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Quantitative Change of Aristolochic Acid Contents by Processing Methods on the Plants of Aristolochiaceae (쥐방울과 한약의 수치에 따른 aristolochic acid 함량변화)

  • Kim, Min-Suk;Lee, Joung-Bok;Park, Si-Hyung;Kim, Dong-Wook;Min, Oh-Jin;Rhyu, Dong-Young
    • Korean Journal of Pharmacognosy
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    • v.38 no.2 s.149
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    • pp.123-127
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    • 2007
  • Aristolochic acid (AA) included in the plants Aristolochiaceae have been well known to be nephrotoxic and carcinogenic inducer and to cause renal disease such as Chinese Herb Nephropathy (CHN). In this study, we used a high performance liquid chromatopaphy-mass spectrometry (HPLC-MS) under the positive ion detection mode for the quantitative change of aristolochic acid-I and-II (AA-I and AA-II) in Aristolochiaceae (Aristolochia contorta Bunge, Aristolochia debilis Sieb. et Zucc., Aristolochia fangchi Wu), some related plants (Cocculus trilobus De candolle, Inula helenium Linne, Saussurea lappa Clarke), and its prescriptions (防己茯笭湯, 定喘散) with or without processing. Here, the processing methods and prescriptions in oriental medicine were generally used to alleviate toxicity or alter property of herbal medicines. However, the concentrations of AA-I and AA-II were highly determined in processed material extracts rather than unprocessed those, not measured in some related plants. Also, the concentrations of AA-I and AA-II even at the prescriptions mixed the plants of Aristolochiaceae were detected to range from 0.73 to 2.53 ppm. Thus, the present results suggest that the content of AA-I and AA-II contained to plants of Aristolochiaceae was not reduced by the processing methods or prescriptions which can induce the physico-chemical change and pharmacological transformation in traditional herbal medicines.

Analysis of Environmental Impacts and Alternative Scenarios of Transportation Stages on Food Miles for Major Imported Crops (푸드마일을 고려한 주요수입곡물의 운송단계별 환경영향 및 저감방안 분석)

  • Kim, Chanwoo;Kim, Solhee;Jung, Chanhoon;Suh, Kyo
    • Journal of The Korean Society of Agricultural Engineers
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    • v.60 no.3
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    • pp.51-61
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    • 2018
  • Transportation and storage technologies, which are key drivers for trade, has increased global trade of agricultural products about 165% from 1995 to 2015. Korea imports 76.2% of grain from major food exporters such as USA, Australia, Brazil, and China. The expected long shipping distances from these countries can seriously cause environmental impacts on various environmental categories such as climate change, particulate matter, and acidification. The goal of this study is to assess the environmental implications focused on greenhouse gases (GHGs) and particulate matters (PMs) emissions of imported grains (wheat, corn, and bean) using food miles analysis and life cycle assessment (LCA). The environmental impacts of imported crops are estimated by transportation modes using the national LCI database provided by Korea Environmental Industry & Technology Institute (KEITI). The results of this study are as follows; (1) Imported wheat comes from USA (29%), AUS (27%), and URK (20%), corn is imported from USA (34%), BRA (29%), and URK (16%), and bean comes from BRA (57%), USA (40%), and CHN (2%); (2) the food miles of imported crops (wheat, corn, and bean) are 3.62E+10, 1.30E+11, and $2.20E+10ton{\cdot}km$, respectively; (3) the potential GHGs and PMs of wheat, corn, and bean are 5.02E+08, 1.67E+09, and 2.84E+08 kg $CO_2e$ and 5.89E+05, 1.83E+06, 3.07E+05 kg $PM_{10}e$, respectively. The outputs of this study could provide environmental impacts and carrying distances of imported agricultural products for preparing a plan to reduce environmental impacts.

CO2 Emission Characteristics of Bunker C Fuel Oil by Sulfur Contents (C 중유의 황 함유량에 따른 CO2 배출 특성)

  • Lim, Wan-Gyu;Doe, Jin-Woo;Hwang, In-Ha;Ha, Jong-Han;Lee, Sang-Sup
    • Journal of Korean Society for Atmospheric Environment
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    • v.31 no.4
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    • pp.368-377
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    • 2015
  • Bunker C fuel oil is a high-viscosity oil obtained from petroleum distillation as a residue. The sulfur content of bunker C fuel oil is limited to 4.0% or even lower to protect the environment. Because bunker C fuel oil is burned in a furnace or boiler for the generation of heat or used in an engine for the generation of power, carbon dioxide is emitted as a result of combustion. The objective of this study is to investigate $CO_2$ emission characteristics of bunker C fuel oil by sulfur contents. Calorific values and carbon contents of the fuels were measured using the oxygen bomb calorimeter method and the CHN elemental analysis method, respectively. Sulfur and hydrogen contents, which were used to calculate the net calorific value, were also measured and then net calorific values and $CO_2$ emission factors were determined. The results showed that hydrogen content increases and carbon content decreases by reducing sulfur contents for bunker C fuel oil with sulfur contents less than 1.0%. For sulfur contents between 1.0% and 4.0%, carbon content increases as sulfur content decreases but there is no evident variation in hydrogen content. Net calorific value increases by reducing sulfur contents. $CO_2$ emission factor, which is calculated by dividing carbon content by net calorific value, decreases as sulfur content decreases for bunker C fuel oil with sulfur contents less than 1.0% but it showed relatively constant values for sulfur contents between 1.0% and 4.0%.

Production of Hydrogen and Carbon Nanotubes from Catalytic Decomposition of Methane over Ni:Cu/Alumina Modified Supported Catalysts

  • Hussain, Tajammul;Mazhar, Mohammed;Iqbal, Sarwat;Gul, Sheraz;Hussain, Muzammil;Larachi, Faical
    • Bulletin of the Korean Chemical Society
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    • v.28 no.7
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    • pp.1119-1126
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    • 2007
  • Hydrogen gas and carbon nanotubes along with nanocarbon were produced from commercial natural gas using fixed bed catalyst reactor system. The maximum amount of carbon (491 g/g of catalyst) formation was achieved on 25% Ni, 3% Cu supported catalyst without formation of CO/CO2. Pure carbon nanotubes with length of 308 nm having balloon and horn type shapes were also formed at 673 K. Three sets of catalysts were prepared by varying the concentration of Ni in the first set, Cu concentration in the second set and doping with K in the third set to investigate the effect on stabilization of the catalyst and production of carbon nanotubes and hydrogen by copper and potassium doping. Particle size analysis revealed that most of the catalyst particles are in the range of 20-35 nm. All the catalysts were characterized using powder XRD, SEM/EDX, TPR, CHN, BET and CO-chemisorption. These studies indicate that surface geometry is modified electronically with the formation of different Ni, Cu and K phases, consequently, increasing the surface reactivity of the catalyst and in turn the Carbon nanotubes/H2 production. The addition of Cu and K enhances the catalyst dispersion with the increase in Ni loadings and maximum dispersion is achieved on 25% Ni: 3% Cu/Al catalyst. Clearly, the effect of particle size coupled with specific surface geometry on the production of hydrogen gas and carbon nanotubes prevails. Addition of K increases the catalyst stability with decrease in carbon formation, due to its interaction with Cu and Ni, masking Ni and Ni:Cu active sites.

Fast Pedestrian Detection Using Estimation of Feature Information Based on Integral Image (적분영상 기반 특징 정보 예측을 통한 고속 보행자 검출)

  • Kim, Jae-Do;Han, Young-Joon
    • Journal of IKEEE
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    • v.17 no.4
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    • pp.469-477
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    • 2013
  • This paper enhances the speed of a pedestrian detection using an estimation of feature information based on integral image. Pedestrian model or input image should be resized to the size of various pedestrians. In case that the size of pedestrian model would be changed, pedestrian models with respect to the size of pedestrians should be required. Reducing the size of pedestrian model, however, deteriorates the quality of the model information. Since various features according to the size of pedestrian models should be extracted, repetitive feature extractions spend the most time in overall process of pedestrian detection. In order to enhance the processing time of feature extraction, this paper proposes the fast extraction of pedestrian features based on the estimate of integral image. The efficiency of the proposed method is evaluated by comparative experiments with the Channel Feature and Adaboost training using INRIA person dataset.

Cell-meditated studies on blooming and growth of potentially ichthyotoxic Cochlodinium polykrikoides(Dinophyceae)

  • Cho, Eun-Seob
    • Proceedings of KOSOMES biannual meeting
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    • 2007.11a
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    • pp.187-188
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    • 2007
  • The fluctuations of biochemical and molecular activities III the harmful dinoflagellate, Cochlodinium polykrikoides, depending on water temperatures, were studied. In genomic DNA concentration, a similar value of 0.6 was shown at $12^{\circ}C$ and $15^{\circ}C$, but significantly increasing DNA from $18^{\circ}C$ (p<0.05), with a maximum of 1.8 at $24^{\circ}C$. After$24^{\circ}C$, the DNA significantly decreased to 0.6. Likely, the concentrations of RNA and total protein were at their highest values of 1.7 and 0.07 g $mL^1$ at $24^{\circ}C$, respectively. In contrast to ONA, RNA and total protein began to increase at $15^{\circ}C$. Oxygen availability between lower and higher temperatures was significantly different and increased from $18^{\circ}C$ according to light intensity, regardless of wavelengths (p<0.05). At $24^{\circ}C$, the highest value of the maximum electron transport rate (ETRmax), ranging from 537.9 (Ch 1) to 602.5 mol electrons $g^{-1}$ Ch1 a $s^{-1}$ (Ch 4), was also shown. Nitrate reductase (NR) and ATPase activities were at their highest values of 0.11 mol $NO_2^-g^{-1}$ Ch1 a $h^{-1}$ and 0.78 pmol 100 $mg^{-1}$ $at^2$ $4^{\circ}C$, respectively. When the cells cultured at $15^{\circ}C$, NR and ATPase activities significantly increased compared to $12^{\circ}C$ (p<0.05). In an analysis of CHN, the concentration of C and N also significantly increased (p<0.05). However, at $27^{\circ}C$, most of the molecular and biochemical movements were much lower, compared to $24^{\circ}C$. These results suggest that C. polykrikoides is very sensitive biochemical and molecular activities depending on water temperatures. Possibly, it is desirable to estimate at $18^{\circ}C$ the initiation of the massive blooming development of C. polykrikoides. In nature, it will be very difficult to maintain the massive blooms after $24^{\circ}C$ because of the possibility of significantly decreasing the molecular movement and activity of C. polykrikoides.

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A Survey on the Job Stress of Home Care Nurses (가정전문간호사의 업무 스트레스)

  • Kim, Hee-Seung;You, So-Young;Kim, Myung-Ja;Baek, Hee-Chong;Kim, Yun-Ok
    • Journal of Home Health Care Nursing
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    • v.10 no.1
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    • pp.34-40
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    • 2003
  • Purpose: The purpose of this study was to investigate the job stress in home care nurses. Method: The subjects were 139 home care nurses of hospital in an urban cities. The data were collected from 26 Man to 27 June by self report adherence questionnaire. Job stress was measured using CHN-PWRSQ(Community Health Nurses Perceptions of Work-Related Stressors Questionnaire). Result: The average score of job stress was 60.8. There were significantly high levels of job stress in those who have less than 10 years office period, those who have less than 2000000 won monthly salary than in their counterparts. With regard to the level of job stress by item, 'driving long distance and traffic jam', 'risk of traffic accident', 'bad weather condition', 'uncooperative family members', and 'uncooperative client/patient' were higher than other items. The age and office period were negatively correlated with job stress. Conclusion: The average score of job stress was 60.8. 'driving long distance and traffic jam', 'risk of traffic accident', 'bad weather condition', 'uncooperative family members', and 'uncooperative client/patient' were higher than other items. The age and office period were negatively correlated with job stress.

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Literature study on autumn-dryness syndrome (추조(秋燥)에 관(關)한 문헌적(文獻的) 고찰(考察))

  • Han, Jae-Soo;Kwon, Hyuk-Sung;Lee, Joo-Hee;Jung, Sung-Ki;Lee, Hyung-Goo
    • The Journal of Korean Medicine
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    • v.15 no.2 s.28
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    • pp.321-333
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    • 1994
  • 1. Autum-dryness syndrome(秋燥) is caused by dry-warm or dry=-cool weather condition when lower-warmer Eumfen(下焦陰分) was injured by jung hyoul hatal(精血下脫) or taking medicines of dryness in autumn. 2. The symptoms of autum-dryness syndrome are headach, fever, chilling, anhydrosis, dry cough, tinnitis, dry lip, dry skin, chest discomfort in cool-dryness syndrome(凉燥) and headach, fever, dry cough, paroxymal cough, dry skin, chest pain, polydipsia, tinnitis, eye redness, sore throat in heat-dryness syndrome(溫燥). 3. Hyangsochongsitang(香蘇蔥頭湯) chn be applied for terating cool-dryness syndrome(凉燥) and chungjogoopyetang(淸燥救肺湯) for heat-dryness syndrome(溫燥). Sang Hang Tang(桑杏湯) can be administered when the evils located in the upper-warmer, and Yukmihwan(六味丸) can be administered when located in the lower-warmer(下焦) 4. According the determination of treatment based on the differentiation of symptoms and signs. When the symptoms of Weifen syndrome(衛分證) are headach, fever, dry lip or chilling or dypsia and the treatment of weifen syndrome apply Hangsosan(行蘇散) or Sang hang tang(桑杏湯). When the symptoms of Qifen syndrome(氣分證) are tinnitis, eye redness, sore throat, chest discomfort, polydipsia, dry cough, watery diarrhea, constipation and Jibaekjihwang(知栢地黃丸) when Ohingulpitang(五仁橘皮湯) Chungjogupyetang(淸燥救肺湯) can are applied for treating Qifen syndrome(氣分證). When the symptoms of younghylfen syndrome(營血分證) are dry cough, watery diarrhea, dypsia, chest discomfort, hematemesis, epistaxis and agyohwang keum tang(阿膠湯) Oknyujun(玉女煎) can be applied for treating Younghyulfen syndrome(營血分證).

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Effects of High Frequency Herbal Medication Administrations on the Renal Functions in Rats -Focusing on Sipjeondaebotang, Bojunikgitang, Ojeoksan and Yukmijihwangtang- (다용 한약처방 투여가 흰쥐의 신장기능에 미치는 영향 -십전대보탕, 보증익기탕, 오적산 및 육미지황탕을 중심으로-)

  • Shin, Gyu-Won;Lee, Sun-Dong;Park, Hae-Mo;Jeon, Sung-Jin;Byun, Jin-Seok
    • Journal of Society of Preventive Korean Medicine
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    • v.9 no.1
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    • pp.119-133
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    • 2005
  • Traditional herbal medicine is widely used among the Korean people, and other eastern Asian countries employ similar therapies as well. In recent years, due to increasing interest in herbal medicines, many researches have been made on the toxicity and side effects of herbal medications. Through private and public media, there have been many opinions suggesting taking herbal medicines is very harmful, especially on the liver and kidney functions. This assertion has been mainly presented by the doctors that practice western medicine, But this assertion is never based on adequate knowledge of herbal medicine. This study aims to provide the evidences that taking herbal medicines is safe on the renal functions. Four frequently used herbal medications(Sipjeondaebotang, Bojungigitang, Ojeoksan, and Yukmijihwangtang) were used to test the toxicity of herbal medicine oh the lab animal model(SD-Rat). There is no significant difference in body weight and kidney weight after herbal medication for 1 month. In all experimental groups, no abnormal findings were observed in histological study, and lab renal function index(BUN, creatinine, uric acid). These results say that four herbal multi-used-medicines, when medicated, is safe from the renal toxicity in lab animal model.

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Analysis of Heavy Metal Toxic Ions by Adsorption onto Amino-functionalized Ordered Mesoporous Silica

  • Showkat, Ali Md;Zhang, Yu-Ping;Kim, Min-Seok;Gopalan, Anantha Iyengar;Reddy, Kakarla Raghava;Lee, Kwang-Pill
    • Bulletin of the Korean Chemical Society
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    • v.28 no.11
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    • pp.1985-1992
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    • 2007
  • Ordered mesoporous silica (MCM-41) materials with different textural properties were prepared using alkyl (dodecyl, cetyl, eicosane) trimethyl ammonium bromide (DTAB, CTAB, ETAB, respectively) as structure directing surfactants, functionalized with amine groups and used as adsorbent for the toxic metal ions, Cr (VI), As (V), Pb (II) and Hg (II). Amino functionalization of mesoporous MCM-41 was achieved by cocondensation of N-[3-(trimethoxysilyl)-propyl] aniline with tetraethyl orthosilicate. Adsorption isotherm and adsorption capacity of the amine functionalized materials for Cr (VI), As (V), Pb (II) and Hg (II) ions were followed by inductively coupled plasma mass spectrometry (ICP-MS). Results demonstrate that amine functionalized MCM-41 prepared with ETAB showed higher adsorption capacity for Cr (VI), As (V), Pb (II) and Hg (II) ions in comparison to MCM-41 prepared with CTAB and DTAB. The higher adsorption capacity for MCM-41(ETAB) was correlated with amine content in the material (determined by CHN analysis) and relative decrease in pore volume and pore diameter. X-ray diffraction (XRD) analysis, nitrogen adsorptiondesorption measurements and Fourier Transform infrared spectrometry (FTIR) were used to follow the changes in the textural parameters and surface properties of the mesoporous materials as a result of amine functionalization to correlate with the adsorption characteristics. The adsorption process was found to depend on the pH of the medium.