• Title/Summary/Keyword: CK2

Search Result 475, Processing Time 0.026 seconds

The Comparison of Clinical Outcomes of Off-pump versus On-pump Coronary Artery Bypass Grafting in Diabetes Patients (당뇨 환자에서 시행한 Off-pump CABG와 On-pump CABG의 비교 연구)

  • 송석원;임상현;홍순창;조수진;장병철;강면식;신혜란;유경종
    • Journal of Chest Surgery
    • /
    • v.37 no.7
    • /
    • pp.553-558
    • /
    • 2004
  • Avoiding cardiopulmonary bypass (CPB) in coronary artery bypass grafting (CAB G) has been known to reduce early mortality and morbidity. Diabetes Mellitus is a significant risk factor for adverse early and late outcomes after CABG. We compared the clinical results of off-pump CABG versus on-pump CABG in diabetes patients. Material and Method: 682 patients (424 off-pump CABG and 258 on-pump CABG) underwent isolated coronary artery bypass grafting between January 2001 and June 2003. Data were collected 242 patient who had diabetes. Among them, 154 patients underwent off-pump CABG and 90 patients underwent on-pump CABG. We analyzed the preoperative risk factors and postoperative results between 2 groups. Result: Two groups did not show statistical differences in age, sex, coronary and operative risk factors. Operative time was significantly shorter in off-pump CABG, however, number of grafts was fewer in off-pump CABG. Postoperative inotropic usage was lower in off-pump CABG. Postoperative CK-MB level was lower in off-pump CABG, and ICU stay and ventilation time was significantly shorter in off-pump CABG. However, there was no statistical difference between 2 groups in operative mortality, reoperation rate, perioperative myocardial infarction, wound infection, renal failure, neurological complications and hospital stay. Conclusion: Off-pump CABG group showed less myocardial damage and early recovery. We concluded that off-pump CABG is the more reasonable technique in diabetes patients although two techniques showed good results. The long-term follow up and prospective study may be warranted.

A Study on Field Application of a Deformable Rod Sensor to Large Diameter Drilled Shafts (대구경 현장타설말뚝에 대한 변형봉 센서의 현장적용성에 관한 연구)

  • 정성기;김상일;정성교;최용규;이민희
    • Journal of the Korean Geotechnical Society
    • /
    • v.19 no.6
    • /
    • pp.15-22
    • /
    • 2003
  • In the conventional load transfer analysis for a steel pipe drilled shaft, it was assumed that the concrete's strain is the same as the measured steel's strain and the elastic modulus of the steel and the concrete calculated by the formular as prescribed by specification is used in the calculation of pile axial load. But, the pile axial load calculation by conventional method differed to some extent from the actual pile load. So, the behavior of a steel pipe drilled shaft could not be analyzed exactly. Thus, the necessity to measure the strain for each pile component was proposed. In this study, a new approach for load transfer measurement of large diameter drilled shafts was suggested ; the strain of each pile component(i. e., steel and concrete) was measured by DRS(Deformable Rod Sensor), the elastic modulus was determined by the uniaxial compression test for concrete specimens made at test site and a value of elastic modulus was evaluated as average tangential modulus corresponding to the stress level of the (0.2-0.6)$f_{ck}$. Field application was confirmed by the results of load transfer measurement tests for 3 drilled shafts. The errors for calculated pile head load were -11 ∼16% and 3.4% separately.

A Potent Tissue Destructive Activity of Secreted Proteins of Aeromonas hydrophila (조직 괴사 활성을 지닌 Aeromonas hydrophila 의 분비 단백질에 관한 연구)

  • Kim, Kyu Lee;Choe, Yunjeong;Kang, Ho Young
    • Journal of Life Science
    • /
    • v.25 no.2
    • /
    • pp.214-222
    • /
    • 2015
  • Aeromonas hydrophila is the most common water fish pathogen and cause diseases such as hemorrhagic septicemia, dropsy, ulceration and asymptomatic septicemia. A. hydrophila secretes many extracellular products (ECPs) which contribute to effective infection, wide distribution and great adaptability to environmental changes. Crude ECPs of A. hydrophila CK257, a strain used in this study, exhibits a toxic activity to the animals including mouse, rabbit and fish. Toxic symptoms were indicated by tissue damage and skin injuries in animal. When ECPs were subcutaneously injected to animals, skin damages were observed, appearing like necrosis. Preliminary research demonstrated that the active factors are protein component. The crude ECPs were collected after ammonium sulfate precipitation of cell-free culture supernatant. ECPs were fractionated with the use gel filtration chromatography. Five ECP fractions were obtained, of which one fraction was found to be toxic to goldfish. MALDI-TOF analyses provided two interesting proteases called M35 and M28. Both M35 and M28 are known as metalloprotease. Accordingly, proteins in an active fraction exhibited caseinolytic activity. These proteins were difference of caseinolytic activity under different metallic ions. Also active fraction has elastolytic activity. These results suggested that peptidase M28 and M35 may be a candidate factor for tissue necrosis activity about infection with A. hydrophila.

Experimental Curvature Analysis of Reinforced Concrete Piers with Lap-Spliced Longitudinal Steels subjected to Seismic Loading (지진하중을 받는 주철근 겹침이음된 철근콘크리트 교각의 곡률분석)

  • Chung, Young-Soo;Park, Chang-Kyu;Song, Hee-Won
    • Journal of the Earthquake Engineering Society of Korea
    • /
    • v.10 no.1 s.47
    • /
    • pp.41-49
    • /
    • 2006
  • Through the 1982 Urahawa-ohi and the 1995 Kobe earthquakes, a number of bridge columns were observed to develop a flexural-shear failure due to the bond slip as a consequence of premature termination of the column longitudinal reinforcement. Because the seismic behavior of RC bridge piers is largely dependent on the performance of the plastic hinge legion of RC bridge piers, it is desirable that the seismic capacity of RC bridge pier is to evaluate as a curvature ductility. The provision for the lap splice of longitudinal steel was not specified in KHBDS(Korea Highway Bridge Design Specification) before the implementation of 1992 seismic design code, but the lap splice of not more than 50%, longitudinal reinforcement was newly allowed in the 2005 version of the KHBDS. The objective of this research is to investigate the distribution and ductility of the curvature of RC bridge column with the lap splice of longitudinal reinforcement in the plastic hinge legion. Six (6) specimens were made in 600 mm diameter with an aspect ratio of 2.5 or 3.5. These piers were cyclically subjected to the quasi-static loads with the uniform axial load of $P=0.1f_{ck}A_g$. According to the slip failure of longitudinal steels of the lap spliced specimen by cyclic loads, the curvatures of the lower and upper parts of the lap spliced region were bigger and smaller than the corresponding paris of the specimen without a lap splice, respectively. Therefore, the damage of the lap spliced test column was concentrated almost on the lower part of the lap spliced region, that appeared io be failed in flexure.

Comparison of Body Weight and Egg Production Ability across Nine Combinations of Korean Indigenous Chicken Breeds (토종닭 종계 9개 조합의 체중 및 산란능력 비교 연구)

  • Kim, Kigon;Park, Byoungho;Jeon, Iksoo;Choo, Hyojun;Cha, Jaebeom
    • Korean Journal of Poultry Science
    • /
    • v.48 no.4
    • /
    • pp.161-168
    • /
    • 2021
  • The present study investigated production traits, including body weight, egg production, egg weight, and egg quality in Korean indigenous parent stocks. Parent stocks produced from a nine-combination association from five pure line strains (C, D, F, K, and Y) were used. The body weight analyses results showed that the CY combination had the highest body weight (1,604.9 g) and the DK combination had the lowest (1,424.4 g). The average age at first egg of the nine combinations was 118.6 days; however, that of the YD combination was 111.6 days, making it the fastest growing combination, whereas the DK combination was the slowest, at 126 days. Hen-day egg production was 74% or more for the CF, CK, and DK combinations. The DK combination hens showed excellent persistence in egg laying. Hen-housed egg production exhibited results similar to those of hen-day egg production. Egg weight was significantly higher in the DK combination than in the other combinations and was observed to increase from 20 (43.9 g) to 40 (58.1 g) weeks. The egg quality analyses results showed that the combinations based on the F and K strains had a bright eggshell color, with relatively high egg weights. Eggshell strength and thickness were the highest in the DK combination (3.8 kg/cm2, 0.38 mm). In summary, the CF and DK combinations showed excellent egg production ability and egg quality, while the YC, YD, and YK combinations with the Y strain as the paternal strain exhibited poor performance.

Seismic Performance of RC Circular Colunm-Bent Piers under Bidirectional Repeated Loadings according to Main Loading Direction (2축 반복하중을 받는 2주형 RC 원형교각의 주하중방향에 따른 내진성능평가)

  • Park, Chang-Kyu;Lee, Beom-Gi;Yun, Sang-Cheol;Chung, Young-Soo
    • Proceedings of the Earthquake Engineering Society of Korea Conference
    • /
    • 2005.03a
    • /
    • pp.284-291
    • /
    • 2005
  • A RC column-bent pier represents one of the most popular piers used in highway bridges. Seismic performance of reinforced concrete (RC) column-bent piers under bidirectional seismic loadings was experimentally investigated. Six column bent-piers were constructed with two circular supporting columns which were made in 400mm diameter and 2,000mm height. Test parameters are different transverse reinforcement and loading pattern. These piers were tested under lateral load reversals with the axial load of $0.1f_{ck}A_g$. Three specimens were subjected to bidirectional lateral load cycles which consisted of two main longitudinal loads and two sub transverse loads in one load cycle. Other three specimens were loaded in the opposite way. Test results indicated that lateral strength and ductility of the latter three specimens were generally bigger than those of the former three specimens. Plastic hinges were formed with the spall of cover concrete and the fracture of the longitudinal reinforcing steels in the bottom plastic hinge of two supporting columns for the former three specimens. Similar behavior was observed in the top and bottom parts of two supporting columns for the latter three specimens.

  • PDF

Stimulatory Effects of Ginsenoside-Rg1 on p56lck Kinase and Cell Proliferation in Jurkat T Cells (Jurkat T 세포에서 Ginsenoside-Rg1이 p561ck Kinase 활성과 세포증식에 미치는 영향)

  • Hong, Hee-Youn;Na, Do-Seong;Kwon, Tae-Ik;Choi, Jung-Kap;Yoo, Gyurng-Soo
    • Journal of Ginseng Research
    • /
    • v.19 no.2
    • /
    • pp.117-121
    • /
    • 1995
  • We studied the effects of ginsenoside-$Rg_1$ (G-$Rg_1$) extracted from Panax ginseng C.A. Meyer on $p56^{kk}$ kinase and cell proliferation in Jurkat T cells. $p56^{kk}$ was maximally activated within 5 min after the treatment of 16.7 $\mu\textrm{g}$/ml of G-$Rg_1$ increasing the activity by 1.2-2 times relative to untreated control, thereafter its activity was gradually decreased to the level of untreated control. The action of EGTA on the kinase was altered by the addition of G-$Rg_1$, accompanying the band shift of $p56^{kk}$ to $p60^{kk}$. In addition, G-$Rg_1$promoted cell proliferation in a concentration-dependent manner. These results suggest that G-$Rg_1$ may be involved in T cell receptor-CD3 (TCR) signaling via the activation of $p56^{kk}$ and the chance of cellular calcium concentration.

  • PDF

Inhibitory Effects of Cabbage Juice and Cabbage-Mixed Juice on the Growth of AGS Human Gastric Cancer Cells and on HCl-Ethanol Induced Gastritis in Rats (양배추즙 및 양배추 혼합즙의 인체위암세포(AGS) 성장 억제효과와 HCl-Ethanol로 유발된 흰쥐의 항위염 효과)

  • Hong, Ye-Ji;Kim, Seong Yoon;Han, Jaegab;Lim, Yaung-Iee;Park, Kun-Young
    • Journal of the Korean Society of Food Science and Nutrition
    • /
    • v.42 no.5
    • /
    • pp.682-689
    • /
    • 2013
  • This study determined the effects of cabbage juice and cabbage-mixed juices on the growth of AGS human gastric cancer cells and their anti-gastritic effects on HCl-ethanol induced gastritis in SD rats. Cabbage juice showed the highest growth inhibition on AGS gastric cancer cells in vitro (42%), compared with chlorella (20%) and kale juice (21%). However, cabbage-chlorella and cabbage-kale juice mixtures (at a 7:3 ratio) showed synergistic effects (57% and 65% inhibitory effects, respectively) on the gastric cancer cells. Inflammatory genes (iNOS, COX-2, TNF-${\alpha}$ and IL-$1{\beta}$) were significantly down-regulated in the mixed juices. Tests of DPPH radical scavenging activity and acid-neutralizing capacity with the mixed juices also showed this trend, as cabbage-chlorella and cabbage-kale mixed juices showed synergistic effects compared to cabbage juice alone. The inhibition rate of acute gastritis induced by HCl-ethanol in rats was 46% with high amounts of cabbage (CH; 800 mg/kg), 71% with high amounts of cabbage and chlorella (CChH; 800 mg/kg), 74% with high amounts of cabbage and kale (CKH; 800 mg/kg), and 75% with cimetidine (positive control) compared with the control. In addition, rates with CChH and CKH showed decreasing gastric secretions with increasing pH. These results show that cabbage juice and cabbage-mixed juices, especially with chlorella or kale, exhibit remarkable anti-gastritic effects and can be administered for a long period for the prevention and treatment of gastric cancer and gastritis.

Cutting Property Analysis of Paprika for Development of Paprika Auto-Harvester (파프리카 자동수확기 개발을 위한 파프리카의 절단 특성 측정)

  • Lee, Bong Ki;Hwa, Ji Ho;Lee, Dae Weon
    • Proceedings of the Korean Society for Agricultural Machinery Conference
    • /
    • 2017.04a
    • /
    • pp.55-55
    • /
    • 2017
  • 본 연구는 파프리카를 자동 수확하기 위한 시스템 개발의 일환으로 수확작업기의 절단장치를 설계하고자 파프리카 과병의 절단특성을 분석하고자 하였다. 파프리카 과병의 절단특성을 분석하기 위하여 사용한 파프리카는 경기도 평택시에서 재배된 파프리카를 사용하였다. 적색 품종인 Nagano RZ와 황색 품종인 Helsinki, 주황색 품종인 Boogie를 사용하였다. 파프리카 과병의 절단 특성을 분석하기 위하여 상기 세 가지 품종의 파프리카 30개씩 총 90개의 파프리카를 사용하여 과병의 중앙 지점을 절단하였다. 절단 특성을 측정하기 위하여 push-pull gauge인 digitect dtg-20을 사용하였으며, 파프리카의 과병의 절단 특성을 측정하기 위하여 일반 농가에서 사용하는 접도 OLFA CK2의 접도의 칼날을 digitect dtg-20에 장착하여 측정하였다. 파프리카 과병의 절단 특성의 시험 항목은 절단강도를 측정하였다. 파프리카의 과병의 절단 특성 측정은 수확작업기의 파프리카 과병의 절단을 위한 절단장치의 설계를 위하여 진행하였다. 파프리카 과병의 절단 특성은 파프리카의 훼손을 최소화한 수확작업을 위한 중요한 요소이다. 파프리카의 과병의 중앙을 절단하여 절단강도와 절단력을 측정하였다. 그 결과 파프리카 과병의 절단강도는 $4.18{\pm}1.18kgf$로 나타났으며, 최대값은 6.91kgf, 최소값은 2.26kgf로 나타났다. 파프리카 과병은 측정된 절단강도의 최대값인 6.91kgf보다 큰 힘을 이용하여 절단하여야 하므로 그에 맞게 수확작업기의 절단장치의 모터를 선정하고 설계가 이루어져야 한다고 판단한다.

  • PDF

The Impact of State Financial Support on Active-Collaborative Learning Activities and Faculty-Student Interaction

  • Choi, Eun-Mee;Park, Young-Sool;Kwon, Lee-Seung
    • The Journal of Industrial Distribution & Business
    • /
    • v.10 no.2
    • /
    • pp.25-37
    • /
    • 2019
  • Purpose - The goal of this study is to analyze the differences in education performances between students of the government's financial support program and those who do not receive support at a local university in Korea. Research design, data, and methodology - The questionnaire used was NASEL. NASEL is considered a highly suitable survey tool for professors, courses, and performances in Korean universities. The 290 students who participated and 44 students do not participate in the financial support program were surveyed for 10 days. The characteristics of students were investigated by frequency analysis and technical statistics. The analysis of student collective characteristics used independent t and f-tests,and one-way ANOVA with IBM SPSS Statistics 22.0 for statistical purposes. Results - The p-value of the group receiving financial support and the group without financial support in active-collaborative learning is 0.167. The p-value of the economically supported group and the non-supported group of the faculty-student interaction is 0.281. The confidence coefficient of the active-collaborative learning questionnaire is 0.861. The reliability coefficient of the questionnaire for the faculty-student interaction questionnaire is 0.871. Conclusions - There are no clear differences in active-collaborative learning and faculty-student interaction between participating and non-participating students in the economic program.