• The Journal of the Korea Contents Association
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• v.10 no.10
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• pp.237-245
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• 2010

Nerve conduction studies (NCS) are the most objective measure of nerve function and essential for the diagnosis of sub-clinical neuropathy in diabetes mellitus and diabetic polyneuropathy (DPN). This study evaluates the characteristic of electrophysiological abnormalities in DPN. Electrodiagnostic data from 120 patients with diabetic polyneuropathies and 77 control subjects were reviewed. Motor nerve conduction velocities (MNCV), distal motor latencies (DML), compound muscle action potential (CMAP) amplitudes, No potential frequency and conduction block were analyzed. Data were normalized based on normative reference values, and the proportion of nerves with abnormal values in the lower and upper limbs were evaluated. DPN was systemic demyelinating peripheral polyneuropathy and more severe abnormal nerve conduction was found in lower limbs than in upper limbs. The abnormal degree was more severe in peroneal nerve. It was no statistically significant difference of conduction block in control and DPN group. Our findings suggest that DPN had more common and severe peroneal nerve involvement in the motor nerve conduction studies (MNCS). These findings have important implications for the electrophysiological evaluation of DPN.

• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.1058-1062
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• 2008

지구 온난화에 의한 대기 순환의 변화와 이에 따른 수증기 수송 및 강수량의 변화는 전지구 및 지역적인 수문환경의 변화를 초래하므로 장기적인 차원의 수자원 계획 수립에는 반드시 기후 변화에 따른 영향이 제대로 반영되어야 한다. 그러나 개별 모델이 사용하는 역학과정과 물리과정의 모수화 및 분해능이 다르고 이에 따른 모의 결과도 다르게 나타나는 등의 상당한 불확실성이 내재되어 있다. 따라서 본 연구에서는 기후변화에 관한 정부간 패널인 IPCC(Intergovernmental Panel on Climate Change)에 참여한 대기해양결합 대순환모델(AOGCMs)이 온실가스 배출 시나리오를 바탕으로 생산한 기온과 강수의 불확실성을 동아시아에 대해 평가하고 이를 바탕으로 미래 기후를 전망하였다. 국립기상연구소 ECHO-G/S 모델과 IPCC 23개 모델의 배출 시나리오(Special Report on Emissions Scenarios, SRES) 자료는 20세기(1900-1999년)와 21세기(2000-2099년)의 200년 동안이고, 관측자료는 영국 CRU(Climate Research Unit) 월평균 2m 기온의 30년(1961-1990년) 평균값과 CMAP 월 평균 강수량의 21년간(1979-1990년) 평균값을 이용하였다. 동아시아지역 기온과 강수의 불확실성을 평가하기 위해서 모델과 관측간 편이, 평균제곱근오차(RMSE) 등의 통계적인 방법을 사용하였다. 동아시아 지역의 연평균 기온은 대체로 모델의 기온이 관측보다 적게 모의되는 음의 편이를 나타내고, 강수는 모델이 관측보다 더 크게 모의 되는 양의 편이를 나타냈다. 계절적으로는 여름철 강수와 봄철 기온의 편이가 크게 나타났다. 연평균 및 겨울철 강수와 기온의 RMSE는 비례하는데 이는 기온 모의성능이 좋은 모델이 강수 모의성능도 좋게 나타나는 것을 의미한다.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.48 no.5
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• pp.102-108
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• 2011

Support vector machines are well known for their outstanding performance in pattern recognition fields. One example of their applications is music/speech classification for a standardized codec such as 3GPP2 selectable mode vocoder. In this paper, we propose a novel scheme that improves the speech/music classification of support vector machines based on the second-order conditional maximum a priori. While conventional support vector machine optimization techniques apply during training phase, the proposed technique can be adopted in classification phase. In this regard, the proposed approach can be developed and employed in parallel with conventional optimizations, resulting in synergistic boost in classification performance. According to experimental results, the proposed algorithm shows its compatibility and potential for improving the performance of support vector machines.

• Annals of Clinical Neurophysiology
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• v.1 no.2
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• pp.118-125
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• 1999

Background and Aims : Nerve conduction study is invaluable in clinical neurology, especially for assessing peripheral neuropathies. Abnormal nerve conduction studies may result not only from peripheral nerve dysfunction itself, but also from other various mechanical, technical, and physiological factors such as age, sex, height and temperature. So we conducted this study to establish the our own normal values. Methods : In this study, from March. 1997 to July. 1998, 40 Korean adults among person came to Health Promotion Center over the age of 20 without any suspicion of neurological deficits were analysed to determine the effect of compound effects of several physiological factors. Results : The nerve conduction velocities of the upper extremity and proximal segments were faster than those of the lower extremity and distal segments. Physiological factors such as age, height and temperature affect the results of nerve conduction studies in multiple regression analysis. The sex difference is recognized over peroneal motor nerve. There are no sex differences in amplitude transformed into normal distribution. The significant physiological factor affecting the amplitude of nerve conduction is age, whereas height and temperature play no role. Conclusions : In multiple regression analysis, height is widespread variable for the nerve conduction velocities and temperature is important variable for lower extremities. The parametric statistical analysis cannot be applied to the amplitude of the compound muscle or nerve action potentials because of marked left shift in distribution. Sqareroot transformation of the CMAP and CNAP may be useful in normalizing the distribution. The most significant physiological factor affection the amplitude is age. Sex differences are not seen in nerve conduction study.

• Annals of Clinical Neurophysiology
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• v.16 no.1
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• pp.21-26
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• 2014

Background: Electrophysiological study has been known as a useful method to evaluate the therapeutic effect of operation in idiopathic carpal tunnel syndrome (CTS). The purpose of this study was to evaluate the clinical and electrophysiological changes after carpal tunnel release (CTR) compared to the preoperative results. Methods: We analyzed the changes of nerve conduction study (NCS) before and after minimal open carpal tunnel release in 18 patients (25 hands) with CTS. Follow-up study was performed over 6 months after operation. Results: Clinical improvement was seen in all cases after CTR. In contrast, electrophysiological improvement was various depending on the parameters; the mean median sensory latency and nerve conduction velocity (NCV) improved significantly (p = 0.001). The mean median motor latency also improved, but NCV and compound muscle action potential (CMAP) amplitude did not change. The extent of improvement was evident in moderate CTS, but not in severe CTS. Conclusions: In this preliminary study, all subjects who underwent CTR achieved a clinical relief along with a significant improvement of electrophysiological parameters such as median sensory latency, sensory NCV and median distal motor latency. After CTR, a number of cases with mild to moderate CTS showed a prominent improvement of clinical and electrophysiological parameters, while fewer improvements were seen in severe CTS, although it did not reach the statistical significance.

• Atmosphere
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• v.31 no.3
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• pp.327-340
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• 2021

In this study, the impact of soil moisture initialization in GloSea5, the operational climate prediction system of the Korea Meteorological Administration (KMA), has been investigated for the period of 1991~2010. To overcome the large uncertainties of soil moisture in the reanalysis, JRA55 reanalysis and CMAP precipitation were used as input of JULES land surface model and produced soil moisture initial field. Overall, both mean and variability were initialized drier and smaller than before, and the changes in the surface temperature and pressure in boreal summer and winter were examined using ensemble prediction data. More realistic soil moisture had a significant impact, especially within 2 months. The decreasing (increasing) soil moisture induced increases (decreases) of temperature and decreases (increases) of sea-level pressure in boreal summer and its impacts were maintained for 3~4 months. During the boreal winter, its effect was less significant than in boreal summer and maintained for about 2 months. On the other hand, the changes of surface temperature were more noticeable in the southern hemisphere, and the relationship between temperature and soil moisture was the same as the boreal summer. It has been noted that the impact of land initialization is more evident in the summer hemispheres, and this is expected to improve the simulation of summer heat wave in the KMA's operational climate prediction system.

• Clinical Pain
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• v.19 no.2
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• pp.80-89
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• 2020

Objective: We compared the regenerative effects of microcurrent therapy (MT) according to the type of electric current, which were direct current microcurrent therapy (DCMT) and alternating current microcurrent therapy (ACMT) on atrophied calf muscle in cast-immobilized rabbit. Method: Rabbits were allocated into control group (sham MT), ACMT group, and DCMT group. Before starting treatment, right gastrocnemius (GCM) muscle was immobilized by cast for 2 weeks. Compound muscle action potential of tibial nerve in nerve conduction study, circumference of calf muscle using a ruler, and thickness of medial and lateral GCM muscle measured by ultrasound, cross sectional area (CSA), and proliferating cell nuclear antigen (PCNA) ratios (%) of muscle fibers were measured on the immunohistochemical analysis. Results: The mean atrophic changes (%) in right medial and lateral GCM muscle thickness, right calf circumference, and amplitude of CMAP of the right tibial nerve in ACMT group and DCMT group were significantly lower than those in control group, respectively (p<0.05). The mean CSA (μm²) of type I and type II and PCNA ratios (%) of medial and lateral GCM muscle fibers in ACMT group and DCMT group were significantly greater than those in control group, respectively (p<0.05). There were no significant differences between the ACMT group and DCMT group at all parameters. Conclusion: This study demonstrated that ACMT and DCMT showed better regeneration effect than sham MT. Microcurrent may be effective in regeneration of atrophied muscle regardless of the type of current.

• Annals of Clinical Neurophysiology
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• v.6 no.1
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• pp.31-34
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• 2004

Backgrounds: The pathway of the sural nerve (SN) is variable, but usually divided into medial and lateral sural branches joining the posterior tibial nerve (PTN) and the peroneal nerve (PN). The sural nerve may be affected by PN palsy. The frequency or the severity of SN involvement in peroneal palsy is not known. The purpose of the study is to investigate the frequency and the severity of the SN involvement by the peroneal nerve palsy. Methods: Total 85 patients were included with peroneal palsy. Amplitudes of distal peroneal, sural, and superficial peroneal nerves (SPN) were compared between normal and paralyzed sides. The frequency and severity of SN involvement by peroneal palsy were investigated. Results: Mean age was $48.4{\pm}17.4$ years old at the time of the test. Peroneal palsy was right side in 32, left in 38, and bilateral in 15 patients. Mean amplitudes of affected distal PN, SPN, and SN were $1.51{\pm}1.64mV$, $3.50{\pm}4.86{\mu}V$, and $10.42{\pm}6.59{\mu}V$ in right side, and $1.19{\pm}1.57mV$, $4.38{\pm}5.67{\mu}V$, and $11.06{\pm}6.87{\mu}V$ in left side, respectively. Sensory nerve action potential (SNAP) amplitude of the SN in the affected side was average $73.7{\pm}33.1%$ of normal, which was significantly lower than that in the normal side(p<0.01). The decrease of the sural SNAP amplitude was more than 15% in 39 out of 70 patients with unilateral peroneal palsy. Peroneal compound muscle action potential (CMAP) amplitude was not correlated with the amplitude of the sural SNAP. By complete peroneal palsy, SN SNAP amplitude was decreased to 4% of SNAP and $57.7{\pm}31.8%$ of that in normal side. Conclusions: PN injury without PTN involvement may induce reduction of sural SNAP amplitude. Because of the anatomic variation of SN, the electrophysiological findings are variable. It should be considered to interpret the location of the PN lesion.

• Annals of Clinical Neurophysiology
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• v.1 no.2
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• pp.91-98
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• 1999

Background : The pathogenesis of acute inflammatory demyelinating polyradiculoneuropathy (AIDP), Guillain Barre syndrome (GBS) is not clear, but it has been known that the immune mechanisms play an important role. Authors performed this study to establish an animal model of experimental allergic neuritis (EAN) by immunizing the myelin components of peripheral nerves and to understand the electrophysiological and histopathological features as well as the ${CD_5}^+$ B-lymphocyte changes in peripheral bloods in the EAN models. Methods : Lewis rats weighing 150-200 gm were injected subcutaneously in soles two times with total myelin, P0, P1, or P2 proteins purified from the bovine cauda eguina. The EAN induction was assessed by evaluating clinical manifestations. The electrophysiological and histopathological features were studied as routine methods. The ${CD_5}^+$ Blymphocytes were double stained using monoclonal FITC conjugated anti-rat CD45RA and R-PE conjugated anti-rat ${CD_5}^+$ antibodies and calculated using a fluorescence activated cell sorter (FACS). Results : The EAN animal models were established. In two out of five, in one out of two, in none out of three, and in none out of one Lewis rats injected with purified total myelin, P0, P1, P2 proteins respectively, They showed slow spontaneous motor activity and weak resistance against pulling back by tails. The typical electrophysiological and histologic findings in total protein and P0 induced EAN animal models were the decreased conduction velocity, the decreased compound muscle action potential (CMAP) amplitude and the dispersion phenomenon. The perivascular infiltrates of lymphocytes with focal demyelinating process were found in light microscopy. The ${CD_5}^+$ B-lymphocyte expression in three EANs were 2.38%, 3.50% 2.50%, which were not significantly increased, compared with those in normal controls. Conclusion : The EAN animal models were successfully established by injecting the total myelin and P0 myelin and they showed electrophysiological and histological features typical of demyelinating process. However they did not show an increased expression of ${CD_5}^+$ B-lymphocyte in peripheral bloods which could be indirect evidence of humoral autoimmunity.

• Journal of Electrodiagnosis and Neuromuscular Diseases
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• v.20 no.2
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• pp.84-90
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• 2018

Objective: To assess the correlation between surface electromyography (SEMG) and conventional EMG in patients with facial nerve palsy. Additionally, compare the discomfort and the time required by the patients in two methods. Method: 36 patients with facial palsy were given nerve conduction studies (NCS) via conventional EMG. Then, the peak root mean square (RMS) values were obtained from the SEMG. We also recorded visual analogue scale (VAS), House-Brackmann scale, and the time required for the examination. Results: Pearson's correlation coefficient between the amplitude loss ratio of the RMS values obtained by SEMG compared to the unaffected side (RSEMG) and the amplitude loss ratio of CMAP amplitudes compared to the unaffected side (RCMAP) was 0.567 at the frontalis, 0.456 at the orbicularis oculi, 0.393 at the nasalis, and 0.437 at the orbicularis oris. An increase in RSEMG is positively correlated with an increase in RCMAP. The mean VAS score with conventional EMG was $3.55{\pm}1.42$, whereas that experienced when using SEMG was $0.11{\pm}0.52$ and the mean time required for conventional EMG was $610{\pm}103.84$ seconds, while that required for SEMG was $420{\pm}86.32$ seconds. Conclusion: This study demonstrated a significant positive correlation between facial muscle activities as measured by SEMG and conventional EMG in patients with facial nerve palsy. SEMG has the benefits of being more comfortable and faster when diagnosing facial palsy.