• Toxicological Research
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• v.34 no.3
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• pp.221-229
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• 2018

Tenofovir nanoparticles are novel therapeutic intervention in human immunodeficiency virus (HIV) infection reaching the virus in their sanctuary sites. However, there has been no systemic toxicity testing of this formulation despite global concerns on the safety of nano drugs. Therefore, this study was designed to investigate the toxicity of Tenofovir nanoparticle (NTDF) on the liver and kidney using an animal model. Fifteen adult male Sprague-Dawley (SD) rats maintained at the animal house of the biomedical resources unit of the University of KwaZulu-Natal were weighed and divided into three groups. Control animals (A) were administered with normal saline (NS). The therapeutic doses of Tenofovir (TDF) and nanoparticles of Tenofovir (NTDF) were administered to group B and C and observed for signs of stress for four weeks after which animals were weighed and sacrificed. Liver and kidney were removed and fixed in formal saline, processed and stained using H/E, PAS and MT stains for light microscopy. Serum was obtained for renal function test (RFT) and liver function test (LFT). Cellular measurements and capturing were done using ImageJ and Leica software 2.0. Data were analysed using graph pad 6, p values < 0.05 were significant. We observed no signs of behavioural toxicity and no mortality during this study, however, in the kidneys, we reported mild morphological perturbations widening of Bowman's space, and vacuolations in glomerulus and tubules of TDF and NTDF animals. Also, there was a significant elevation of glycogen deposition in NTDF and TDF animals when compared with control. In the liver, there were mild histological changes with widening of sinusoidal spaces, vacuolations in hepatocytes and elevation of glycogen deposition in TDF and NTDF administered animals. In addition to this, there were no significant differences in stereological measurements and cell count, LFT, RFT, weight changes and organo-somatic index between treatment groups and control. In conclusion, NTDF and TDF in therapeutic doses can lead to mild hepatic and renal histological damage. Further studies are needed to understand the precise genetic mechanism.

• Journal of Convergence for Information Technology
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• v.10 no.4
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• pp.124-132
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• 2020

In this study, the positive thinking, academic self-efficacy, and school adjustment of freshman dental hygiene students were identified. The correlation between each variable was identified and the influencing factors were investigated. Data collection was conducted from October 1 to October 21, 2019 on 213 freshman dental hygiene students in Gyeonggi-do, Chungcheong-do, Jeolla-do, and Gyeongsang-do regions. According to the study, the significant influence of freshman dental hygiene students' school adjustment was in the order of academic self-efficacy, positive thinking, and career program experience, and the most influential factors were academic self-efficacy, and the regression model explained was 47.7%. Since this study has been investigated and conducted on some freshman dental hygiene students, there is a limit to generalizing the results, subsequent studies will require continuous study of various variables for positive thinking and academic self-efficiency to school adjustment. However, based on this study, it is meaningful that it can be used as data to supplement the prior study related to school adjustment, and by presenting factors related to the school adjustment of freshman dental hygiene students, it is thought that it became basic data that confirmed the necessity of developing the school adjustment program.

• Journal of Convergence for Information Technology
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• v.10 no.11
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• pp.302-312
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• 2020

This study examined whether there is a difference in cost asymmetry between a corporate listed on KOSDAQ and a corporate listed on KOSPI, and whether there is a difference in cost asymmetry depending on the size of the listed corporate. In the previous study, cost asymmetry was examined only for listed corporate, but the difference in size between KOSDAQ-listed corporate and KOSPI-listed corporate was not examined. However, according to many studies, since the characteristics of corporate and firm risks are different between corporate listed on KOSPI and corporate listed on KOSDAQ, or even for listed corporate, such an impact may affect the decision-making of internal resource allocation. The analysis was conducted that there would be a difference in the impact. For this study, the results of analyzing the KOSPI and KOSDAQ markets from 2011 to 2019 using the cost behavior model of Anderson et al. (2003), There was a difference in cost behavior in the KOSPI and KOSDAQ markets. Overall, as in previous studies, Cost Stickiness was appeared. but in the case of the KOSPI market, Cost Stickiness was mitigated.It was found that corporate with large corporate size made the decision to dispose of idle resources more clearly when sales decreased. In addition, it was observed that the higher the foreign investor's ownership ratio, the KOSPI market, and the larger the corporate size, the more clearly the Stickiness of cost was mitigated. This study expands research on cost asymmetry and reveals that there is a difference between the KOSPI market and the KOSDAQ market, and between the size of the corporate, and has a differentiation from previous studies.

• Journal of Convergence for Information Technology
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• v.8 no.2
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• pp.121-131
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• 2018

The purpose of this study is to analyze whether the cosmetic interest of middle school female students(n=126) is related to purchase satisfaction by using purchase behavior and informatization level as control variables. Based on the research model, three hypotheses were set and statistical tests were conducted. The results of this study are as follows. First, middle school female students used cosmetics from elementary school and cosmetics education was requested from elementary school. Therefore proper early education on cosmetic use is needed. Second, the degree of interest and purchasing behavior of cosmetics was positively correlated with the purchase satisfaction of cosmetics. Third, the purchasing behavior of cosmetics was found to have a more effect on purchase satisfaction than the cosmetics interest. Especially, 'cosmetics purchase behavior' had a moderating effect on purchase satisfaction. Fourth, there was no difference in the average among the grades about cosmetics category(cosmetic interest, purchase behavior, informatization level, purchase satisfaction). This study needs to pay more attention to cosmetics purchasing behavior, which has the greatest effect on the satisfaction of cosmetics purchasing among middle school girls, and suggests that further studies will be continued to expand the range and ages in the future.

• Journal of Convergence for Information Technology
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• v.8 no.2
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• pp.219-225
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• 2018

The objectives of this study is to analyze the impact of open information innovation which consisted of external technology acquisition and external technology exploitation on export performance by integrating with strategic alliance factors. This study empirically analyzed six hypotheses in 201 sample using the PLS (Partial Least Square) of the structural equation model to verify the moderating effects of organizational culture on the relationship among open information innovation, strategic alliance and export performance. As a result, external technology acquisition dose not affect strategic alliances. On the other hand, external technology exploitation has a positive impact on strategic alliances. Strategic alliances also have a positive impact on export performance. As a result of the moderating effect analysis, the interaction between organizational culture and external technology acquisition has positively influenced strategic alliances. In addition, the moderating effect of organizational culture and external technology exploitation has a significant effect on strategic alliances. However, moderating effect of organizational culture and strategic alliance dose not affect export performance. This study has a contribution to the analysis of the moderating effects of organizational culture. In the future, integrated analysis of open information innovation and external factors is needed.

• Journal of Convergence for Information Technology
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• v.7 no.4
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• pp.105-111
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• 2017

With the emergence of the fourth industrial revolution, more and more attempts have been made to apply IoT technology to the manufacturing process and launch the product. In this paper, we propose IoT authentication scheme based on hash chain which can easily apply IoT device to small and medium enterprises in Korea. In the proposed method, the companies that installed IoT devices suitable for the manufacturing environment are selected to maintain the linkage between IoT devices so that product information and release information can be efficiently collected and managed during the entire manufacturing process. In addition, the proposed scheme is characterized in that it does not require an additional encryption / decryption algorithm because the authentication information of the IoT device is constructed based on a hash chain. As a result of the performance evaluation, the efficiency of the manufacturing process was improved by 18.5% and the processing of the manufacturing process with the IoT device was shortened by 20.1% on the average according to the application of the IoT device. In addition, the labor cost reduction costs in the manufacturing process decreased by an average of 30.7%.

• Journal of Convergence for Information Technology
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• v.7 no.6
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• pp.35-43
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• 2017

The purpose of this study was to analyze the converged influencing factors on the stages of exercise behavior changes in shift work nurses. The subjects were 120 shift work nurses working in hospitals who understood the purpose of the study and agreed to participate in the study. Data were analyzed using frequency, percentage, mean, standard deviation, t-test, $X^2$ test, and multiple logistic regression analysis. The exercise motivation factors of shift work nurses had a significant effect on stages of exercise behavior change (${\beta}=2.480$, p=.022), health status perceptions(${\beta}=1.151$, p=.013). Social support factors (${\beta}=1.819$, p=.002) and marital status (${\beta}=-1.820$, p=.004) also had significant effects on the stages of exercise behavior change of shift work nurses. In other words, subjects with change in exercise behavior had 11.9 times higher motivation and 3.1 times higher health status perception than those without change in exercise behavior, social support was 6.1 times higher, and unmarried subjects showed 16 times showed higher than that of married subjects. Therefore, it is important to develop a strategy to practice continuous and regular exercise in consideration of the exercise motivation, social support, and health status perception of the nurses in shift work.

• Journal of Convergence for Information Technology
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• v.7 no.2
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• pp.101-109
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• 2017

This study was undertaken to understand how reference groups, convenience and pursuit of information affect subscription-based Webtoon service usage through reliability and curiosity, through which this study provides some suggestions for developing Webtoons and increasing profitability of service providers. Therefore, the reliability and feasibility analysis were conducted for 449 readers who used the paid webtoon more than once. In addition, the causality test was conducted to verify the research model. As a result of the research, this study shows the following implications: First, it is recommended that webtoon service providers produce webtoons with the webtoonists who have more expertise developing new webtoons. Second, webtoon service providers should focus on advertising during the episodes that are currently being subscribed to, or in the next episodes in order to stimulate the usage needs of readers rather than focusing on advertising the products related to the characters and their development and sales. Third, webtoon service providers are supposed to develop webtoons by using materials that can appear in everyday life. Fourth, webtoon service providers should continue their research in order to develop high quality products and express the unique characteristics of their advertisements by increasing investment in the development of products and advertising.

• Journal of Convergence for Information Technology
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• v.8 no.3
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• pp.153-160
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• 2018

This article examines actions of the department of a university according to Higher Education Evaluation Policy as a case on the department of Christian education of A University. This article consists of background and policy Higher Education Evaluation and actions of the department of Christian education. Specialization, curriculum, management of instructional quality, educational achievement, student support and cooperation of local community as category of trends of the department of Christian education are discussed. Aim of education, model of human resource, educational objects, and key-competency as the specialization of department of Christian education are discussed. Curriculum of department suggests students career track which is related to their career. Positive guidance counseling are implemented for rate of recruit related to educational achievement. Non-subject matter program of University and Department are introduced for students's support. 60 hours of educational service and other educational activities are carried out for local community. Principal, chaplain of school and teachers are invited for educational practical affairs of education. The result of this article can be used as a basic reference for the direction of the higher education.

• Journal of Convergence for Information Technology
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• v.8 no.4
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• pp.237-245
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• 2018

The purpose of this study is to suggest the improvement plan for an effective benefit sharing support policy through empirical analysis on the benefit sharing operation of government as well as the benefit sharing support policy of government affecting firm performance. Therefore, this study analyzed current problems on benefit sharing operation of government as well as performed a survey for 225 participating and cooperation firms regarding firm performance. This study found some improvements such as insufficient diverse incentive measures leading to the difficulty of participating firm's increase and spread, insufficient substantial benefit sharing such a cash allocation between consignment firms, the increase of biz management system model failing to induce innovation of new technology or product, and difficult spread into 2nd, 3rd cooperative firms besides 1st ones, meanwhile, verifying the positive influence of government benefit sharing support policy on both participating and cooperation firms, especially on the performance of cooperation firms. As a further study, it is necessary to increase the objectiveness and accuracy of a research through verification of the interrelationships between firm statue and performance on the basis of more objective and quantitative data such a sales increase or R&D capability of cooperation firms.