• Geomechanics and Engineering
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• 제9권5호
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• pp.645-667
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• 2015

Single treatment and staged treatments in vertical wells are widely applied in sandstone and mudstone thin interbedded (SMTI) reservoir to stimulate the reservoir. The keys and difficulties of stimulating this category of formations are to avoid hydraulic fracture propagating through the interface between shale and sand as well as control the fracture height. In this paper, the cohesive zone method was utilized to build the 3-dimensional fracture dynamic propagation model in shale and sand interbedded formation based on the cohesive damage element. Staged treatments and single treatment were simulated by single fracture propagation model and double fractures propagation model respectively. Study on the changes of fracture vicinity stress field during propagation is to compare and analyze the parameters which influence the interfacial induced stresses between two different fracturing methods. As a result, we can prejudge how difficult it is that the fracture propagates along its height direction. The induced stress increases as the pumping rate increasing and it changes as a parabolic function of the fluid viscosity. The optimized pump rate is $4.8m^3/min$ and fluid viscosity is $0.1Pa{\cdot}s$ to avoid the over extending of hydraulic fracture in height direction. The simulation outcomes were applied in the field to optimize the treatment parameters and the staged treatments was suggested to get a better production than single treatment.

• 한국항행학회논문지
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• 제25권5호
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• pp.384-389
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• 2021

네트워크 기반 무인기 제어통신 시스템을 위한 복잡도와 성능을 고려한 지상국 최적 안테나 패턴 설계 방식을 제시하였다. 다수개의 측면 섹터와 한 개의 상향 섹터로 구성되는 지상국 안테나의 섹터 수, 수평/수직 빔폭, 틸팅각도 등 안테나 설계 파라미터의 변화에 따른 수직/수평 각도 별 안테나 이득을 모델링하고, 가상의 3차원 공간 내에서 각 파라미터의 변화가 신호 대 잡음 비 (SNR : signal to noise ratio) 분포에 미치는 영향을 분석하였다. 다양한 파라미터 중 측면 섹터의 틸팅 각도가 성능에 가장 큰 영향을 미치는데, 지상국 간 거리가 길수록, 최고 고도가 높을수록, 측면 섹터 수가 작을수록 틸팅 각도를 낮춰야 함을 확인할 수 있었다. 또한 최저 SNR 최대화 측면에서는 측면 섹터 수직 빔폭을 늘리는 것이 유리하지만 평균 SNR 측면에서는 수직 빔폭을 줄이는 것이 유리함을 확인하였다.

• Geomechanics and Engineering
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• 제17권6호
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• pp.535-541
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• 2019

Combining the radial well drilling and hydraulic fracturing technique, the production capacity of the reservoirs with low-permeability can be improved effectively. Due to the existence of radial holes, the stress around the well is redistributed, and the initiation and propagation of hydraulic fractures are different with those in traditional hydraulic fracturing. Therefore, it is necessary to study the influences of radial horizontal wells on hydraulic fracturing. The laboratory experiment was conducted to simulate the hydraulic fracturing on the physical model with radial holes. The experimental results showed that, compared with the borehole without radial holes, the sample with radial hole in the direction of maximum horizontal stress was fractured with significantly lower pressure. As the angle between direction of the horizontal hole and the maximum horizontal stress increased, the breakdown pressure grew. While when the radial hole was drilled towards the direction of the minimum horizontal stress, the breakdown pressure increased to that needed in the borehole without radial holes. When the angle between the radial hole and the maximum horizontal stress increase, the pressure required to propagate the fractures grew apparently, and the fracture become complex. Meanwhile, the deeper the radial hole drilled, the less the pressure was needed for fracturing.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8651-8656
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• 2014

Purpose: To study the expression of angiogenin-2 (Ang-2) and its receptor Tie-2 in colorectal cancer and discuss the possible mechanisms behind this process. Materials and Methods: Using the streptavidin-peroxidase (SP) immunohistochemical method, paraffin sections from 100 colorectal cancer samples and 10 samples from tumor-adjacent normal tissue (> 2 cm from the edge of the gross tumor) were tested for protein expression of Ang-2, Tie-2, PI3K, and AKT. Reverse transcription-polymerase chain reaction and Western blots were further used to measure expression of the 4 genes and proteins in 20 freshly-resected colorectal cancer samples and tumor-adjacent normal tissues. Results: In colorectal cancer tissues, the expression of the Ang-2, Tie-2, PI3K, and AKT genes and their proteins was significantly higher than in tumor-adjacent normal tissues. Protein expression in poorly-differentiated adenocarcinoma was higher than that in well and moderately differentiated adenocarcinoma. According to Duke's classification, the protein expression in Stages C and D was significantly higher than that in Stages A and B. In the group with lymphatic metastasis, the protein expression was higher than that without lymphatic metastasis. Conclusions: In colorectal cancer, the expression of the Ang-2, Tie-2, PI3K, and AKT genes and their proteins is markedly higher than those in tumor-adjacent normal tissues. No correlation was observed between protein expression and gender, location, or histologic type. Correlations did exist between protein expression and differentiation level, stage of Duke's classification, and lymphatic metastasis; in colorectal cancer tissues with lower differentiation levels, higher stages of Duke's classification, and lymphatic metastasis, the expression of all 4 proteins was higher. The study of their expression patterns and relationships with aggression and metastasis will provide a valuable experimental foundation for assessing prognosis and targeted therapy of colorectal cancer.