• Title/Summary/Keyword: CLEARANCE

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A Study on Prototype Model for Mesoscopic Evacuation Using Cube Avenue Simulation Model (Cube Avenue 시뮬레이션 모델을 이용한 중규모 재난대피 프로토타입 모델 연구)

  • Sin, Heung Gweon;Joo, Yong Jin
    • Spatial Information Research
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    • v.21 no.5
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    • pp.33-41
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    • 2013
  • Recently, the number of disasters has been seriously increasing. The total damages by the natural or man-made disasters during the past years resulted in tremendous fatalities and recovery costs. It is necessary to have efficient emergency evacuation management which is concerned with identifying evacuation route, and the estimation of evacuation and clearance times. An emergency evacuation model is important in identifying critical locations, and developing various evacuation strategies. In that existing evacuation models have focused on route analysis for indoor evacuation, there are only a few models for areawide emergency evacuation analysis. Therefore, we developed a mesoscopic model by using Cube Avenue and performed evacuation simulation, targeting road network in City of Fargo, North Dakota. Consequently, a mesoscopic model developed in this study is used to carry out dynamic analysis using network and input variable of existing travel demand model. The results of this study show that the model is an appropriate tool for areawide emergency evacuation analysis to save time and cost. Henceforth, the results of this study can be applied to develop a disaster evacuation model which can be used for a variety of disaster simulation and evaluation based on scenarios in the local metropolitan area.

A Case of Pulmonary Alveolar Proteinosis Associated with Pulmonary Tuberculosis (폐결핵과 병발된 폐포단백증 1예)

  • Park, Min Sik;Jung, Sung Chang;Jin, Myoung In;Lee, Jin Bae;Lim, Sang Hyuk;Park, Sung Hun;Chung, Seung Hie;Shin, Tae Rim;Hyun, Dae Sung;Lee, Sang Chae;Yun, Kil Suk;Kwon, Kun Young
    • Tuberculosis and Respiratory Diseases
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    • v.52 no.4
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    • pp.411-418
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    • 2002
  • Pulmonary alveolar proteinosis(PAP) is a disorder in which an insoluble, proteinaceous material, rich in phospholipids, is deposited in the alveoli and bronchioles. The deficiency in the clearance and degradation of the intra-alveolar phospholipoproteinaceous material in PAP most likely represents a dysfunction of the type II pneumocytes. Although the pathogenesis and causative treatment of PAP is unclear a whole lung bronchopulmonary lavage is a relatively safe and effective treatment. Here we experienced a case of pulmonary alveolar proteinosis in a 62 year old female patient who had pulmonary tuberculosis approximately 20 years ago. She complained of aggravated dyspnea and chronic cough, and presented fine inspiratory crackles at both lung fields, diffuse ground glass opacity with some area of consolidation and smooth interlobular septal thickenings in both upper, right middled lobes, and a portion of right lower lobe. Optical microscopy of the lung tissue obtained by and open lung biopsy revealed many granulomas containing acid-fast smear positive bacilli and diffuse homogeneous PAS-positive fluid in the alveolar space. Immunohistochemical stain showed surfactant. A in the alveolar space. Antituberculosis drugs with bronchoalveolar lavage were used to treat the disease. Thereafter she showed improvement in her symptoms and a partial improvement in the chest X-ray and HRCT findings. We present a case of PAP associated with pulmonary tuberculosis.

Development of Design Technology of Korean Style Air-Inflated Double-Layer Plastic Greenhouse (한국형 공기주입 이중피복 플라스틱온실의 설계기술 개발)

  • Lee, Hyun-Woo;Sim, Sang-Youn;Nam, Hyo-Seok;Nam, Sang-Woon;Kim, Young-Shik
    • Journal of Bio-Environment Control
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    • v.18 no.3
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    • pp.185-191
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    • 2009
  • The construction of experimental greenhouses, operating test, and analysis on variation of different environment factors were conducted to provide fundamental data for design of Korean style air-inflated double-layer plastic greenhouse. The development of technology of attaching plastic to the structure and fasteners to be able to keep airtight was required in order to maintain proper static pressure in air space of double layer coverings. The insulation effect of air inflated greenhouse was better than conventional type. The temperature of arch type roof was greater about $2^{\circ}C$ than peach type roof in air inflated greenhouse. It was recommended that the plastic should be attached at the edges without clearance length in order to ease installation and raise airtightness of double layer coverings. The transmittance of arch type roof was greater than peach type in air inflated one span greenhouse. The transmittance of air inflated greenhouse was greater than conventional type due to frame ratio and distance between double layers in three span greenhouse. The condensation occurred on conventional type greenhouse was more than air inflated type. It was required to examine for a long time in order to analyze it quantitatively.

An Analysis on the Vibration Characteristic of a Automobile at the Sudden Change of an Accelerator under Traveling (주행중 가속페달의 급조작시 승용차의 진동 특성 해석)

  • 홍동표;정태진;김상수
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 1994.04a
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    • pp.76-81
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    • 1994
  • 승용차에 있어 엔진의 공회전시나 주행중에 발생하는 여러 형태의 진동 및 소음의 저감은 승차감 및 차량의 안정성에 있어 중요한 과제가 되고 있다. 이러한 소음, 진동은 주로 엔진에서 발생하는 토크의 비주기적인 변동성분이 클러치(clutch), 변속기(transmission), 구동축을 거쳐 바퀴로 전달되는 과정에서 발생한다. 셔플(shuffle)은 주행중 가속페달(accelerator)을 급조작(tip-in, tip-out)하였을 때 차량이 전후로 과도적으로 울렁거리는 종진동 현상을 말하며, 이것은 가속페달의 급조작으로 인해 엔진토크가 큰 변동을 일으키고, 동력전달계를 통해 타이어에 전달된 이 토오크는 타이어축에서 구동측으로 역토오크를 발생시키기 때문에 발생한다. 여기서 팁-인(tip-in)이란 승용차를 저속으로 운전하다가 갑자기 가속페달을 밟는 경우를 말하며, 팁-아웃(tip-out)은 반대로 고속상태에서 갑자기 가속페달을 떼는 경우를 말한다. 실험과 시뮬레이션을 사용한 자동차 동력전달계의 비틀림 진동에 대한 연구는 이미 여러 연구자들에 의해 보고되었다. H.Arai은 2자유도 비선형 모델을 사용하여 클러치 접속시 발생하는 외란과 계의 안정성을 고려하여 시뮬레이션을 수행하였고, M.Kataoka는 기어의 공차(clearance)를 고려한 변속기의 강제 비틀림 진동을 실험과 시뮬레이션을 통하여 해석하였다. 그리고, Wu Hui-Le는 자동차 동력전달계의 비틀림 진동 현상을 실험과 이론적인 계산을 통해 연구하였고, R.J.Comparin는 치타음의 발생구조와 특성을 고찰하고 비서형 비틀림 공진 저감에 의한 치타음 저감 기법에 대하여 연구하였다. 또한 G.J.Fudala는 다자유도 모델을 이용하여 클러치의 비틀림 특서엥 따라 주파수분석을 수행하여 치타음 저감 방법을 연구하였고, T.Sakai는 5자유도 모델을 이용하여 엔진 공회전시 발생하는 치타음에 대해 이론과 실험을 통해 해석하고, 엔진 회전수 변동, 클러치 특성, 변속기의 드래그(drag) 토크의 영향과 치타음 저감을 위한 개선된 클러치 특성을 제시하였다. 이 외에도 Thomas C.T.와 E.P.Petkus는 특정 차량에 대한 동력전달계의 비틀림 진동 현상에 대해 연구하였다. 이러한 연구들로 볼 때, 자동차 동력전달계에서 발생하는 진동은 이론과 실험을 통해 그 해석이 가능하며 설계에 매우 유용하게 이용되고 있음을 알 수 있다. 따라서, 본 연구는 4 실린더 4 싸이클 1.5 L 엔진을 장착한 경승용차의 실차 주행실험을 통해 가속 페달의 급조작에 따른 차체의 종진동 현상을 측정하고, 엔진-변속기-타이어-차체의 반환정계 4자유도 진동모델로 시뮬레이션을 수행하여 실차 주행실험의 결과치와 비교, 분석한 후 클러치 비틀림 특성을 비롯한 자동차 동력전달계의 각 설계인자들이 차체의 종진동에 어떠한 영향을 미치는가를 해석하고자 한다.

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A Study on Library Engagement and Models for Support of MOOC (온라인 대중공개강좌(MOOC)를 위한 도서관 지원 서비스 모델 연구)

  • Son, Taeik
    • Journal of the Korean Society for Library and Information Science
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    • v.50 no.3
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    • pp.293-308
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    • 2016
  • Many universities are offering some of their offline courses for anyone to learn free online as an MOOC format. University libraries In response to changing university conditions, foreign university libraries are struggling to redefine their roles and provide new services. This study aimed to find the trends and models to support MOOCs in foreign libraries and Library and information science domain by conducting a systematic review of studies on foreign library and information journals which have been published from 2012 to 2015. A total of 34 out of 348 studies were included in the final analysis. This study also aimed to present the limits and the future models of MOOC support direction. The relevant articles could be identified, two criteria: 24 MOOCs studies relating to Libraries and 10 MOOCs studies related to LIS. The selected articles were summarized and analyzed yearly. The study identifies elements of library MOOC support models in 5 areas including MOOC design (copyright clearance and consulting, content licensing, open content), production support (course production, video editing, librarian MOOC production), management support (instructional design and content creation, students support), evaluation (MOOC data collection, analysis), reuse (MOOC metadata management, archive structure). Based on these findings, this study suggested the models of library MOOC support and set the theoretical fundamentals.

Trends in Epidemiology, Clinical and Histopathological Characteristics of Breast Cancer in Iran: Results of a 17 Year Study

  • Afsharfard, Aboulfazl;Mozaffar, Mohammad;Orang, Elahe;Tahmasbpour, Eisa
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6905-6911
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    • 2013
  • Background: Breast cancer (BC) is the top cancer among women worldwide and the most frequent malignancy among Iranian women over the past few decades. The increasing trend and high mortality rate of BC in the developing world necessitates studies concentrating on its characteristics in countries in Asia. The current study focused on clinical and histopathological features of BC among Iranian females. Materials and Methods: This retrospective study involved 714 Iranian patients with histopathologically proven BC undergoing resection of primary tumours and axillary clearance. Demographic, clinical and histopathological data were obtained and studied between ten year age groups (${\leq}40$ years, 41-50 years, 51-60 years, 61-70 years, and ${\leq}71$ years) in four chronologic phases from 1994-2009. Results: Mean age of patients was $49.4{\pm}13.1$ years. Most of cases (33.2%) were in 41-50 group. Mean size of primary tumors was $3.94{\pm}2.47$ cm and 87.1% of cases had infiltrative ductal carcinoma. Modified radical mastectomy was the most common method of surgery carried out (48.8%). Some 57.1% of tumors were in pT2 and tumor size decreased significantly during the period (p<0.05). The most common BC stage was llla (27%). Lower BC stages (0 and 1) constituted 13.9% of the diagnosed tumors. Our series of patients aged ${\leq}40$ had larger tumors (mean $4.73{\pm}3.02$ cm) compared to older age groups (p=0.003). Lower stages (0 and I) were more frequent among the oldest patients while nearly 50% of patients aged ${\leq}40$ had tumor stage III. We also observed a significant decreasing trend in the mean LN count (p<0.05) and blood vessel invasion (p=0.023) from younger to older age groups. Conclusions: More aggressive disease for younger age groups, earlier peak incidence age and high rate of advanced BC at the time of diagnosis among Iranian women, were the main findings of this study.

Development of Signal Control Strategy for Oversaturated Intersections Using Wayside Video Equipment (노변영상장비를 활용한 과포화 신호제어전략 개발)

  • Lee, Hyun;Kim, Won-Ho
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.12 no.4
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    • pp.11-21
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    • 2013
  • The conventional real-time signal control strategy for oversaturated situation generally requires a number of detectors at the intersection in order to identify the queue length at each approach. Also, existing strategy for the spillback has limited effect due to the temporal spillback control which only reduce the green split at the approach. In this study, a signal control system utilizing the imagery information from ITS roadside equipment is developed for operation of oversaturated intersections. The strategy calculates the saturation ratio based on the queue length extracted from ITS RSE, and designs the signal control variables according to the saturation ratio. The signal control strategy is divided into two phases: oversaturated and supersaturated. In oversaturated conditions, timing plan for main approach is optimized by the queue length. In oversaturated conditions where spillback might occur, the signal timing is designed in order to avoid the spillback. To increase field adaptability, the strategy is designed to adjust the split length, all-red-time, and clearance time, and keep the major signal control variables intact. The result of the simulation shows that in oversaturated conditions, the improvement is similar to the real-time signal control system. In case of, oversaturated conditions, however, the effect of the strategy is superior to that of a real-time system.

Effects of a Home Respiratory Management Program on Unmet Healthcare need and Healthcare resource utilizations for Patients applying Home Mechanical Ventilator with Amyotrophic Lateral Sclerosis (가정형 인공호흡기 사용 중인 재가 근위축성 측삭증후군 환자의 가정간호기반 호흡관리 프로그램이 미충족의료와 의료자원이용에 미치는 효과)

  • Hwang, Moon Sook;Park, Jin-Hee
    • Journal of Industrial Convergence
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    • v.17 no.4
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    • pp.77-86
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    • 2019
  • The purpose of this study was to identify the effect of Home Health Nursing based Respiratory Management Program (HHNbRMP) on unmet healthcare need and healthcare resource utilizations of patients applying the home mechanical ventilator in the home with amyotrophic lateral sclerosis. The subjects of this study were 40 patients placed in an experimental group(n=19) and a control group(n=21), respectively. This HHNbRMP based on Cox's interaction model was consisted of cognitive assent (education, specialized medical care, case management), internal motivation (airway clearance, thoracic and air accumulated exercise) and psychological response (meditation & active listening). The intervention was applied to experimental group during 12 weeks. As variables was measured at baseline, twelve, twenty-four weeks and healthcare unmet need, resource utilizations (admission, out patient department, emergency room) was measured at 24 weeks. The data were analyzed by t-test, ANOVA and Repeated Measures ANCOVA. This intervention was not effective the unmet healthcare need. But the admission in to the hospital among the healthcare resource utilizations variables showed a significant difference at twenty-four weeks(t=4.17, p=.049). This results suggest that applying this program tailored to patients condition, utility of medical resource would be decreased, specially admission.

Pharmacokinetic Preformulation Study of rH IL-2 (인터루킨-2의 제제설계를 위한 체내 동태학적 연구)

  • Seo, Min-Seok;Shim, Chang-Koo;Kwon, Jong-Bum;Na, Do-Sun;Lee, Sun-Bok;Hahm, Kyung-Soo;Han, Moon-Hi
    • YAKHAK HOEJI
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    • v.34 no.4
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    • pp.238-243
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    • 1990
  • Pharmacokinetic characteristics of recombinant human interleukin-2 (rH IL-2) wre studied in the rat. First, different doses of rH IL-2 ranging from 6,400 to 1,600,000 U/kg were injected intravenously and the effect of dose size on the pharmacokinetics was examined. There was no dose dependency in the pharmacokinetics of rHIL-2 in the dose range of 6,400-40,000 U/kg. But at the dose of 1,600,000 U/kg, there was a severe hemolysis throughout the experiment and the pharmacokinetic parameters such as Vdss and CLt were significantly increased compared to those obtained from lower doses. It also showed that this drug is hardly distributed to the peripheral tissues and hardly eliminated from the body, since the valume of distribution (Vdss) and total body clearance (CLt) were 45-75 ml/kg and 1-2 ml/min/kg, respectively. The Vdss is close to the actual plasma volume and the CLt is less than glomerular filtration rate (GFR). Therefore it seemed that rH IL-2 is distributed only in the plasma pool and hardly filtered in the kidney due to its very large molecular weight. Second, rH IL-2 was administered to the rat via several routes such as hepatic portal vein (PV), intraperitoneal (IP), peroral (PO) and intranasal (IN) routes. The bioavailabilities (BA) of PV, IP, PO and IN routes were 96.8, 4.9, 0 and 0.1%, respectively. The addition of some nasal absorption enhancers such as taurocholate, taurodeoxycholate, glycocholate and glycodeoxycholate did not increase the BA of intranasaly administered rH IL-2. The result is contrast to the effect of these bile salts on the nasal absorption of ${\alpha}-inteferon$. Considering it together with the pharmacokinetic parameters, very large molecular weight of rH IL-2 seemed again to be the cause to very poor membrane permeability.

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Renal Toxicity of High-dose Intravenous Immunoglobulin in Children with Kawasaki Disease and Idiopathic Thrombocytopenic Purpura (가와사끼병과 특발성 혈소판 감소성 자반증 환아에서 고용량 정주용 면역글로불린의 신독성 유무)

  • Jung Ji Ah;Kim Hye Soon;Seo Jeong Wan;Lee Seung Joo
    • Childhood Kidney Diseases
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    • v.2 no.2
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    • pp.133-137
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    • 1998
  • Purpose : To investigate renal toxicity of high-dose intravenous immunoglobulin(IVIG) in children with Kawasaki disease and idiopathic thrombocytopenic purpura. Methods : 23 children with Kawasaki disease and 7 children with idiopathic thrombocytopenic purpura who were treated with high-dose IVIG(2 g/kg) were evaluated for the change of urine output, blood urea nitrogen(BUN), serum creatinine(Scr), creatinine clearance(Ccr), tubular reabsorption of phosphorus(TRP), fractional excretion of sodium(FENa), 24hour urine ${\beta}_2$-microglobulin/creatinine(${\beta}_{2}MG/cr$) ratio and urine microalbumin/creatinine(MA/cr) ratio at post-IVIG 1 and 3 day. Results : There was no significant change of urine output, BUN, Scr, Ccr, TRP, 24hour urine ${\beta}_{2}MG/cr$ and MA/cr ratio after high-dose IVIG treatment. Transient increase of FENa at post-IVIG 1 day was the only significant change. Conclusion : There was no significant renal toxicity of high-dose IVIG in children with Kawasaki disease and idiopathic thrombocytopenic purpura who had normal renal function.

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