• 한국영어학회지:영어학
• /
• 제1권3호
• /
• pp.437-456
• /
• 2001

This paper raises a question on the theoretical background behind the English education at the elementary school level. The Critical Period Hypothesis (CPH), supporting the common belief of the earlier the better in foreign language learning, which has promoted the strong trend toward teaching English in Korean elementary schools, is analyzed to determine whether it provides a comprehensible picture to explain age-related factors and whether it is a valid hypothesis which can be applicable in an EFL situation such as Korea. This paper concludes that CPH itself is still considered as an impending hypothesis full of unresolved issues and that the present educational situation of Korean elementary schools is rather far from the environment in which the ideas of CPH could practically apply, and thus it may be desirable to find alternative theoretical backgrounds from which the educational programs can be developed and further expanded.

• Journal of Microbiology and Biotechnology
• /
• 제16권9호
• /
• pp.1441-1447
• /
• 2006

The light perception and phototransformation of phytochromes are the first process of the phytochrome-mediated light signal transduction. The chromophore ligation and its photochromism of various site-specific and deletion mutants of pea phytochrome A and bacterial phytochrome-like protein (Cph1) were analyzed in vitro. Serial truncation mutants from the N-terminus and C-terminus indicated that the minimal N-terminal domain for the chromophore ligation spans from the residue 78 to 399 of pea phytochrome A. Site-specific mutants indicated that several residues are critical for the chromophore ligation and/or photochromism. Histidine-324 appears to serve as an anchimeric residue for photochromism through its H-bonding function. Isoleucine-80 and arginine-383 playa critical role for the chromophore ligation and photochromism. Arginine-383 is presumably involved in the stabilization of the Pfr form of pea phytochrome A. Apparently, the amphiphilic ${\alpha}$-helix centered around the residue-391 is in the chromophore pocket and critical for the chromophore ligation.

• Journal of Acupuncture Research
• /
• 제19권2호
• /
• pp.51-64
• /
• 2002

류마티스 관절염의 쥐의 활액에서 단백분해효소, 산화제와 유리기에 대한 녹용약침의 비특이적 면역억제효과를 연구하였다. 일련의 실험표본으로서 여러가지 세포질, 리소좀, 기질 백분해효소의 제 활성을 RA대조군과 녹용약침군의 활액에서 카르보닐기 유도로 생성되는 유리기-유발 단백질손상과 항산화를 비교하였다. 전반적으로 단백분해효소활성이 정상군과 비교하여 RA대조군에서 유의성 있게 증가하였다. 세포질 단백분해효소들은 정상군과 RA군의 차이에서는 유의성이 없었다. 녹용약침처리($100{\mu}g/kg$)결과 세포질, 리소좀, 기질 단백분해효소생성을 억제하였으며, RA군과 녹용약침군 또는 정산군 사이에 활액 또는 세포질 항산화에서 유의성 있는 차이가 없음에도 불구하고, RA군 활액의 단백질손상을 유발하는 유리기는 녹용약침군과 정산군에 비교하여 약 2배 정도 높았다. 이상의 결과에서 단백분해효소와 유리기는 RA유발시 단백질손상을 유도하는 물질로 밝혀졌으며, 따라서 단백분해효소 저해와 유리기소거능을 갖는 치료법개발이 새로운 RA예방치료법으로 제시되었다. 나아가서 여러가지 기질특이성을 갖는 활액내 단백분해효소류(cysteine, serine, metallo proteinases와 peptidases)에 대한 효과적인 저해제개발이 필요한 것으로 보인다. 따라서 본 녹용약침은 이와 같은 새로운 개념의 2가지(유리기제거, 단백분해활성) 관절염치료 요소를 충족하는 약리활성을 포함하는 훌륭한 제제로 평가된다.

• Bulletin of the Korean Chemical Society
• /
• 제15권10호
• /
• pp.821-824
• /
• 1994

• Journal of Radiation Protection and Research
• /
• 제14권2호
• /
• pp.23-29
• /
• 1989

이중관 형태의 라돈 표준선원을 제작하여 루카스셀의 계수치 (cph)를 라돈농도로 나타내기 위한 환산인자를 측정한 결과 라돈 표준선원을 실온으로 하였을 때는 0.031$\pm$0.001 (pCi/l)/(cph/Cell)였다. 사무실 내에서 라돈과 라돈 자핵종의 농도를 측정한 값은 $^{222}Rn,\;{\rightarrow}^{218}Po\;{\rightarrow}^{214}Pb,\;{\rightarrow}^{214}Bi$ 의 평균 농도가 각각 0.87, 0.53, 0.35, 0.26 pCi/l 였다. 이때 전체 방사평형인자와 WL의 평균 값은 각각 0.40, 3.33${\times}10^{-3}$ 이며 측정 지점에서 연간 피폭되는 방사선량으로 환산하면 약 30 mren 이다.

• 한국영어학회지:영어학
• /
• 제1권4호
• /
• pp.587-608
• /
• 2001

When teaching English in elementary schools was introduced in Korea in 1997, the theoretical basis was the critical period hypothesis (CPH). The object of this study was to test whether the Korean situation satisfies the conditions for the CPH such as the amount of English input and needs. As a test for this, English input and needs were compared in Korea, the U.S.A. and Singapore. The items for English input were on a continuum of primary to secondary sources and the items for English needs were on a continuum of immediate to future needs. The 0-5 scale was used. The result showed that the total means of English input were 4.87, 4.62, and 1.05 for children in the U.S.A., Singapore and Korea respectively. The total means of English needs were 4.32, 3.81, and 1.52 for children in the U.S.A., Singapore and Korea respectively. These figures show that Korean children's levels of both input and needs were from “almost none” to “little,” while those of children in the U.S.A. and Singapore were from “much” to “very much.” This shows that teaching English in Korea presently is far from meeting the conditions that are expected by the CPH. As an alternative to explain what happens cognitively to Korean children, this paper suggests the automatization and proceduralization processes.

• Journal of Oral Medicine and Pain
• /
• 제48권3호
• /
• pp.112-117
• /
• 2023

Coronoid process hyperplasia (CPH) of the mandible is a rare condition in which abnormal elongation of the coronoid process leads to chronic mandibular hypomobility. CPH causes impingement or impedance of the coronoid process on the inner surface of the frontal part of the zygomatic bone during mouth opening. The lack of significant symptoms makes the diagnosis difficult. Its etiology remains inconclusive despite several theories being suggested. In this report, three reviewed cases are presented. All three patients visited our clinic with limited mouth opening as the chief complaint. Standard clinical and radiographic examinations were conducted under the initial impression of temporomandibular disorders (TMDs), and restricted jaw movements were confirmed in all cases. The absence of improved signs and symptoms following conservative treatment for TMDs or the indeterminate plain radiographs required the attending clinicians to consider three-dimensional imagery. Computed tomography revealed bilateral coronoid hyperplasia in all cases and impingement on the zygomatic bone in two of the three cases. After concluding that this condition caused the patients' limited mouth opening, the patients were referred to the Department of Oral and Maxillofacial Surgery for possible bilateral coronoidectomy or coronoidotomy. CPH usually presents no symptoms apart from a progressive reduction of mouth opening over time. Diagnosis is often delayed, and patients may undergo unnecessary treatment procedures. Clinicians should be aware of this condition and exercise caution in the differential diagnosis of patients with chronic mandibular hypomobility.

• Macromolecular Research
• /
• 제10권3호
• /
• pp.178-180
• /
• 2002

The conducting behavior of dendritic carbosilanes including palladium ions (Pd$^{2+}$) has been measured. The palladium ion containing dendrimers were prepared by the addition of palladium dichloride to double-layered dendritic carbosilanes, which consist of phenylethynyl groups (-C≡CPh) on the outmost periphery as well as phenylethenyl and propyleneoxy groups (-CH=CPh- and (CH$_2$)$_3$O-) in the inner shell. By measuring conductivities, palladium ion containing dendrimers revealed an increasing tendency according to the increasing number of double bonds in the inner shells of dendritic carbosilanes.s.

• 산업경영시스템학회지
• /
• 제21권46호
• /
• pp.59-72
• /
• 1998

This study is concerned in manufacturing cell formation with operation sequences. Operation sequences must be reflected for manufacturing cell formation anyway, because the primary aim of cellular manufacturing system is to minimize the inter-cell flows, and inter-cell flows are differed by operation sequences. In this study we propose flow-similarity(FS) of reflecting both inter-machine similarity and direct/indirect flow, and then apply the modified P-median model for grouping machines. We also use machine cell-part handling frequency(CPH) so as to be assigned parts to the machine cells having the most CPH. We confirm this approach through an application example. The performance of this approach(FS-model) is evaluated and compared with P-median model and F-model through computational experiments.

• 한국대기환경학회:학술대회논문집
• /
• 한국대기환경학회 1997년도 한국대기보전학회 추계학술대회 요지집
• /
• pp.66-67
• /
• 1997