• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5945-5950
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• 2015

A 6-year retrospective cohort study was conducted among Thai hematologic malignancy (HM) patients receiving intensive chemotherapy. Of the 145 eligible patients receiving 893 chemotherapy sessions, 46.9% were female, median age was 52 years, and the most common HM diagnosis was diffuse large B-cell lymphoma (46.2%). Febrile neutropenia (FN) occurred in 14.9% of chemotherapy sessions with an incidence of 24.8 per 1,000 chemotherapy cycles per year. Independent factors associated with FN were receiving the first chemotherapy cycle [adjusted hazard ratio (aHR) 4.1], having hemoglobin ${\leq}100g/L$ (aHR 3.7) and platelet ${\leq}140,000/{\mu}L$ (aHR 2.7) on chemotherapy day and receiving acute myeloid leukemia regimens (aHR 20.8). Granulocyte colony stimulating factor was significantly associated with reduced rate of FN when given in those receiving CHOP regimen. With the median follow-up time of 16 months, the overall survival time was significantly longer in patients without FN than those with FN (61.7 vs. 20.8 months; p<0.001).

• 한국전산유체공학회지
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• 제21권3호
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• pp.24-30
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• 2016

In the water purification plant, the mixture of water and chemical from the mixing basin enters the flocculation basin. The rotating flocculators are generally used for the efficient flocculation of dregs. In this paper, the performance of flocculators of a vertical paddle type, widely used in the typical flocculation basins, and a hydro-foil type, recently disseminated in the field, are compared with each other by use of the numerical method. Also the characteristics and the efficiency are analyzed with CFD techniques. The strain rate and the eddy viscosity are compared for two types to predict the mixing efficiency, and the maximum speed and its location are pursued from the computed data. The hydrofoil type shows that the eddy viscosity is enhanced 1.66 to 3.03 times larger than that of vertical paddle type, and also produced 1.87 to 1.95 times larger flocs for each stage. However, the rapid rotation of hydrofoil may chop the floc to small size due to the higher turbulence intensity. From the result of computation, the strong and weak points of each type have been analyzed for the decision making.

• Clinical and Experimental Reproductive Medicine
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• 제42권1호
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• pp.1-7
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• 2015

Stress coping mechanisms are critical to minimize or overcome damage caused by ever changing environmental conditions. They are designed to promote cell survival. The unfolded protein response (UPR) pathway is mobilized in response to the accumulation of unfolded proteins, ultimately in order to regain endoplasmic reticulum (ER) homeostasis. Various elements of coping responses to ER stress including Perk, Ask1, Bip, Chop, Gadd34, Ire1, Atf4, Atf6, and Xbp1 have been identified and were found to be inducible in oocytes and preimplantation embryos, suggesting that, as a normal part of the cellular adaptive mechanism, these coping responses, including the UPR, play a pivotal role in the development of preimplantation embryos. As such, the UPR-associated molecules and pathways may become useful markers for the potential diagnosis of stress conditions for preimplantation embryos. After implantation, ER stress-induced coping responses become physiologically important for a normal decidual response, placentation, and early organogenesis. Attenuation of ER stress coping responses by tauroursodeoxycholate and salubrinal was effective for prevention of cell death of cultured embryos. Further elucidation of new and relevant ER stress coping responses in periimplantation embryos might contribute to a comprehensive understanding of the regulation of normal development of embryonic development and potentiation of embryonic development in vitro.

• Journal of Gastric Cancer
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• 제17권2호
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• pp.180-185
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• 2017

Despite the decreasing incidence and mortality from gastric cancer, it remains a major health problem worldwide. Ninety percent of cases are adenocarcinomas. Here, we report a case of gastric adenocarcinoma developed after successful treatment of prior primary gastric diffuse large B-cell lymphoma (DLBCL). Our patient was an elderly man with primary gastric DLBCL in whom complete remission was achieved after R-CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone plus rituximab) chemotherapy. Helicobacter pylori infection persisted despite adequate treatment leading to sustained chronic gastritis. The mean time to diagnose metachronous gastric carcinoma was seven years. We believe that a combination of many risk factors, of which chronic H. pylori infection the most important, led to the development of gastric carcinoma following primary gastric lymphoma. In summary, patients who have been successfully treated for primary gastric lymphoma should be followed up at regular short intervals. H. pylori infection should be diagnosed promptly and treated aggressively.

• Molecules and Cells
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• 제43권1호
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• pp.76-85
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• 2020

MARCH5 is a RING finger E3 ligase involved in mitochondrial integrity, cellular protein homeostasis, and the regulation of mitochondrial fusion and fission. To determine the function of MARCH5 during development, we assessed transcript expression in zebrafish embryos. We found that march5 transcripts were of maternal origin and evenly distributed at the 1-cell stage, except for the mid-blastula transition, with expression predominantly in the developing central nervous system at later stages of embryogenesis. Overexpression of march5 impaired convergent extension movement during gastrulation, resulting in reduced patterning along the dorsoventral axis and alterations in the ventral cell types. Overexpression and knockdown of march5 disrupted the organization of the developing telencephalon and diencephalon. Lastly, we found that the transcription of march5 was tightly regulated by the transcriptional regulators CHOP, C/EBPα, Staf, Znf143a, and Znf76. These results demonstrate the essential role of March5 in the development of zebrafish embryos.

• 대한두경부종양학회지
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• 제24권1호
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• pp.69-72
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• 2008

Lymphomas of the nasal sinuses are relatively uncommon and represent less than 1% of all head and neck malignancies. Most common symptoms are nasal obstruction, epistaxis, rhinorrhea. We report a case of primary extranodal diffuse large B-cell non-Hodgkin's lymphoma in nasal sinuses accompanying with exophthalmos. A 70-year-old male patient was referred to our hospital with exophthalmos and severe septal deviation. We conducted endoscopic biopsy with septoplasty and biopsy result was diffuse large B-cell lymphoma. He received chemotherapy(R-CHOP) and radiotherapy. At follow-up, he remained free of disease.

• Biomolecules & Therapeutics
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• 제27권1호
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• pp.41-47
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• 2019

The apoptotic effects of shikonin (5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione) on the human colon cancer cell line SNU-407 were investigated in this study. Shikonin showed dose-dependent cytotoxic activity against SNU-407 cells, with an estimated $IC_{50}$ value of $3{\mu}M$ after 48 h of treatment. Shikonin induced apoptosis, as evidenced by apoptotic body formation, sub-G_1$ phase cells, and DNA fragmentation. Shikonin induced apoptotic cell death by activating mitogen-activated protein kinase family members, and the apoptotic process was mediated by the activation of endoplasmic reticulum (ER) stress, leading to activation of the $PERK/elF2{\alpha}/CHOP$ apoptotic pathway, and mitochondrial $Ca^{2+}$ accumulation. Shikonin increased mitochondrial membrane depolarization and altered the levels of apoptosis-related proteins, with a decrease in B cell lymphoma (Bcl)-2 and an increase in Bcl-2-associated X protein, and subsequently, increased expression of cleaved forms of caspase-9 and -3. Taken together, we suggest that these mechanisms, including MAPK signaling and the ER- and mitochondria-mediated pathways, may underlie shikonin-induced apoptosis related to its anticancer effect.

• 식품과학과 산업
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• 제49권4호
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• pp.31-39
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• 2016

The reasons for selecting insects as future food are high growth and feed conversion rates, reproduce quickly, low environmental footprint, valuable source of nutrients, and source of a various undeveloped functional materials. Since 2014, Tenebrio molitor larva, Protaetia brevitarsis larva, Allomyrina dichotoma larva, and Gryllus bimaculatus were registered as new food in Korea because it has been scientifically proven that they are not harmful to eat and nutritious. Therefore they can be legally produced and sold as food. Accordingly, there are 7 species of edible insects including grasshopper, silkworm pupa, and Baekgangjam in Korea. To improve aversion to edible insects, using their powder, chop, and gravy hidden their morphology, we developed more than 100 different kinds of recipes for general food menu, held several times tasting events to be familiar with edible insect food, and published cookbooks. Moreover, we developed more than 50 kinds of recipes for patients. To eat the insect food more and more people, we have been analyzed various function of insects. If health food based on the results of functional analysis is developed, edible insect's value will be raised. If various insect foods are developed and consumed by people, edible insect market will grow up more than 100 billion won in 2020.

• Journal of the Korean Wood Science and Technology
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• 제52권3호
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• pp.276-288
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• 2024

This study was conducted to reproduce the woodworking process of Baekje wooden storage facilities. Green timber of Quercus spp. was processed using ancient woodworking tools, and the tool-trace formed in this process were compared with the tool-trace of actual excavated artifacts. In the tool-trace analysis, the length and shape of the tool-trace were objectively recorded using a 3D Scan, and that were difficult to confirm with photograph were confirmed through stereoscopic microscope. As a result, there were two types of adze's tool-trace. One of them is minute straight Blade-top trace line when trimming the wood surface and the other is Plucked trace that appear when strongly chop at the wood. When a chisel bat was not used, a long and wide continuous shape blade trace was produced. And when the chisel head was struck with the chisel bat, a straight blade-top trace was regularly observed. Saw-trace was identified in several layers with fine straight stripes. Through this, it was found that the tool-trace of the woodworking tools, which is estimated to have been used in each process, and the tool-trace remaining in the Baekje wooden storage facility coincide.

• 생명과학회지
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• 제34권2호
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• pp.113-121
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• 2024

ER (Endoplasmic reticulume) 스트레스반응은 difenoconazole 등과 같은 다양한 독성물질에 의한 독성반응 동안에 유도되지만, 농업 및 산업에서 전반적으로 사용되는 화학물질로 간독성(Hepatotoxicity)을 유도하는 1,2,3-Trichloropropane (TCP)와의 연관성은 연구된 바 없다. 따라서, 본 연구에서는 TCP처리로 유발된 간독성(Hepatotoxicity) 유발과정 동안에 ER스트레스의 유발기전에 대해 연구하기 위하여, TCP로 처리된 SD(Sprague Dawley)랫드에서 간독성, apoptosis 그리고 ER스트레스에 대한 지표들의 변화를 분석하였다. 그 결과, TCP 처리그룹은 Vehicle 처리그룹에 비하여 체중과 식이 섭취량이 감소하였고, 간 조직에서 괴사(Necrosis)와 공포화(Vaculation) 등이 유의적으로 증가하였다. 또한, apoptosis 관련 인자인 Bax/Bcl-2와 Cleaved Caspase-3(Cas-3)/Cas-3의 발현은 Vehicle 처리그룹보다 TCP 처리그룹에서 유의적으로 증가하였다. ER스트레스 반응지표 분석에서, C/EBP homologous protein (CHOP), p-eukaryotic translation initiation factor 2 alpha subunit (eIF2α), p-iniositor-requiring enzyme 1α (IRE1α)의 발현은 TCP100 처리그룹에서만 증가하였다. 하지만 Growth arrest and DNA damage-34 (GADD34)와 X-box binding protein-1 (XBP1)의 전사는 TCP200 처리그룹에서 유의적으로 변화되었다. 따라서, 이러한 결과는 ER스트레스반응은 TCP 처리에 의해 유도된 간독성과정 동안에 unfolded protein response (UPR) pathway의 조절을 통해 성공적으로 유도됨을 제시하고 있다.