• Journal of the Society of Naval Architects of Korea
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• v.38 no.4
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• pp.23-29
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• 2001

An Obstacle Avoidance System(OAS) of Underwater Vehicle(UV) in diving and steering plane is investigated. The concept of Imaginary Reference Line(IRL), which acts as the seabed in the diving plane, is introduced to apply the diving plane avoidance algorithm to the steering plane algorithm. Furthermore, the distance to the obstacle and the slope information of the obstacle are used for more efficient and safer avoidance. As for the control algorithm, the sliding mode controller is adopted to consider the nonlinearity of the equations of motion and to get the robustness of the designed system. To verify the obstacle avoidance ability of the designed system, numerical simulations are carried out on the cases of some presumed three-dimensional obstacles. The effects of the sonar and the clearance factor used in avoidance algorithm are also investigated. Through these, it is found that the designed avoidance system can successfully cope with various obstacles and the detection range of sonar is proven to bea significant parameter to the performance of the avoidance.

• Archives of Pharmacal Research
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• v.19 no.5
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• pp.359-367
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• 1996

The pharmacokinetics of LB20304 was investigated following intravenous (IV) and oral administration to rats and dogs. Additionally, in vitro metabolism and serum protein binding studies were also conducted. The total body clearance, apparent volume of distribution, terminal half-life, and extent of bioavailability were 21.8 ml/min/kg, 2265 ml/kg, 93.6 min, and 30.8% for rats; and 7.95 ml/min/kg, 4144 ml/kg, 363 min, and 81.1% for dogs, respectively. LB20304 was stable in the liver microsome containing NADPH generating system and its serum protein binding was 58.5-65.8% for rats, 19.1-29.6% for dogs, and 56.9-59.6% for humans. Its tissue concentration levels in lever, stomach, small intestine, and kidney were 9.5 to 26.1 times greater than plasma level, but the concentration in testis was quite low and that in brain was negligible in rats. The 48 hr urinary recovery of the dose was 44% for IV dosing and 14% for oral dosing, shereas the 48 hr biliary recovery of the dose was 6.4% for IV dosing and 4.5% for oral dosing in rats. In summary, the pharmacokinetic properties of LB20304 were characterized by its good oral absorption, long plasma half-life, and good tissue distribution.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.12
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• pp.46-55
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• 2014

PCB design technology for high-speed transmission line has been developed continuously. Adapting to the high capacity of the communication system, switch fabric interface used for backplane is being standardized to accommodate more than 10Gbps serial interface. In this paper, various computer simulations are performed to compare the performance of each transmission line per length according to PCB material, and also to analyze the effect from via stub length and crosstalk, for the purpose of applying 11.5Gbps serial interface as a switch fabric interface in tera-bit switching system. As a result of the simulation, important design issues, such as PCB material of each board supporting 8dB improvement in transmission loss using low loss PCB, maximum available stub length on transmission line via, whether or not to apply the backdrill process to the via, and the clearance of the differential pair between transmission lines, are determined. The most efficient system architecture which could be applied 11.5Gbps serial interface in all switch fabric interfaces is defined from the simulation results.

• Environmental Mutagens and Carcinogens
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• v.22 no.1
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• pp.39-46
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• 2002

Obesity is a complex metabolic disorder with a strong genetic component. There are many candidate genes for obesity and its related phenotypes. We studied genetic variations between Korean obese and lean groups. Polymorphisms investigated were the Msp I polymorphism of the $\alpha$$_{2A}$-adrenergic receptor ($\alpha$$_{2A}$-AR) gene, the Mnl I polymorphism of the $\alpha$$_2$-adrenergic receptor ($\alpha$$_2$-AR) gene, the BstO I polymorphism of the $\beta$$_3$-adrenergic receptor ($\beta$$_3$-AR) gene, the Pml I polymorphism of the lamin A/C (LMNA) gene, the Hga I polymorphism of the clearance receptor (NPRC) gene, the Msp I polymorphism of the leptin gene, BclI polymorphism of the uncoupling protein 1 (UCPI) gene and the Hha I polymorphism of the fatty acid binding protein 2 (FABP2) gene. Among these genetic markers, Pml I polymorphism at the LMNA gene and Bcl I polymorphism at the UCP1 gene were significantly associated with obesity. However, further studies are required whether thease findings are reproduced in large population, although two polymorphisms might be useful as genetic markers in the ethiology of obesity in Korean population.ion.

• Tuberculosis and Respiratory Diseases
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• v.40 no.4
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• pp.416-423
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• 1993

Pulmonary alveolar proteinosis(PAP) is thought to be a rare disease of unknown etiology characterized by the accumulation of strong PAS-positive lipoproteinaceous material in the pulmonary alveolar spaces. The defect in the clearance and degradation of intra-alveolar phospholipoproteinaceous material in PAP likely represents dysfunction of type II pneumocytes. Although the causative treatment of PAP is not well known, yet whole lung bronchopulmonary lavage is a relatively safe and effective treatment. We experienced three cases of PAP, which were confirmed by light and electron microscopic examinations of lung tissues obtained by open lung biopsy, transbronchial lung biopsy and lung lavage, so we present 3 cases of PAP with a review of the literature.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.21 no.1
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• pp.48-53
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• 1999

Purpose: The aim of this study was to investigate the improvement of referred symptoms of TMJ internal derangement after open surgery of TMJ. Materials and Methods: The present study focused referred symptoms such as headache, neck pain, shoulder pain and evaluated the incidences and changes in their improvement at 1, 3, 6, 12 months after surgery in 118 patients who had TMJ internal derangement and received meniscoplasty(or meniscorrhaphy) and eminectomy at TMJ clinic of Yonsei University, Yongdong Severance Hospital, between 1992 and 1997. Results: One hundred eighteen patients(102 females, 16 males) with mean age of 29.6 years(range, 14 to 74) were included in this study and the mean follow-up period was 19.5 months(range, 12 to 60). The incidences of headache, neck pain, shoulder pain among the surgically treated TMJ internal derangement patients were 66.9%, 28.8%, 28.0% before surgery. Thirty-two preoperative severe(+++) headache patients were all improved their headache at 1, 3, 6 months after surgery, but slight relapse(9.4%) was found at 12 months after surgery. The clearance rate of preoperative neck and shoulder pain were 91.2% and 90.9% at 1 month after surgery and all of these groups had no pain at 12 months after surgery. Conclusions: Referred symptoms of TMJ internal derangement such as headache, neck pain, shoulder pain were dramatically improved after surgical treatment of TMJ.

• Physical Therapy Korea
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• v.9 no.4
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• pp.1-11
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• 2002

본 연구의 목적은 이중과업 방법론(dual task methology)을 사용해서 젊은 사람과 노인을 대상으로 독립된 두 사건(two separate concurrent events)을 동시에 수행하는데 요구되는 주의력에 대한 분석과 노인에서의 특징적 차이를 찾는 것이다. 본 실험은 대상자가 힘판(force plate) 위에서 장애물(10cm) 보행시에 경피자극(cutaneous stimulation)에 대하여 마이크로 스위치(micro-switch)를 사용하여 반응하면서 시행되었다. 힘판과 시간(temporal events) 그리고 반응시간(reaction time)에 관한 자료들은 1000 Hz의 주파수로 수집되었다. 반응시간은 대상자들이 서 있는 상태(baseline) 장애물 보행시(dual task)에서 수집되었다. 반응시간은 아중과업 조건에서 대상자 모두에게서 긴 것으로 나타났으며 특히 노인에서 정상 성인보다 반응시간이 긴 것으로 나타났다. 이중과업 조건 하에서 노인 대상자가 정상 성인에 비해 발가락이 장애물에 닫지 않고 통과할 수 있는 공간, 즉 토우 클리어런스( toe-clearance)와 슬관전 굴곡(knee flexion) 각도가 훨씬 큰 것으로 나타났다. 이중과업 조건하에서 모든 대상자가 족관절 배측굴곡(ankle dorsiflexion) 각도를 감소시키는 것으로 나타났다. 노인들은 젊은 대상자들보다 훨씬 더 긴(124 ms) 유각시간을 보여 주었으며 정상 장애물 보행시 유각 시간은 이중과업보다 50 ms 긴 것으로 나타났다. 이러한 보행 특성의 차이는 노인대상자들이 젊은 대상자들보다 장애물 보행시에 이중과업의 영향을 더 받았기 때문인 것으로 판단된다. 이중 과업 시행시 이러한 토우 클리어런스의 감소와 장애물 통과시에 보행 속도의 증가는 아마도 낙상의 가능성을 증가시키는 요인이 될 수 있는 것으로 보여진다. 본 연구의 결과는 다중과업(multitasks)을 필요로 하는 보행 훈련 프로그램(gait training program)의 개발과 시행에 있어서 기초적인 자료를 제공할 수 있는 것으로 보여진다.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2015.10a
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• pp.208-210
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• 2015

After the huge explosive accident in port of Tianjin, it is being strengthened on the dangerous goods regulations. This also has been make an extra impact which must meet international standards and even different parts became possible import customs regulations exporting from Korea. Since 2004, internationally in compliance with the enforced the transport of dangerous goods regulations (IMDG Code), but becomes substantial damage to the domestic industry that exports of dangerous goods is a lot of difficulties in the logistics of efficiency due to possible follows only the clearance to the needs of the Chinese Government. In Korea and secure hazardous materials management needs have emerged, but piecemeal ad hoc policy is connected economically costly and unnecessary regulations weighted long-term safe at the same time enables continuation of the development of the only domestic chemical industry to find effective hazardous materials management plan it is.

• Geomechanics and Engineering
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• v.10 no.5
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• pp.599-615
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• 2016

The present research presents experimental and finite element studies to investigate the behavior of piled raft-tunnel system in a sandy soil. In the experimental work, a small scale model was tested in a sand box with load applied vertically to the raft through a hydraulic jack. Five configurations of piles were tested in the laboratory. The effects of pile length (L), number of piles in the group and the clearance distance between pile tip and top of tunnel surface (H) on the load carrying capacity of the piled raft-tunnel system are investigated. The load sharing percent between piles and rafts are included in the load-settlement presentation. The experimental work on piled raft-tunnel system yielded that all piles in the group carry the same fraction of load. The load carrying capacity of the piled raft-tunnel model was increased with increasing (L) for variable (H) distances and decreased with increasing (H) for constant pile lengths. The total load carrying capacity of the piled raft-tunnel model decreases with decreasing number of piles in the group. The total load carrying capacity of the piles relative to the total applied load (piles share) increases with increasing (L) and the number of piles in the group. The increase in (L/H) ratio for variable (H) distance and number of piles leads to an increase in piles share. ANSYS finite element program is used to model and analyze the piled raft-tunnel system. A three dimensional analysis with elastoplastic soil model is carried out. The obtained results revealed that the finite element method and the experimental modeling are rationally agreed.

• Bulletin of the Society of Naval Architects of Korea
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• v.11 no.2
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• pp.23-40
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• 1974

Semisubmersible 해양석유시추선의 기본설계에 필요한 파랑중(波浪中)에서 운동(運動)을 계산(計算)하는 이론적방법(理論的方法)을 제시하고 "MOHOLE"과 "SEDCO 1350-F" 석유시추선들의 운동(運動)을 해석하였다. 이 규칙파에서 운동계산을 불규칙해양파(波)에 적용하는 응용해석을 보여주었다. 현재 이론적 방법으로는 6자유도(自由度)의 운동을 해양파의 어떤 방향에 대해서도 정확히 계산할 수 있으며 계산의 정확성은 수조(水槽)에서의 모형선의 운동측정치와 실선(實船)의 운동측정치와 비교하여 증명되었다. 또 현재의 방법은 종전에 개발된 방법보다 더 일반적(一般的)인 경우를 다룰 수 있으며 결과치도 더 정확하다. 극소운동특성을 갖는 해양석유시추선과 부체(浮體)해양구조물의 설계는 경비가 비싸고 시간이 많이 드는 모형실험보다는 유체역학적(流體力學的) Parameters를 신속 정확히 자주 변경 검토해야 하는 기본설계단계에서는 정확한 이론적인 전자계산기에 의한 계산방법이 절실히 필요하다. 예상(豫想)과 같은 부가질량(附加質量)과 감쇠력(減衰力)은 Resonance 운동주기에서만 운동에 영향을 준다. 해양구조물에 작용하는 파력(波力)은 Froude-Krilov force, 부가질량(附加質量) 및 감쇠력(減衰力)과 Restoring force로 구성했으며 규칙파(規則波)에서의 6자유도(自由度) 운동방정식은 본 논문에 제시된 실험측정치(値)와 실험으로 정확도가 증명된 이론치(値)의 부가질량과 감쇠력 계수(係數)를 써서 풀었다. 규칙파(規則波)에서의 계산된 운동을 Pierson Moskowitz 해양파(海洋波) 스펙트럼과 linear superposition principle에 의해 불규칙해양파(不規則海洋波)에서의 운동을 계산하는데 사용했다. 불규칙파(不規則波)에서의 운동은 운동스펙트럼과 통계적 운동치로 나타냈다. 현재의 계산방법은 실제 기본설게에 사용되어 왔으며, 다른 응용분야는 파랑중(波浪中)에서의 파면(波面)과 Deck간(間)의 Clearance, 계류선(係留線)의 동장력(動張力)계산의 기본 Data 및 기본설계의 Draft 등 Parameters를 통(通)한 Optimum Design 등(等)이다. 파(波)의 한 방향(方向)에 대(對)한 전자계산기(電子計算機)(IBM 370 또는 CDC 6400)에 의한 운동계산은 10초(秒)미만밖에 안걸린다. 또 현재의 계산방법은 해양석유시추선뿐 아니라 이와 비슷한 부체(浮體)해양구조물과 Pipe-laying선(船) 또 Supply Boat설계(設計)에도 쓰여지고 있다.