• Journal of Environmental Impact Assessment
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• v.15 no.1
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• pp.1-12
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• 2006

Changes in the soil physical property and the topographic condition derived from agricultural activities like as farming activities, land clearance and cutting down resulted in environmental and economic problems including the outflow of nutrient from farms and the water pollution. Several theories on the soil conservation have been developed and reviewed to protect soil erosion in the regions having a high risk of erosion. This study was done using the USLE model developed by Wischmeier and Smith (1978), and model for the slope length and steepness made by Desmet and Govers (1996), and Nearing (1997) to evaluate the potential of the soil erodibility. Therefore, several results were obtained as follows. First, factors affecting the soil erosion based on the USLE could be extracted to examine the erosion potential in farms. Soil erodibility (K), slope length (L), and slope steepness (S) were used as main factors in the USLE in consideration of the soil, not by the land use or land cover. Second, the soil erodibility increased in paddy soils where it is low in soil content, and the very fine sandy loam exists. Analysis of the slope length showed that the value of a flat ground was 1, and the maximum value was 9.17 appearing on the steep mountain. Soil erodibility showed positive relationship to a slope. Third, the potential soil erodibility index (PSEI) showed that it is high in the PSEI of the areas of steep upland and orchard on the slope of mountainous region around Dokjigol mountain, Dunji mountain, and Deummit mountain. And the PSEI in the same land cover was different depending on the slope rather than on the physical properties in soil. Forth, the analysis of land suitability in soil erosion explained that study area had 3,672.35ha showing the suitable land, 390.88ha for the proper land, and 216.54ha for the unsuitable land. For unsuitable land, 8.71ha and 6.29ha were shown in fallow uplands and single cropping uplands, respectively.

• Korean journal of food and cookery science
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• v.17 no.4
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• pp.338-343
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• 2001

This study was carried out to analyze the characteristics of Dongchimi(watery radish kimchi) juice while fermenting the samples prepared at various salt concentrations(2, 2.5, and 3 %) and fermentation temperatures(4$^{\circ}C$, 12$^{\circ}C$, and 12$^{\circ}C$ for 12 hr followed by 4$^{\circ}C$). The changes in colour, total vitamin C and free sugar contents were analyzed, and sensory evaluation was performed. As the fermentation proceeded, the “L” value was decreased and “a” and “b” values were increased in all samples. Total vitamin C contents increased up to 26-33 days and decreased thereafter in the samples fermented at 4$^{\circ}C$ and those fermented at 12$^{\circ}C$ followed by 4$^{\circ}C$. In Dongchimi fermented at 12$^{\circ}C$, vitamin C contents increased up to 12-15 days. Glucose, fructose and sucrose were detected in Dongchimi juice. The total content of free sugars in Dongchimi juice was the highest in the samples fermented at 12$^{\circ}C$ followed by 4$^{\circ}C$ . Sensory evaluation was performed for sour taste, salty taste, carbonated flavor, offensive odor, overall preference and clearance of the juice. In overall preference, Dongchimi juice fermented at 12$^{\circ}C$ followed by 4$^{\circ}C$ was the best.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.6
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• pp.185-195
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• 2017

In recent years, unexpected bridge fire accidents have increased because of augmenting the number of traffic volumes and hazardous materials by the increment in traffics and distribution business. Furthermore, in accordance with the effort of using the under space of bridges, the ratio of occupied by combustible materials like oil tanker or lorry has been increased. As a result, the occurrence of bridge fire has been growing drastically. In order to mitigate the accident of bridge fire, risk assessment of bridge fire has been studied, however, practical risk models considering safety from users' viewpoints were scarce. This study represented quantitative risk assessment model applicable to national road bridges in Korea. The primary factors with significant impacts on bridge fire accidents was chosen such as clearance height, materials of bridges, arrival time of fire truck and fire intensity. The selected factors were used for Fire Dynamics Simulation (FDS) and the peak temperature calculated by FDS in accordance with the fire duration and fire intensity. The risk assessment model in bridge fire reflected the FDS analysis results, the fire damage criteria, and the grade of fire truck arrival time was established. Response plans for bridge fire accidents according to the risk assessment output has been discussed. Lastly, distances between bridges and fire stations were calculated by GIS network analysis. Based on the suggested assessment model and methodology, sample bridges were selected and graded for the risk assessment.

• Fire Science and Engineering
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• v.24 no.2
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• pp.145-153
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• 2010

Korea was experienced more forest fire occurrence compared to an area. As a forest fire occurrence from man caused burning for a farming increased and was one of the main reasons of forest fire occurrence in Korea, agriculturist-was a main reason of forest fire occurrence-opinion analysis was needed for forest fire prevention from this reason. Therefore, we asked agriculturist who live in province frequently experienced a forest fire from the burning for farming to answer questions. In result, a half of the respondents have a burning experience for farming and the main reason of the burning was the clearance around farmlands. In result of survey about recognition rate of forest fire prevention policy (forest fire season, incineration inhibition within 100 m from forest, license system for burning, joint burning system by a rural community, imposing a fine for burning) was almost high except license system for the burning, In the result about analysis according to ages and provinces, the recognition rate was high in province experienced severe forest fire damage and low in below 40 years group. So, the direction of forest fire prevention policy would need to be mediated in the view of agriculturist who need to use a fire because of farming labor shortage and higher age. And a consolidated education of forest fire prevention would be needed to agriculturist who live in province experienced rarely forest fire and in below 40 years group.

• Genomics & Informatics
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• v.16 no.3
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• pp.52-58
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• 2018

In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials. During conducting a first-in-human trial for a new molecular entity, we were able to determine the mechanism of dichotomized variability in plasma drug concentrations, which appeared closely related to adverse drug reactions (ADRs) through integrated omics analysis. The pharmacogenomics screening was performed from whole blood samples using the Affymetrix DMET (Drug-Metabolizing Enzymes and Transporters) Plus microarray, and confirmation of genetic variants was performed using real-time polymerase chain reaction. Metabolomics profiling was performed from plasma samples using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A GSTM1 null polymorphism was identified in pharmacogenomics test and the drug concentrations was higher in GSTM1 null subjects than GSTM1 functional subjects. The apparent drug clearance was 13-fold lower in GSTM1 null subjects than GSTM1 functional subjects (p < 0.001). By metabolomics analysis, we identified that the study drug was metabolized by cysteinylglycine conjugation in GSTM functional subjects but those not in GSTM1 null subjects. The incidence rate and the severity of ADRs were higher in the GSTM1 null subjects than the GSTM1 functional subjects. Through the integrated omics analysis, we could understand the mechanism of inter-individual variability in drug exposure and in adverse response. In conclusion, integrated multi-omics analysis can be useful for elucidating the various characteristics of new drug candidates in early phase clinical trials.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.8 no.1
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• pp.103-125
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• 2002

This experimental study was carried out to evaluate the anti-tumor and the immunomodulatory effects of Jiaweicitaowan(加未慈桃丸) against cancer. The in vitro anti-tumor effects were evaluated by MTT assay. The cytotoxicity, extension of survival days, the effect of inhibition solid tumor which was induced sarcoma 180, and the changes of body weight were evaluated for in vivo effects of anti-tumor. To evaluate the immunomodulatory effects of Jiawei- citaowan(加未慈桃丸), delayed type hypersensitivity, hemagglutinin, hemolysin titers for humoral immune response, rosette forming cells for cell-mediated immune response, natural killer cell activity, proliferation of lymphocyte, productivty of Interleukin-2, and carbon clearance were measured with methotrexate treated mice. The results were as follows; 1. In the case of existence ability of tumor cell, IC50 had an anti-tumor ativity resulted 2.52mg/ml to SNU-C4. 0.41mg/ml to SNU-396, resulted to 0.09mg/mlSNU-1. 2. The groups of Jiaweicitaowan(加未慈桃丸) 10mg/ml, 20mg/kg had no body weight loss. reduction in intake of water and feed, so these had no toxicity. 3. In the case of the effect of extention of existence. the group of 20mg/kg Jiaweicitaowan(加未慈桃丸) extract treated group was showed 250% in ILS. 4. The effect of inhibition solid tumor was significantly decreased in both 10mg/kg, 20mg/kg of Jiaweicitaowan(加未慈桃丸) extract treated groups as compared with control group S. The groups of 10mg/kg, 20mg/kg Jiaweicitaowan(加未慈桃丸) had significant effect of body weight change compared to control group. 6. Delayed type hypersensitivity was not significant in both Jiaweicitaowan(加未慈桃丸) extract treated groups as compared with control group. 7. Hemagglutinin and Hemolysin titers were significantly increased by dose-dependent. so these results showed that the humoral immume respose was activated. 8. For the effect of rosette formimg cells was not significant in hoth Jiaweicitaowan(加未慈桃丸) extract treated groups as compared with control group. 9. Natural killer cell activity was significantly increased in both Jiaweicitaowan(加未慈桃丸) extract treated groups as compared with control group in the ratio of 100: 1, 50: 1 of effector and target cells, but in the ratio of 10:1, the Jiaweicitaowan(加未慈桃丸) extract treated groups were not significant. 10. The proliferation of lymphocyte and productivty of Interleukin-2 were significantly increased by dose-dependent in both 10mg/ kg, 20mg/ kg of Jiaweicitaowan(加未慈桃丸) extract treated groups as compared with control group. 11. In the phagocytic effect, the 20mg/kg of Jiaweicitaowan(加未慈桃丸) extract treated group showed the increasing effect with significance as compared with control group. According to the results, we can suggest that Jiaweicitaowan(加未慈桃丸) has the antitumor and the immunomodulatory effects.

• Journal of Veterinary Clinics
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• v.29 no.2
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• pp.130-133
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• 2012

The purpose of this study is to assess the relationship between glomerular filtration rate (GFR) and age by using dynamic computed tomography (CT) and Patlak plot analysis in dogs. Fifteen dogs were used in this study. CT-GFR study was performed under general anesthesia using propofol and isoflurane. 1 ml/kg dosage of 300 mgI/ml iohexol was administered at a rate of 3 ml/s during GFR measurement. CT-GFR was determined with a single-slice dynamic acquisition and Patlak plot analysis. The individual and global GFR values were calculated to plasma clearance per body weight (ml/min/kg). Bodyweight ($mean{\pm}SD$) ranged from 2.0 to 5.7 kg ($3.31{\pm}1.13$ kg). Age ranged from 3 years to 13 years old ($7.14{\pm}3.30$). $Mean{\pm}SD$ creatinine ($0.53{\pm}0.34 $mg/dl), phosphorus ($4.1{\pm}1.2$ mg/dL), and albumin ($3.3{\pm}0.3$ mg/dL) concentrations and urine protein-to-creatinine ratios (all ratios were < 0.5) were within reference ranges. Abdominal ultrasonography revealed small-sized renal calculi, mineralization, or renal cyst at eight dogs. The global CT-GFR ranges shown in this study was 2.57 to 6.60 ml/min/kg. In this study, there was no trend toward weight-adjusted CT-GFR with increasing age. We found no relationships between age-related kidney dysfunction in fifteen dogs. Small-sized renal calculi or cysts did not affect renal function in this study. However, it is thought that a large sample size may have been required to document an age effect.

• Korean Journal of Food Science and Technology
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• v.37 no.1
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• pp.103-107
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• 2005

Immunomodulatory activities of crude ${\beta}$-glucans extracted from oat bran under different conditions, fractions A ($55^{\circ}C,\;5%,\;pH\;6$), B ($45^{\circ}C,\;15%,\;pH\;6$), C ($50^{\circ}C,\;20%,\;pH\;7$), D ($50^{\circ}C,\;0%,\;pH\;7$), and E ($50^{\circ}C,\;10%,\;pH\;9$) were investigated. All crude ${\beta}$-glucan fractions stimulated macrophages, producing nitric oxide dose-dependently, and, efficiently promoted nitric oxide production in presence of IFN-${\gamma}$. Except for fraction C, in vivo test indicated fractions B, D, and E (100 mg/kg) substantially enhanced carbon-phagocytic indices of blood macrophages by oral administration of crude ${\beta}$glucan for 7 days prior to carbon injection. These immunomodulatory effects could be determined with extraction conditions of crude ${\beta}$-glucan.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.9 no.1
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• pp.101-110
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• 2010

In this study, a prediction model for incident reaction time was developed so that we can cope with the increasing demand for information related to the accident reaction time. For this, the time for dealing with accidents and dependent variables were classified into incident grade, A, B, and C. Then, fifteen independent variables including traffic volume, number of accident-related vehicles and the accidents time zone were utilized. As a result, traffic volume, possibility of including heavy vehicles, and an accident time zone were found as important variables. The results showed that the model has some degree of explanatory power. In addition, when the CHAID Technique was applied, the Answer Tree was constructed based on the variables included in the prediction model for incident reaction time. Using the developed Answer Tree model, accidents firstly were classified into grades A, B, and C. In the secondary classification, they were grouped according to the traffic volume. This study is expected to make a contribution to provide expressway users with quicker and more effective traffic information through the prediction model for incident reaction time and the Answer Tree, when incidents happen on expressway

• Journal of Radiation Protection and Research
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• v.15 no.2
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• pp.41-49
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• 1990

$^{88}SrCl_2$ was injected to the tail vein of Wistar rats and investigated its distribution and clearance in the tissues and blood. We also measured the changes in Sr binding to the blood plasma protein by administrating chelating agents and organic acids. For the blood, 60% of the Sr occurred in the plasma and 40% on the cell membrane. Fifty percent of Sr in the blood plasma was bound to plasma protein. Sr on the cell membrane seemed to be bound loosely. The binding in the lymphocyte was higher than in the erythrocyte .and granulocyte. Within one hour Sr was quickly disappeared from the blood stream, to be accumulated in the bone. Twenty four hours after the injection, Sr decreased rapidly in the organs of soft tissue, but slowly in the bone. The binding of Sr to plasma protien decreased from 57% of the control to 27-33% in the group treated with chelating agents, EDTA, EGTA and DTPA and to 19% and 40% in the groups treated with organic acids, citrate and oxalate, respectively.