• IMMUNE NETWORK
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• 제3권2호
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• pp.83-88
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• 2003

The number of umbilical cord blood transplantation is increasing worldwide as it has expanded the ability of the transplantaion community to meet the growing needs of their patients. Clinical data over the last decade show promising results in transplantation using both related as well as unrelated cord bloods. Cord blood banks are essential for the clinical use for transplantation and are now established around the world with the major efforts to standardize banking in collection, processing and distribution of cord blood for providing the highest quality stem cells for the patients. In Korea, Medipost, Histostem and some regional cord blood banks were established some years ago and collected thousands of cord blood for public but it had some limitations and was not expanded as the cord blood transplantation was not covered by medical insurance. Recently with the change in the policy of medical insurance to cover the cord blood transplantation, several venture companies are showing great interests in cord blood banking and trying to establish private cord blood banks in Korea. This review article discusses the current status of cord blood transplantaion and also the clincial use of stem cells from cord blood.

• 대한지역사회영양학회지
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• 제7권4호
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• pp.578-584
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• 2002

This study was designed to investigate the association between the period of engraftment and the nutritional status of patient s undergoing bone marrow transplantation for acute myelogenous leukemia (AML). Nutritional status was evaluated by body mass index (BMI), percentage of ideal body weight (PIBW), percentage of weight loss, and serum albumin, total protein (T protein), hemoglobin (HGB) and hematocrit (HCT) levels on the day prior to transplantation and on the day of bone marrow transplantation. The periods of engraftment were determined by absolute neutrophil counts (ANC) above $500/mm^3$ from the day of bone marrow transplantation. The study subjects were 80 patients (55 males, 25 females) with acute myelogenous leukemia admitted to the University Hospital in Seoul. The result of this study is as follows : Tie nutritional status values of the majority of patients on the day prior to transplantation were in the normal range except for HGB and HCT ; however, during hospitalization, all of the levels of the nutritional status values were significantly decreased. The periods of engraftment of the abnormal group according to their BMI, PIBW, HGB and HCT levels on the day of bone marrow transplantation showed no difference when compared to the normal group. However, the periods of engraftment of the abnormal group, according to the percentage of weight loss, albumin, and T protein levels were significantly decreased when compared to the normal group. Therefore, the nutritional status of patients at the time of transplant had a noticeable influence on the periods of engraftment. Our results suggested that nutritional status is a critical factor of engraftment in BMT during pre-transplant and post-transplant. Futhermore, we recommend that the process of nutritional preparation for the transplant should initiate immediately after the transplant decision has been made.

• 한국환경생태학회지
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• 제26권3호
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• pp.394-405
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• 2012

본 연구는 매립공사로 인해 훼손되는 토취장을 대상으로 생태계 훼손에 따른 이식방안을 제안하고자 하였다. 연구대상지는 전라남도 광양시 중군동에 위치하며 전체 면적은 약 $199,026m^2$이나 토취에 의해 훼손되는 지역은 약 $84,200m^2$로 이들 지역에 대하여 생태계 훼손에 따른 이식방안을 제시하고자 하였다. 본 연구대상지내 분포하는 식생구조 및 발달과정, 지형 및 토양의 이화학적 특성, 연륜구조 등을 종합적으로 분석하여 훼손이 불가피한 대상지의 이식방안을 제안하고자 하였다. 분석결과, 본 연구에서 군락이식과 수목이식으로 구분하여 기존 신갈나무림과 곰솔림을 모델로 식재방안을 제안하였다. 훼손지의 군락이식에 있어서는 신갈나무숲을 조성하여 자연림의 복원을 도모하며, 이식량에 있어서는 교목층의 신갈나무 89주, 아교목층 153주, 관목층 661주가 적정할 것으로 조사되었으며 수목이식은 기존의 곰솔 이식으로 교목층의 곰솔 2,648주이었고, 전체 표토 이식량은 $15,353m^3$로 산출되었다. 본 연구결과는 매립에 따른 훼손지의 문제점을 해결하기 위한 생태계 보상 및 훼손 저감장치로서 유용하게 작용할 것으로 판단된다.

• 한국조경학회지
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• 제30권6호
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• pp.66-78
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• 2003

The purpose of this study was to minimize the forest disturbance around an entry road of a power transmission tower construction site between Taean and Sinsesan, Chungnam. The main study field was classified into existing materials and a GIS, remote sensing analysis, and a field examination. This information was used to identify the most suitable entry road using a degree of green naturality map, eco-naturality map, actual vegetation map, and a forest state map as the existing materials. Also, the study used an normalized difference vegetation index, altitude and slope map in order to make the evaluation materials which used an remote sensing image, and GIS. This data was used to choose an optimum area, and diagnosed the current condition of the vegetation with a field survey of the area. It analyzed vegetation structure, species diversity, the age of trees in a field examination. Subsequently, we proposed four area types based on the analysis results--preservation area, transplantation area, restoration area and development area. As a result, the preservation area was categorized into 8 grades, according to the degree of green naturality, large area of breast diameter at Pinus densiflora community, competition area of Pinus densiflora and Quercus spp. and Quercus spp. community of over 20 years old. A transplantation area established 46 optimum areas according to the GIS analysis and vegetation investigation results. Vegetation restoration plan for disturbance area should be made based on ecological value of existing vegetation to worthwhile area as Quercus spp. mixing forest proposed. The development area selected a ecological worthless place as an artificial forest where Pinus densiflora and Pinus thunbergii growth is poor. This research results suggest that restoration of vegetation will be possible in the real world. Also, ecological restoration guidelines will be made through building and analyzing data base and routine monitoring of transplantation and restoration area.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권4호
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• pp.207-218
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• 2013

Long term outcomes after liver transplantation are major determinants of quality of life and of the value of this heroic treatment. As short term outcomes are excellent, our community is turning to take a harder look at long term outcomes. The purpose of this paper is to review these outcomes, and highlight proposed treatments, as well as pressing topics needing to be studied. A systemic review of the English literature was carried in PubMed, covering all papers addressing long term outcomes in pediatric liver transplant from 2000-2013. Late outcomes after pediatric liver transplant affect the liver graft in the form of chronic liver dysfunction. The causes include rejection particularly humoral rejection, but also de novo autoimmune hepatitis, and recurrent disease. The metabolic syndrome is a major factor in long term cardiovascular complication risk. Secondary infections, kidney dysfunction and malignancy remain a reality of those patients. There is growing evidence of late cognitive and executive function delays affecting daily life productivity as well as likely adherence. Finally, despite a good health status, quality of life measures are comparable to those of children with chronic diseases. Long term outcomes are the new frontier in pediatric liver transplantation. Much is needed to improve graft survival, but also to avoid systemic morbidities from long term immunosuppression. Quality of life is a new inclusive measure that will require interventions and innovative approaches respectful not only on the patients but also of their social circle.

• 한국자원식물학회지
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• 제22권1호
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• pp.102-110
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• 2009

본 연구는 2006년 7월부터 2008년 4월까지 한국 서남해안의 대표적인 18개 해안 염습지에서 생육지와 토양특성을 조사하여 서남해안 염습지 식생복원을 위한 기초자료를 제시하였다. 조사지역은 염습지의 생육지 유형에 따라 1차적으로 해안성 염습지와 하구성 염습지로 구분하고, 2차적으로 해안성 염습지는 점토성 염습지, 사질성 염습지, 사구성 염습지, 하구성 염습지는 염소택지와 기수성 염습지로 구분하였다. 생육지 유형별 주요 식물군락은 점토성 염습지에서는 갈대군락, 천일사초군락, 칠면초군락, 사질성 염습지에서는 갈대군락, 갯잔디군락, 천일사초군락, 퉁퉁마디군락, 큰비쑥군락, 해홍나물군락, 사구성 염습지에서는 갯그령군락, 통보리사초군락, 순비기나무군락, 염소택지에서는 갈대군락, 갯잔디군락, 해홍나물군락, 천일사초군락, 하구 염습지에서는 칠면초군락, 갈대군락, 천일사초군락, 나문재군락으로 나타났다. 염생식물 군락분포지역의 토양 환경은 염생식물의 생육지 특성에 따른 염생식물군락과 토양의 차이가 나타났다. 따라서 해안 염습지를 복원할 경우, 염습지를 대상으로 생육지 토양의 물리적 특성, 이화학적특성을 파악하여 생육지 조건에 맞는 염생식물을 선정하고, 이식한 후 자연식생이 형성된 지역을 중심으로 점차 확장시킴으로써 염생식물이 안정적으로 정착, 발아, 생장하는데 유리할 것이다.

• IMMUNE NETWORK
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• 제22권6호
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• pp.44.1-44.28
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• 2022

Gut dysbiosis is one of prominent features in inflammatory bowel diseases (IBDs) which are of an unknown etiology. Although the cause-and-effect relationship between IBD and gut dysbiosis remains to be elucidated, one area of research has focused on the management of IBD by modulating and correcting gut dysbiosis. The use of antibiotics, probiotics either with or without prebiotics, and fecal microbiota transplantation from healthy donors are representative methods for modulating the intestinal microbiota ecosystem. The gut microbiota is not a simple assembly of bacteria, fungi, and viruses, but a complex organ-like community system composed of numerous kinds of microorganisms. Thus, studies on specific changes in the gut microbiota depending on which treatment option is applied are very limited. Here, we review previous studies on microbial modulation as a therapeutic option for IBD and its significance in the pathogenesis of IBD.

• 한국조경학회지
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• 제35권6호
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• pp.48-63
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• 2008

This research is to apply suitable natural ecosystem evaluation criteria in order to develop the ecosystem conservation, restoration and ways to build substitute habitats as a compensation plan for damaged soundly natural ecosystems in small-scale projects such as resource recovery facility, filtration, etc. The environmental ecology evaluation i.e. generally based on their actual vegetation, community structure, wildlife, water system survey were measured the primary plans for reflecting unique natural environment level of site. As a result, it is necessary to conserve the land in fallow type of wetland, good conservative condition of deciduous forest, wetlanded watercourse for amphibia and reptiles crossing. However, the plan of filtration plant was destroyed wetland(sound ecosystem), natural forest, asian toad spawning area. According to the result of it schemed to build alternative wetland and spawning area, plan to healthy ecosystem and surface soil transplantation as compensation plan. The alternative wetland and spawning area are not only created a various water levels like depth of water is $0{\sim}30cm,\;30{\sim}60cm$, more than 1.5m but also it leads to asian toad spawning and wildlife inhabitant. Moreover, the ecosystem and surface soil transplantation be applied to use the Quercus acutissima forest resources(114 upper trees, 71 canopy trees, 401 shrubs) and surface soil$(5,072m^3)$ in ecology creation sets.

• The Korean Journal of Pain
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• 제35권1호
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• pp.43-58
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• 2022

Background: Current therapies are quite unsuccessful in the management of neuropathic pain. Therefore, considering the inhibitory characteristics of GABA mediators, the present systematic review and meta-analysis aimed to determine the efficacy of GABAergic neural precursor cells on neuropathic pain management. Methods: Search was conducted on Medline, Embase, Scopus, and Web of Science databases. A search strategy was designed based on the keywords related to GABAergic cells combined with neuropathic pain. The outcomes were allodynia and hyperalgesia. The results were reported as a pooled standardized mean difference (SMD) with a 95% confidence interval (95% CI). Results: Data of 13 studies were analyzed in the present meta-analysis. The results showed that administration of GABAergic cells improved allodynia (SMD = 1.79; 95% CI: 0.87, 271; P < 0.001) and hyperalgesia (SMD = 1.29; 95% CI: 0.26, 2.32; P = 0.019). Moreover, the analyses demonstrated that the efficacy of GABAergic cells in the management of allodynia and hyperalgesia is only observed in rats. Also, only genetically modified cells are effective in improving both of allodynia, and hyperalgesia. Conclusions: A moderate level of pre-clinical evidence showed that transplantation of genetically-modified GABAergic cells is effective in the management of neuropathic pain. However, it seems that the transplantation efficacy of these cells is only statistically significant in improving pain symptoms in rats. Hence, caution should be exercised regarding the generalizability and the translation of the findings from rats and mice studies to large animal studies and clinical trials.

• Journal of Ecology and Environment
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• 제30권3호
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• pp.251-255
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• 2007

Self-thinning was measured in Salix communities on Bam Island in Seoul at various age stages. $D^2H$ was used to estimate tree biomass, where D is stem diameter at breast height or 10 cm height for plants with height <1.5 m, and H is height. A log-log plot of density versus $D^2H$ and correlation analysis indicated a significant relationship between density and biomass with equation 'log $D^2H$ = -1.27 log N + 7.06'. This indicates that self-thinning affects biomass in the Salix community with -1.27 as the thinning coefficient. If we assume a thinning exponent -3/2, then the allometric coefficient of the equation, log w = a log $D^2H$ + b, is 1.18. This is much higher than that for any other species studied in Korea. There were statistically significant relationships between age and density and between age and basal area and these relationships suggest guidelines for transplantation of willows and for the assessment of Salix community restoration projects in riverine wetlands based on standard density, basal area, and age. The results of this study may also increase understanding of succession processes in Salix community restoration in riverine wetlands.