• Title/Summary/Keyword: CS model

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Degradation of Insect Humoral Immune Proteins by the Proteases Secreted from Enterococcus faecalis

  • Park, Shin-Yong;Kim, Koung-Mi;Kim, Ik-Soo;Lee, Sang-Dae;Lee, In-Hee
    • International Journal of Industrial Entomology and Biomaterials
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    • v.13 no.1
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    • pp.37-43
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    • 2006
  • Enterococcus faecalis was isolated from the body fluid of dead Galleria mellonella larvae. Upon injection of E. faecalis into the hemocoel of G. mellonella, the bacteria destroyed parts of humoral defense systems in the hemolymph. In a test for the proteolytic activity of E. faecalis CS, it was confirmed that the enzyme degraded three well-known a-helical antimicrobial peptides, cecropin A, melittin and halocidin, and abolished their activities. We also determined putative cleavage sites on the primary sequences of three peptides through purification and mass analysis of peptide fragments digested by E. faecalis CS. Furthermore it was found that apolipophorin-III, recently known as a critical recognition protein for invading microbes in the hemolymph of G. mellonella, was also degraded by E. faecalis CS. Taken together, the present work shows that the protease in secretions from E. faecalis destroyed two critical humoral immune factors in the hemolymph of G. mellonella larvae. In addition, this paper demonstrates that the relationship between the host insect and the pathogenic bacteria might provide a valuable model system to study the enterococcal virulence mechanism, which may be relevant to mammalian pathogenesis.

Oxidative Stress in Ovariectomy Menopause and Role of Chondroitin Sulfate

  • Ha, Bae-Jin
    • Archives of Pharmacal Research
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    • v.27 no.8
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    • pp.867-872
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    • 2004
  • Oxidative stress due to reactive oxygen species (ROS) can cause oxidative damage to cells. Cells have a number of defense mechanisms to protect themselves from the toxicity of ROS. Mitochondria are especially important in the oxidative stress as ROS have been found to be constantly generated as an endogen threat. Mitochondrial defense depends mainly on super-oxide dismutase (SOD) and glutathione peroxidase (GPx), whereas microsomal defense depends on catalase (CAT), which is an enzyme abundant in microsomes. SOD removes superoxide anions by converting them to $H_2O$$_2$, which can be rapidly converted to water by CAT and GPx. Also, GPx converts hydroperoxide (ROOH) into oxidized-glutathione (GSSG). Ovariectomized (OVX) rats are used as an oxidative stress model. An ovariectomy increased the levels of MDA, one of the end-products in the lipid peroxidative process, and decreased levels of the antioxidative enzymes; SOD, CAT and GPx. However, Chondroitin sulfate (CS) decreased the levels of MDA, but increased the levels of SOD, CAT and GPx in a dose-depen-dent manner. Moreover, inflammation and cirrhosis of liver tissue in CS- treated rats were sig-nificantly decreased. These results suggest that CS might be a potential candidate as an anti oxidative reagent.

NuDE 2.0: A Formal Method-based Software Development, Verification and Safety Analysis Environment for Digital I&Cs in NPPs

  • Kim, Eui-Sub;Lee, Dong-Ah;Jung, Sejin;Yoo, Junbeom;Choi, Jong-Gyun;Lee, Jang-Soo
    • Journal of Computing Science and Engineering
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    • v.11 no.1
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    • pp.9-23
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    • 2017
  • NuDE 2.0 (Nuclear Development Environment 2.0) is a formal-method-based software development, verification and safety analysis environment for safety-critical digital I&Cs implemented with programmable logic controller (PLC) and field-programmable gate array (FPGA). It simultaneously develops PLC/FPGA software implementations from one requirement/design specification and also helps most of the development, verification, and safety analysis to be performed mechanically and in sequence. The NuDE 2.0 now consists of 25 CASE tools and also includes an in-depth solution for indirect commercial off-the-shelf (COTS) software dedication of new FPGA-based digital I&Cs. We expect that the NuDE 2.0 will be widely used as a means of diversifying software design/implementation and model-based software development methodology.

Multitask Transformer Model-based Fintech Customer Service Chatbot NLU System with DECO-LGG SSP-based Data (DECO-LGG 반자동 증강 학습데이터 활용 멀티태스크 트랜스포머 모델 기반 핀테크 CS 챗봇 NLU 시스템)

  • Yoo, Gwang-Hoon;Hwang, Chang-Hoe;Yoon, Jeong-Woo;Nam, Jee-Sun
    • Annual Conference on Human and Language Technology
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    • 2021.10a
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    • pp.461-466
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    • 2021
  • 본 연구에서는 DECO(Dictionnaire Electronique du COreen) 한국어 전자사전과 LGG(Local-Grammar Graph)에 기반한 반자동 언어데이터 증강(Semi-automatic Symbolic Propagation: SSP) 방식에 입각하여, 핀테크 분야의 CS(Customer Service) 챗봇 NLU(Natural Language Understanding)을 위한 주석 학습 데이터를 효과적으로 생성하고, 이를 기반으로 RASA 오픈 소스에서 제공하는 DIET(Dual Intent and Entity Transformer) 아키텍처를 활용하여 핀테크 CS 챗봇 NLU 시스템을 구현하였다. 실 데이터을 통해 확인된 핀테크 분야의 32가지의 토픽 유형 및 38가지의 핵심 이벤트와 10가지 담화소 구성에 따라, DECO-LGG 데이터 생성 모듈은 질의 및 불만 화행에 대한 양질의 주석 학습 데이터를 효과적으로 생성하며, 이를 의도 분류 및 Slot-filling을 위한 개체명 인식을 종합적으로 처리하는 End to End 방식의 멀티태스크 트랜스포머 모델 DIET로 학습함으로써 DIET-only F1-score 0.931(Intent)/0.865(Slot/Entity), DIET+KoBERT F1-score 0.951(Intent)/0.901(Slot/Entity)의 성능을 확인하였으며, DECO-LGG 기반의 SSP 생성 데이터의 학습 데이터로서의 효과성과 함께 KoBERT에 기반한 DIET 모델 성능의 우수성을 입증하였다.

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Sensitivity Analysis of Input Parameters for a Dynamic Food-Chain Model DYNACON (동적섭식경로모델 DYNACON에 대한 입력변수의 민감도분석)

  • Hwang, Won-Tae;Lee, Geun-Chang;Han, Moon-Hee;Cho, Gyu-Seong
    • Journal of Radiation Protection and Research
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    • v.25 no.1
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    • pp.11-19
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    • 2000
  • The sensitivity analysis of input parameters for a dynamic food chain model DYNACON was conducted as a function of deposition date for the long-lived radionuclides $(^{137}Cs,\;^{90}Sr)$. Also, the influence of input parameters for the short and long-terms contamination of selected foodstuffs (cereals, leafy vegetables, milk) was investigated. The input parameters were sampled using the LHS technique, and their sensitivity indices represented as PRCC. The sensitivity index was strongly dependent on contamination period as well as deposition date. In case of deposition during the growing stages of plants, the input parameters associated with contamination by foliar absorption were relatively important in long-term contamination as well as short-term contamination. They were also important in short-term contamination in case of deposition during the non-growing stages. In long-term contamination, the influence of input parameters associated with foliar absorption decreased, while the influence of input parameters associated with root uptake increased. These phenomena were more remarkable in case of the deposition of non-growing stages than growing stages, and in case of $^{90}Sr$ deposition than $^{137}Cs$ deposition. In case of deposition during growing stages of pasture, the input parameters associated with the characteristics of cattle such as feed-milk transfer factor and daily intake rate of cattle were relatively important in contamination of milk.

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Integration of the Korea Sport System: Feasibility of the Canadian LTAD framework (캐나다 Long-Term Athlete Development(LTAD) 고찰을 통한 국내 스포츠시스템의 통합모델과 운영방안)

  • Lee, Eun-Young;Lim, Heejun;Won, Doyeon;Jeon, Justin Y.;Chung, Jaeyong
    • 한국체육학회지인문사회과학편
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    • v.55 no.5
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    • pp.619-633
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    • 2016
  • In March 26th, 2016, two major sport organizations of South Korea, Korean Olympic Committee and the Korean Council of Sports for All, have merged with the ultimate goal of improving health and wellness among Korean people through sport and physical activity participation. Integration of sport system intended to shift the paradigm from "old" to "new", and can be a catalyzer to promote Korea as a developed nation with the delivery of quality sport. This study critically reviewed the Canadian Sport for Life-Long-Term Athlete Development (CS4L-LTAD) which serves as a platform to integrate and operate sport organizations in Canada, and discussed the feasibility and adaptability of CS4L-LTAD in the Korean context. This study also introduced Integrated Model for Korea Sport System developed based on the CS4L-LTAD framework, and addressed key strategies that will drive to the successful implementation of the model. The Integrated Model for Korea Sport System offers ways to improve the quality of sport and physical activity for all Koreans by linking sport, recreation, physical education, and health, and by aligning programs and services across different settings: school, elite, and community sports. The recent restructure and redesign of Korea sport system will play vital roles in promoting the overall welfare of all Koreans, regardless of one's sex, age, disability, and sociodemographic status by providing inclusive, ethical, and holistic framework that is appropriate for the Korea sport system.

Modeling and Simulation of Platform Specific Model in MPSoC Environment (MPSoC용 임베디드 소프트웨어의 PSM 모델링 및 시뮬레이션)

  • Song, In-Gwon;Oh, Gi-Young;Hong, Jang-Eui;Bae, Doo-Hwan
    • Journal of KIISE:Software and Applications
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    • v.34 no.8
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    • pp.697-707
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    • 2007
  • Since embedded software is very dependent for target hardware architecture, characteristics of the platform must be considered when designing the software. Furthermore, MPSoCs consists of heterogeneous hardware components that are specified in micro level. Thus mapping of embedded software for MPSoCs should be considered the characteristics. In this paper, we provide an approach to automatic mapping PIM (Platform Independent Model) of an embedded software to PSM(Platform Specific Model) for MPSoC(Multi Processor System On Chip) and verify its effectiveness with simulation. In the proposed approach, tasks are derived from an object oriented model based on the UML (Unified Modeling Language). And then the types of the derived tasks are identified. With the identified types and inter relationship between tasks, the tasks are assigned to appropriate heterogeneous hardware components. We expect that the approach improve accuracy of the assigning and concurrency of the deployed software.

A Study on Drying Characteristics and Drying Model Development of Korean Ginseng (인삼의 건조특성 구명 및 건조모델 개발에 관한 연구)

  • Choe, Byeong-Min;Lee, Jong-Ho;Park, Seung-Je
    • Journal of Ginseng Research
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    • v.16 no.2
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    • pp.111-123
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    • 1992
  • Drying characteristic data for peeled ginseng were obtained to determine dominant drying factors and fitted with five selected drying models and an empirical model. Among air temperature, relative humidity and diameter of ginseng root, drying air temperature was found to be the most influencing factor on drying rate. Drying velocity appeared faster as the drying temperature increased but its effect was less at high temperature than at low temperature. Quality change during the drying process did not occur except when relative humidity was 75fb. At high relative humidity, skin color of ginseng was turned to light brown. Approximate-Diffusion and the Empirical model for drying were in a good agreement with experimental data. The models are as follows; $.$ Approximate-Diffusion model MR = A$.$exe(-k$.$1) A = 1.72 + 0.407 In(D) - 0.0000963T3 - 0.358 In(RH) + 0.0000945 RH2 B= 1.01 + 0.0195RH - 0.O0518D2 + 0.0708 In(T) - 0.492 In(RHI-D.0000933RH2$.$Empirical model MR= Cl + Cs$.$In(t) Cl= 1.14+0.382 In(D)-0.00008477a-0.139 In(RH)+0.0000664RH2 Cs=0.440-0.0224 In(D)-0.193 In(T)+0.0000464T2-0.00000771RH2

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Fairness, Satisfaction, Intention to Repurchase, and Negative WOM in the Process of Service Recovery (서비스 회복과정에서 공정성과 만족, 그리고 재구매 의도와 부정적 구전)

  • Jeong, Yong-Gil
    • The Journal of the Korea Contents Association
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    • v.17 no.6
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    • pp.424-435
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    • 2017
  • Because services are delivered through the behaviors of people, it is very difficult to do the quality control and services failures are often happened. If services failures are not recovered by appropriate methods, customers make the negative word-of-mouth communications and have the negative intention to repurchase. The service recovery paradox demonstrates the importance of service recovery after the service failures. The purpose of this study is to investigate the antecedents of customer satisfaction of service recovery(CS), and its consequences of the CS. Independent variables of CS are distributive justice, procedural justice, and interactional justice, and dependent variables of CS are negative word of mouth communication and intention to repurchase. Data are collected using the scenario method. Research model and hypotheses are tested empirically using the statistical packages such as SPSS and AMOS.