• The Korean Journal of Food And Nutrition
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• v.21 no.3
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• pp.336-343
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• 2008

This study was conducted to investigate the effects of caffeine on lipid and mineral content in the serum of rats given a caffeine free diet(FC), a low caffeine diet(LC), a medium caffeine diet(MC), a high caffeine diet(HC) or a super-high caffeine diet(SHC) for 5 weeks. Thirty male Sprague-Dawley rats(body weight, $110{\pm}0.3$ g) were blocked into 5 groups and fed diets with or without pure caffeine. Caffeine intake models showed a lower mean-weight gain, food intake and food efficiency in the high caffeine diet groups(MC, HC and SHC groups) than the groups receiving a caffeine free or low caffeine diet(FC and LC groups). Serum total lipid, total cholesterol and LDL-cholesterol levels decreased, but the serum HDL-cholesterol level increased according to the increase in caffeine intake. Serum total lipid, HDL-cholesterol and serum triglyceride were significantly lower in the HC and SHC groups than the FC group. All of the serum minerals decreased as caffeine intake increased. Serum iron, calcium, magnesium and phosphorus significantly decreased in the HC and SHC groups compared to the FC group. Caffeine intake was associated with less weight gain and reduced serum total cholesterol, triglyceride and total lipid. The results suggest that rats fed high amounts of caffeine may be susceptible to osteoporosis due to their low levels of calcium, magnesium and phosphorus.

• Journal of Nutrition and Health
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• v.26 no.9
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• pp.1118-1128
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• 1993

This study was undertaken to investigate the acute effect of caffeine consumption on the change of mineral concentration in serum and urinary mineral excretion in healthy young females. On two separate mornings at one week intervals, each subject drank a coffee which contained no caffeine and 3mg/kg body weight caffeine. To obviate dietary effects on mineral concentration in serum and urine, each subject fasted at least ten hours before consuming the test beverage. At one, two, three and four hours, serum and urine production collected seperately for measurement of sodium, potassium, calcium, phosphorus and magnesium concentration. The results were as following : 1) Mean age of subjects was 20.6$\pm$0.32, Mean body mass index of subjects was 21.64$\pm$0.89, which was within $\pm$10% of ideal body weight. 2) Total urine volume of caffein groups for 4 hour after caffeine consumption was higher than that of decaffeine one, but urine pH was unchanged after caffeine consumption. Total urinary four hour excretion of creatinine was not affected by caffeine consumption and creatinine clearance also was not different from the control value. 3) In serum, mean three hour content of sodium(p<0.01) and phosphorus was higher in the subject given the caffeine. Mean serum magnesium and calcium contents were lower in caffeine group than that of decaffeine one. Mean serum magnesium content for three hour after caffeine ingestion was affected by caffeine consumption(p<0.001). Mean serum content of potassium was unaffected by caffeine consumption. 4) Total urinary four hour excretion of sodium, increased significantly after caffeine consumption(p<0.05), while total urinary four hour excretion of potassium, calcium, phosphorus and magnesium was unchanged after caffeine intake. Urinary excretion of Na, Ca, P and Mg was greatest at one hour after caffeine consumption, especially urinary sodium and potassium excretion was significantly high(p<0.05, p<0.01). The above results show that only 3mg caffeine per kg body weight increase the urinary macro mineral excretion in healthy young females.

• Preventive Nutrition and Food Science
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• v.19 no.4
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• pp.367-372
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• 2014

Caffeine is widely consumed and well known for stimulating the central nervous system. When developing new foods and beverages that contain caffeine, it is important to explore the potential synergistic effects of consuming amino acids and other food ingredients with caffeine on humans. Given the physiological pathways affected by the amino acid ornithine, consumption of ornithine with caffeine may have synergistic effects. The purpose of the present study was to examine the effect of consuming caffeine with ornithine in humans. The study used a randomized, placebo-controlled, double-blinded crossover design. The subjects were all healthy office workers who ingested the placebo, 100 mg caffeine, or 100 mg caffeine plus 200 mg ornithine in the morning and completed questionnaires about their mood. Office workers who consumed the combination of caffeine and ornithine had higher mood ratings 8 h after consumption than office workers who consumed caffeine alone. The results of the present study suggest that there is a unique synergistic effect between caffeine and ornithine on the mood of healthy office workers and that ornithine may potentiate the effects of caffeine.

• The Korean Journal of Food And Nutrition
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• v.17 no.4
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• pp.442-449
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• 2004

The purpose of this study was to examine the antioxidative activities and tissue cell of mouse liver added caffeine. The body weight of all experimental groups increased during experimental periods, but the body weight of caffeine-containing groups were lower than those of any other experimental groups. Superoxide dismutase and catalase activities tended to decrease significantly with caffeine-containing groups, but increased in control and ginseng-containing groups. Hydroperoxide contents were increase significantly with caffeine-containing groups. Lipid peroxidation levels decreased in ginseng-containing groups, but it increased significantly with caffeine-containing group. Protein contents were a tendency of similar between control and ginseng-containing groups, but it showed a increasing tendency in caffeine-containing groups. Microscopic observation of mouse liver cell were similar tissue in ginseng and caffeine-containing groups, but it showed somewhat more injuring only at the liver cell of anhydrous caffeine group, and became the suspicion in liver diseases. This results show that antioxidative activities are slightly higher in non-caffeine and ginseng-containing drinks than caffeine-cotaining drinks. From this standpoint, we suggest that too much drinking of caffeine-containing drinks for a long time is undesirable.

• Korean Journal of Clinical Pharmacy
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• v.22 no.2
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• pp.167-175
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• 2012

Different studies have been conducted regarding caffeine as psychostimulant drugs and its effects as well as determination in various materials. Since, coffee and tea are most drinkable beverage in the world and their major constituent is caffeine. So, analysis of the effect of equal amount of caffeine in coffee and tea with respect to SD rats was studied. The present methodology was purposed to determine and validate caffeine amount in different brands of coffee and tea, and canvass locomotor and behavioral patterns of SD rats after administrating coffee and tea orally consisting of same amount of caffeine (10, 30 mg/kg). Determination of caffeine in different brands of coffee and tea and validation of caffeine were evaluated using HPLC. Depending upon different brands of tea and coffee, caffeine amount was altered. Meanwhile, amount of caffeine in tea was directly proportional to the temperature of liquid. Coffee and tea (Instant Maxim original coffee$^{(R)}$ and earl grey black tea$^{(R)}$) consisting 10, 30 mg/kg of caffeine were studied in SD rats for locomotor activity and behavioral patterns using Tru Scan 99. The locomotor activities of SD rats were increased after administration of coffee and tea consisting caffeine compared to water. The coffee consisted of higher amount of caffeine exhibited steep movement of SD rats. Similarly, rearing and scratching of SD rats as frequency and duration were increased in coffee and tea consisting caffeine compared with water. The study revealed that coffee and tea had effects in locomotor activity and behavioral patterns of SD rats.

• Korean journal of food and cookery science
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• v.30 no.5
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• pp.650-662
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• 2014

This study was conducted to identify middle school students' caffeine intake from their favorite foods containing caffeine as well as several factors related to their intake. The objects of the investigation were 369 middle school students in the urban area of Changwon-si and 358 middle school students in the rural area of Haman-gun. The average height was 162.3cm, average weight was 52.3 kg and average BMI was 19.8. The food habit score was generally positive at an average of 3.37. The food habit scores of rural area students were higher than those of urban area students (p<.05). The average stress score was somewhat low at 2.82. The stress index for rural students was lower than that of urban students (p<.01). The recognition of caffeine in favorite foods was 8.12 out of a 12 point scale. The average nutritional knowledge score regarding caffeine was very low at 3.08 out of a 10 point scale. The main reason for selecting favorite foods was 'taste'. The percentage of students who don't check food labels was 49.1%. 'House' was the main location while 'good taste' was the biggest reason for eating caffeine-containing foods. The main side effect of caffeine intake was 'nausea'. The average daily caffeine intake for all subjects was 26.96 mg, with the urban students averaging 27.90 mg and the rural students averaging 25.99 mg. The correlations between several factors and caffeine intake were examined. Food habit showed a negative correlation with stress score and caffeine intake. Nutritional knowledge and recognition of caffeine had positive correlations with caffeine intake. Hence nutritional education about caffeine should be emphasized to improve students' healthy food habits.

• Journal of the Korean Home Economics Association
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• v.12 no.34
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• pp.737-741
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• 1974

Coffee is a popular beverage with many people at home and in the tea-room, Caffeine is a major chemical compound of the coffee. A little caffeine is a stimulant to the movement and spiritual nerve, but much caffeine influences sleep, nervousness, non-concentration, headache and giddliness depending upon each person. The writhe expresses the result of the caffeine content in the coffee which is collected from the coffee-shapes of Seoul. The contents are as follows : 1) Caffeine content of the coffee of the tea-room was researched dividing into the contral Seoul city and the outskirts of Seoul. 2) Caffeine content of the coffee in the outskirts tea-rooms is 0.32-1.23 mg/ml and the average is 0.546 mg/ml (SD 0.19). 3) Caffeine content of the coffee of the central city is 0.34-0.73 mg/ml and the average is 0.513 mg/ml (SD 0.12). 4) There was no difference between the outskirts and the central city. 5) Caffeine content of the coffee of the tea-rooms according to each season is going to be researched.

• Journal of Nutrition and Health
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• v.43 no.5
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• pp.475-488
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• 2010

The daily caffeine intake from elementary school children's favorite foods was surveyed and evaluated. Children may respond to caffeine differently from adults because they have different physiological makeup and are functionally immature. Therefore, caffeine exposure may have more serious consequences for children than for adults, irrespective of sensitivity. Their preference, perception, and intake of caffeine from children's favorite foods were investigated by questionnaire for 355 children. The order of children's preference over foods containing caffeine was ice cream and ices, confectionary, milk and milk products, and soft beverage. The daily caffeine intake of children was estimated to range from 0.16 to 917.28 mg/day, with an average of $36.04\;{\pm}\;82.7$ mg/day and $36.9\;{\pm}\;96.0$ mg/day for boys and girls, respectively. The daily caffeine intake according to body weight was $1.08\;{\pm}\;2.23$ mg/kg and $1.12\;{\pm}\;2.66$ mg/kg for boys and girls, respectively. The percentage of acceptable daily intake (ADI) of caffeine was 43.4% for boys and 44.9% for girls. The sources of caffeine for boys and girls were soft beverage (18.3 mg and 16.1 mg), milk and milk products (8.9 mg and 8.5 mg), ice cream and ices (5.7 mg and 7.3 mg), chocolate (1.6 mg and 3.2 mg), and confectionery (1.6 mg and 1.8 mg).

• Journal of Nutrition and Health
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• v.30 no.10
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• pp.1160-1169
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• 1997

The purpose of this research was to investigate the effects of caffeine and calcium levels on calcium utilization in female rats of different ages. Calcium utilization was compared in female rats of different age( 4 weeks and 12 months) fed various levels of caffeine(0 and 7 mg/100g body weight) and calcium (50, 100 and 200% of requirement) for 3 weeks. Feed intake of the caffeine groups were lower than that of the no-caffeine groups. body weight gain was lowest in the high-caffeine and low-calcium group. Serum calcium levels of young rats were higher than those of adult rats. There were no significant differences in tibial calcium content among the caffeine and calcium -groups. Fecal calcium excretion increased as the level of dietary calcium was increased. Urinary calcium excretion increased as the levels of caffeine and dietary calcium were increased. With increasing levels of dietary calcium , daily calcium retention was accelerated, but apparent calcium absorbability was diminished. The results of this study suggest that caffeine consumption promotes urinary calcium excretion. However, increase in dietary calcium resulted in higher calcium retention . These findings indicate that high caffeine consumption may increase dietary calcium requirements. Therefore, it could be suggested that the supplementation of dietary calcium may counteract the negative effect of caffeine intake on calcium utilization.

• Journal of Environmental Science International
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• v.27 no.12
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• pp.1205-1214
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• 2018

During the past few decades, significant increase in the consumption of coffee has led to rapid increase in the production of coffee waste in South Korea. Spent coffee waste is often treated as a general waste and is directly disposed without the necessary treatment. Spent Coffee Grounds (SCGs) can release several organic contaminants, including caffeine. In this study, leaching tests were conducted for SCGs and oxidative degradation of caffeine were also conducted. The tested SCGs contained approximately 4.4 mg caffeine per gram of coffee waste. Results from the leaching tests show that approximately 90% of the caffeine can be extracted at each step during sequential extraction. Advanced oxidation methods for the degradation of caffeine, such as $UV/H_2O_2$, photo-Fenton reaction, and $UV/O_3$, were tested. UV radiation has a limited effect on the degradation of caffeine. In particular, UV-A and UV-B radiations present in sunlight cause marginal degradation, thereby indicating that natural degradation of caffeine is minimal. However, $O_3$ can cause rapid degradation of caffeine, and the values of pseudo-first order rate constants were found to be ranging from $0.817min^{-1}$ to $1.506min^{-1}$ when the ozone generation rate was $37.1g/m^3$. Additionally, the degradation rate of caffeine is dependent on the wavelength of irradiation.