• 동의생리병리학회지
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• 제20권5호
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• pp.1311-1314
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• 2006

This study was peformed to investigate possible mechanisms underlying possible effect of Coicis Semen composition (CSC) on inflammatory diseases using in vivo model of RA in the mice. Results are summarized as follows. In production of inflammatory cytokines, INF-${\gamma}$ in the spleen and IL-6 in the serum were decreased by CSC treatment. TNF-${\alpha}$ in serum was significantly decreased, IL-4 in the spleen was significantly increased by CSC treatment. In production of rheumatoid factors, IgM and IgG were significantly decreased by CSC treatment. The present data suggest that CSC treatment can improve pathological damage by CIA. So we expect that CSC should be used as a effective drugs for not only rheumatoid arthritis but also another autoimmune disease. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.

• 한국건설순환자원학회논문집
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• 제10권4호
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• pp.402-410
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• 2022

본 연구에서는 초고성능 강섬유 보강 콘크리트(UHPC)의 재료특성을 고려하기 위해 해석프로그램 LS-DYNA에 있는 CSC모델의 입력상수값 보정기법을 제안하였다. 1축 압축, 3축 압축, 압력-체적 변형률 곡선, 동적증가계수 등 이전 재료단위 실험 연구결과를 기반으로 입력상수값 보정을 수행하였다. 단일요소 해석결과를 실험결과와 비교하여 보정기법의 검증을 수행하였다. 또한, 유한요소모델을 구축하고 충격 및 폭발해석을 수행하여 UHPC 구조물 해석 수행 시 보정된 CSC 모델의 적용 가능성을 확인해보았다.

• 약학회지
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• 제55권3호
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• pp.251-259
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• 2011

Cigarette smoke condensate (CSC) is known to be carcinogenic compound. CSC contains many organic compounds such as polycyclic aromatic hydrocarbons (PAHs), and heterocyclic amine compounds (HCAs). Reactive oxygen species (ROS) are also generated and induce oxidative DNA damage during the metabolism of CSC. The rat microsome mediated and DNA repair enzyme treated comet assays together with conventional comet assay were performed to evaluate the mechanisms of CSC genotoxicity. The organic extract of CSC induced oxidative and microsome mediated DNA damage. Vitamin C as a model antioxidant reduced DNA damage in endonuclease III treated comet assay. One of flavonoid, galangin as a CYP1A1 inhibitor, reduced DNA damage in the presence of S-9 mixture. The ethanol extracts of the mixed vegetables (BV) or the mixed fruits (BF) showed potent inhibitory effects against CSC induced DNA damage with oxidative DNA lesions and in the prescence of S-9 mixture. These results indicate that BV and BF could prevent CSC-induced cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 in mammalian cells.

• 정보처리학회논문지D
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• 제13D권3호
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• pp.405-414
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• 2006

최근 기업의 경영환경은 매우 급격히 변화하고 있으며, 시장으로부터 지속적으로 고객가치 향상에 대한 압력을 받고 있다. 따라서 기업들은 고객 가치향상을 위해 시장 환경에 맞는 다양한 전략적, 전술적 경영합리화 방안을 마련하여 추진하고 있다. 또한 IT 기술의 급속한 발전으로 IT의 생활화가 빠른 속도록 우리 생활에 접목되면서 CSC(Consolidated Service Center)의 기능과 역할에 혁신적인 변화가 일어나고 있다. 인적, 물리적인 판매조직 및 기능이 점차 축소되고 CSC 기능의 급속한 팽창과 함께 CSC 업무가 각광을 받으면서 기업의 핵심영역으로 부상하고 있다. 이중에서도 전략적 중요도가 상대적으로 낮은 사업부분에 대해 효율적인 프로세스 구축, 비 부과 업무의 제거, 분산된 프로세스와 조직의 통합, 의사결정을 위한 분석 업무의 강화 등 업무처리비용 절감과 업무향상을 위해 ITSM서비스를 도입하거나 도입을 고려하는 기업들이 늘어나고 있는 추세이다. 보다 효율적인 비즈니스 프로세스를 관리하고, 빠르게 변화하는 업무를 비즈니스 프로세스 모델링하고 그에 필요한 응용프로그램의 개발이 필요하다. 따라서 본 논문에서는 기존의 BPM(Business Process Model)에 ITIL Process를 적용하여 확장된 CSC를 제안하였으며, 동적 비즈니스 프로세스의 변화를 효율적으로 관리하기 위해 ITIL 모델링 도구인 ITSM(IT Service Management)로 구현하였다.

• Steel and Composite Structures
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• 제28권4호
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• pp.483-494
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• 2018

In this research the effect of high strength concrete (HSC) on shear capability of the channel shear connectors (CSC) in the steel concrete composite floor system was estimated experimentally and analytically. The push-out test was carried out for assessing the accurateness of the proposed model (nonlinear and finite element model) for the test specimens. A parametric analysis was conducted for predicting the shear capacity of the connectors (CSC) in the HSC. Eight push-out specimens of different sizes with different strength levels were tested under the monotonic loading system. The aim of this study was to evaluate the efficacy of the National Building Code of Canada (NBC) of Canada for analysing the loading abilities of the CSC in the HSC. Using the experimental tests results and verifying the finite element results with them, it was then confirmed by the extended parametric studies that the Canadian Design Code was less efficient for predicting the capacity of the CSC in the HSC. Hence, an alternative equation was formulated for predicting the shear capacity of these connectors during the inclusion of HSC for designing the codes.

• Journal of Veterinary Science
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• 제23권6호
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• pp.89.1-89.7
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• 2022

It is challenging to diagnose metastatic tumors whose cellular morphology is different from the primary. We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical analyses for critical diagnostic and cancer stem cell (CSC) markers. To generate a tumor xenograft model, we subsequently transplanted the tissue pieces from the PAC into athymic nude mice. Immunohistochemical examination was performed for diagnostic (TTF-1, Napsin A, and SP-A) and CSC markers (CD44 and CD133). The use of CSC markers together with diagnostic markers can improve the detection and diagnosis of canine primary and metastatic adenocarcinomas.

• 산업경영시스템학회지
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• 제36권3호
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• pp.8-16
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• 2013

Determining relative importance among many quality attributes under financial constraints is an important task. The weighted value of an attribute particularly in QFD, will influence on engineering characteristics and this will eventually influence the whole manufacturing process such as parts deployment, process planning, and production planning. Several scholars have suggested weighting formulas using CSC (Customer Satisfaction Coefficient) in the Kano model. However, previous research shows that the validity of the CSC approaches has not been proved systematically. The aim of the present study is to address drawbacks of CSC and to develop APC (Average Potential Coefficient), a new approach for weighting of quality attributes. For this, the current study investigated 33 quality attributes of e-learning and conducted a survey of 375 university students for the results of APC, the Kano model, and the direct importance of the quality attributes. The results show that the proposed APC is better than other approaches based on the correlation analysis with the results of direct importance. An analysis of e-leaning's quality perceptions using the Kano model and suggestions for improving e-learning's service quality are also included in this study.

• 한국의류산업학회지
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• 제18권1호
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• pp.103-112
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• 2016

This research was designed to figure out the perception and attitude of university students toward urban outdoor wear and to provide the guidelines for product quality improvement using Kano model. A total of 270 responses were analyzed by SPSS 20.0 through frequency and factor analysis. Respondents' levels for outdoor activity & outdoor products possession being still low, steady growth in urban outdoor wear market is expected. A total of eight quality factors were identified through factor analysis; suitability, production quality, functionality, ease of care, fabric performance, portability, fashionability, and symbolism. Based on Kano model, quality factors of urban outdoor wear were categorized into three groups: one-dimensional; indifferent; and must-be quality factor. It was found that consumers were satisfied with urban outdoor wear only when it meets the needs for suitability for body types and ease of care, meaning that manufactures should be cautious not to lose these features. Being must-be quality factor, production quality(form stability, quality of subsidiary materials), and fabric performance such as colorfastness should be basically satisfied. The relative importance of each quality feature on satisfaction/dissatisfaction was investigated using CSC(customer satisfaction coefficient). Based on the CSC, every item was classified again. Attractive quality features with large CSC were shown in suitability factor. Must-be quality features with small CSC were mainly shown in functionality and fabric performance factors. These findings imply that manufactures of urban outdoor wear should not only maintain the production quality but also focus on suitability features to differentiate their product with previous products.

• 경영과학
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• 제12권1호
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• pp.51-60
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• 1995

This paper presents a workload based model and cell design support system (CDSS) in manufacturing cell design. The proposed model consider manufacturing factor such as machine capacity, production volume, process time, and cell size. Based on those information, workload is calculated and according to the workload, the relationship between machine and part is represented by the workload matrix. To form the manufacturing cell, correlation similarity coefficient (CSC) among machines are calculated and a pair of machines that has the highest value of CSC is assigned to a machine cell. Repeat the above steps until the desired manufacturing cells are obtained. Finally, a cell design support system that could increase the efficiency in the application of a proposed model is developed. The proposed model and CDSS are illustrated by a numerical example.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.5947-5954
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• 2012

The cancer stem cell (CSC) model states that cancers are organized in cellular hierarchies, which explains the functional heterogeneity often seen in tumors. Like normal tissue stem cells, CSCs are capable of self-renewal, either by symmetric or asymmetric cell division, and have the exclusive ability to reproduce malignant tumors indefinitely. Current systemic cancer therapies frequently fail to eliminate advanced tumors, which may be due to their inability to effectively target CSC populations. It has been shown that embryonic pathways such as Wnt, Hedgehog, and Notch control self-renewal and cell fate decisions of stem cells and progenitor cells. These are evolutionary conserved pathways, involved in CSC maintenance. Targeting these pathways may be effective in eradicating CSCs and preventing chemotherapy or radiotherapy resistance.