제28권1호
• /
• pp.21-23
• /
• 1984

High performance amino acid analyzing method has been developed for the routine analysis of taurine in preparations. Ion-exchange resin #2619 Hitachi Custom Ion-Exchange Resin, $2.6(I.D.){\times}150$(length)mm was used as column, buffer I, pH 3.3 as mobile phase. The retention time of taurine was 7 minutes. Calibration curve by peak height for standard taurine was linear from 2.5ppm to 25ppm. The reproducibility showed relative standard deviation $\pm$1.9% when analyzed 10 times for standard solution. The samples could be continuously analyzed without regenerating the resin between samples. Five samples were applied to column every 12 min. and then the resin was regenerated for 30 min. during one analyzing cycle time, 90 min. The automatic amino acid analyzer has made it possible to assay multiple samples in a relatively short period of time using the analytical magnetic program card. The high sensitivity and specificity of the analytical column of the automatic amino acid analyzer permits the routine analysis of taurine in preparations.