• Radiation Oncology Journal
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• v.23 no.2
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• pp.98-105
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• 2005

Purpose : The objective of our study was to evaluate the immunohistochemical expression of p53 and bax proteins as prognostic markers in FIGO stage IIb invasive squamous cell carcinoma of the uterine cervix. Materials and Methods : Sixty-five cases of squamous cell carcinoma of the cervix (stage IIb) that were diagnosed from October 1995 to December 2003 were analyzed retrospectively for the bax and p53 expression. These expressions were determined immunohistochemically and they were correlated to the patients' overall survival and disease-free survival. Results : The overall 5-year survival (OS) rate and the disease-free survival (DFS) rate were $65.1\%$ and $62.9\%$, respectively. p53 and bax immunoreactivity was seen in $26.2\%$ and $52.3\%$ of cases, respectively, with variable levels of expression. On the univariate analysis, only p53 positivity correlated with poor survival in DFS (log-rank test p=0.027), but this significance was not maintained on multivariated analysis by Cox's regression. The nine cases with the immunophenotype ps3+/bax- had the poorest survival. Conclusion : Neither p53 nor bax expression are Independent predictors of the prognosis for stage IIb cervical squamous cancers. Evaluation of p53 and bax co-expression may affect the clinical outcome and further investigation is needed.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.1
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• pp.85-88
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• 2015

This study attempted to establish an HPLC analysis method for determination of marker compounds as a part of material standardization for the development of health functional food materials from Perilla frutescens Britton var. acuta Kudo. The quantitative determination method of rosmarinic acid as a marker compound of P. frutescens Britton var. acuta Kudo extract (PFE) was optimized by HPLC analysis using a C18 column ($4.6{\times}150mm$, $5{\mu}m$) with 0.1% acetic acid as the elution gradient and methanol as the mobile phase at a flow rate of 1 mL/min and detection wavelength of 280 nm. The HPLC/UV method was applied successfully to quantification of the marker compound in PFE after validation of the method with linearity, accuracy, and precision. The method showed high linearity in the calibration curve at a coefficient of correlation ($R^2$) of 0.9995, and the limit of detection and limit of quantitation were $0.36{\mu}g/mL$ and $1.2{\mu}g/mL$, respectively. Relative standard deviation (RSD) values of data from intra- and inter-day precision were less than 3.21% and 1.43%, respectively. Recovery rate test at rosmarinic acid concentrations of 12.5, 25 and $50{\mu}g/mL$ scored between 97.04~98.98% with RSD values from 0.25~1.97%. These results indicate that the established HPLC method is very useful for the determination of marker compound in PFE to develop a health functional material.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.11
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• pp.41-47
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• 2016

High efficiency video coding (HEVC) employs a coding tree unit (CTU) to improve the coding efficiency. A CTU consists of coding units (CU), prediction units (PU), and transform units (TU). All possible block partitions should be performed on each depth level to obtain the best combination of CUs, PUs, and TUs. To reduce the complexity of block partitioning process, this paper proposes the PU mode skip algorithm with region of interest (RoI) selection using motion vector. In addition, this paper presents the CU depth level skip algorithm using the co-located block information in the previously encoded frames. First, the RoI selection algorithm distinguishes between dynamic CTUs and static CTUs and then, asymmetric motion partitioning (AMP) blocks are skipped in the static CTUs. Second, the depth level skip algorithm predicts the most probable target depth level from average depth in one CTU. The experimental results show that the proposed fast CU decision algorithm can reduce the total encoding time up to 44.8% compared to the HEVC test model (HM) 14.0 reference software encoder. Moreover, the proposed algorithm shows only 2.5% Bjontegaard delta bit rate (BDBR) loss.

• Journal of the Korean Geosynthetics Society
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• v.17 no.3
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• pp.19-32
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• 2018

Gravel Compaction Pile (GCP) method is currently being designed and constructed by empirical method because quantitative design method has not been developed, leading to various types of and frequent destruction such as expansion failure and shear failure and difficulties in establishing clear cause and developing measure to prevent destruction. In addition, despite the difference with domestic construction equipment and material characteristics, the methods applied to the overseas ground is applied to the domestic as it is, leading to remarkable difference between applied values and measured values in variables such as bearing capacity and the settlement amount. The purpose of this study was, therefore, to propose a reasonable and safe design method of GCP method by analyzing the settlement and stress behavior characteristics according to ground strength change under GCP method applied to domestic clay ground. For the purpose, settlement amount of composite ground, stress concentration ratio, and maximum horizontal displacement and expected location of GCP were analyzed using ABAQUS. The results of analysis showed that the settlement and Settlement reduction rate of composite ground decreased by more than 60% under replacement ratio of 30% or more, that the maximum horizontal displacement of GCP occurred at the depth 2.6 times pile diameter, and that the difference in horizontal displacement is slight under replacement ratio of 30%.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.29 no.2
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• pp.169-197
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• 2018

The research aims to analyze current university information disclosure services in the perspectives of both university records management and services and to recommend ways to improve the current university information disclosure systems and services. The research collects and analyzes various raw data such as laws, guidelines, and manuals of university information disclosure services and the portal site of 'Higher Education in Korea' also known as 'dae-hak-al-ri-mi', and data on each homepage of 40 cooperative universities selected as the research sample. At the result, the research found some limits in the current operation of university information disclosure services: first, the information posted on the university disclosure information system is mostly focused on administrative information rather than information related to research or education within universities. Second, there are the high rate of error and frequent modification in the information posted on the disclosure information system. Third, the menus on both the information disclosure system and homepages of each cooperative university are useless or contents of the menus are empty. The research suggests some solutions to improve these problems: it is required to make up the current legal systems for university information disclosure services and to cooperate all organizations and universities related to university information disclosure services within the united system and rule. Also, it is crucial to attach the metadata of the disclosed information when to post the information to the university disclosure information systems. Finally, it is necessary for each university to employ archivists not only to develop qualified university records to maintain the unique roles and value of universities but also to disclose reliable and authentic information to users and manage the university information disclosure systems effectively and efficiently.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.6
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• pp.637-644
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• 2012

In a nuclear power plant, fretting wear due to impact motion between U-tubes and support structures located in steam generators can cause serious problems. In order to guarantee the reliability of the steam generator, the damage due to fretting wear should be thoroughly investigated. The purpose of this study is to elucidate the fretting wear mechanism qualitatively and quantitatively. Hence, fretting wear simulation is performed for the environments to which the actual steam generators in nuclear power plants are exposed. Initial experimental results are obtained for various experimental parameters, and the effect of the work rate and temperature on fretting wear is evaluated. In water, the wear coefficients for $90^{\circ}C$, $200^{\circ}C$, and $340^{\circ}C$ are found to be $9.051{\times}10^{-16}\;Pa^{-1}$, $3.009{\times}10^{-15}\;Pa^{-1}$, and $2.235{\times}10^{-15}\;Pa^{-1}$, respectively. It is also found that the wear coefficient at room temperature is larger than that at low temperature in water because of the dynamic viscosity of water.

• Journal of Korean Society of Disaster and Security
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• v.12 no.3
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• pp.35-49
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• 2019

Currently in 2018, Korea has over 600 operating sewage disposal facilities. The law requires a sewage treatment plant to treat 500 tons or more of water per day, and a small-decentralized sewage treatment facility in a community to treat 50 tons or more to less than 500 tons of water per day. However, most facilities fulfill neither the quantity nor the quality requirements from the original design for such reasons as inflow of rainwater and ground water due to deterioration of pipelines and unauthorized input of wastewater in the pipelines. The research has selected 2 representative cases among the technical diagnosif sewage pipelines in many regions within the country to use it as the baseline of: hourly flowrate and BOD water quality analysis in both clear and rainy days, proper plant operation through inflow rate and ratio calculation, and diagnostic evaluation for deterioration of the pipelines and their accessary structures. This also suggests facilities that treats 500 tons or more of inflow per day to sample and analyze the water hourly for 24 hours once a week in both clear weather and rainy weather considering the influence of rainfall on a regular basis.

• Applied Chemistry for Engineering
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• v.28 no.4
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• pp.404-409
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• 2017

Natural polymer chitosan has been widely applied to medical fields due to its biochemical activities such as anticancer, antibacterial and lowering cholesterol in addition to biocompatibility and biodegradability. Currently, researches are being actively conducted to develop various drug-encapsulated chitosan nanoparticles for curing different diseases by applying chitosan to a drug delivery system. The free amine ($-NH_2$) group present in chitosan can bind to various hydrophobic groups by physical and chemical modification and the chitosan with hydrophobic groups can form shell-core nanoparticles by self-assembly when dispersed in water. In addition, an insoluble drug can increase the solubility against water when it was encapsulated in the core of chitosan nanoparticles. Also, the therapy effect can be maximized by minimizing side effects of drugs such as proteins, anticancer drugs and vaccines when they were encapsulated in the core of chitosan nanoparticles. Moreover, it is possible to control the particle size and release rate according to the hydrophobic group introduced to chitosan, so that it can be applied to a wide range of medical fields. The purpose of this review is to discuss the preparation and property of chitosan nanoparticles modified with various hydrophobic groups, and the application to drug delivery systems according to their property.

• Journal of Food Hygiene and Safety
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• v.33 no.1
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• pp.65-70
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• 2018

Monitoring of Listeria monocytogenes, the causative agent of listeriosis, in food is inportant for public health. The Korean Food Standards Codex has adopted a 'zero-tolerance' policy for L. monocytogenes. The standard detection method of L. monocytogenes is based on enrichment. Thus, proper enrichment methods need to be instituted to ensure quality control of the detection procedures. In this study, the growth of L. monocytogenes and Listeria innocua as a mixed culture in Listeria enrichment broth (LEB) was monitored during artificial contamination of enrichment culture. We confirmed competitive growth or interspecies inhibitory activity of L. monocytogenes and L. innocua. Interspecies growth differences and the inhibitory activity of different inoculation and mixtures L. innocua against L. monocytogenes were examined. The concentration of L. monocytogenes must be 2.0 log CFU/mL or more than L. innocua to grow better than L. innocua. It is known that Listeria spp. and L. monocytogenes show growth difference during LEB, resulting in the risk of false-negative results. The inhibition of L. monocytogenes by L. innocua was always observed when present at lower concentrations. However, it was confirmed that L. innocua suppressed when L. monocytogenes was present at a higher concentration. Therefore if a mixture of Listeria spp. is present, detecting L. monocytogenes is difficult. Thus, a new enrichment broth to improve the detection rate of L. monocytogenes is needed.

• Journal of Veterinary Clinics
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• v.27 no.6
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• pp.718-722
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• 2010

To investigate patterns and severity of hunting-related emergency traumatic injuries in wild boar hunting dogs. One hundred wild boar hunting dogs with emergency traumatic injuries sustained during wild boar hunting as a result of wild boar attack and accidental shooting of ensnarement in a trap. The retrospective study involved 100 dogs brought to CAMC for treatment of emergency traumatic injury sustained during wild boar hunting in Jeon-buk province from August 2007 to April 2008. Medical information obtained from the medical records included signalment; cause of injury; number, location and severity of injuries; and mortality. The 100 patients displayed 136 injuries (single injury in 71 dogs and multiple injuries in 29 dogs). Causes of the emergency traumatic injuries were wild boar attack (n = 92), accidental shooting (n = 7), and entrapment (n = 1). The thoracic area was the most common site of injury. The most common injury severity score (ISS) was code 2. The mortality rate was 9%, and all deaths involved thoracic injury. Emergency traumatic injuries sustained during wild boar hunting are most commonly thoracic injuries caused by prey attack. The nature of the injuries can differ from those typically encountered by small animal veterinarians.