• Title/Summary/Keyword: CK2

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Effects of Chaenomelis fructus on the Muscle Atrophy Induced by Hindlimb Suspinsion in Rats (목과(木瓜)가 흰쥐의 후지체공(後肢滯空)에 의한 근강축(筋萎縮)에 미치는 영향(影響))

  • Kim, Na-Ri;Kim, Yeong-Gyun;Gwon, Jeong-Nam
    • The Journal of Internal Korean Medicine
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    • v.17 no.1
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    • pp.66-80
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    • 1996
  • This experimental Study was designed to investigate the effect of Chaenomelis Fructus on the muscle atrophy induced by hindlimb suspension in rats. The result are follows; 1. Chaenomelis Fructus significantl inhibited the increase of the activity of CK in serum. 2. Chaenomelis Fructus significantly inhibited the increase of the quantity of creatine in serum. 3. Chaenomelis Fructus significantl inhibited the increase of the activity of aldolase in serum. 4. Chaenomelis Fructus significantly inhibited the increase of the activity of LDH in serum. 5. Chaenomelis Fructus significantl inhibited the increase of the activity of AST in serum. 6. Chaenomelis Fructus inhibited the increase of the activity of ALT in serum. Based on the these results, it is concluded that the clinical application of Fructus chaenomelis can help cure muscle atrophy.

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Preparation of Traditional Malt-Sikhye 1. Preparation by Malt and Amyolytic Enzymes (전통식혜제조 - 제 1보 엿기름과 효소를 이용한 제조)

  • 안용근
    • The Korean Journal of Food And Nutrition
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    • v.12 no.2
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    • pp.164-169
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    • 1999
  • To develope the scientific preparation method of Dorean traditional rice drink 'Sikhye', effect of malt and commercial amylolytic enzymes in preparation of malt-Sikhye were studied. amylase activity of malt used in this study was 9,725unit/g. In malt-Sikhye preparation effective saccharifying conditions were 4% of malt 20% of rice at 6$0^{\circ}C$ for 5hour. Commercial amylolytic enzymes such as $\beta$-amylase(Bio-zyme ML Himaltosin GL) $\alpha$-amylase(Bokhabhyoso 5000, Teramyl and Fungamyl) and pulluanase(en-zyme CK-20) were not effective in saccharification for Sikhye preperation.

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Security Analysis of Secure Password Authentication for Keystroke Dynamics (Keystroke Dynamics를 위한 안전한 패스워드 인증기법의 보안 분석)

  • Song Hyun-Soo;Kwon Tae-Kyoung
    • Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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    • 2006.06a
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    • pp.202-206
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    • 2006
  • 오늘날 패스워드 인증과 키 분배는 컴퓨터 환경에서 중요하다. 패스워드 기반의 시스템은 패스워드를 사용자가 기억하기 쉽다는 장점 때문에 널리 사용 되고 있다. 하지만, 패스워드는 작은 공간에서 선택되어지기 때문에 패스워드 추측 공격을 포함한 다양한 공격에 취약점을 나타낸다. 본 논문에서는 최근에 제안된 새로운 패스워드 인증 기법을 분석하고, 서버 위장 공격, 서버 속임 공격과 패스워드 추측 공격에 취약하다는 것을 보인다. 또한, 패스워드 기반의 기법을 설계할 때는 주의해야 한다는 점에 대해 논하고, IEEE 1363.2와 같은 표준을 사용해 CK 프로토콜을 강하게 하는 법에 대해 간단히 보인다.

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Performance of High-Strength Concrete T-Shaped Structural Wall (고강도 콘크리트를 사용한 T형 벽체의 구조성능)

  • 강병국;하상수;이용택;이리형;천영수;윤영호;양지수
    • Proceedings of the Korea Concrete Institute Conference
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    • 2000.10a
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    • pp.727-732
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    • 2000
  • Four 1/2-scale wall specimens with flange are tested. The purpose of this study is to investigate experimentally structural behavior of flanged walls in wall slab system apartment buildings considering effective width of flange wall. Main variables are the length of web wall and concrete strength. Cyclic lateral loads are applied at the top of the walls. A constant axial load of approximately $0.1f_{ck}\cdotA_g$ is maintained during the testing. Test result shows that the capacity of the wall was governed by aspect ratios rather than concrete strengths and that initial stiffness and strength of specimens is increased with increasing the stiffness of web wall.

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Nonlinear Analysis of Concrete Filled Steel Tubular Column under Concentric Axial Load (중심축력하의 콘크리트 충전 각형강관 기둥의 비선형 해석)

  • 김선웅;홍성걸
    • Proceedings of the Korea Concrete Institute Conference
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    • 2003.11a
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    • pp.613-616
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    • 2003
  • Steel-concrete composite columns are used extensively in modern buildings. Extensive research on composite columns in which structural steel are in concrete have been carried out. In-filled composite columns, however have received limited attention compared to encased columns. In this paper, interrelationship of parameters is examined into analyzing and comparing with data through ABAQUS program and experiment on concrete filled tubular column under axial load and propriety of model is checked out by FEM analysis. The main variations of this paper are width-thickness ratio of the section(B/t =33.3, 38.9, 44.4), concrete strength($f_{ck}$=240, 360kgf/$\textrm{cm}^2$), and width-length ratio($L_o$/B=8.0, 10.0, 12.0, 15.0, 20.0). The ultimate value obtained through analysis is compared with test value and calculated by design code of other countries and previous studies.

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Seismic Ductility Assessment of RC Bridge Piers With Minor Earthquake Damage By the Quasi Static Test (유사정적실험에 의한 지진이력 철근콘크리트 교각의 내진 연성도 평가)

  • 이은희;정영수;박창규;김영섭
    • Proceedings of the Korea Concrete Institute Conference
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    • 2003.05a
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    • pp.505-511
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    • 2003
  • Experimental investigation was conducted into the flexure/shear-critical behavior of earthquake-damaged reinforced concrete columns with lap splicing of longitudinal reinforcement in the plastic hinge region. Six test specimens in the aspect ratio of 2,5 were made with test parameters: confinement ratios, lap splices, and retrofitting FRP materials. They were damaged under series of artificial earthquakes of which magnitude could be compatible in Korean peninsula. Directly after the pseudo-dynamic test, damaged columns were retested under inelastic reversal cyclic loading simultaneously under a constant axial load, P=$0.1f_{ck}A_g. Residual seismic performance of damaged columns was evaluated and compared to that of the corresponding original columns. Test results show that RC bridge piers with lap-spliced longitudinal steels in the plastic hinge region appeared to fail at low ductility. This was due to the debonding of the lap splice, which resulted from insufficient development of the longitudinal steels. The specimens externally wrapped with composite FRP straps in the potential plastic hinge region indicated significant improvement both in flexural strength and displacement ductility, and strain energy ductility.

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Development of E. coli Expression System to Overproduce a Harmful Protein, Carboxypeptidase Taq.

  • Lee, Sang-Hyeon
    • Journal of Life Science
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    • v.11 no.2
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    • pp.108-110
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    • 2001
  • The E. coli expression system to overproduce a harmful protein, carboxypeptidase Taq was developed. Since expression plasmid pCK305N containing the colicin promoter already has the initiation codon on the restriction site, the initiation codon of the CPase Taq gene was removed. Expression plasmid pCP4-col includes the entire CPase Taq gene, which is directed by the colicin promoter. E. coli cells harboring pCP-col produced a high amount of the enzyme when they were cultured in the present of mitomycin C (0.4 ${\mu}g$/ml). An amount of purified enzyme produced by pCP4-col directed by the colicin promoter was 10.5 mg. This result indicated that the novel E. coli expression system controlled by the colicin promoter could produce almost twice amounts of CPase Taq than the conventional system controlled by the tart promoter.

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Behavior of Steel Beam-High Strength Concrete Column Joint Subjected to Cyclic Loadings (철골보-고강도 콘크리트 기둥 접합부의 거동에 관한 연구)

  • Shin, Sung-Woo;Lee, Kwang-Soo;Seo, Seon-Min
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.4 no.3
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    • pp.205-210
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    • 2000
  • The objective of this study is to investigate the structural behavior of steel beam-high strength concrete column joints subjected to reversed cyclic loadings. The variables of the experimental study is amount of steel plates at the beam-to-column joint panel zone. Three specimens were prepared and tested under constant uniaxial load($0.2f_{ck}A_g$) to reinforced high strength concrete column, and the reversed cyclic loads were applied to end of steel beams, The failure modes, hysteresis loop, stiffness degradations and energy dissipation capacities were analyzed and compared for test variables.

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An Experimental Evaluation of Seismic Performancef for Damaged Reinforced Concrete Bridge Piers. (손상된 철근콘크리트 교각의 내진성능평가를 위한 실험연구)

  • 박창규;이은희;이대형;정영수
    • Proceedings of the Earthquake Engineering Society of Korea Conference
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    • 2003.03a
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    • pp.385-392
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    • 2003
  • Experimental investigation was conducted into the flexure/shear-critical behavior of earthquake-damaged reinforced concrete columns with lap splicing of longitudinal reinforcement in the plastic hinge region. Six test specimens in the aspect ratio of 2.5 were made with test parameters: confinement ratios, lap splices, and retrofitting FRP materials. They were damaged under series of artificial earthquakes that could be compatible in Korean peninsula. Directly after the pseudo-dynamic test, damaged columns were retested under inelastic reversal cyclic loading simultaneously under a constant axial load, P = 0.1 $f_{ck}$ $A_{g}$. Residual seismic performance of damaged columns was evaluated and compared to that of the corresponding original columns. Test results show that RC bridge piers with lap-spliced longitudinal steels in the plastic hinge region appeared to fail at low ductility. This was due to the debonding of the lap splice, which resulted from insufficient development of the longitudinal steels. The specimens externally wrapped with composite FRP straps in the potential plastic hinge region indicated significant improvement both in flexural strength and displacement ductility.y.

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Nucleotide and Deduced Amino Acid Sequences of Rat Myosin Binding Protein H (MyBP-H)

  • Jung, Jae-Hoon;Oh, Ji-Hyun;Lee, Kyung-Lim
    • Archives of Pharmacal Research
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    • v.21 no.6
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    • pp.712-717
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    • 1998
  • The complete nucleotide sequence of the cDNA clone encoding rat skeletal muscle myosin- binding protein H (MyBP-H) was determined and amino acid sequence was deduced from the nucleotide sequence (GenBank accession number AF077338). The full-length cDNA of 1782 base pairs(bp) contains a single open reading frame of 1454 bp encoding a rat MyBP-H protein of the predicted molecular mass 52.7kDa and includes the common consensus 1CA__TG' protein binding motif. The cDNA sequence of rat MyBP-H show 92%, 84% and 41% homology with those of mouse, human and chicken, respectively. The protein contains tandem internal motifs array (-FN III-Ig C2-FN III- Ig C2-) in the C-terminal region which resembles to the immunoglobulin superfamily C2 and fibronectin type III motifs. The amino acid sequence of the C-terminal Ig C2 was highly conserved among MyBPs family and other thick filament binding proteins, suggesting that the C-terminal Ig C2 might play an important role in its function. All proteins belonging to MyBP-H member contains `RKPS` sequence which is assumed to be cAMP- and cGMP-dependent protein kinase A phosphorylation site. Computer analysis of the primary sequence of rat MyBP-H predicted 11 protein kinase C (PKC)phosphorylation site, 7 casein kinase II (CK2) phosphorylation site and 4N-myristoylation site.

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