• Title/Summary/Keyword: CM산업

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Production of Antihypertensive Constituents from Ganoderma lucidum IY005 by Fermentation Using Industrial Wastes (산업폐자원을 이용한 발효에 의한 영지의 항고혈압 성분의 생산)

  • Lee, Kweon-Haeng;Jeong, Hoon;Kim, Young-Il;Kim, Byong-Kak
    • The Korean Journal of Mycology
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    • v.19 no.1
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    • pp.79-84
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    • 1991
  • Fruit bodies of Ganoderma lucidum have been used for most pharmacological studies, but pharmacological effects are likely variable because the habitats and strains of Ganoderma lucidum are different. Therefore, their fermentation is required to produce constant and reliable pharmacolo­gical constituents from Ganoderma lucidum. During the studies of medium for industrial application. it was found that ginseng root residues, remaining after being extracted with ethanol, were a good carbon source for a fermentation of Genoderma lucidum and a corn steep liquor was also economical for the nitrogen source. Yield of the mycelial cultured in ginseng root residues and corn steep liquor was 2.5 times higher than that in glucose and peptone, known as a conventional medium of Ganoderma lucidum. The polysaccharide content of the extracts from the cultured mycelia was higher than that from fruit bodies, but protein content was vice versa. Extracts of the cultured mycelia were more effective and lasting than extracts of the fruit bodies in decreased hypertention of spontaneously hypertensive rats (SHR).

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Space Business and Applications of Vacuum Technology (우주개발과 진공기술의 응용)

  • Lee, Sang-Hoon;Seo, Hee-Jun;Yoo, Seong-Yeon
    • Journal of the Korean Vacuum Society
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    • v.17 no.4
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    • pp.270-277
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    • 2008
  • Vacuum is any air or gas pressure less than a prevailing pressure in an environmental or, specifically, any pressure lower than the atmospheric pressure and is used by a wide variety of scientists and engineering - including clean environment, thermal insulation, very long mean free path, plasma, space simulation[1]. The space environment is characterized by such a severe condition as high vacuum, and very low and high temperature. Since a satellite will be exposed to such a space environment as soon as it goes into its orbit, space environmental test should be carried out to verify the performance of the satellite on the ground under the space environmental conditions. A general and widely used method to simulate the space environment is using a thermal vacuum chamber which consists of vacuum vessel and thermally controlled shroud. As indicated by name of vacuum chamber, the vacuum technology is applied to design and manufacture of the thermal vacuum chamber. This paper describe the vacuum technology which is applied to space business.

A Study on Competency Evaluation and Improvement Plan of Electrical Construction Management Using Importance-Performance Analysis (IPA를 활용한 전기공사 건설사업관리 역량 평가 및 개선방안 연구)

  • Kim, Seungbeum;Byun, Jeongyoon;Kim, Juhyung;Kim, Jaejun
    • Korean Journal of Construction Engineering and Management
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    • v.15 no.3
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    • pp.103-112
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    • 2014
  • Since recent construction projects become larger and complicated, the level of difficulty of management skill is rising, and the risk is increasing accordingly so the necessity of improving management skill of projects is increasing. In order to solve this problem, Construction Management system was preferentially introduced in construction projects but in case of domestic construction industry, separate contracts by business boundary are being made so the actual state is that the function of the Construction Management system is not properly operated over the overall projects. The partial operation of Construction Management system like this may impose many restrictions on converged and combined projects such as smart grid and intelligent buildings etc. in the future. For improvement of management skill of domestic construction projects, the competence of project management skill by work areas that can overcome heterogeneity of the current project management skill shall be secured, and any factor that impedes cooperation ability shall be found and that shall be solved. Therefore, the difference of work competency of project management system of construction and electrical construction is to be analyzed by utilizing IPA model in this study, and a plan to introduce the project management system of electrical construction for efficient operation of projects is to be looked into.

Characterization and Cloning of a Phytase from Escherichia coli WC7. (Escherichia coli WC7가 생산하는 Phytase의 효소특성과 그 유전자의 클로닝)

  • 최원찬;오병철;김형권;강선철;오태광
    • Microbiology and Biotechnology Letters
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    • v.30 no.1
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    • pp.1-7
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    • 2002
  • Phytase from Escherichia coli WC7 was purified from cell extracts and its molecular mass was estimated to be 45 kDa by SDS-PAGE. Its optimum temperature and pH for phytate hydrolysis was 6$0^{\circ}C$ and pH 5.0, respectively. The enzyme was stable up to 6$0^{\circ}C$ and over broad pH range (pH 2-12). The enzyme had higher affinity for sodium phytate than p-nitrophenylphosphate (pNPP). That is, the apparent Km value for sodium phytate and pNPP were $0.15\pm$0.02 mM and 2.82$\pm$0.05 mM, respectively. The gene encoding the phytase was cloned in E. coli XL1-Blue. Sequence analysis showed an open reading frame of 1241 Up encoding a signal peptide (22 aa) and a mature enzyme (410 aa). WC7 phytase was expressed up to 17.5 U/ml in the transformed E. coli XL1-Blue/pUEP, which was 23-fold higher than the activity from wild strain.

Lever Arm Compensation of Reference Trajectory for Flight Performance Evaluation of DGPS/INS installed on Aircraft (항공기에 탑재된 DGPS/INS 복합항법 장치의 비행 시험 성능 평가를 위한 기준궤적의 Lever Arm 보정)

  • Park, Ji-Hee;Lee, Seong-Woo;Park, Deok-Bae;Shin, Dong-Ho
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.40 no.12
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    • pp.1086-1092
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    • 2012
  • It has been studied for DGPS/INS(Differential Global Positioning System/Inertial Navigation System) to offer the more precise and reliable navigation data with the aviation industry development. The flight performance evaluation of navigation system is very significant because the reliability of navigation data directly affect the safety of aircraft. Especially, the high-level navigation system, as DGPS/INS, need more precise flight performance evaluation method. The performance analysis is performed by comparing between the DGPS/INS navigation data and reference trajectory which is more precise than DGPS/INS. The GPS receiver, which is capable of post-processed CDGPS(Carrier-phase DGPS) method, can be used as reference system. Generally, the DGPS/INS is estimated the CG(Center of Gravity) point of aircraft while the reference system is output the position of GPS antenna which is mounted on the outside of aircraft. For this reason, estimated error between DGPS/INS and reference system will include the error due to lever arm. In order to more precise performance evaluation, it is needed to compensate the lever arm. This paper presents procedure and result of flight test which includes lever arm compensation in order to verify reliability and performance of DGPS/INS more precisely.

A Study on the Occurrence of Seedlings and Saplings of Korean fir (Abies koreana E.H. Wilson) on the East slope of Mt. Hallasan National Park (한라산국립공원 동사면의 구상나무(Abies koreana E.H. Wilson) 유묘 및 치수 발생 현황)

  • Lee, Jong-Won;Choi, Im Jun;Lee, Su Hong;Lim, Won Taek;Kim, Jin-Won;Kang, Shin-Ho
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2019.04a
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    • pp.36-36
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    • 2019
  • 본 연구는 한라산국립공원 동사면에 위치한 구상나무숲 장기생태 모니터링 5ha 조사지역 ($20{\times}20m$, 125개 방형구)에서 구상나무의 유묘 및 치수 발생 현황을 파악하기 위하여 수행되었다. 조사는 2016년 6~8월 사이에 $5{\times}5m$ 방형구 125곳에 대해 계통추출법을 적용하여 실시하였다. 조사한 전체 125개 방형구 중에서 54개에서만 유묘가 관찰되었으며, 그 내용은 유묘 615개체 및 치수 1개체로 총 616개체가 발견되었다. 그러나 과반수의 71개 방형구에서 치수뿐만 아니라 유묘도 출현하지 않았다. 심지어 전체 125개 방형구에서 유묘가 가장 많이 관찰된 방형구(2-6지역, 95개체)를 제외하면, 나머지 124개 방형구의 평균 유묘 개체수는 4.2개로 매우 적었고 높이도 35cm 이하에 불과했다. 이와 함께 장기생태 모니터링 조사 지역 내에서 $1{\times}1m$ 방형구 183곳에 대해 단순 무작위 추출법으로 발생지 조사를 수행하였다. 발생지 조사 결과 유묘 2,518개체, 치수 2개체 및 유목 2개체 등 총 2,522개체가 발견되어 계통추출법을 적용한 조사와 유사한 결과가 나타났다. 본 연구를 통해 한라산국립공원 동사면 구상나무숲 내에서 구상나무 유묘의 발생은 어느 정도 이루어지고 있으나, 교란으로 인하여 치수로의 발달이 제한되는 것으로 판단된다. 여러 교란 요인 중에서 조사된 총 3,138개체 중 12.1%, 381개체에서 유제류인 노루에 의한 섭식이 확인되어 노루의 섭식이 유묘 발생 및 치수 발달에 교란을 야기하는 가장 중요한 요인으로 추정해볼 수 있다. 한반도 특산식물 구상나무의 보전 대책 수립을 위한 유묘 및 치수 교란 원인에 대한 지속적인 모니터링이 진행되어야 한다고 사료된다.

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Effects of amprolium hydrochloride on expression of drug metabolizing enzyme genes in olive flounder Paralichthys olivaceus (Amprolium hydrochloride가 넙치 Paralichthys olivaceus의 약물대사 유전자 발현에 미치는 영향)

  • Sang Hyup Park;Chang Han Kim;Jeong-wan Do;Hye-Sung Choi;Yi Kyung Kim
    • Journal of fish pathology
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    • v.36 no.2
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    • pp.337-348
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    • 2023
  • This study was undertaken to evaluate the effect of amprolium hydrochloride on detoxification process of olive flounder Paralichthys olivaceus. A series of two experiment was performed based on the LD50 value obtained for amprolium. First, thirty flounder (average weight 230.27 g; average length 27.99 cm) was randomly allocated into five groups. Treatment was carried out using intra-muscular injection of amprolium at the dose levels of 4, 8, 16, and 32 mg/kg body weight. At 8, 24 and 48 h post injection, liver and kidney were collected for expression assay of drug metabolizing enzymes and pro-inflammatory cytokine genes. We found that the interleukin-1β (IL-1β) mRNA level were induced at 32 mg/kg and CYP1A genes showed the opposite pattern, while UDP-glucuronosyl-transferase (UGT1A7) and GST were significantly reduced in the liver. Moreover, the suppression of drug metabolizing enzymes and cytokine gene in the kidney was observed after treatment. Another treatment was carried out using intramuscular injection with 4, 8, 16, and 32 mg/kg and 60, 80, 100, 120 mg/kg body weight. At 6 days post injection, liver was collected. The IL-1β expression was markedly induced in the experimental group treated with 4 mg/kg. In addition, glutathione S-transferase (GST) mRNA level was higher in the group with 4 mg/kg. In conclusion, our data suggests that amprolium seem to cause direct or indirect physical, or biological toxicity of flounders, although this drug is considered one of the safest synthetic anticoccidial drugs of the livestock industry.

Ex situ combined in situ target strength of Japanese horse mackerel using a broadband echosounder (중심 주파수 200 kHz의 과학어군탐지기를 활용한 전갱이의 광대역 주파수 특성)

  • Myounghee KANG;Hansoo KIM;Dongha KANG;Jihoon JUNG;Fredrich SIMANUNGKALIT;Donhyug KANG
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.60 no.2
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    • pp.142-151
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    • 2024
  • Recently, domestic fishing production of Japanese horse mackerel has been continuously decreasing. To achieve sustainable fishing of this species, it is essential to acquire its target strength (TS) for accurate biomass estimation and to study its ecological characteristics. To date, there has been no TS research using a broadband echosounder targeting Japanese horse mackerel. In this study, for the first time, we synchronized an underwater camera with a broadband frequency (nominal center frequency of 200 kHz, range: 160-260 kHz) to measure the TS according to the body size (16.8-35.5 cm) and swimming angle of the species. The relationship between Japanese horse mackerel length and body weight showed a general tendency for body weight to increase as length increased. The pattern of the frequency spectra (average values) by body length exhibited a similar trend regardless of body length, with no significant fluctuations in frequency observed. The lowest TS value was observed at 243 kHz while the highest TS values were recorded at 180 and 257.5 kHz. The frequency spectra for the swimming angles appeared to be flat at angles of -5, 0, 30, 60, 75, and 80° while detecting more general trends of frequency spectra for swimming angle proved challenging. The results of this study can serve as fundamental data for Japanese horse mackerel biomass estimation and ecological research.

Nutritional and Organoleptic Evaluations of the By-products from Chlorella vulgaris after Lipid Extraction (Chlorella vulgaris의 지질 추출 후 부산물의 영양학적 및 관능적 평가)

  • Oh, Sung-Ho;Choi, Woon-Yong;Seo, Yong-Chang;Kim, Ga-Bin;Lee, Shin-Young;Jeong, Kyung-Hwan;Kang, Do-Hyung;Lee, Hyeon-Yong
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.39 no.6
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    • pp.920-926
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    • 2010
  • Marine alga, Chlorella vulgaris, was extracted by chloroform-methanol (2:1, v/v) solvents for lipid extraction at $35^{\circ}C$ for five hours (HCM-35) and its process was compared with conventional lipid extraction condition such as chloroform-methanol (2:1, v/v) at $65^{\circ}C$ for one hour (CM-65). This low temperature extraction process showed that 80% of total lipid was extracted and its residues contained relatively unchanged amounts of intact proteins and other minerals as well as amino acid profiles. Interestingly enough, the weight fraction of carbohydrate in the residues slightly increased due to less denaturation at low process temperature. The biological activities of the residues such as cytotoxicity and immune cell growth activation were not much changed after being extracted. The sensory evaluation were found to be very favorable for being used as a food additive and/or food supplement. This result could also help to maintain the economic feasibility of utilizing marine resources in food and other relevant industries.

Effects of ADCYP1R1, FABP3, FABP4, MC4R, MYL2 Genotypes on Growth Traits in F2 Population Between Landrace and Jeju Native Black Pig (제주재래흑돼지와 Landrace의 F2 집단에서 ADCYP1R1, FABP3, MC4R, MYL2 유전자형이 성장형질에 미치는 효과)

  • Han, Sang-Hyun;Shin, Kwang-Yun;Lee, Sung-Soo;Ko, Moon-Suck;Jeong, Dong-Kee;Jeon, Jin-Tae;Cho, In-Cheol
    • Journal of Animal Science and Technology
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    • v.50 no.5
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    • pp.621-632
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    • 2008
  • Genetic polymorphisms was investigated at five single nucleotide polymorphisms(SNP) sites in four porcine genes(ADCYAP1R1, FABP3, MC4R, and MYL2) and analyzed their statistical association with growth traits in F2 reciprocal-crossbred population between Landrace and Jeju native black pig(JNP). All populations, JNP, Landrace and their F2 were polymorphic for all five SNP loci tested, however, the homozygote T/T of FABP3 g.-158T>C and the homozygote G/G of ADCYAP1R1 intron 2 337A>G were not found in JNP and Landrace, respectively. The genotypes of ADCYAP1R1 were significantly associated with body weights(BW) at 3 weeks and at 20 weeks(P<0.05), respectivley, those of FABP3 g.-135delT were associated with late average daily gain(LADG) (P<0.01), and those of FABP3 g.-158T>G were associated with body weights during late growth period such as, BW20 and LADG(P<0.01). Those of MC4R were also significantly associated with BW10 suggesting by the difference of early average daily gain(EADG) (P<0.05), and with LADG(P<0.01). The body length of F2 animals was affected by the genotypes of ADCYAP1R1, MC4R, and MYL2(P<0.05), respectively. Among these, MC4R A/A homozygotes showed over 3 cm longer in body length than those of other genotypes. As the useful basic information, these results suggested that SNP markers showing statistical association with growth traits and the results help to select the sires of JNP for improving the productivity in JNP-related crossbreeding system in pig industry and also to construct the molecular breeding system for breed improvement of JNP itself.