• YAKHAK HOEJI
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• v.56 no.6
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• pp.377-381
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• 2012

The histidine-rich $Ca^{2+}$ binding protein (HRC) is a $Ca^{2+}$ binding protein in the sarcoplasmic reticulum (SR). In this study, we examined whether the HRC is involved in the regulation of cardiac contraction and $Ca^{2+}$ signaling using HRC knock-out (KO) mouse ventricular myocytes. In field-stimulated single mouse ventricular myocytes, cell shortenings and $Ca^{2+}$ transients were measured using a video edge detection and a confocal $Ca^{2+}$ imaging, respectively. Compared with the wide-type (WT) myocytes, the magnitudes of cell shortenings were significantly larger in HRC KO cells (P<0.01, WT vs. KO). The rate of contraction and relaxation was significantly accelerated in HRC KO myocytes (P<0.05 and P<0.01, respectively, WT vs. KO). The magnitudes of $Ca^{2+}$ transients were increased by HRC KO (P<0.01, WT vs. KO). In addition, the decay of the $Ca^{2+}$ transient was faster in HRC KO cells than in wild-type cells P<0.01, WT vs. KO). These results suggest that HRC may suppress SR $Ca^{2+}$ releases and decay of $Ca^{2+}$ transients during action potentials, thereby attenuating ventricular contraction and relaxation.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.4
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• pp.362-368
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• 2005

The pH, alkalinity and calcium hardness could be adjusted by $CO_2$, $Ca(OH)_2$, and $Na_2CO_3$ addition in the water treatment process for corrosion protection of the water pipes. This research was performed to investigate the effect on the variation of water quality on the unit process by addition $CO_2$, $Ca(OH)_2$, and $Na_2CO_3$ in water treatment process. Carbon dioxide and lime were added before the coagulation basin and soda ash was added after the BAC process. pH and aklainity were increased at coagulation basin then after the water qualities had sustained similiarly to BAC process. There was no effect on turbidity and DOC removal efficiency during experimental period by addition\ $CO_2$, $Ca(OH)_2$, and $Na_2CO_3$ solution was added into clear well, the last process for optimum control of CCPP and is used mainly to control pH and alkalinity. In this research, average pH, alkalinity, and calcium hardness in treated water were 8.39, 61.4 mg/L as $CaCO_3$, 59.4 mg/L as $CaCO_3$, respectively and CCPP of treated water was higher than 29.5 mg/L to BAC process water, so adjusted water was expected to prevent internal corrosion of water pipe.

• Korean Journal of Food Science and Technology
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• v.27 no.3
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• pp.318-323
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• 1995

To improve wastewater treatment in a confectionery factory and to optimize chemical coagulation process, this study was performed. $COD_{Mn}$ and total solid of untreated wastewater were $200{\sim}820ppm\;and\;860{\sim}1350ppm$, respectively. Composition of total solid was sugar 40%, protein 10%, hexane-soluble 20%, and ash 30%. Turbidity at 650 nm and the amount of suspended solid (SS) showed correlation, thus turbidity could be used for the on-line measurement of SS. The most effective combination of coagulants for the removal of $COD_{Mn}$ and SS was that of $Al_2(SO_4)_3\;and\;Ca(OH)_2$. The optimal concentration of $Al_2(SO_4)_3\;and\;Ca(OH)_2$ was 480 ppm and 200 ppm, respectively. Optimal retention time of wastewater for $Al_2(SO_4)_3$ addition $Ca(OH)_2$ addition : flocculation was 2 : 2 : 10 min. Multiple treatment of $Al_2(SO_4)_3:Ca(OH)_2$ overcame coagulation inhibition by gelatin and detergent, and addition of microbial sludge reduced it.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.1
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• pp.179-184
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• 2020

Cellular automata (CA), which is known as a pseudo random number generator due to its excellent randomness, has various applications. Cho et al. designed a CA-based shrinking generator to generate a long period of nonlinear sequence. In addition, chaotic cat maps have been studied by many researchers as the complex nonlinear dynamics systems with sensitivity in initial conditions and unpredictable characteristics. In this paper, we propose a new image encryption method using nonlinear sequence generated by CA-based shrinking generator with maximum period and 3D chaotic cat map for high security.

• The Journal of Korean Physical Therapy
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• v.27 no.5
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• pp.292-298
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• 2015

Purpose: The purpose of this study was to examine the effects of dual tasks on balance and postural control during standing in patients with cerebellar ataxia (CA). It was hypothesized that CA patients would exhibit different sway characteristics of the center of mass (COM) depending on the complexity of the secondary cognitive tasks compared with normal control subjects. Methods: A total of 8 patients with CA and age-matched healthy control subjects participated in this study. They were instructed to perform two balance tasks (non-dual and dual movement) with 3 different complexity of dual tasks. Range, variability, and velocity of COMs were measured. Results: According to the results CA patients showed deficits in balance and postural control with increased dual-task complexity during the static balance task in saggital sway movements. However, there was no significant difference in static balance in frontal sway. With higher difficulty in the cognitive task, CA patients took longer to stabilize their body center, while normal control subjects showed no change between conditions. In addition, CA patients had a greater COM resultant velocity during recovery in the dual-task condition compared with the single-task condition. These findings indicate that CA patients had defendable compensatory strategies in performing dual tasks. Conclusion: In conclusion, CA patients appeared to manage the priority to balance and postural control. Particularly in a situation with a postural threat such as when potential consequences of the loss of stability increase, they appeared to prioritize the control of balance and posture over the performance of the secondary task.

• YAKHAK HOEJI
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• v.38 no.1
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• pp.57-66
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• 1994

We studied the effect of eicosanoids on the content of energy metabolites and the intrasynaptosomal $Ca^{++}([Ca^{++}]_i)$ concentration in cerebral ischemic rats. An ischemic model was made by bilateral carotid artery ligation (BCAL) and by incubation of synaptosomes under aglycemic and $N_2$ gas bubbling condition. The content of ATP, creatine phosphate and glucose decreased at 15 minutes after BCAL while that of lactate increased in male Wistar rats. Oral administration of EPA(100 mg/ml/Kg/day) or DHA(16 mg/ml/Kg/day) for 6 weeks improved both the decreases and the increase of the cerebral energy metabolites. In addition, the increase of $[Ca^{++}]_i$, under BACL was suppressed by EPA or DHA treatment. When the both Wistar rats and SHR were administered orally with EPA or DHA for 6 weeks, the effect on the increase of $[Ca^{++}]_i$ under ischemia by $N_2$ gas bubbling were protected. From these results, it may be that EPA or DHA treatment were greatly contributed to preservation of ischemic cerebral energy metabolism and $Ca^{++}$ concentration.

• Journal of the Korean Ceramic Society
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• v.29 no.4
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• pp.65-65
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• 1992

Role of CaO in the sintering of 12Ce-TZP ceramics was studied. The addition of small amounts of CaO increase the densification rate of 12Ce-TZP by altering lattice defect structure and the diffusion coefficient of the rate controlling species, namely cerium and zirconium cations. CaO also inhibits grain growth during sintering and allows the sintering process to proceed to theoretical density by maintaining a high diffusion flux of vacancies from the pores to the grain boundaries. The inhibition of grain growth is accomplished by the segregation of solute at the grain boundaries, causing a decrease in the grain boundary mobility. The segregation of calcium was revealed by AES study.

• Korean Journal of Environmental Biology
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• v.21 no.3
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• pp.303-307
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• 2003

Tributyltin (TBT) used world-wide in antifouling paints toy ships is a wide-spread environmental pollutant. At low doses, antiproliferative modes of action have been shown to be involved, whereas at higher doses apoptosis seems to be the mechanism of toxicity in reproductive organs by TBT. In this study, we investigated that the mechanisms underlying apoptosis induced by TBT in R2C cell. Effects of TBT on intracellular $Ca^{2+}$ level and reactive oxygen species (ROS) were investigated in R2C cells by fluorescence detector. TBT significantly induced intracellular $Ca^{2+}$ level in a time-dependent manner. The rise in intracellular $Ca^{2+}$ level was followed by a time-dependent generation of reactive oxygen species (ROS) at the cytosol level. Simultaneously, TBT induced the release of cytochrome c from the mitochondrial membrane into the cytosol. Furthermore, ROS production and the release of cytochrome c were reduced by BAPTA, an intracellular $Ca^{2+}$ chelator, indicating the important role of $Ca^{2+}$ in R2C during these early intracellular events. In addition, Z-DEVD FMB, a caspase -3 inhibitor, decreased apoptosis by TBT. Taken together, the present results indicated that the apoptotic pathway by TBT might start with an increase in intracellular $Ca^{2+}$ level, continues with release of ROS and cytochrome c from mitochondria, activation of caspases, and finally results in DNA fragmentation.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.1
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• pp.51-57
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• 2010

It was hypothesized that NaF induces calcium sensitization in $Ca^{2+}$-controlled solution in permeabilized rat mesenteric arteries. Rat mesenteric arteries were permeabilized with $\beta$-escin and subjected to tension measurement. NaF potentiated the concentration-response curves to $Ca^{2+}$ (decreased $EC_{50}$ and increased $E_{max}$). Cumulative addition of NaF (4.0, 8.0 and 16 mM) also increased vascular tension in $Ca^{2+}$-controlled solution at pCa 7.0 or pCa 6.5, but not at pCa 8.0. NaF-induced vasocontraction and $GTP{\gamma}S$-induced vasocontraction were not additive. NaF-induced vasocontraction at pCa 7.0 was inhibited by pretreatment with Rho kinase inhibitors H1152 or Y27632 but not with a MLCK inhibitor ML-7 or a PKC inhibitor Ro31-8220. NaF induces calcium sensitization in a $Ca^{2+}$ dependent manner in $\beta$-escin-permeabilized rat mesenteric arteries. These results suggest that NaF is an activator of the Rho kinase signaling pathway during vascular contraction.

• Journal of the Korean Society for Heat Treatment
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• v.29 no.4
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• pp.168-175
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• 2016

Influence of trace amount of Ca addition on the corrosion resistance was comparatively investigated in solutionized Mg-4%Zn and Mg-4%Zn-0.1%Ca alloys. In as-cast state, the alloys were characterized by primary ${\alpha}-(Mg)$ dendrite with MgZn intermetallic compound particles. After solution-treatment, both alloys consisted of single ${\alpha}-(Mg)$ phase by dissolution of the compound particles into the matrix. It was found from the immersion and electrochemical corrosion tests that the Mg-4%Zn alloy had better corrosion resistance than the Mg-4%Zn-0.1%Ca alloy. Morphological and compositional analyses on the surface corrosion products indicate that the incorporation of Ca oxide with low PBR value into the surface corrosion products would be responsible for the decreased corrosion resistance of the Ca-containing alloy.