• 전자공학회논문지
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• 제50권5호
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• pp.269-274
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• 2013

본 연구에서는 전기식 밸브 액추에이터의 개폐 정도를 입력신호에 비례하여 제어하기 위한 PCU (Proportional Control Unit), CPT (Current Position Transmitter)와 액추에이터의 회전위치를 측정하는 Rotary Absolute Optical Encoder를 설계 및 제작 하였고, DAQ 하드웨어와 LabView를 사용한 테스트 시스템을 설계하여 성능시험을 하였다. PCU는 1-5V, 0-5V, 0-10V, 2-10V 전압 신호와 4-20mA의 전류신호를 일정한 범위의 0.5-2.5V 전압신호로 변환하도록 설계하였다. CPT는 MCU의 PWM 신호를 입력받아 밸브의 개폐 정도를 4-20mA의 전류신호로 출력 하도록 하였다. Infrared LED와 Infrared Transistor를 사용하여 20bit Optical Encoder를 개발하였으며, Main Board와 Serial 통신을 하도록 설계하였다. DAQ 하드웨어와 Labview를 통한 테스트 결과 PCU는 ${\pm}0.003V$, CPT는 ${\pm}0.01mA$의 오차범위 내에서 작동하여 산업용 밸브 액추에이터가 안정적으로 작동하는 것을 관찰하였으며, Encoder는 $11.25^{\circ}$의 분해능을 갖고, 최대 32,768 회의 모터회전수 범위까지 측정할 수 있도록 하였다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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• pp.71-71
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• 1993

Carboxylesterase is widely distributed in the tissues of vertebrates, insects, plants and mycobacteria. Among various tissues of animals and humans, the highest esterase activity with various substrates is found in the liver. Kidney has moderate carboxylesterase activity in the proximal tubules. Considerable esterase activity is also found in the small intestine epithet elial cells and serum of mammals. Besides these tissues, carboxylesterase has been found in the lung, testis, adipose tissue, nasal mucosa and even in the central nervous system. Hepatic microsomal carboxylesterase catalyzes the hydrolysis of a wide variety of endogenous and exogenous compounds such as carboxylester, thioester and aromatic amide. Since carboxylesterases are important for metabolic activation of prodrugs and detoxification of xenobiotics, differences in substrate specificity and immunological properties of this enzyme are important in connection with choosing a suitable laboratory animal for the evaluation of biotransformation and toxicity of drugs. On the other hand, liver, kidney, intestine and serum were found to contain multiple forms of carboxylesterases in animal species and humans. In fact, we have purified more than fifteen isoforms of carboxylesterases from microsomes of liver, kidney and intestinal mucosa of nine animal species and humans. and characteristics of these isoforms were compared each other in terms of their physical and immunochemical properties. On the other hand, we have reported that hepatic microsomal carboxylesterases are induced by many exogenous compounds such as phenobarbital, polycyclic aromatic hydrocarbons, Aroclor 1254, aminopyrine and clofibrate. Later, we showed that some isoforms of hepatic carboxylesterase were induced by glucocorticoids such as dexamethasone and 16 ${\alpha}$-carbonitrile, but other isoforms were rather inhibited by these compounds. These findings indicate that involvement of carboxylesterases in the metabolism and toxicity of drugs should be explained by the isoforms involved. Since 1991, we have carried out detailed research investigating the types of carboxylesterases involved in the metabolic activation of CPT-11, a derivative of camptothecin, to the active metabolite, SN-38. The results obtained strongly suggest that some isoforms of carboxylesterase of liver microsomes and intestinal mucosal membrane are exclusively involved in CPT-11 metabolism. In this symposium, the properties of carboxylesterase isoforms purified from liver, kidney and intestine of animal species and humans are outlined. In addition, metabolism of CPT-11, a novel antitumor agent, by carboxylesterases in relation to the effectiveness will also be discussed.

• 한국지반공학회논문집
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• 제36권10호
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• pp.57-71
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• 2020

본 연구에서는 2017년 11월 15일 포항지진 시 액상화 위험도가 높았던 5개소의 부지에 대해 액상화 가능성을 재분석하였다. 액상화 지진 하중은 포항 지진파를 지반예측운동방정식(Ground motion prediction equation, GMPE)로 산정한 응답스펙트럼에 보정한 결과를 입력 지진파로 사용하였다. 지반의 액상화 저항력은 현장 시험 중 표준관입시험(Standard Penetration Test, SPT)과 콘관입시험(Cone penetration test, CPT)을 통해 결정되었다. 한편, 액상화 발생 가능성은 지반 액상화 지수(LPI)를 통해 정량화되었으며 이를 기존 연구 결과와 비교하였다.

• 대한물리의학회지
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• 제11권4호
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• pp.105-114
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• 2016

PURPOSE: This study is to investigate the therapeutic effect of Tetrax on balance dysfunction caused by ataxia in cerebellar stroke. METHODS: A total of thirty subjects with cerebellar stroke were recruited. The participants was divided into two groups, the experimental (n=15) and the control group (n=15). Tetrax training and conventional physical therapy (CPT) were performed in experimental group, whereas the patients in the control group were treated with CPT twice a day. Each session of the Tetrax and CPT was carried out for 30 minutes, 5 times per week for 4 weeks. Korean version of the Scale for the Assessment and Rating of Ataxia (K-SARA) was the primary outcome measure, and the secondary outcomes covered Berg balance scale (BBS), falling index (FI), Timed up and go (TUG), and modified Barthel index of Korean version (K-MBI). All outcome measures were evaluated before and after 4 weeks. RESULTS: K-SARA was decreased significantly after 4 weeks intervention in both the experimental (p<.05) and the control group (p<.05). Furthermore, the experimental group produced significantly better outcomes in K-SARA, BBS, FI, and TUG compared with the control group (p=.012, p=.027, p=.008, and p=.048). There were significant correlations between K-SARA and BBS, FI, TUG, and K-MBI (p<.001, p<.001, p=.004, and p<.001). CONCLUSION: The restoration of ataxia was related with the improvement of the balance, falling risk, mobility, and activity of daily living. Tetrax training was effectively aided recovery of ataxia after cerebellar stroke.

• 대한기계학회논문집A
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• 제23권11호
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• pp.1982-1992
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• 1999

This paper presents a novel concept of cargo handling system adapted for a sea port subjected to severe time-varying tide. The proposed system can perform loading or unloading by using a sort of hydraulic elevator associated with real-time position control. In order to achieve a proof-of-concept, a small-sized laboratory model of the cargo handling system is designed and built. The model consists of three principal components container palette transfer (CPT) car, platform with lifting columns, and cargo ship. The platform activated by electro-rheological (ER) valve-cylinders is actively controlled to track the position of the cargo ship subjected to be varied due to the time-varying tide and wave motion. Following the derivation of the dynamic model for the platform and cargo ship motions, an appropriate control scheme is formulated and implemented. The location of the CPT car is sensed by a set of photoelectric switches and controlled via sequence controller. On the other hand, a sliding mode controller (SMC) is adopted as the position controller for the platform. Both simulated and measured control results are presented to demonstrate the effectiveness of the proposed cargo system.

• 한국컴퓨터정보학회논문지
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• 제23권11호
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• pp.129-135
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• 2018

In this study, we designed a model that can measure the level of user's concentration by measuring and analyzing EEG data of the subjects who are performing Continuous Performance Test based on visual stimulus. This study focused on alpha and beta waves, which are closely related to concentration in various brain waves. There are a lot of research and services to enhance not only concentration but also brain activity. However, there are formidable barriers to ordinary people for using routinely because of high cost and complex procedures. Therefore, this study designed the model using the portable EEG measurement device with reasonable cost and Visual Continuous Performance Test which we developed as a simplified version of the existing CPT. This study aims to measure the concentration level of the subject objectively through simple and affordable way, EEG analysis. Concentration is also closely related to various brain diseases such as dementia, depression, and ADHD. Therefore, we believe that our proposed model can be useful not only for improving concentration but also brain disease prediction and monitoring research. In addition, the combination of this model and the Brain Computer Interface technology can create greater synergy in various fields.

• 한국지반공학회논문집
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• 제26권11호
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• pp.47-61
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• 2010

연직배수공이 매설되는 점토지반에서 압밀속도를 예측하기 위해서는 다양한 종류의 고급 실내 및 현장토질실험을 수행하여 합리적으로 수리학적 특성치를 결정하는 것이 바람직하다. 그러나 실무에서와 같이 보편적인 수행할 경우에 수리학적 특성을 합리적으로 규명하는 것이 우선 필요하다. 이를 위하여 낙동강 허구의 범람원 지역에 속하는 5개 지점을 선정하여 수많은 CPT 소산시험, 보편적인 실내 투수 및 압밀실험을 실시하였으며, 그들을 이용하여 종합적으로 분석하였다. 그 결과, 이 점토의 수평방향 압밀계수($C_{h,NC}$) 및 투수계수($k_{h,OC}$)는 Balight & Levadoux(1986)의 제안법을 적용한 CPT소산시험결과가 가장 적합한 것으로 나타났다. 여기서 $C_{h,NC}$와 $k_{h,OC}$는 각각 $0.4{\sim}3.0\;cm^2/sec$ 및 $(1{\sim}3){\times}10^{-9}m/sec$ 범위에 있으며, 두 값은 깊이에 따라 약간씩 증가 및 감소하는 경향을 보였다. 이러한 퇴적환경을 잘 반영하는 것으로 해석되었다.

• 한국지반공학회논문집
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• 제24권11호
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• pp.71-77
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• 2008

본 연구에서는 CPT 결과인 콘관입저항치 $q_c$값을 이용하여 말뚝의 극한수평단위지지력을 산정법을 제안하고자 한다. 이는 기존의 지반물성평가를 이용하여 평가되어 오던 간접적인 방법과 비교하여, 현장측정치의 직접적 적용을 위한 극한수평단위지지력 산정법 개발을 목표로 하고 있다. 점착력이 없는 사질토 지반을 대상으로 측정된 콘관입저항치 $q_c$값은 사질토지반에서 중요한 요소인 상대밀도, 연직응력, 수평응력에 대한 함수로 표현되며, 이는 기존에 제안되어온 극한수평지지력의 산정에 고려되는 요소들과 유사하다. 이러한 역학적 유사성을 바탕으로 CPT결과를 이용한 극한수평단위지지력 산정식을 제안하였다. 이는 점착력이 없는 사질토에 대상으로 하고 있으며, 그에 대한 해석을 위해 해석대상지반을 대상으로 제안된 산정식의 신뢰성을 확보하였다 극한수평단위지지력의 측정값과 예측값에 따른 비교에 대해 표준편차는 0.279를 보였으며, COV는 0.272의 값을 보여 측정된 극한수평단위지지력과 대체적으로 유사한 결과를 보였으며, 전반적으로 제안식에 의해 예측된 극한수평단위지지력이 실내모형실험을 통한 측정값에 근접함을 알 수 있다.

• The Journal of Korean Physical Therapy
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• 제23권2호
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• pp.53-59
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• 2011

Purpose: This study was designed to compare the effects of transcutaneous electrical nerve stimulation (TENS) and silver spike point (SSP) therapy on current perception threshold (CPT) and mechanical pain threshold (MPT). Methods: Forty-five healthy adult male and female subjects were studied. Fourteen of them were males and twenty-one were females. Subject were randomly assigned to receive; (1) TENS (80/120 Hz alternating frequency), (2) SSP (3 Hz), or (3) no treatment (control group). Electric stimulation was applied over LI4 and LI11 on acupuncture points of the left forearm for 30 minutes. CPT and MPT were recorded before and after electrical stimulation. The data were analyzed using linear mixed models, with group treated as a between subject factor and time a within-subject factor. Results: At 30 minutes after cessation of electrical stimulation the CPT of C fibers and A${\delta}$fibers was reduced in the TENS group that of C fibers was reduced in the SSP group (p<0.05). After cessation of electrical stimulation, the MPT of C fibers and A${\delta}$fibers increased in the TENS group, and that of A${\delta}$fibers increased in the SSP group (p<0.05). Conclusion: After TENS and SSP stimulation, MPT of C fibers and A${\delta}$fibers were selectively increased. In particular, the TENS group showed increases in both C and A${\delta}$fibers, while the SSP group showed increases only in A${\delta}$fibers.

• The Journal of Korean Physical Therapy
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• 제26권6호
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• pp.442-448
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• 2014

Purpose: The objective of this study is to evaluate the effect of neuro-feedback training and transcutaneous electrical nerve stimulation (TENS) on stress, quantitative sensory threshold and pain in patients suffering from tension type headache. Methods: 22 participants who passed the preliminary evaluation were enrolled in the study and 11 participants were randomly assigned to each group. The control group (n=11) was subject to the TENS treatment of which was composed of a 20-minute session for 5 times a week during 4 weeks, and the experimental group (n=11) was subject to both neuro feedback training and TENS treatment for 10 minutes a day and 5 days a week during 4 weeks. The Perceived Stress Scale (PSS) was used to measure a level of stress and the quantitative sensory testing (QST) was used for the measurement of cold pain threshold (CPT) and heat pain threshold (HPT); A degree of pain was evaluated through the headache impact test-6 (HIT-6). Results: In comparision of all dependent variables between the control and subject groups, there were significant differences in stress, quantitative sensory threshold and pain after the treatment (p<0.05), and the experimental group showed significant differences in stress, CPT, HPT and pain (p<0.05) and the control group showed only a significant difference in HPT (p<0.05). Conclusion: Findings of this study demonstrate that the concomitant administration of the TENS treatment and neuro feedback training is effective on alleviation of stress, quantitative sensory threshold and pain in patients with tension type headache.