• Archives of Plastic Surgery
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• v.49 no.2
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• pp.258-265
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• 2022

Background Chitosan (CS) is a well-known antimicrobial dressing material. Moreover, widely used amniotic membranes contain growth factors beneficial for wound healing. Herein, we created a novel amnion-conjugated CS-alginate membrane dressing and tested its wound healing potency in a diabetic swine model. Methods The bovine amniotic powder growth factor contents were evaluated by protein assay, and the powder's wound healing effects were assessed in vitro by HaCaT cell scratch closure. In vivo, two minipigs developed streptozotocin-induced diabetes. Serial serum glucose measurements and intravenous glucose tolerance tests were performed to confirm their diabetic status. Twelve square-shaped wounds created on each pig's back were randomly divided into control (n = 4), CS (n = 4), and amnion-CS (AC; n = 4) groups and treated accordingly with different dressings. Wound healing in each group was assessed by measuring wound contraction over time, capturing wound perfusion with indocyanine green (ICG) angiography, and histologically analyzing inflammatory markers. Results Amniotic powder elution promoted HaCaT cell migration in the scratch wound model, suggesting its beneficial in vitro wound healing effects. In vivo, the CS and AC groups showed earlier wound contraction initiation and reepithelialization and earlier wound perfusion improvement by ICG angiography than the control group. Additionally, the wound size of the AC group at week 3 was significantly smaller than those in the control group. There was no significant difference in the numbers of acute and chronic inflammatory cells between the groups. Conclusion The amnion-conjugated CS-alginate membrane, as well as CS dressing alone, could be a favorable dressing option for diabetic wounds.

• Journal of Korean Society for Atmospheric Environment
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• v.31 no.6
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• pp.573-584
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• 2015

In this study, the atmospheric dispersion of radioactive material ($^{137}Cs$) was simulated with regard to its impact within a 50-km radius from the Kori Nuclear Power Plant (NKPP) based on two different types of models (the non-steady-state puff model CALPUFF and the lagrangian model HYSPLIT) during the spring of 2012 (May 2012). The dispersion distribution of $^{137}Cs$ calculated in the CALPUFF model was similar to that of the HYSPLIT model, but the magnitudes of differences in its spatio-temporal concentrations between the two models were different. The $^{137}Cs$ concentrations simulated by the CALPUFF were significantly lower than those of the HYSPLIT due to a limitation of puff models (e.g. puff size growth over time). The CALPUFF had the advantage of determining the dispersion of radioactive materials and their impacts on the surrounding regions, compared with the HYSPLIT that had high concentrations of $^{137}Cs$ in only small local areas with the movement of air masses along the local winds.

• Management & Information Systems Review
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• v.18
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• pp.41-67
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• 2006

Value Creation issue for customers is emerging from the college education. Most colleges are facing to cope with over-supplied education facility problems against reducing population to apply to enter universities/colleges. The best way to overcome those problems might be to implement the Customer Satisfaction Management Strategy as if they were private firms for making profit. The main purpose in this study is to provide guidelines for CS strategy with a private college. It is focused on designing research plans and searching CS index. The process of this study is as follows; - Introduced the value creation strategy for customers with private colleges. - Proposed the CS management which is very important for enhancing competitive power - Evaluate various models to measure service quality and CSI for college service. - Provided some guidelines to research design of CS according to 6 customer categories. - Proposed some methodologies to apply a service quality measurement model. - Suggested a revised model from SERVPERF to adapt with college customers satisfaction. The result from this study showed that Customer Satisfaction Management would be the most important strategy to cope with confronting difficulties for private college and the revised model from SERVPERF would be an alternative solution. Further study is essential to assure the suggested model is valuable for private colleges because empirical test has not completed yet.

• Journal of Korean Institute of Industrial Engineers
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• v.32 no.2
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• pp.153-162
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• 2006

Customer satisfaction is an ever-growing concern of management throughout the world. To find the way to increase customer satisfaction, we must understand customer requirements. Kano distinguishes between three types of product requirements (must-be, one-dimensional, attractive requirement) which influence customer satisfaction in different ways when met. In this paper, potential customer satisfaction improvement (PCSI) index was developed using Kano model and CS coefficient. Timko has developed customer satisfaction (CS) coefficient based on Kano model. The PCSI index represents how much a service feature can increase the degree of customer satisfaction when the service feature is fully fulfilled. In order to explain the meaning of PCSI index, a case syudy of a Family Restaurant is done. It is also discussed how to use the index strategically.

• Journal of Pharmaceutical Investigation
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• v.35 no.4
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• pp.279-285
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• 2005

Ground CS-891 (N-[1-(4-methoxyphenyl)-1-methylethyl]-3-oxo-4-aza-5a-androst-1-ene-$17{\beta}$-carboxamide) of poorly water soluble drug was obtained using a Heiko Seisakusho model TI-100 vibration mill, and samples with different crystallinity were prepared at mixture ratios of 10:0, 7:3, 5:5, 3:7 and 0:10 (intact;ground CS-891). Physicochemical characterizations were obtained using qualitative and quantitative X-ray diffractometry, different scanning calorimetry (DSC), scanning electron microscopy (SEM), Quantasorb surface area analyzer, and controlled atmosphere microbalance. With increase of amorphous CS-891 in mixture ratios, the intensities of X-ray diffraction peaks of crystalline CS-891 were decreased, whereas surface area, water absorption, and exothermic peaks in DSC were increased. The apparent solubility of ground CS-891 was $4.4\;{\mu}g/ml$ and the solubility of intact CS-891 was $3.1\;{\mu}g/ml$ at $37{\pm}1^{\circ}C$. The apparent precipitation rates of CS-891 in a supersaturated solution during the solubility test were increased with an increase of amorphous CS-891, and a crystalline form of CS-891 transformed from amorphous CS-891 after the solubility test was found by X-ray diffraction analysis, DSC and SEM. The dissolution profiles of CS-891 with different crystallinity at $37{\pm}1^{\circ}C$ by the USP paddle method were investigated, and the apparent dissolution rate constant of ground CS-891 was about 5.9-fold higher than that of intact CS-891. A linear relationships between the crystallinity of CS-891 and the apparent dissolution rate constant (r>0.96) were obtained.

• The Korea Journal of Herbology
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• v.33 no.6
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• pp.79-86
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• 2018

Objectives : Hemorrhoids are one of the most common diseases in humans. Jingyoganghwaltang (JG) and Cheongsimhwan (CS) have been used for treating hemorrhoids in Korean traditional clinical practice. The present study was designed to evaluate the traditional effects of JG and CS on the experimental hemorrhoid model in rats. Methods : Hemorrhoids are closely related to inflammation. Accordingly, we examined the nitric oxide (NO) production in macrophage cell line in order to evaluate the anti-inflammatory effect. The expression levels of inflammation related genes including IL-1 beta, IL-6, INOS, and TNF-alpha were examined via a real-time quantitative PCR. Croton oil-induced hemorrhagic animal model was used to test the in vivo efficacy against hemorrhoids. The rectal tissues were weighed and the inflammatory proteins were measured to confirm the anti-inflammatory effects. Results : JG and CS have a statistically significant effect on inhibition of NO production and on the reduction of inflammatory gene expression such as IL-1 beta, IL-6, INOS, and TNF-alpha. The synergistic effects of co-treatment of JG and CS were found out in the IL-6 gene expression. The in vivo study using croton oil-induced hemorrhoid model in rat was performed to check the co-treatment effects. As a result, the co-treatment reduced the inflammation of the rectal tissue and decrease the inflammation related protein productions including ICAM1, MMP2 and MMP9. Conclusions : These results suggest that JG and CS co-treatment demonstrated anti-inflammatory effects in croton oil-induced hemorrhoid model in rat.

• Proceedings of the Korean Society for Quality Management Conference
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• 2006.04a
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• pp.210-215
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• 2006

The environment of the enterprise changes very quickly, and the customers' needs ate becoming to be various. Only the enterprise can be securing a competitive high position if the enterprise knows well with the customer. Therefore, the enterprise must be confronted appropriately which grasps the requirement of he customer. The Kano presents quality dualism, it complemented a different meaning problem point and the Timko presented the customer satisfaction coefficient. But the model of the Timko which committed the error as well that does not consider the indifferent quality of he Kano. Hence, with this research hat proposes the method of analyzes the client demands accurately through Modified CS-coefficient. Then, apply the method on to the multiplex theater.

• Journal of The Korean Association of Information Education
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• v.24 no.4
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• pp.301-311
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• 2020

A model of cooperative learning, Pair Programming was applied to regular class for middle school students. Algorithm and programming skill were taught through the pair programming for two week and the achievement was analyzed based on 4Cs(Critical thinking, Communication, Collaboration, Creativity) proposed by the NEA(National Education Association). The control group was statistically significant on Critical Thinking between pre-test and post-test1, while the experimental group was statistically significant on all measurements of 4Cs. Between pre-test and post-test2, the control group showed overall little difference in range of 0.2 points on the 4Cs average scores. while the experimental group was statistically significant on all measurements of 4Cs. Between post-test1 and post-test2, there was no significant difference on 4Cs average scores in both groups. The experimental group showed higher score results on all 4Cs than the control group. This study verifies that the benefits of Pair Programming on 4Cs.

• Journal of The Korean Astronomical Society
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• v.37 no.4
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• pp.257-259
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• 2004

We compare the results of the surveys of starless cores performed with CS (2-1) and (3-2) lines to study inward motions in the cores. The velocity shifts of the CS(3-2) and (2-1) lines with respect to $N_2H^+$ are found to correlate well with each other and to have similar number distributions, implying that, in many cores, systematic inward motions of gaseous material may occur over a range of density of at least a factor ${\~}$4. Fits of the CS spectra to a 2-layer radiative transfer model in ten infall candidates suggest that the median effective line-of-sight speed of the inward-moving gas is ${\~}0.07 km\;s^{-l}$ for CS (3-2) and ${\~} 0.04 km\;s^{-l}$ for CS(2-1). Considering that the optical depth obtained from the fits is usually smaller in CS(3-2) than in (2-1) line, this may indicate that CS(3-2) usually traces inner, denser gas with greater inward motions than CS(2-1) implying that many of the infall candidates have faster infall toward the center. However, this conclusion may not be representative of all starless core infall candidates, due to the statistically small number analyzed here. Further line observations will be useful to test this conclusion.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.2 no.2
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• pp.145-153
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• 2004

H$_2$SO$_4$ and citric acid were used as additives for the electrokinetic remediation experiment to increase removal efficiency of $^{137}$ Cs and $^{60}$ Co from the radioactive soil waste stored for more than 10 years. The average effluent velocity discharged from the elctrokinectic remediation experimental column was 2.0${\times}$10$^{-2}$ cm/min and the discharged soil wastewater volume for 10 days is 3.6 pore volume of the column. 97% of $^{60}$ Co in the column was decontaminated for 10 days of operation, while only 54% of $^{137}$ Cs was decontaminated. These results are considered that the absorption equilibrium coefficient of $^{137}$ Cs is higher than that of $^{60}$ Co. The predicted values of the residual concentration by the proposed mathematical model were well coincided with the experimental results within the experimental error range