• Journal of Korea Multimedia Society
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• v.21 no.7
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• pp.779-786
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• 2018

In this paper, we are applied a nerve network to allow for the reflection of data learning methods in their overall forms by using cluster data rather than data learning by the stages and then selected a nerve network model and analyzed its variables through learning by the cluster. The CkLR algorithm was proposed to analyze the reaction variables of clustering outcomes through an approach to the initialization of K-means clustering and build a model to assess the prediction rate of clustering and the accuracy rate of prediction in case of new data inputs. The performance evaluation results show that the accuracy rate of test data by the class was over 92%, which was the mean accuracy rate of the entire test data, thus confirming the advantages of a specialized structure found in the proposed learning nerve network by the class.

• Journal of the Korea Concrete Institute
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• v.28 no.3
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• pp.365-373
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• 2016

Ultra-High-Performance Steel Fiber-Reinforced Concrete (SUPER Concrete) exhibits improved compressive and tensile strengths far superior to those of conventional concrete. These characteristics can significantly reduce the cross sectional area of the member and the anchorage strength of a headed bar is expected to be improved. In this study, the anchorage strengths of headed bars with $4d_b$ or $6d_b$ embedment length were evaluated by simulated exterior beam-column joint tests where the headed bars were used as beam bars and the joints were cast of 120 or 180 MPa SUPER Concrete. In all specimens, the actual yield strengths of the headed bars over 600 MPa were developed. Some headed bars were fractured due to the high anchorage capacity in SUPER Concrete. Therefore, the headed bar with only $4d_b$ embedment length in 120 MPa SUPER Concrete can develop a yield strength of 600 MPa which is the highest design yield strength permitted by the KCI design code. The previous model derived from tests with normal concrete and the current design code underestimate the anchorage capacity of the headed bar anchored in SUPER Concrete. Because the previous model and the current design code do not consider the effects of the high tensile strength of SUPER Concrete. From a regression analysis assuming that the anchorage strength is proportional to $(f_{ck})^{\alpha}$, the model for predicting anchorage strength of headed bars in SUPER Concrete is developed. The average and coefficient of variation of the test-to-prediction values are 1.01 and 5%, respectively.

• Journal of Chest Surgery
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• v.22 no.4
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• pp.580-588
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• 1989

The potential for enhancing myocardial protection by adding high-energy phosphate to cardioplegic solutions [St. Thomas Hospital solution] was investigated in a rat heart model of cardiopulmonary bypass and ischemic arrest. Creatine phosphate was evaluated as an additive to the St. Thomas Hospital cardioplegic solution. Creatine phosphate 10.0 mmol/L as the optimal concentration which improved recovery of aortic flow and cardiac output after a 30 minute period of normothermic [37oC] ischemic arrest. In comparing mechanical function in both groups the mean postischemic recoveries of aortic flow, cardiac output, stroke volume and stroke work [expressed as a percentage of its preischemic control] were significantly greater in STH-CP group than in CP- free control group. In addition to improving function and decreasing CK release, CP reduced reperfusion arrhythmias significantly decreasing the time between cross-clamp removal and return to regular rhythm from 81.8 * 13.9 [sec] in CP-free group to 35.9 * 6.8 [sec] in CP group [P< 0.05] so, exogenous CP exerts potent protective and antiarrhythmic effects when added to the St. Thomas Hospital cardioplegic solution. However, the mechanism of action remains to be elucidated.

• Proceedings of the Korea Concrete Institute Conference
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• 2003.11a
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• pp.613-616
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• 2003

Steel-concrete composite columns are used extensively in modern buildings. Extensive research on composite columns in which structural steel are in concrete have been carried out. In-filled composite columns, however have received limited attention compared to encased columns. In this paper, interrelationship of parameters is examined into analyzing and comparing with data through ABAQUS program and experiment on concrete filled tubular column under axial load and propriety of model is checked out by FEM analysis. The main variations of this paper are width-thickness ratio of the section(B/t =33.3, 38.9, 44.4), concrete strength($f_{ck}$=240, 360kgf/$\textrm{cm}^2$), and width-length ratio($L_o$/B=8.0, 10.0, 12.0, 15.0, 20.0). The ultimate value obtained through analysis is compared with test value and calculated by design code of other countries and previous studies.

• Journal of Korean Society of Transportation
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• v.25 no.1 s.94
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• pp.81-91
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• 2007

Incheon International Airport (IIAC) has been named "best airport worldwide" according to the AETRA Passenger survey Program that was jointly administered by Airports Council International (ACI) and the International Air Transport Association (IATA) in 2005. This paper identifies eight dimensions underlying the overall service qualify in passenger terminals. These eight elements were found from literature reviews through relevant documents. The research explains the linkage between the overall satisfaction with IIAC and five services that influence that satisfaction. The five services are the following: service quality of passenger terminals, commercial facility services, easy access by transportation, service quality of the airlines, and contributions to the community by IIAC. The data envelopment analysis (DEA) designed by Cook and Kress (CK Model) was used to maximize the efficiency of commercial facility services, easy access by transportation, service qualify of the airlines, and contributions to the community by IIAC because the model best provided practical plans for a more competitive airport. This paper has three significant results. First, it includes research of passenger terminal-oriented service quality. Second, the author researches service qualify focusing on a three-cornered relation among passengers, airline employees, and IIAC. Third, the paper contains research of service quality focusing on IIAC's employees.

• Journal of Ginseng Research
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• v.47 no.1
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• pp.106-116
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• 2023

Background: Pirarubicin (THP) is an anthracycline antibiotic used to treat various malignancies in humans. The clinical usefulness of THP is unfortunately limited by its dose-related cardiotoxicity. Ginsenoside F1 (GF1) is a metabolite formed when the ginsenosides Re and Rg1 are hydrolyzed. However, the protective effects and underlying mechanisms of GF1 on THP-induced cardiotoxicity remain unclear. Methods: We investigated the anti-apoptotic and anti-oxidative stress effects of GF1 on an in vitro model, using H9c2 cells stimulated by THP, plus trigonelline or AKT inhibitor imidazoquinoxaline (IMQ), as well as an in vivo model using THP-induced cardiotoxicity in rats. Using an enzyme-linked immunosorbent test, the levels of malondialdehyde (MDA), brain natriuretic peptide (BNP), creatine kinase (CK-MB), cardiac troponin (c-TnT), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and glutathione (GSH) were determined. Nuclear factor (erythroid-derived2)-like 2 (Nrf2) and the expression of Nrf2 target genes, including heme oxygenase-1 (HO-1), glutathione-S-transferase (Gst), glutamate-cysteine ligase modifier subunit (GCLM), and expression levels of AKT/Bcl-2 signaling pathway proteins were detected using Western blot analysis. Results: THP-induced myocardial histopathological damage, electrocardiogram (ECG) abnormalities, and cardiac dysfunction were reduced in vivo by GF1. GF1 also decreased MDA, BNP, CK-MB, c-TnT, and LDH levels in the serum, while raising SOD and GSH levels. GF1 boosted Nrf2 nuclear translocation and Nrf2 target gene expression, including HO-1, Gst, and GCLM. Furthermore, GF1 regulated apoptosis by activating AKT/Bcl-2 signaling pathways. Employing Nrf2 inhibitor trigonelline and AKT inhibitor IMQ revealed that GF1 lacked antioxidant and anti-apoptotic effects. Conclusion: In conclusion, GF1 was found to alleviate THP-induced cardiotoxicity via modulating Nrf2 and AKT/Bcl-2 signaling pathways, ultimately alleviating myocardial oxidative stress and apoptosis.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.17 no.1
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• pp.79-87
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• 2022

Recently, as the awareness of the necessity of entrepreneurship education has spread in secondary education, the competency of educators in the field of education has become more important. This study tried to derive the priority of education needs by exploring the competency of educators to practice entrepreneurship education and the result from analysis of the difference in importance and performance. For conducting the analysis, this study conceptualized entrepreneurship education competency based on the TPACK (Technological Pedagogical Content Knowledge) model and developed a questionnaires to measure those competencies. Using TPACK and developed questionnaires, a survey was conducted on 217 secondary school teachers who were interested in entrepreneurship education, and derived the difference between importance-level and current-level was analyzed with a t-test. As a result of the study, for all sub-factors of TPACK, the mean of importance-level was higher than the mean of current-level, indicating that educational prescription was required. Also, as a result of analysis of Borich's requirements and The Locus for Focus Model, it was found that the factor with the highest priority in education was CK(Content Knowledge). Based on the results of study, implications for strengthening competencies for entrepreneurship educators were derived.

• Journal of the Korea institute for structural maintenance and inspection
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• v.7 no.4
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• pp.159-169
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• 2003

In the ACI Code, the empirical equations governing deep beam design are based on low-strength concrete specimens with $f_{ck}$ in the range of 14 to 40MPa. As high-strength concrete(HSC) is becoming more and more popular, it is timely to evaluate the application of HSC deep beam. For the shear strength prediction of HSC deep beams, this paper proposed Softened Strut-and-Tie Model(SSTM) considered HSC and bending moment effect. The shear strength predictions of the proposed model, the Appendix A Strut-and-Tie Model of ACI 318-02, and Eq. of ACI 318-99 11.8 are compared with the experimental test results of 4 deep beams and the collected experimental data of 74 HSC deep beams, compressive strength in the range of 49~78MPa. The proposed SSTM performance consistently reproduced 74 HSC deep beam measured shear strength with reasonable accuracy for a wide range of concrete strength, shear span-depth ratio, and ratio of horizontal and vertical reinforcement.

• Molecules and Cells
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• v.25 no.4
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• pp.531-537
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• 2008

Abnormal activation of nuclear factor kappa B ($NF-{\kappa}B$) probably plays an important role in the pathogenesis of Duchenne's muscular dystrophy (DMD). In this report, we evaluated the efficacy of curcumin, a potent $NF-{\kappa}B$ inhibitor, in mdx mice, a mouse model of DMD. We found that it improved sarcolemmic integrity and enhanced muscle strength after intraperitoneal (i.p.) injection. Histological analysis revealed that the structural defects of myofibrils were reduced, and biochemical analysis showed that creatine kinase (CK) activity was decreased. We also found that levels of tumor necrosis factor alpha ($TNF-\alpha$), interleukin-1 beta ($IL-1\beta$) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration. EMSA analysis showed that $NF-{\kappa}B$ activity was also inhibited. We thus conclude that curcumin is effective in the therapy of muscular dystrophy in mdx mice, and that the mechanism may involve inhibition of $NF-{\kappa}B$ activity. Since curcumin is a non-toxic compound derived from plants, we propose that it may be useful for DMD therapy.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.04a
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• pp.141-146
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• 1996

Hand posture and force, which define aspects of the way an object is grasped, are features of robotics manipulation. A means for specifying these grasping "flavors" has been developed that uses an instrumented glove equipped with joint and force sensors. The new grasp specification system is being used at the Pennsylvania State University (Penn State) in a Virtual Reality based Point-and-Direct(VR-PAD) robotics implementation. In the Computer Integrated Manufacturing (CIM) Laboratory at Penn State, hand posture and force data were collected for manipulating bricks and other items that require varying amounts of force at multiple pressure points. The feasibility of measuring desired grasp characteristics was demonstrated for a modified Cyberglove impregnated with FSR (Force Sensitive Resistor) pressure sensors in the fingertips. A joint/force model relating the parameters of finger articulation and pressure to various lifting tasks was validated for the instrumented "wired" glove. Operators using such a modified glove may ultimately be able to configure robot grasping tasks in environments involving hazardous waste remediation, flexible manufacturing, space operations and other flexible robotics applications. In each case, the VR-PAD approach improved the computational and delay problems of real-time multiple-degree-of-freedom force feedback telemanipulation.ck telemanipulation.