• The Korean Journal of Physiology and Pharmacology
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• v.25 no.3
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• pp.189-195
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• 2021

Fluoxetine (FLX), a selective serotonin reuptake inhibitor antidepressant, exhibits various other mechanisms of action in numerous cell types and has been shown to induce cell death in cancer cells, paving the way for its potential use in cancer therapy. The aim of this study was to determine the off-target effects of the anti-depressant drug FLX, on the human ovarian granulosa tumor COV434 cells stimulated by forskolin (FSK), by measuring the real-time kinetics of intracellular cyclic AMP (cAMP), ATP level, cytoplasmic calcium ([Ca2+]cyt) and survival of COV434 cells. We show that incubating COV434 cells with FLX (between 0.6 and 10 μM) induces a decrease in intracellular cAMP response to FSK, a drop in ATP content and stimulates cytoplasmic Ca2+ accumulation in COV434 cells. Only the highest concentrations of FLX (5-10 μM) diminished cell viability. The present report is the first to identify an action mechanism of FLX in human tumor ovarian cells COV434 cells and thus opening the way to potential use of fluoxetine as a complementary tool, in granulosa tumor treatments.

• Journal of Energy Engineering
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• v.22 no.2
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• pp.197-204
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• 2013

A cyclic variability has long been recognized as limiting the range of operating conditions of spark ignition engines, in particular, under idling conditions. The coefficient of variation (COV) in indicated mean effective pressure (IMEP) defines the cyclic variability in indicated work per cycle, and it has been found that vehicle drivability problems usually result. For analysis of the cyclic variations in spark ignition engines at idling, the results show that cyclic variability by the COV, COV of IMEP, the lowest normalized value (LNV), and burn angles can help to design the spark ignition engine.

• The Pure and Applied Mathematics
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• v.4 no.2
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• pp.137-144
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• 1997

In this paper we consider covering problems in spherical geometry. Let $cov_q{S_1}^n$ be the smallest radius of q equal metric balls that cover n-dimensional unit sphere ${S_1}^n$. We show that $cov_q{S_1}^n\;=\;\frac{\pi}{2}\;for\;2\leq\;q\leq\;n+1$ and $\pi-arccos(\frac{-1}{n+1})$ for q = n ＋ 2. The configuration of centers of balls realizing $cov_q{S_1}^n$ are established, simultaneously. Moreover, some properties of $cov_{q}$X for the compact metric space X, in general, are proved.

• Journal of the Korean Society of Radiology
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• v.13 no.5
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• pp.773-778
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• 2019

Images using X-rays are essential to diagnosis, but noise is inevitable in the image. To compensate for this, a total variation (TV) algorithm was presented to reduce the patient's exposure dose while increasing the quality of the images. The purpose of this study is to verify the effect on the image quality in radiographic imaging according to the thickness of the additional filtration plate through simulation, and to evaluate the usefulness of the TV algorithm. By using the Geant4 Application for Tomographic Emissions (GATE) simulation image, the actual size, shape and material of the Polymethylmethacrylate (PMMA) phantom were identical, the contrast to noise ratio (CNR) and coefficient of variation (COV) were compared. The results showed that the CNR value was the highest and the COV the lowest when applying the TV algorithm. In addition, we can acquire superior CNR and COV results with 0 mm Al in all algorithm cases.

• Journal of the Korean Society of Radiology
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• v.13 no.5
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• pp.765-771
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• 2019

Noise in skull X-ray imaging is inevitable, which reduces imaging quality and diagnostic accuracy and increases errors due to the nature of digital imaging devices. Increasing the dose can attenuate noise, but that could lead to big problems with higher exposure dose received by patients. Thus, noise reduction algorithms are actively being studied at low doses to solve dose problems and reduce noise at the same time. Wiener filter and median filter have been widely used, with the disadvantages of poor noise reduction efficiency and loss of much information about imaging boundary. The purpose of this study is to apply total variation (TV) algorithm to skull X-ray imaging that can compensate for the problems of previous noise reduction efficiency to assess quantitatively and compare them. For this study, skull X-ray imaging is obtained using various kVp and mAs using the skull phantom using the X-ray device of Siemens. In addition, contrast to noise ratio (CNR) and coefficient of variation (COV) are compared and measured when noisy image, median filter, Wiener filter and TV algorithm were applied to each phantom imaging. Experiments showed that when TV algorithms were applied, CNR and COV characteristics were excellent under all conditions. In conclusion, we've been able to see if we can use TV algorithm to improve image quality and CNR could be seen to increase due to the decrease in noise as the amount of increased mAs. On the other hand, COV decreased as the amount of increased mAs, and when kVp increased, noise was reduced and the transmittance was increased, so COV was reduced.

• Journal of Korea Technology Innovation Society
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• v.12 no.2
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• pp.413-429
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• 2009

As science and technology which the society requires become highly advanced and complicated, the need of so-called Convergence Technology(CovT) is getting more significant. The major developed countries are presenting their own vision and strategies of CovT to take the lead of future society and global economies. In Korea, each ministries and government offices are suggesting their own directions of promoting CovT and supporting the related programs. This paper investigates the overall status of national and international R&D activities related to CovT in order to invigorate the related national R&D programs and maximize their effectiveness. It also purports to realize the growth potential and a ripple effect of CovT, such as new business creation and fulfillment of public needs, so that secure new CovT in an early stage. Based on the analysis of the overall status of national R&D programs, we redefine and re-categorize the CovT, which is especially oriented to the development of government support policy, and present the customized strategies to each categories.

• Journal of the Korean Society of Radiology
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• v.17 no.1
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• pp.1-9
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• 2023

For optimal image quality of computer tomography angiography (CTA), different iodine concentrations and scan parameters were applied to quantitatively evaluate the image quality characteristics of filtered back projection (FBP), hybrid-iterative reconstruction (hybrid-IR), and deep learning reconstruction (DLR). A 320-row-detector CT scanner scanned a phantom with various iodine concentrations (1.2, 2.9, 4.9, 6.9, 10.4, 14.3, 18.4, and 25.9 mg/mL) located at the edge of a cylindrical water phantom with a diameter of 19 cm. Data obtained using each reconstruction technique was analyzed through noise, coefficient of variation (COV), and root mean square error (RMSE). As the iodine concentration increased, the CT number value increased, but the noise change did not show any special characteristics. COV decreased with increasing iodine concentration for FBP, adaptive iterative dose reduction (AIDR) 3D, and advanced intelligent clear-IQ engine (AiCE) at various tube voltages and tube currents. In addition, when the iodine concentration was low, there was a slight difference in COV between the reconstitution techniques, but there was little difference as the iodine concentration increased. AiCE showed the characteristic that RMSE decreased as the iodine concentration increased but rather increased after a specific concentration (4.9 mg/mL). Therefore, the user will have to consider the characteristics of scan parameters such as tube current and tube voltage as well as iodine concentration according to the reconstruction technique for optimal CTA image acquisition.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.33 no.12
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• pp.19-28
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• 2017

The purpose of this study is to propose a design methodology to build temporary isolation rooms when infectious diseases suddenly occur in a certain region, such as the case of MERS-Cov in South Korea in 2015. Although most big hospitals usually have isolation rooms, they are expensive and dangerous to run such facilities on normal and typical days. To deal with these problems in this research, shipping containers are chosen as devices used to build the temporary isolation rooms near the original hospital. To do so, firstly, a prototype for the temporary isolation room was designed with the three part modules. The first part is for the medical team; the second part including the isolation rooms is for patients; the third part is for medical selection rooms to test the specimens. Secondly, the plan was compared with the MERS-Cov infection control guidelines. Finally this prototype is applied into the Yong-in Yon-sei severance hospital and then evaluated through a CFD simulation using STAR-CCM+(ver.9.06) for checking infectious bacterium movement in this prototype. The result showed that the prototype is effectively safe for patients tested as negative, patients waiting to be tested, and the medical team.

• Geomechanics and Engineering
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• v.36 no.6
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• pp.631-640
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• 2024

In the traditional slope stability analysis, ignoring the spatial variability of slope soil will lead to inaccurate analysis. In this paper, the K-L series expansion method is adopted to simulate random field of soil strength parameters. Based on Random Limit Equilibrium Method (RLEM), the influence of variation coefficient and fluctuation range on reliability of soil slope supported by micro-pile is investigated. The results show that the fluctuation ranges and the variation coefficients significantly influence the failure probability of soil slope supported by micro-pile. With the increase of fluctuation range of soil strength parameters, the mean safety factor of the slope increases slightly. The failure probability of the soil slope increases with the increase of fluctuation range when the mean safety factor of the slope is greater than 1. The failure probability of the slope increases by nearly 8.5% when the fluctuation range is increased from δ_v=2 m to δ_v =8 m. With the increase of the variation coefficient of soil strength parameters, the mean safety factor of the slope decreases slightly, and the probability of failure of soil slope increases accordingly. The failure probability of the slope increases by nearly 31% when the variation coefficient increases from COV_c=0.2, COV_φ=0.05 to COV_c=0.5, COV_φ=0.2.

• Journal of the Korean Society of Radiology
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• v.14 no.5
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• pp.511-515
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• 2020

In this study, we evaluated image quality for new Gadolinium Aluminum Gallium Garnet (GAGG) scintillation material based on the Geant4 Application for Tomographic Emission (GATE) simulation tool. The gamma camera detectors with GAGG and NaI scintillation were designed. In particular, we modeled modified body phantom by National Electrical Manufacturers Association International Electrotechnical Commission to evaluate the simulated images. To analysis the image performance, the contrast to noise ratio (CNR) and coefficient of variation (COV) were used by drawn the region of interests, respectively. Based on the CNR and COV results, the CNR value for GAGG material is higher approximately 17 % than NaI material. In addition, the COV value for GAGG material is lower approximately 17 % than NaI material. In conclusion, we confirmed the performnace of GAGG based gamma camera is useful to improve the image quality for the nuclear medicine instrumentation.