• Korean Journal of Bronchoesophagology
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• v.15 no.2
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• pp.36-41
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• 2009

Background : Controversy exists whether patients with esophageal carcinoma are best managed with classical Ivor Lewis esophagectomy(ILO) as combined thoracic and abdominal approach or transhiatal esophagectomy(THO). The THO approach is known to be superior with respect to operative time, morbidity and mortality, and length of stay, especially at poor pulmonary function patient, but may represent an inferior cancer operation due to inadequate mediastinal clearance compared with ILO. Accordingly, we estimated the THO role at esophageal cancer to compare each operative approach. Material and Method : From January 2002 to December 2007, we performed a retrospective review of all esophagectomies performed at Keimyung University Dongsan Medical Center; 36 underwent THO, and 11 underwent ILO. Result : There were all men and squamous cell carcinoma but 1 woman at ILO group, 2 women at THO group. There were no significant differences between THO and ILO with age, sex, location of tumor, mean tumor length. There were significant differences at preoperative pulmonary function test(In ILO group, average FEV1 is $2.65{\pm}0.6\;L/min$ and iIn THO group, average FEV1 is $2.07{\pm}0.7\;L/min$). The amount of blood transfusion, hospital stay, leak rates and respiratory complication, hospital mortality rate were not significantly different. Conclusion : There was no significant difference in the post-operative complication, hospital mortality rate, long-term survival of patients of both operative method. THO method had lower mobidity and mortality at poor pulmonary function patient than ILO method. Hence, THO is a valid alternative to ILO for patients with poor general condition or expected post-operative respiratory complication.

• Journal of the Ergonomics Society of Korea
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• v.31 no.3
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• pp.437-444
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• 2012

The purpose of this study was to suggest appropriate human model for ergonomic evaluation considering working postures on 3D space. Background: Traditionally extreme design rules have been widely utilized at the stage of designing products. Body size of 5th percentile and 95th percentile in stature has been generally selected for controllability and clearance evaluation, respectively. However, these rules had limitations in reflecting working posture in ergonomic evaluation. Method: In order to define working posture on 3D space, not only sagittal plane but also lateral plane was considered. Kinematic linkage body model was utilized for representation of working posture. By utilizing the anthropometric data of 2,836 South Korean male populations, the point cloud for end points of linkage models was derived. The individuals who were lacking in certain controllability were selected as human models for the evaluation. Result: In case of standing posture it was found that conventional approach is proper for all controllability evaluations. Contrary to standing posture, tall people had less controllability on control location below shoulder point in sitting posture. Conclusion: From the derived proper range on controllability, ergonomic evaluation rule was suggested according to working posture especially in standing and sitting. Application: The results of the study are expected to aid in selection of appropriate human model for ergonomic evaluation and to improve the usability of products and work space.

• Journal of the Ergonomics Society of Korea
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• v.29 no.2
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• pp.203-210
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• 2010

For the development of a better product which fits to the target user population, physical workloads such as reach and visibility are evaluated using digital human simulation in the early stage of product development; however, ergonomic workload assessment mainly relies on visual observation of reach envelopes and view cones generated in a 3D graphic environment. The present study developed a quantitative assessment method of physical workload in a digital environment and applied to the evaluation of a Korean utility helicopter (KUH) cockpit design. The proposed assessment method quantified physical workloads for the target user population by applying a 3-step process and identified design features requiring improvement based on the quantified workload evaluation. The scores of physical workloads were quantified in terms of posture, reach, visibility, and clearance, and 5-point scales were defined for the evaluation measures by referring to existing studies. The postures of digital humanoids for a given task were estimated to have the minimal score of postural workload by finding all feasible postures that satisfy task constraints such as a contact between the tip of the index finger and a target point. The proposed assessment method was applied to evaluate the KUH cockpit design in the preliminary design stage and identified design features requiring improvement. The proposed assessment method can be utilized to ergonomic evaluation of product designs using digital human simulation.

• Journal of the Society of Disaster Information
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• v.10 no.4
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• pp.598-608
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• 2014

The first operation of alarm system starts at a detector. And the largest effect is produced on the operation of detector by the fire source position and installation position. Nevertheless, the Korean standard for the installation of detector only specifies matters of fire detector installation according to area and height, without consideration of installation position and fire source position. Therefore, this study carried out a fire test in consideration of detector installation position and fire source position (5 places) in order to minimize casualties owing to the fast operation of fire detector when a fire occurred. Considering that it took the longest time for a detector close to a wall to work in the results of this test, it was possible to find that a minimum clearance to the wall was required.

• Childhood Kidney Diseases
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• v.11 no.1
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• pp.100-105
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• 2007

Cockayne syndrome is a rare autosomal recessive disorder characterized by cachectic dwafism, mental retardation, loss of facial subcutaneous adipose tissue, microcephaly and photosensitive dermatitis. It is associated with renal abnormalities characterized by hyalinization of glomeruli, atrophy of tubules and interstitial fibrosis. To our knowledge, this is the first report of a case of Cockayne syndrome with FSGS in Korea. A 7-year old boy was admitted for evaluation of hypertension and proteinuria, which were detected 2 month ago. He was followed for short stature(<3 percentile), mental retardation(IQ 55), strabismus and dental caries since 3 years ago. He also showed microcephaly, a bird-like face and relatively large hands and feet. Laboratory findings showed decreased creatinine clearance($C_{Cr}$ 76.1 mL/min/$1.73m^2$) and proteinuria(1,548 mg/day). Renal biopsy demonstrated focal segmental glomerulosclerosis of the hilar type with large hyaline deposits, moderate tubular atrophy and interstitial fibrosis. His cardinal features, mental retardation, and renal biopsy findings were consistent with Cockayne syndrome. We report here a very rare case of Cockayne syndrome with FSGS presenting with proteinuria and hypertension.

• The Journal of Korean Physical Therapy
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• v.25 no.4
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• pp.204-209
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• 2013

Purpose: Children with cerebral palsy generally have a high incidence of respiratory problem, resulted from poor coughing, airway clearance problem, respiratory muscle weakness, kyphoscoliosis and so forth. The purpose of this study is to investigate the possible factors that can be affected to forced vital capacity (FVC) in children with cerebral palsy. Methods: Total thirty six children with diplegic and hemiplegic cerebral palsy were recruited in this study. They were evaluated by general demographic data (i.e., age, gender, body mass index (BMI)) and variables related to respiratory functions (i.e., chest mobility, waist mobility, maximal phonation time, and maximum inspiratory/expiratory pressure (MIP/MEP)). The correlation between forced vital capacity and the rested variables were analyzed, and multiple regression with stepwise method was conducted to predict respiratory function, in terms of FVC as the dependent variable, and demographic and other respiratory variables as the independent variable. Results: FVC showed a significant correlation with waist mobility (r=0.59, p<0.01), maximal phonation time (r=0.48, p<0.05), MIP (r=0.73, p<0.01), and MEP (r=0.60, p<0.01). In addition, the multiple regression analysis model indicated that FVC could be predicted by the assessment of each waist mobility and MIP. Conclusion: These finding suggest that respiratory function is related to body size and respiratory muscle strength, and that BMI, waist mobility, and MIP can be predictable factors to affected respiratory function in term of FVC.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.21 no.6
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• pp.562-569
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• 2011

In this study linear and nonlinear dynamic stability characteristics of a medium-size high-speed turbocharger, whose rotor is supported by two 3-lobe journal bearings, are analyzed to evaluate and identify the effects of its bearing design variables. The rotor has the rated speed of 40,500 rpm and maximum continuous speed of 45,000 rpm. At first, utilizing the linear stability analysis method, bearing designs of yielding stable or unstable LogDecs as small as possible are searched by manipulating with machined bearing clearances and preloads. As next, utilizing the nonlinear analysis method, limit cycles of the rotor responses at the rated and maximum continuous speeds are simulated to check their acceptances. Results have shown that for the turbocharger rotor-bearing system considered, the 3-lobe journal bearing design with a smaller machined clearance and a larger preload are preferred for the stable rotor responses. More importantly, since there exists a good correlation between the linear and nonlinear stability analysis results, it is concluded that firstly the linear stability analysis method may be applied to screen quickly the ranges of bearing designs for stable or least unstable solutions and then, lastly the nonlinear stability analysis method may be deployed to check an absolute motion stability in terms of the limit cycle.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.26 no.5
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• pp.559-566
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• 2016

This study shows a development procedure and results of noise reduction for a new developed FF 8th speed automatic transmission. Based on planetary gear operating frequency analysis using PTA(planetary transmission analysis) program developed in 2012, It is expected that gear noise of the rear planetary gear set could be recognized easily in the concept design stage. Therefore, pRMC (planetary run many cases) analysis program that is developed in 2012 was applied to minimize the planetary gear noise level and noise distributions versus torque. To minimize noises coming from oil pump and final gears of a new transmission, several changes were applied, such as changing the clearance of double angular ball bearing, the oil pump rotor tooth number from 9 to 11 and the oil pump type from parachoid to megafloid and so on. Besides, stiffness values of the transmission case and the mount bracket were measured and reinforced properly. Finally, The total noise of the new FF 8th speed automatic transmission was developed successfully. Furthermore, E.O.L. testers also have been adapted to control the noise quality of automatic transmission assembly in the manufacturing factory. This paper could provide practical solutions to the automatic transmission NVH problems.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.5
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• pp.1281-1287
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• 2003

In this research 2 sample compounds are made and analyzed in terms of the in vivo and in vitro effects on the ovariectomized rats. The 2 compounds are prescribed based on pathologic patterns of osteoporosis, and added calcium citrate from tuna bone powder. SG is for menopausal women(Type I osteoporosis) and GN is for senile men(Type II osteoporosis). Through these, SG manifested Significant effects on the T4, osteocalcin level, and through the histological changes of osteoid tissues and lipocytes. On the other hand GN showed significant increase on the biochemical markers of osteocalcin, TALP, even in histological features and bone mineral density and intensity of femur it showed meaningful changes. But In the results of RT-PCR on the IL-1β, IL-6, TNF α, there weren't coherent results with in vivo test, that is they were increased in the sample compound group than control group. These increase of bone resorption was seemed that those cytokines had the osteoclasts promote their own resorptive functions after fragments of bone tissues were increased in the cavity. And this clearance of inner fragments help the bone to strengthen its own substance. Putting together above facts, the sample compounds, SG and GN, made of tuna bone powder and herbal solutions are predicted that there would be pharmacological actions improving the osteoporosis initiated from the disorders of calcic absorption and increase of bone resorption. And GN has more effective actions than SG at least in the animal model.

• Biomolecules & Therapeutics
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• v.6 no.4
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• pp.389-394
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• 1998

Cyclosporine (CsA) is a major immunosuppressive drug used widely to prevent organ allograft rejection. fits potential organotoxicity by prolonged use is known to cause both direct tissue damage and indirect pharmacokinetic interactions with other drugs. This study was performed to determine the effect of nicardipine (NCP) on the pharmacokinetic parameters of CsA in Sprague-Dawley rats. Each rat was administered with CsA in saline-treated group or in NCP-treated group which was pretreated with NCP (5 mg/kg/12 hours, i.p.) for 6 days. The plasma CsA concentration were analyzed by reversed HPLC: UV system at 0.5, 1, 2, 4, 6, and 8 hours after bolus injection of CsA (10 mg/kg). Pharmacokinetic parameters (mean$\pm$ SD, n=7) such as initial plasma concentration (C(0)), mean residence time (MRT), steady-state volume of distribution (Vdss), terminal half-life (t$\frac{1}{2}$($\beta$)) and plasma clearance (CLp) of CsA in each groups (saline-group vs NCP-group) were determined as follows: C(0) (5.66$\pm$ 1.98 vs 17.98$\pm$2.36, p<0.01); Vdss (2.68$\pm$ 1.6 vs 0.94 $\pm$ 0.25, p<0.01); CLp (0.53 $\pm$0.18 vs 0.21 $\pm$0.06, p<0.01). Therefore, Our results indicate that nicardipine significantly affects the pharmacokinetic parameters of cyclosporme, especially C(0), Vdss, and CLp in NCP-treated group. We suggest that the significant pharmacokinetic interaction between cyclosporine and nicardipine should be considered and cyclosporine level should be closely monitored and dosage reduction made as necessary in clinical situation that was coadministered with CsA and NCP.