• Journal of Microbiology and Biotechnology
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• 제17권10호
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• pp.1712-1716
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• 2007

To generate new scaffold candidates as highly selective and potent cyelin-dependent kinase (CDK) inhibitors, structure-based drug screening was performed utilizing 3D pharmacophore conformations of known potent inhibitors. As a result, CR229 (6-bromo-2,3,4,9-tetrahydro-carbolin-1-one) was generated as the hit-compound. A computational docking study using the X-ray crystallographic structure of CDK2 in complex with CR229 was evaluated. This predicted binding mode study of CR229 with CDK2 demonstrated that CR229 interacted effectively with the Leu83 and Glu81 residues in the ATP-binding pocket of CDK2 for the possible hydrogen bond formation. Furthermore, biochemical studies on inhibitory effects of CR229 on various kinases in the human cervical cancer HeLa cells demonstrated that CR229 was a potent inhibitor of CDK2 ($IC_{50}:\;3\;{\mu}M$), CDKI ($IC_{50}:\;4.9\;{\mu}M$), and CDK4 ($IC_{50}:\;3\;{\mu}M$), yet had much less inhibitory effect ($IC_{50}:>20\;{\mu}M$) on other kinases, such as casein kinase 2-${\alpha}1$ (CK2-${\alpha}1$), protein kinase A (PKA), and protein kinase C (PKC). Accordingly, these data demonstrate that CR229 is a potent CDK inhibitor with anticancer efficacy.

• PNF and Movement
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• 제16권2호
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• pp.229-238
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• 2018

Purpose: This study aimed to compare the immediate effects of various contract-relax (CR) techniques on the peck force and passive range of motion (ROM) of knee extension. Methods: This study recruited 17 adult males and females who obtained below $90^{\circ}$ in straight leg raising. The subjects randomly performed one of three different CR techniques (direct CR, indirect CR, and modified CR) on the right knee extension four times per day for three days. The subjects' peck force during each CR and their passive knee extension on the hip at a $90^{\circ}$ flexed position before and after each CR were measured. Results: The peck force was significantly higher in the direct and modified CR than in the indirect CR. The ROM in the passive knee extension significantly increased after direct and indirect CR. Comparing between each CR, the passive knee extension range was significantly more improved in the direct and indirect CR than in the modified CR. Conclusion: Direct and indirect CR are more effective than modified CR in the ROM of passive knee extension. The study results suggest that the modified CR did not have the same effect on the ROM of the knee extension as the direct and indirect CR and that further research is needed to recruit more subjects and to determine the effects on different muscles after modified CR.

• 센서학회지
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• 제16권3호
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• pp.229-233
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• 2007

The indium tin oxide (ITO) films were deposited on CR39 substrate using DC magnetron sputtering. The ITO thin films deposited at room temperature because CR39 substrate its glass-transition temperature is $130^{\circ}C$. The ITO thin films used bottom and top electrode and for organic thin film transparent transistors (OTFTs). The ITO thin film electrodes electrical properties and optical transparency properties in the visible wavelength range (300-800 nm) strongly dependent on volume of oxygen percent. For the optimum resistivity and transparency of the ITO thin film electrode achieved with a 75 W plasma power, 10 % volume of oxygen and a 27 nm/min deposition rate. Above 85 % transparency in the visible wavelength range (300-800 nm) measured without post annealing process and a low resistivity value $9.83{\times}10^{-4}{\Omega}cm$ was measured thickness of 300 nm. All fabrication process of ITO thin films did not exceed $80^{\circ}C$.

• 산업기술연구
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• 제21권A호
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• pp.221-229
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• 2001

The effect of Mo underlayer on the magnetic properties of CoCrTa/Cr films deposited on glass substrates were investigated. The coercivity increased and the coercivity squareness decreased by introducing Mo underlayer. The coercivity increase was attributed to the increase of in-plane c-axis orientation and magnetic isolation of Co grains deposited on Cr/Mo underlayer. The decrease of coercivity squarenesses seemed to be caused by the increase of magnetic isolation. The increase of magnetic isolation of Co grains was attributed to the diffusion of Mo atoms into grain boundaries of Co films and the physical isolation of Co grains. The coercivity of CoCrTa/Cr/Mo showed maximum values at Mo thickness of $400{\AA}$. The appearance of the maximum coercivity at that thickness was attributed to the development of strong $Co(10{\bar{1}}0)$ and $Co(10{\bar{1}}1)$ preferred orientation.

• 한국안광학회지
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• 제18권1호
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• pp.85-91
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• 2013

목적: 본 연구는 근시안에서 현성굴절검사(manifest refraction: MR)와 조절마비굴절검사(cycloplegic refraction: CR)값을 비교하여 연령과 근시도에 따라 차이가 있는지 알아보고자 하였다. 방법: 근시성 굴절이상을 가진 229명 ($25.3{\pm}11.9$세)을 대상으로 조절마비제(cyclogyl 1%) 점안 전과 후에 자각적 굴절검사를 시행하였다. 결과: 조절마비제 점안 전 후 평균굴절력을 비교 조사하였더니, 근시 0.19 D, 난시 0.02 D 감소하였고 난시방향은 1.85도 차이를 보였다. 근시도의 변화는 30~40대에서 가장 높게 나타났으며, 229명(458안) 중 근시도수에서 0.50 diopter(D) 이상의 차이를 보이는 경우는 73안(16%)으로 근시도가 높은 군일수록 오차율이 높게 나타났다. 결론: 현성굴절검사와 조절마비굴절검사 값을 비교해 본 결과 연령에 따른 근시도의 변화는 유의하지 않았으나, 근시도가 높은 군일수록 오차율이 유의하게 높은 것으로 나타났다.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2003년도 하계학술연구발표회 및 한.일 공동심포지엄
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• pp.228-229
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• 2003

• 한국표면공학회지
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• 제24권4호
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• pp.222-229
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• 1991

The oxidation behavior of Ni-6wt.% Cr alloys with various concentration of alumina dispersions(5vol.% 10vol.%) was determined at 1000 and 110$0^{\circ}C$ in oxygen of 1 atm. pressure. Some general observations were ascertained. These include: (a) the addition of alumina dispersoids significantly increased the oxidation resistance of Ni-6wt.% Cr alloy; (b) the rate of oxidation was distinctly decreased as a function of the volume percent of oxide dispersion; and (c) the presence of alumina dispersions promoted the formation of continous, protective Cr2O3 layer at 6 wt.% Cr.

• Elastomers and Composites
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• 제55권3호
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• pp.229-234
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• 2020

Automobile wiper blades are generally treated with chlorine to lower their friction coefficient with the windshield surface. This treatment could affect the crosslink density measurement of rubber vulcanizates, a material used in windshield wipers, which would consequently alter its chemical and physical properties. Therefore, this study evaluated the influence of chlorination on crosslink density measurements of natural rubber (NR) vulcanizates using a vehicle wiper blade. A method for determining the degree of chlorination was developed where the interaction parameter between the rubber and the swelling solvent was corrected. A decrease in the rubber sample swelling ratio was observed upon chlorination, and the chlorination penetrated less than 1% of the sample thickness. The chlorinated NR was assumed to be chloroprene rubber (CR), which was used to correct the interaction parameter. The results showed the CR contributed approximately 7% to the parameter.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2009년도 추계학술대회 논문집
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• pp.226-229
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• 2009

The present works were performed that titanium foil was anodized in various dilution ratios of seawater and distilled water with 10V external voltage applied, then annealed at $450^{\circ}C$ to obtain $TiO_2$ on the Ti substrate. The prepared samples were characterized by instruments (XRD, SEM, and photocurrent) and used to investigate rate of hydrogen production in photoelectrochemical cell as well as Cr(VI) reduction. As the results of experiments, the anodized $TiO_2$ in seawater electrolytes, which are ranged from 15 to 50 times dilution of seawater, was showed a relatively higher hydrogen production (ca. 97~110 umol/hr-$cm^2$) and Cr(VI) reduction (ca. 95% reduction).

• 한국임상수의학회지
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• 제20권2호
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• pp.229-232
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• 2003

Ultrasonographic examination of the stifle joint four clinically and radiographically normal adult dogs was performed before and after inducing the cranial cruciate ligament (CrCL) rupture of the bilateral stifle surgically. At Pre- or post-surgery, the hyperechoic patella ligament and the echogenic infrapatella fat interfered the visualization of the CrCL by the plain scanning method. However when the stifle joint was imaged by the scanning method injecting normal saline within the joint capsule, the hyperechogenic ligament was visualized by the separation of the infrapatella fat and the CrCL and the contrast effect of anechoic saline. When the stifle joint was imaged by the real time scanning method after the induction of the surgical rupture, fluttering of the ligament and anechoic area between the bone and the CrCL was identified due to the lack of tonicity and continuity of the ligament. Enlargement of the ligament because of its increased diameter as well as fluttering of the CrCL and the increased joint space's thickness was visualized. Consequently, confirming fluttering of the CrCL, increased ligament diameter and anechoic region between the CrCL and the bone, ultrasonographic examination is a valuable diagnostic tool as well as cranial drawer test and radiographic examination.