• The Korean Journal of Nuclear Medicine Technology
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• v.21 no.2
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• pp.55-64
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• 2017

Purpose Recently, with the spread of SPECT/CT, various image correction methods can be applied quickly and accurately, which enabled us to expect quantitative accuracy as well as image quality improvement. Among them, the Collimator Detector Response(CDR) recovery is a correction method aiming at resolution recovery by compensating the blurring effect generated from the distance between the detector and the object. The purpose of this study is to find out quantitative change depending on the change in detection distance in SPECT/CT images with CDR recovery applied. Materials and Methods In order to find out the error of acquisition count depending on the change of detection distance, we set the detection distance according to the obit type as X, Y axis radius 30cm for circular, X, Y axis radius 21cm, 10cm for non-circular and non-circular auto(=auto body contouring, ABC_spacing limit 1cm) and applied reconstruction methods by dividing them into Astonish(3D-OSEM with CDR recovery) and OSEM(w/o CDR recovery) to find out the difference in activity recovery depending on the use of CDR recovery. At this time, attenuation correction, scatter correction, and decay correction were applied to all images. For the quantitative evaluation, calibration scan(cylindrical phantom, $^{99m}TcO_4$ 123.3 MBq, water 9293 ml) was obtained for the purpose of calculating the calibration factor(CF). For the phantom scan, a 50 cc syringe was filled with 31 ml of water and a phantom image was obtained by setting $^{99m}TcO_4$ 123.3 MBq. We set the VOI(volume of interest) in the entire volume of the syringe in the phantom image to measure total counts for each condition and obtained the error of the measured value against true value set by setting CF to check the quantitative accuracy according to the correction. Results The calculated CF was 154.28 (Bq/ml/cps/ml) and the measured values against true values in each conditional image were analyzed to be circular 87.5%, non-circular 90.1%, ABC 91.3% and circular 93.6%, non-circular 93.6%, ABC 93.9% in OSEM and Astonish, respectively. The closer the detection distance, the higher the accuracy of OSEM, and Astonish showed almost similar values regardless of distance. The error was the largest in the OSEM circular(-13.5%) and the smallest in the Astonish ABC(-6.1%). Conclusion SPECT/CT images showed that when the distance compensation is made through the application of CDR recovery, the detection distance shows almost the same quantitative accuracy as the proximity detection even under the distant condition, and accurate correction is possible without being affected by the change in detection distance.

• Journal of The Korean Society of Clinical Toxicology
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• v.14 no.2
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• pp.107-114
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• 2016

Purpose: The incidence of glufosinate poisoning is gradually increasing, and it can be fatal if severe poisoning occurs. However, factors useful for predicting the post-discharge neurological prognosis of patients who have ingested glufosinate have yet to be identified. Our objective was to evaluate the utility of the acute physiology and chronic health evaluation (APACHE) II score measured in the emergency department for predicting the neurological prognosis. Methods: From April 2012 to August 2014, we conducted a retrospective study of patients who had ingested glufosinate. The outcome of the patients at discharge was defined by the Cerebral Performance Category Score (CPC). The patients were divided into a good prognosis group (CPC 1, 2) and a poor prognosis group (CPC 3, 4, 5), after which the APACHE II scores were compared. The Hosmer-Lemeshow test and the area under the receiver operating characteristic (ROC) curve from patients determined calibration and discrimination. Results: A total of 76 patients were enrolled (good prognosis group: 67 vs poor prognosis group: 9). The cut-off value for the APACHE II score was 12 and the area under the curve value was 0.891. The Hosmer and Lemeshow C statistic x2 was 7.414 (p=0.387), indicating good calibration for APACHE II. Conclusion: The APACHE II score is useful at predicting the neurological prognosis of patients who have ingested glufosinate.

• Journal of Radiation Protection and Research
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• v.23 no.4
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• pp.267-271
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• 1998

It is required to measure air density correction factor at the time of absorbed dose calibration or measurement. In general, thermometer and barometer are widely used for air density correction. However, this can be done using the radioactive check device with better accuracy. The measurements of air density correction were performed by using the radioactive check device, Unidos electrometer, and 0.6 cc Farmer-type ion chamber of PTW under the different environmental conditions. Above experiments were repeated with thermometer and barometer. By comparing the two methods, they were within the difference of 0.2 %. The overall uncertainty for the dose found in thermometer and barometer was 1.2 - 1.6 %, depending upon either one step or two, whereas the overall uncertainty for the radioactive check device was 1.02 %. This method may reduce the possible error which could occur when thermometer and barometer are not calibrated at regular basis.

• Journal of Korean Society on Water Environment
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• v.26 no.5
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• pp.841-849
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• 2010

Soil erosion is an natural phenomenon. However accelerated soil erosion has caused many environmental problems. To reduce soil loss from a watershed, many management practices have been proposed worldwide. To develop proper and efficient soil erosion best management practices, soil erosion rates should be estimated spatially and temporarily. The Universal Soil Loss Equation (USLE) and USLE-based soil erosion and sediment modelling systems have been developed and tested in many countries. The Sediment Assessment Tool for Effective Erosion Control (SATEEC) system has been developed and enhanced to provide ease-of-use interface to the USLE users. However many researchers and decision makers have requested to enhance the SATEEC system for simulation of soil erosion and sediment reflecting effects of single storm event. Thus, the SATEEC R factors were estimated based on 5 day antecedent rainfall data. The SATEEC 2.1 daily R factor was applied to the study watershed and it was found that the R2 and EI values (0.776 and 0.776 for calibration and 0.927 and 0.911 for validation) with the daily R were greater than those (0.721 and 0.720 for calibration and 0.906 and 0.881 for validation) with monthly R, which was available in the SATEEC 2.0 system. As shown in this study, the SATEEC with daily R can be used to estimate soil erosion and sediment yield at a watershed scale with higher accuracy. Thus the SATEEC with daily R can be efficiently used to develop site-specific soil erosion best management practices based on spatial and temporal analysis of soil erosion and sediment yield at a daily-time step, which was not possible with USLE-based soil erosion modeling system.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.1
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• pp.54.2-54.2
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• 2014

IGRINS (Immersion GRating Infrared Spectrograph) is a high spectral resolution near-infrared spectrograph that has been developed in a collaboration between the Korea Astronomy & Space Science Institute and the University of Texas at Austin. By using a silicon immersion echelle grating, the size of the fore optics is reduced by a factor of three times and we can make a more compact instrument. One exposure covers the whole of the H- and K-band spectrum with R=40,000. While the operation of and data reduction for this instrument is relatively simple compared to other grating spectrographs, we still need to operate three infrared arrays, cryostat sensors, calibration lamp units, and the telescope during astronomical observations. The IGRINS Instrument Control Software consists of a Housekeeping Package (HKP), Slit Camera Package (SCP), Data Taking Package (DTP), and Quick Look Package (QLP). The SCP will do auto guiding using a center finding algorithm. The DTP will take the echellogram images of the H and K bands, and the QLP will confirm fast processing of data. We will have a commissioning observations in 2014 March. In this poster, we present the performance of the software during the test observations.

• Analytical Science and Technology
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• v.26 no.2
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• pp.125-134
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• 2013

This study was demonstrated to estimate the measurement uncertainty of 23 multiple-component amino acids from beef bone extract by high performance liquid chromatography (HPLC). The sources of measurement uncertainty (i.e. sample weight, final volume, standard weight, purity, standard solution, calibration curve, recovery and repeatability) in associated with the analysis of amino acids were evaluated. The estimation of uncertainty obtained on the GUM (Guide to the expression of uncertainty in measurement) and EURACHEM document with mathematical calculation and statistical analysis. The content of total amino acids from beef bone extract was 36.18 g/100 g and the expanded uncertainty by multiplying coverage factor (k, 2.05~2.36) was 3.81 g/100 g at a 95% confidence level. The major contributors to the measurement uncertainty were identified in the order of recovery and repeatability (25.2%), sample pretreatment (24.5%), calibration-curve (24.0%) and weight of the reference material (10.4%). Therefore, more careful experiments are required in these steps to reduce uncertainties of amino acids analysis with a better personal proficiency improvement.

• Korean Journal of Pharmacognosy
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• v.46 no.2
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• pp.160-166
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• 2015

Yijung-tang (YJT) is a traditional herbal formula comprising 4 medicinal herbs. In the present study, we performed the simultaneous analysis for three compounds of YJT and examined anti-allergic effects in vitro. The column for separation of three compounds was used Gemini C18 column and maintained at 40$^{\circ}C$. The mobile phase for gradient elution consisted of two solvent systems. To evaluate Th2 chemokines, YJT was treated into tumor necrosis factor (TNF)-${\alpha}$ and interferon (IFN)-${\gamma}$-stimulated HaCaT cells, and performed ELISA for thymus and activation regulated chemokine (TARC) and regulated on activation, normal T-cell expressed and secreted (RANTES). To measure Th2 cytokines, YJT was added into primary mouse splenocytes, and performed ELISA for interleukin (IL)-4, 5, 13. Calibration curves were acquired with r² >0.9999. The contents of liquiritin, glycyrrhizin, and 6-gingerol in YJT were 4.50 mg/g, 11.10 mg/g, and 1.33 mg/g, respectively. YJT inhibited production of TARC and RANTES in TNF-${\alpha}$ and IFN-${\gamma}$-treated HaCaT cells. YJT also reduced production of IL-4, 5, and 13 in primary mouse splenocytes. In conclusion, our data will be a valuable information to improve quality control and anti-allergic effects of YJT.

• Journal of the Korean Wood Science and Technology
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• v.45 no.5
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• pp.572-579
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• 2017

Determination of the wood content in wood plastic composite (WPC) is crucial to form reliable WPC market. WPC with simple formulation consisting of only two components (wood flour and polypropylene) was examined using thermogravimetric analysis (TGA) and accelerator mass spectrometry (AMS) for determining wood content in the WPC. TGA method using derivative peak temperature (DTp) of polypropylene under low heating rate ($5^{\circ}C/min$) showed more reliable calibration curve and lower error factor compared to method of using the percentage of weight loss of wood flour. In addition, AMS using bio-based carbon content showed greater reliability for the determination of wood content in the WPC in comparison with the TGA method.

• Analytical Science and Technology
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• v.31 no.3
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• pp.107-111
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• 2018

Currently, ultraviolet-visible spectrophotometry and titration methods are used for assay tests of tramadol hydrochloride injection and raw material in the Korean Pharmacopoeia XI (KP XI). Titration has also been used in the British Pharmacopoeia (BP 2013) for the assay test of tramadol hydrochloride, and the HPLC assay for tramadol hydrochloride raw material has been used in the United States Pharmacopeia (USP 39). In this study, we developed an alternative HPLC assay method for tramadol hydrochloride injection that is up to date and specific, and employs the same method as tramadol hydrochloride capsules. Validation of the HPLC method was conducted to determine linearity, precision, accuracy, system suitability, and robustness. The linearity of the calibration curves in the desired concentration range was good ($r^2$ > 0.9999). RSDs of intra-day precision obtained were 0.05-0.08 % and inter-day precision obtained were 0.08-0.19 %. Accuracy was obtained with recoveries in the range of 98.16 % and 100.90 %. As a result of the system's suitability, the RSD of both retention time and the peak area obtained were 0.07 %. The values of the plate number and tailing factor of tramadol hydrochloride obtained were 7076 and 1.16, respectively. Because of the intermediate precision and robustness of the developed assay, it is expected to become a valuable tool for revising the Korean Pharmacopoeia (KP XI).

• Proceedings of the Korean Geotechical Society Conference
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• 2010.03a
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• pp.324-337
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• 2010

For the development of load and resistance factor design, reliability analysis is required to calibrate resistance factors in the framework of reliability theory. The distribution of measured-to-predicted pile resistance ratio was constructed based on only the results of load tests conducted to failure for the assessment of uncertainty regarding pile resistance and used in the conventional reliability analysis. In other words, successful pile load test (piles resisted twice their design loads without failure) results were discarded, and therefore, were not reflected in the reliability analysis. In this paper, a new systematic method based on Bayesian theory is used to update reliability index of driven steel pile piles by adding more pile load test results, even not conducted to failure, into the prior distribution of pile resistance ratio. Fifty seven static pile load tests performed to failure in Korea were compiled for the construction of prior distribution of pile resistance ratio. Reliability analyses were performed using the updated distribution of pile resistance ratio and the total load distribution using First-order Reliability Method (FORM). The challenge of this study is that the distribution updates of pile resistance ratio are possible using the load test results even not conducted to failure, and that Bayesian update are most effective when limited data are available for reliability analysis or resistance factors calibration.