• Molecules and Cells
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• v.45 no.12
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• pp.923-934
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• 2022

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great potential in applications such as regenerative medicine, cardiac disease modeling, and in vitro drug evaluation. However, hPSC-CMs are immature, which limits their applications. During development, the maturation of CMs is accompanied by a decline in their proliferative capacity. This phenomenon suggests that regulating the cell cycle may facilitate the maturation of hPSC-CMs. Aurora kinases are essential kinases that regulate the cell cycle, the role of which is not well studied in hPSC-CM maturation. Here, we demonstrate that CYC116, an inhibitor of Aurora kinases, significantly promotes the maturation of CMs derived from both human embryonic stem cells (H1 and H9) and iPSCs (induced PSCs) (UC013), resulting in increased expression of genes related to cardiomyocyte function, better organization of the sarcomere, increased sarcomere length, increased number of mitochondria, and enhanced physiological function of the cells. In addition, a number of other Aurora kinase inhibitors have also been found to promote the maturation of hPSC-CMs. Our data suggest that blocking aurora kinase activity and regulating cell cycle progression may promote the maturation of hPSC-CMs.

• Journal of Korea Technology Innovation Society
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• v.8 no.1
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• pp.154-182
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• 2005

Many government agents are willing to provide better service to citizen via information technologies. This is called e-Government, and it needs a CMS to manage numerous contents. However, a CMS doesn't manage contents from the viewpoint of quality. In this research, the QCMS the system to manage contents by using information resource registry, is proposed. Information resource registry includes a flow chart and four matrices. Behavioral patterns of organizations and contents can be got from information resource registry. It makes a top manager understand the state of the business and make proper strategic decisions. The strategies can improve the business. Through the case of a public enterprise, we examine how the QCMS works and makes strategies from behavioral patterns of organizations and contents.

• Journal of Digital Contents Society
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• v.4 no.1
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• pp.23-34
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• 2003

The number of internet users rapidly increases, it has development of various learning method and education-contents. Currently, it has increasing of management, maintenance and reusing of education-contents through CMS (Content Management System) and SCORM(Shareable Content Object Reference Model) standard but actually, it has not more service for customer, In this paper, we propose CMS(Content Management System) using the supporting self learning method for increasing teaming effective of customer.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.04a
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• pp.773-775
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• 2015

복잡한 그리드 컴퓨팅 환경에서 수행한 잡의 성패율을 낮추는 것은 그리드 환경의 효율성과 선순환을 위한 필수적인 요건이다. 본 논문에서는 데이터마이닝의 대표적인 방법인 결정트리의 C4.5 알고리즘을 이용하여 WLCG에서 수행한 CMS 잡 모니터링 결과에 대한 오류를 예측하는 모델을 설계하고 구현하였다. 제안한 예측 모델은, 1) CMS 대시보드에서 모니터링 결과 데이터를 추출하여 오라클 테이블에 로딩한다. 2) 결정트리인 C4.5 알고리즘을 기반으로 Oracle Data Miner에서 예측 모델링을 수행한다. 3) C4.5의 파라미터를 조절하여 적절한 예측결과 값을 도용한다.

• Journal of the Korean Chemical Society
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• v.54 no.3
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• pp.323-328
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• 2010

In this work, an intention to synthesize the carbon molecular sieve (CMS) with ideal sieving properties from palm shell has been attempted. The process includes three main stages: carbonization, carbon dioxide activation and polymer deposition using polyfurfuryl alcohols. Palm shell based activated carbon (AC) produced by carbon dioxide activation was used as raw material in synthesis of CMS. After preparing palm shell based AC, optimum concentration ratio of furfuryl alcohols and formaldehyde to AC for CMS synthesis was obtained in this study. Deposition of polyfurfuryl alcohols on the palm shell based AC was then carried out prior to carbonization. These polymer deposited AC was subjected to carbonization at $700-900^{\circ}C$ under inert condition. All the microporous materials were analyzed using micromeritics ASAP/2020. The results show that optimum concentration ratio of furfuryl alcohol and formaldehyde to AC is 1:2.5. The micropore with pore width less than 7 ${\AA}$ was formed on the polymer deposited AC at $700^{\circ}C$, $800^{\circ}C$ and $900^{\circ}C$ for 1.5 hours. Carbonization temperature at $900^{\circ}C$ for 1.5 hours was found to be optimum for CMS synthesis. The CMS produced under this condition has pore width of 5.884 ${\AA}$.

• Archives of Pharmacal Research
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• v.27 no.10
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• pp.1065-1072
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• 2004

Depression is associated with a dysfunctional serotonin (5-hydroxytryptamine; 5-HT) system. More recently, several lines of evidence suggest that an important factor in the development of depression may be a deficit in the function and expression of $5-HT_{1A}$ receptors. The present study assessed if Nelumbinis Semen (N. s.) had an anti-depression effect through reversing a decrease in $5-HT_{1A}$receptor binding in rats with depression-like symptoms induced by chronic mild stress. Using a $5-HT_{1A}$ receptor binding assay, with a specific $5-HT_{1A}$receptor agonist, 8- OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin), the mechanism of the anti-depression effect of N. s. on rats was investigated, and the effects compared with two well-known antidepressants, Hyperium Perforatum (St. Johns Wort) and fluoxetine (Prozac). Animals were divided into five groups: the normal (N) group without chronic mild stress (CMS), the control (C) group under CMS for 8 weeks, the Nelumbinis Semen (N. s.) treatment group under CMS for 8 weeks, the Hyperium Perforatum (H. p.) treatment group under CMS for 8 weeks and finally, the fluoxetine (F) treatment group under CMS for 8 weeks. Each treatment was administered to rats during the last 4 weeks of the 8-week CMS. A sucrose intake test was performed to test the anti-depression effect of N. s. The N. s. treatment significantly reversed the decreased sucrose intake under CMS (P<0.05 compared to control group under CMS). In the CA2 and CA3 regions of the hippocampus, both N. s. and H. p. reversed the CMS-induced decrease in $5-HT_{1A}$receptor binding. In the I to II regions of the frontal cortex, N. s. and H. p. also reversed the CMS-induced decrease in$5-HT_{1A}$receptor binding, and even showed a significant increase in $5-HT_{1A}$receptor binding compared to the F treatment group (N. s. vs. P, p<0.05, H. p. vs. P, p<0.05). However, in the hypothalamus, all treatments reversed the CMSinduced decrease in $5-HT_{1A}$receptor binding. This reversal effect of N. s. on the decrease in $5-HT_{1A}$receptor binding in the frontal cortex, hippocampus and hypothalamus of rat brains was very similar to that of H. p, but different from that of F. It is concluded that N. s. presents an anti-depression effect through enhancing $5-HT_{1A}$receptor binding.

• Carbon letters
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• v.24
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• pp.55-61
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• 2017

Carbon micropatterns (CMs) were fabricated from a negative-type SU-8 photoresist by proton ion beam lithography and pyrolysis. Well-defined negative-type SU-8 micropatterns were formed by proton ion beam lithography at the optimized fluence of $1{\times}10^{15}ions\;cm^{-2}$ and then pyrolyzed to form CMs. The crosslinked network structures formed by proton irradiation were converted to pseudo-graphitic structures by pyrolysis. The fabricated CMs showed a good electrical conductivity of $1.58{\times}10^2S\;cm^{-1}$ and a very low surface roughness.

• Proceedings of the Korean Vacuum Society Conference
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• 2015.08a
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• pp.123-123
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• 2015

Al doped ZnO(AZO) films as a transparent conductive oxide (TCO) electrode were deposited on glass, polyethylene naphthalate (PEN) and polyethylene terephthalate (PET) at room temperature by a conventional rf-magneton sputtering (CMS) and a facing target sputtering (FTS) using Al2O3 and ZnO targets. In order to investigation of AZO properties, the structural, surface morphology, electrical, and optical characteristics of AZO films were respectively analyzed. The resistivities of AZO films using FTS system were $6.50{\times}10-4{\Omega}{\cdot}cm$ on glass, $7.0{\times}10-4{\Omega}{\cdot}cm$ on PEN, and $7.4{\times}10-4{\Omega}{\cdot}cm$ on PET substrates, while the values of AZO films using CMS system were $7.6{\times}10-4{\Omega}{\cdot}cm$ on glass, $1.20{\times}10-3{\Omega}{\cdot}cm$ on PEN, and $1.58{\times}10-3{\Omega}{\cdot}cm$ on PET substrates. The AZO-films deposited by FTS system showed uniform surface compared to those of the films by CMS system. We thought that the films deposited by FTS system had low stress due to bombardment of high energetic particles during CMS process, resulted in enhanced electrical conductivity and crystalline quality by highly c-axis preferred orientation and closely packed nano-crystalline of AZO films using FTS system.

• Magazine of the Korean Society of Agricultural Engineers
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• v.38 no.1
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• pp.90-97
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• 1996

In Korea, total sediment discharge of a river has been estimated simply by using certain sediment transport formulas including, among others, Einstein's formula. Those formular, however, are known not to be reliable enough for the result calculated by them to be used directly to river planning and management. Therefore, the study used the Modified Einstein Procedure to the estimation of total sediment discharge, because this method is reliable estimated by measurement. Here, measurement of sediment discharge used depth integrating method. The major results obtained from the study for estimation by depth integrating method of sediment discharge in Naeseong stream are as follow; 1 The sedeiment characteristics of Naeseong stream are; The distribution of sediment grain size shows that silt and clay are 55% and sand is 45%. and the bed load sediment grain size is constituted that sand contained with the grain size from O.062mm to 2.0mm is 80% 2. The sediment rating formulas derived from the regression analysis between the sediment discharge and flow discharge are; Seogpo-Gyo : Qs=$0.017 \times 10^{-4} Q^{2.352}$, where discharge is l0cms $0.074 \times 10^{-4} Q^{2.066}$, where discharge is l0cms

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.1
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• pp.45-54
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• 2011

This paper discuss about structure modification method of the reciprocating compressor to reduce its vibration and noise in small refrigeration system. The structure modification is applied using analytic FE models and then applying suggested Component Mode Synthesis(CMS) algorithms. The efficient CMS algorithms to a compressor's fixed base design problem are analytically tried and verified from some experiments.