• Analytical Science and Technology
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• v.6 no.3
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• pp.255-259
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• 1993

${\beta}$-Carboline alkaloids of Polygala tenuifolia (Polygalaceae), an expectorant, tonic and sedative drude drug, were determined by HPLC. The alkaloids were separated by RP-18 column with gradient elution of 0.01M potassium phosphate buffer(pH=3.5) and acetonitrile and detected at UV 254nm. Two methods for the preparation of alkaloid fraction were compared. One was solvent extraction method using acid and base, and the other was solid phase extraction with ion exchange resin (Amberlyst 15). A more refined HPLC chromatogram was obtained using the solid phase extraction method. The alkaloidal contents in P. tenuifolia determined by this method were : harman $2.8{\times}10^{-3}%$, norharman $1.7{\times}10^{-3}%$, 1-carbomethoxy-${\beta}$-carboline $1.3{\times}10^{-3}%$, 1-carboethoxy-${\beta}$-carboline $1.4{\times}10^{-3}%$ and perlolyrine $3.3{\times}10^{-3}%$, respectively.

• Journal of the Korean Applied Science and Technology
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• v.35 no.4
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• pp.1134-1144
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• 2018

Cetane Number is one of the quality standard for diesel, which assesses the compatibility of ignition quality of diesel compression in diesel engines. Cetane number must be upper 52 to keep the recent diesel quality standards. It is known that if cetane number is high, there will be shorter ignition delay periods than being lower. On the other hands, if cetane number is too high that exceeds the quality standard, there will increase the air pollution and decrease of the fuel efficiency because incomplete combustion. In South Korea, various methods are being used to measure the cetane number such as cetane number that used CFR engine, cetane index from calculate density and distillation temperature and derived cetane number to make up for CFR engine that ignition delay in high temperature is implemented. In this study will be conducted by collecting the diesel from the major oil companies, and try to analyze the correlation between the different methods of cetane number with various factors. At the results of this study, it was shown that the cetane index is high then cetane engine and derived cetane number. therefore it will be necessary to additional research for out of cetane number quality standards.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.229-229
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• 1994

선택성이 높고 뛰어난 약효를 지닌 항 바이러스제의 개발은 신약개발의 중요한 영역중에 하나이다. 현재 AIDS 치료제로 사용되고 AZT를 비롯하여 항virus 효과를 나타내는 약물의 대부분은 구조적으로 nucleoside계에 속하는 화합물로서 수 많은 약리학적 연구 및 합성 화학적 연구가 이루어져 왔다. 특히 합성 화학적 측면에서 이들 화합물의 합성은 크게 두가지로 나누어지는데 그것은 sugar 부위의 변형을 통한 방법과 염기 부위의 변형을 통한 방법에 의해 새로운 항 바이러스제를 개발하는 것이다. 최근의 연구 동향에 있어서 주목할 만한 변화의 하나는 sugar 부위의 구조적 변형을 시도하는데 있어서 종래의 5원환 형태에서 환이 개열된 형태의 acyclic nucleoside에 대한 연구가 이루어져 좋은 효과를 거두고 인다는 사실이다. Acyclovir, Ganciclovir등 의 개발이 그것이다. 본 연구에서는 종래의 acyclic nucleoside가 ribose sugar의 2'번 및 3'번 탄소를 제거한 acyclic ether 형태로 되어있는 것과는 다르게 ether 부위의 산소를 탄소 치환한 carbo-acyclic nucleoside를 합성하고자 하였다. Acyclic nucleoside를 합성하고자 하였다. Acyclic nucleoside의 side chain의 conformation이 항 바이러스 작용을 나타내는데 필수 불가결한 점을 감안할때, carbo-acyclic nucleoside계 화합물은 보다 다양하게 변형될 수 있는 장점을 가지고 있다. 이러한 관점에서 side chain의 2'번 및 3'번 탄소는 side chain의 conformation을 좌우하는 결정적 요인으로 작용할 것으로 판단된다. 따라서 본 연구에서는 이들 탄소를 중심으로한 분자수식을 시도하기로 하고 bioisosterism을 이용하여 3'위치의 수소를 fluoride로 치환한 화합물을 설계하여 합성을 시도하였다.silyl group-5'-무치환 화합물을 tosyl, azido화 한다음 desilylation하여 얻었다. 목적하는(1) 화합물의 diasteromer 인 2',3'-dihydroxy-5'-무치환 유도체(3)는 (4)화합물 합성시 얻은 hemiactal을 key intermediate로 하여 TsNHNH$_2$, NaB(CN)H$_3$ 및 NaOAc로 처리하므로서 얻을수 있었다. 이들 화합물들의 각종 DNA 및 RNA virus에 대한 항 바이러스작용을 검토한 결과 현저한 항 바이러스 작용을 나타내지 않았다.분화유도 활성을 나타내어 항종양제로의 개발에 많은 흥미가 기대된다.기대된다.oxylic acid (compound 10)를 합성하였다.10^{－7}$ M)에 의한 단백인산화에 대하여는 더 미약한 억제-효과를 나타내었다. 이상의 결과는 PDE-1과 항우울약들의 항혈소판작용은 PKC-기질인 41-43 kD와 20 kD의 인산화를 억제함에 기인되는 것으로 사료된다.다. 것으로 사료된다.다.바와 같이 MCl에서 작은 Dv 값을 갖는데, 이것은 CdCl$_{4}$$^{2-}$ 착이온을 형성하거나 ZnCl$_{4}$$^{2-}$ , ZnCl$_{3}$$^{-}$같은 이온과 MgCl$^{+}$, MgCl$_{2}$같은 이온종을 형성하기 때문인것 같다. 한편 어떠한 용리액에서던지 NH$_{4}$$^{+}$의 경우 Dv값이 제일 작았다. 바. 본 연구의 목적중의 하나인 인체유해 중금속이온인 Hg(II), Cd(II)등이 NaCl같은 염화물이 함유된 시료용액에 공해이온으로 존재할 경우 흡착에 의한 제거가 가능하다. 한편 이같은 중금속이온의 흡착실험은 특히 해수중의 금속이온의 회수연구에도

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.4
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• pp.49-58
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• 2007

Hierarchical Mobile IPv6 (HMIPv6) has been proposed by Internet Engineering Task Force (IETF) to compensate for such problems as handover latency and signaling overhead in employing Mobile IPv6 (MIPv6). HMIPv6 supports micro-mobility within a domain and introduces a new entity, namely mobility anchor point (MAP) as a local home agent. However, HMIPv6 causes load concentration at a particular MAP and longer handover latency when inter-domain handover occurs. In order to solve such problems, this paper establishes a virtual domain (VD) of a higher layer MAP and proposes a MAP changing algorithm in which the routing path changes between mobile node (MN) and correspondent node(CN) according to the mobile position and the direction of the MN before inter-domain handover occurs. The proposed algorithm not only enables complete handover binding-update of the on-link care of address (LCoA) only when inter-domain handover occurs, but concentrated load of a particular MAP is distributed as well. This is because the MNs registered with higher layer MAP and lower layer MAP coexist in the VD. We simulate the performance of the proposed algorithm and compare with HMIPv6.

• Journal of radiological science and technology
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• v.40 no.1
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• pp.7-12
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• 2017

The study was performed to investigate the bacteriological contamination of portable digital radiography system and their detectors in a university hospital. CNS and VRE were detected in the samples collected from vinyl cover on detectors used for the infection control patients. On the other hand, no bacteria was detected in the samples collected from detectors with vinyl cover removed. In the series of imaging of patients from general wards, no bacteria was detected from the patient 1. However, CNS was detected from the patients 2 and 3, CNS and Enterococcus faecalis detected from the patient 4, CNS and Enterococcus casseliflavus detected from the patient 5, and CNS, Enterococcus casseliflavus, and Klebsiella pneumoniae all detected from the patient 6. CNS and Enterococcus faecium were detected in the controller handle of collimator. Also, CNS was detected from the handle of detector and exposure switch. In the treatment gloves of the radiological technologist after the imaging, CNS, Enterococcus gallinarum, and Klebsiella pneumoniae were detected. Therefore, it is recommended for DR portable to take images after sterilizing the detector after taking each image and to use disposable vinyl covers on detectors to remove after imaging. And treatment gloves must be changed after each imaging. Also, hospital infection via portables must be prevented by complete sterilization of the controller handles of collimator which are in frequent contact during imaging and infection education of employees.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.315-315
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• 2018

L-THIA ACN-WQ 2016 모형 개선 연구에서는 침투량 산정, 다중 기상지점 등 유역 규모 확대를 목적으로 엔진 개선과 모형의 최적 매개변수 선정을 위해 최적화 알고리즘을 활용한 자동보정 모듈을 개발하였다. 개선된 침투량 초기손실 산정 계수를 적용한 침투량 산정 방법을 Green-Ampt 모형의 침투량 산정 결과와 비교한 결과 편차는 매우 작았으며, Green-Ampt 모형을 통해 산정된 침투량 범위 내에 분포되어 개선된 침투량 산정 방법의 결과가 유효한 값을 의미하는 것으로 나타났다. 이렇게 도출된 초기손실 산정 계수를 관계식으로 개발하여 L-THIA ACN-WQ 2018 모형 내에서 CN에 따른 초기손실량이 산정되도록 하였고, 이를 기반으로 침투량 및 기저유출량이 산정된다. 유역 규모 확대를 위해 다중 기상지점이 적용되도록 엔진 코드를 개선하였으며, 평창A와 고부A 유역을 대상으로 단일 기상지점과 다중 기상지점 적용에 따른 유출 해석을 유량지속곡선을 통해 비교 한 결과 다중 기상지점 적용에 따라서 평창A와 고부A 유역 모두 유황구간이 크게 달라지는 것으로 나타났다. 특히 고부A 유역은 우황 변동 특성이 크게 나타났는데, 지역적 강우 특성이 뚜렷한 유역에서는 유출해석에 매우 중요한 영향인자로 작용되는 것으로 알 수 있었다. 마지막으로 L-THIA ACN-WQ 2018모형을 이용함에 있어 유역 특성에 알맞은 최적 매개변수 산정을 위해 유량 및 TN, TP 자동보정 툴을 개발하였다. 자동보정툴은 2개의 보정방안으로 개발하였다. 첫 번째는 유역 전체에 대해 하나의 최적매개변수를 도출하는 것이며, 두번째는 유역 내 다중 보정 지점을 통해 소유역별 최적매개변수를 도출하는 것이다. 이를 통해 사용자는 모형의 활용 목적 및 가용 가능한 보정 자료 등을 고려하여 모형의 최적 매개변수를 도출할 수 있다. 이렇게 개선된 L-THIA ACN-WQ 2018 모형을 총량단위유역 한강 평창A와 금강 고부A에 적용한 결과 유량은 NSE 0.76, 0.85로 매우 높게 나타났으며, TN, TP의 NSE는 0.64 ~ 0.86 로 매우 높은 적용성 결과가 도출되었다. Ryu(2016)의 연구 결과와 비교해보면 평창A는 NSE와 $R^2$ 수치로는 큰 차이를 보이지 않았지만, 유량 모의에서 일별 예측값 변화 폭에 큰 변화가 있는 것으로 나타났다. 기존 L-THIA ACN-WQ 2016모형 결과에서는 일별 유량의 변동성이 매우 크지만, L-THIA ACN-WQ 2018 모형에서는 일별 유량 변동폭이 크게 감소하여, 유량 모의에 큰 개선 효과가 있는 것으로 나타났다

• Pediatric Infection and Vaccine
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• v.12 no.1
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• pp.67-74
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• 2005

Purpose : The incidence of mortality associated with respiratory difficulties is decreasing nowadays contributed to the development of neonatology. However, complications associated with mechanical ventilator are increasing. This study is to determine clinical manifestations, diagnositc availability of the endotracheal tip culture in patients with Ventilator-Associated Pneumonia(VAP) in neonatal intensive care unit(NICU). Methods : A retrospective analysis of 50 neonates who were admitted to the NICU of Kangnam Sacred Heart Hospital and had given mechanical ventilator from 1 January 2000 to 30 June 2003. VAP group defined as neonates who had pneumonia with mechanical ventilation longer than 48 hours. They were classified into VAP group(n=13) and control group (n=37) and the prevalence, microorganisms cultured from the endotracheal tube tip and risk factors were investigated. Results : The prevalence of VAP was 26.0%(n=13) and the most dominant microorganism cultured in our NICU was methicillin-resistant coagulase negative staphylococcus(MR-CNS) in 4 cases. Other microorganisms were Pseudomonas, Enterobacter, methicillin-resistant Staphylococcus aureus(MRSA) and Klebsiella. Gestational age, birth weight, Apgar score, respiratory distress syndrome, retinopathy of prematurity, bronchopulmonary dysplasia, sepsis, renal failure, pulmonary hemorrhage, pneumothorax were not different significantly between two groups except intraventricular hemorrhage(P<0.001) and patent ductus arteriosus(P<0.05). Duration of hospital stay and mortality rate were also not different significantly. Conclusion : VAP occurred at a significant rate among mechanically ventilated NICU patients. Despite of limitation of encotracheal tip culture, the most common microorganism was MR-CNS. We should be aware of occurrence of VAP in NICU neonate who were with mechanical ventilator and should treat with great care.

• Korean Journal of Soil Science and Fertilizer
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• v.45 no.5
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• pp.842-847
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• 2012

This study was conducted to estimate the greenhouse gas emissions on local government levels from 1990 to 2010 using 2006 IPCC guideline methodology. To calculate greenhouse gas emissions based on the 16 local governments, emission factor and scaling factor were used with default value and activity data came from the food, agricultural, forestry and fisheries statistical yearbook of MIFAFF (Ministry for Food, Agriculture, Forestry, and Fisheries). The total emissions in crop sector gradually decreased from 1990 to 2010 due to a decline in agricultural land and nitrogen fertilizer usage. The annual average emission of greenhouse gas was the highest in Jeonnam (JN) with 1,698 Gg $CO_2$-eq and following Chungnam (CN), Gyungbuk (GB), Jeonbuk (JB) and Gyunggi (GG). The sum of top-six locals emission had occupied 83.4% of the total emission in cropland sector. The annual average emissions in 1990 by applying 2006 IPCC guideline were approximately 43% less than the national greenhouse gas inventory by 1996 IPCC guideline. Jeonnam (JN) province occupied also the highest results of greenhouse gas emission estimated by gas types (methane, nitrous oxide and carbon dioxide) and emission sources such as rice cultivation, agricultural soil, field burning of crop residue and urea fertilizer.

• The Korean Journal of Pesticide Science
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• v.16 no.1
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• pp.11-20
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• 2012

As increasing the use of pesticides both in number and amount to boost crop production, consumer concerns over food quality and safety with respect to residual pesticides are also continuously increasing. However, there is still lacking of information that can effectively help to remove residual pesticides in foods. In recent years, contaminant removal by gas (or) glow discharge plasma (GDP) attracts great interests on environmental scientists because of its high removal efficiency and environmental compatibility. It was shown to be effective for the removal of some organophosphorus pesticides, phenols, benzoic acid, dyes, and nitrobenzene on solid substrate or in aqueous solution. This work mainly focuses on the removal of wide range of residual pesticides from fresh fruits and vegetables. As for preliminary study, the experiments were carried out to investigate whether GDP can be used as an effective tool for degrading target pesticides or not. With this objective, 60 selected pesticides drop wised onto glass slides were exposed to two types of GDP, dielectric barrier discharge plasma (DBDP) and low pressure discharge plasma (LPDP), for 5 min. Then, they were washed with 2 mL MeCN which were collected and used for determination of remaining concentration of pesticides using LC-MS/MS. Among selected pesticides, degradation of 18 pesticides (endosulfan-total was counted as one pesticide) by GDP could not be examined because control treatments, which were left in ambient environment, of those pesticides recovered less than 70% or even did not recover. However, majority of tested pesticides (42) were degraded by both types of GDP with satisfactory recovery (>80%) of control sample. Pesticides degradation ranged from 66.88% to 100% were achieved by both types of plasma except clothianidin which degradation in LPDP was 26.9%. The results clearly indicate that both types of gas discharge plasma are promising tools for degrading wide range of pesticides on glass substrate.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.29 no.4
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• pp.381-392
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• 2011

Pollutant loads calculated with unit factor method can not identity seasonal variations of pollutant inputs. Estimation of pollutant loads considering rainfall runoff can overcome these limits. SCS curve number method was applied to estimate runoff of each event of Koeup watershed of Koheung estuary lake. SCS curve numbers were calculated based upon land use, soil types of the catchment using GIS. Point and nonpoint source pollutant loads were summed up for total loads estimation. Those from nonpoint source were estimated by multiplying the calculated runoff and expected mean concentrations (EMC) presented by the Minister of Environment of Korea. DEM can present three dimensional views of a terrain, identity stream networks and flow accumulation. Furthermore, it can examine accumulated pollutant loads of specific point of a catchment. Therefore, cell based pollutant load estimation was attempted using DEM. ArcView was utilized to collect, store and manipulate spatial and attribute data of pollutant sources and features of the catchment. Cell-based DEM which was established by the GRID module of ARC/INFO was employed to estimate flows and pollutant loads.