• IMMUNE NETWORK
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• 제13권5호
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• pp.194-198
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• 2013

Recent papers have shown that the initial event in the pathogenesis of autoimmune type 1 diabetes (T1D) comprises sensing of molecular patterns released from apoptotic ${\beta}$-cells by innate immune receptors such as toll-like receptor (TLR). We have reported that apoptotic ${\beta}$-cells undergoing secondary necrosis called 'late apoptotic' ${\beta}$-cells stimulate dendritic cells (DCs) and induce diabetogenic T cell priming through TLR2. The role of other innate immune receptors such as TLR7 or TLR9 in the initiation of T1D has also been suggested. We hypothesized that TLR2 blockade could inhibit T1D at the initial step of T1D. Indeed, when a TLR2 agonist, $Pam3CSK_4$ was administered chronically, the development of T1D in nonobese diabetic (NOD) mice was inhibited. Diabetogenic T cell priming by DCs was attenuated by chronic treatment with $Pam3CSK_4$, indicating DC tolerance. For the treatment of established T1D, immune tolerance alone is not enough because ${\beta}$-cell mass is critically reduced. We employed TLR2 tolerance in conjunction with islet transplantation, which led to reversal of newly established T1D. Dipeptidyl peptidase 4 (DPP4) inhibitors are a new class of anti-diabetic agents that have beneficial effects on ${\beta}$-cells. We investigated whether a combination of DPP4 inhibition and TLR2 tolerization could reverse newly established T1D without islet transplantation. We could achieve normoglycemia by TLR2 tolerization in combination with DPP4 inhibition but not by TLR2 tolerization or DPP4 inhibition alone. ${\beta}$-cell mass was significantly increased by combined treatment with TLR2 tolerization and DPP4 inhibition. These results suggest the possibility that a novel strategy of TLR tolerization will be available for the inhibition or treatment of established T1D when combined with measures increasing critically reduced ${\beta}$-cell mass of T1D patients such as DPP4 inhibition or stem cell technology.

• 한국전자통신학회논문지
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• 제10권5호
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• pp.565-570
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• 2015

확산 스펙트럼 통신은 낮은 도청확률과 작은 잡음 채널의 영향 때문에 많은 시스템에서 사용이 증가하고 있다. 기존의 디지털 확산 스펙트럼 시스템의 한계 중 하나는 동기 코드 확산에 대한 필요성이다. 카오스 통신 시스템은 동기 없이 구현 할 수 있고 보안성도 우수하며 간단한 송수신기 구조로 디지털 확산 스펙트럼 통신에 많이 사용하고 있다. 본 논문에서는 카오스 신호를 디지털 통신시스템에 사용하기 위해 디지털 변복조의 반송파 대신 사용하였으며 여러 가지의 카오스 변조 방식들 중에서 차동 CSK(Differential Chaos Shift Keying) 사용한다. DCSK 복조기는 카오스 신호 위상을 복구 할 필요 없이 데이터를 감지하기 때문에 효율적이다. 또한 Matlab/Simulink를 이용하여 DCSK 변조기 및 복조기의 설계하고 성능을 분석하고 송신신호의 수신 신호를 비교하여 송수신 신호가 같은 것을 확인하고 확산 인자에 따른 BER의 성능을 평가한다.

• 한국해양학회지
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• 제9권1_2호
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• pp.10-18
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• 1974

The cold water mass around the southeast coast of the Korean Peninsula is analyzed by using CSK data from 1966 through 1970. It is shown that this water mass flows down from the region offshore of Jukbyun to the area of Youngil Bay along the 100meter contour line of bottom topography. In ordinary summer conditions when the current velocity in the Korea Strait is usually above about 50cm/sec and the wind direction is southwest, the cold water ascends to the surface and makes the surface temperature gradient large, unless disturbed by a tropical cyclon. The bottom water of the Korea Strait is formed by the stratification after the Tsushima intermediate water and the Japan Sea intermediate water have been mixed. In winter the Tsushima intermediate water with high salinity sinks rapidly around the inlet of the Japan Sea and prevents the Japan Sea intemediate water from entering the Korea Strait.

• 한국해양학회지
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• 제8권1호
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• pp.4-8
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• 1973

Recent dynamic computations of zonal flow and analysis of oceanographic data of CSK in winter indicate year-to year variations in the location and dynmic structure of the Subtropic Countercurrent in the western North Pacific. In January 1966, the Subtropical Countercurrent migrated southward to 21$^{\circ}$- 22$^{\circ}$N Lat in association with the subsurface Subtropical Convergence. At the area of 25$^{\circ}$- 26$^{\circ}$N Lat, another surface thermal front was formed along which a stronger eastward flow of approximately 0.4kt is seen. On the section of 142$^{\circ}$E Long in January 1967, eastward flow appears at every interval of 2$^{\circ}$latitude in the northern waters of 20$^{\circ}$N Lat.

• Clinical and Experimental Pediatrics
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• 제52권6호
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• pp.667-673
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• 2009

목 적 : TLR2는 숙주의 항결핵 방어면역의 중요한 역할을 하는 것으로 알려져 있다. 본 연구는 BCG 접종 후 발생한 화농성 림프절염 환자 단핵구에서 TLR2의 발현과 TLR2 리간드 자극에 의한 $TNF-{\alpha}$와 IL-6의 생성을 조사하여 화농성 림프절염 발병과 TLR2의 연관성을 알아보고자 하였다. 방 법 : BCG 접종 후 발생한 화농성 림프절염 환자 16명과 건강 대조군 10명의 말초 혈액에서 단핵구를 분리하고, TLR2 리간드인 Pam3CSK4로 자극한 후 유세포분석과 역전사중합효소반응을 이용하여 TLR2의 발현을 측정하였고, 자극 후 $TNF-{\alpha}$와 IL-6의 생성을 측정하여 TLR2의 발현 정도를 간접적으로 조사하였다. 결 과 : BCG 접종 후 발생한 화농성 림프절염 환자 단핵구의 TLR2 발현 정도($3.39{\pm}1.2%$)는 대조군($4.64{\pm}2.6%$)에 비하여 유의하게 감소하였고, 단핵구 자극에 의한 $TNF-{\alpha}$와 IL-6의 생성도 대조군($TNF-{\alpha}$, $1,098.5{\pm}94.3pg/mL$; IL-6, $6,696.3{\pm}544.3pg/mL$)에 비하여 환자군($TNF-{\alpha}$, $775.5{\pm}60.8pg/mL$; IL-6, $4,645.8{\pm}583.9pg/mL$)에서 유의하게 감소하였다. 그리고 자극 시간에 따른 TLR2 발현 정도와 $TNF-{\alpha}$와 IL-6의 생성 증가가 유사한 양상을 나타내었다. 결 론 : 본 연구의 결과에서 BCG 접종 후 발생한 화농성 림프절염 환자군 단핵구의 TLR2 발현 감소가 연관되어 있고, M. bovis BCG의 리간드 인식에 TLR2가 관여함을 추정할 수 있다.

• The Korean Journal of Physiology and Pharmacology
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• 제19권4호
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• pp.365-372
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• 2015

Aripiprazole (ARI) is a commonly prescribed medication used to treat schizophrenia and bipolar disorder. To date, there have been no studies regarding the molecular pathological and immunotoxicological profiling of aripiprazole. Thus, in the present study, we prepared two different formulas of aripiprazole [Free base crystal of aripiprazole (ARPGCB) and cocrystal of aripiprazole (GCB3004)], and explored their effects on the patterns of survival and apoptosis-regulatory proteins under acute toxicity and cytotoxicity test conditions. Furthermore, we also evaluated the modulatory activity of the different formulations on the immunological responses in macrophages primed by various stimulators such as lipopolysaccharide (LPS), pam3CSK, and poly(I:C) via toll-like receptor 4 (TLR4), TLR2, and TLR3 pathways, respectively. In liver, both ARPGCB and GCB3004 produced similar toxicity profiles. In particular, these two formulas exhibited similar phospho-protein profiling of p65/nuclear factor $(NF)-{\kappa}B$, c-Jun/activator protein (AP)-1, ERK, JNK, p38, caspase 3, and bcl-2 in brain. In contrast, the patterns of these phospho-proteins were variable in other tissues. Moreover, these two formulas did not exhibit any cytotoxicity in C6 glioma cells. Finally, the two formulations at available in vivo concentrations did not block nitric oxide (NO) production from activated macrophage-like RAW264.7 cells stimulated with LPS, pam3CSK, or poly(I:C), nor did they alter the morphological changes of the activated macrophages. Taken together, our present work, as a comparative study of two different formulas of aripiprazole, suggests that these two formulas can be used to achieve similar functional activation of brain proteins related to cell survival and apoptosis and immunotoxicological activities of macrophages.

• 한국위성정보통신학회논문지
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• 제10권1호
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• pp.62-66
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• 2015

본 논문은 디지털 사이니지의 다양한 콘텐츠 유형과 활용범위에 대하여 소개하고 송수신 거리를 늘리기 위하여 기존의 통신 방식을 분석하였다. 디지털 사이니지를 장거리에서 구현하기 위하여 기존의 모듈레이션 기법들을 결합한 하이브리드 모듈레이션 기법을 제안하고 성능을 분석하였다. 그리고 실제 채널에서의 성능을 검증하기 위해 USRP 장비를 이용하여 심벌을 매핑하고 가시광 통신 송수신 모듈로 데이터를 송수신하는 실험을 수행하였다. 기존의 QAM 방식을 이용한 데이터 수신거리와 송수신 파워를 실험을 통하여 확인하였다. 제안된 하이브리드 모듈레이션 기법을 이용한 데이터 수신거리와 송수신 파워가 기존 QAM 방식보다 뛰어남을 보였다.

• Journal of the korean society of oceanography
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• 제35권4호
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• pp.161-169
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• 2000

A seasonal circulation in the East China Sea and the Yellow Sea and its possible cause have been studied with CSK data during 1965-1989. Water mass distributions are clear in winter, but not in summer because the upper layer waters are quite influenced by atmosphere. To solve the problem, a water mass analysis by mixing ratio is used for the lower layer waters. The results show that the distribution of Tsushima Warm Current Water expands to the Yellow Sea in winter and retreats to the East China Sea in summer. It means that there is a very slow seasonal circulation between the East China Sea and the Yellow Sea: Tsushima Warm Current Water flows into the Yellow Sea in winter and coastal water flows out of the Yellow Sea in summer. By the circulation, the front between Tsushima Warm Current Water and coastal water moves toward the shelf break in summer so that the flow is faster in the deeper region. The process eventually makes the transport in the Korea Strait increase. The Kuroshio does not seem to influence the process. A possible mechanism of the process is the seasonal change of sea surface slope due to different local effects of surface heating and diluting between the East China Sea and the Yellow Sea.

• 대한원격탐사학회지
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• 제37권1호
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• pp.57-67
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• 2021

An earthquake occurred on 17 November 2017 in Pohang, South Korea with a strength of 5.4 Mw. This is the second strongest earthquake recorded by local authorities since the equipment was first installed. In order to improve understanding of earthquakes and surface deformation, many studies have been conducted according to these phenomena. In this research, we will estimate the surface deformation using the Okada model equation. The SAR images of three satellites with different wavelengths (ALOS-2, Cosmo SkyMed and Sentinel-1) were used to produce the interferogram pairs. The interferogram is used as a reference for surface deformation changes by using Okada to determine the source of surface deformation that occurs during an earthquake. The Non-linear optimization (Levemberg-Marquadrt algorithm) and Monte Carlo restart was applied to optimize the fault parameter on modeling process. Based on the modeling results of each satellite data, the fault geometry is ~6 km length, ~2 km width and ~5 km depth. The root mean square error values in the surface deformation model results for Sentinel, CSK and ALOS are 0.37 cm, 0.79 cm and 1.47 cm, respectively. Furthermore, the results of this modeling can be used as learning material in understanding about seismic activity to minimize the impacts that arise in the future.

• Journal of Microbiology and Biotechnology
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• 제20권12호
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• pp.1724-1734
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• 2010

A phosphate-solubilizing bacterial strain isolated from Hippophae rhamnoides rhizosphere was identified as Rahnella sp. based on its phenotypic features and 16S rRNA gene sequence. The bacterial strain showed the growth characteristics of a cold-adapted psychrotroph, with the multiple plant growth-promoting traits of inorganic and organic phosphate solubilization, 1-aminocyclopropane-1-carboxylate-deaminase activity, ammonia generation, and siderophore production. The strain also produced indole-3-acetic acid, indole-3-acetaldehyde, indole-3-acetamide, indole-3-acetonitrile, indole-3-lactic acid, and indole-3-pyruvic acid in tryptophan-supplemented nutrient broth. Gluconic, citric and isocitric acids were the major organic acids detected during tricalcium phosphate solubilization. A rifampicin-resistant mutant of the strain exhibited high rhizosphere competence without disturbance to the resident microbial populations in pea rhizosphere. Seed bacterization with a charcoal-based inoculum significantly increased growth in barley, chickpea, pea, and maize under the controlled environment. Microplot testing of the inoculum at two different locations in pea also showed significant increase in growth and yield. The attributes of cold-tolerance, high rhizosphere competence, and broad-spectrum plant growth-promoting activity exhibited the potential of Rahnella sp. BIHB 783 for increasing agriculture productivity.