• Journal of Ginseng Research
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• v.43 no.4
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• pp.589-599
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• 2019

Background: Panax ginseng Meyer is known as a conventional herbal medicine, and ginsenoside Rg1, a steroid glycoside, is one of its components. Although Rg1 has been proved to have an antiobesity effect, the mechanism of this effect and whether it involves adipose browning have not been elucidated. Methods: 3T3-L1 and subcutaneous white adipocytes from mice were used to access the thermogenic effect of Rg1. Adipose mitochondria and uncoupling protein 1 (UCP1) expression were analyzed by immunofluorescence. Protein level and mRNA of UCP1 were also evaluated by Western blotting and realtime polymerase chain reaction, respectively. Results: Rg1 dramatically enhanced expression of brown adipocyte-especific markers, such as UCP1 and fatty acid oxidation genes, including carnitine palmitoyltransferase 1. In addition, it modulated lipid metabolism, activated 5' adenosine monophosphate (AMP)-activated protein kinase, and promoted lipid droplet dispersion. Conclusions: Rg1 increases UCP1 expression and mitochondrial biogenesis in 3T3-L1 and subcutaneous white adipose cells isolated from C57BL/6 mice. We suggest that Rg1 exerts its antiobesity effects by promoting adipocyte browning through activation of the AMP-activated protein kinase pathway.

• ETRI Journal
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• v.45 no.3
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• pp.462-478
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• 2023

In quantum computing, the use of Pauli frames through software traces of classical computers improves computation efficiency. In previous studies, error correction and Pauli operation tracking have been performed simultaneously using integrated Pauli frames in the physical layer. In such a complex processing structure, the number of simultaneous operations processed in the physical layer exponentially increases as the distance of the surface code encoding logical qubit increases. This study proposes a Pauli frame management architecture partitioned into two layers for a lattice surgery-based surface code and describes its structure and operation rules. To evaluate the effectiveness of our method, we generated a random circuit according to the gate ratios constituting the commonly known quantum circuits and compared the generated circuit with the existing Pauli frame and our method. Simulations show a decrease of about 5% over traditional methods. In the case of experiments that only increase the code distance of the logical qubit, it can be seen that the effect of reducing the physical operation through the logical Pauli frame becomes more important.

• Journal of KIISE:Computer Systems and Theory
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• v.29 no.7
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• pp.384-393
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• 2002

A Parallel file system is normally used to support excessive file requests from parallel applications in a cluster system, whereas prefetching is useful for improving the file system performance. This paper proposes a new prefetching method, Fips(dynamic File Prefetching Scheme based on file access patterms), that is particularly suitable for parallel scientific applications and multimedia web services in a parallel file system. The proposed prefetching method introduces a dynamic prefetching scheme to predict data blocks precisely in run-time although the file access patterns are irregular. In addition, it includes an algorithm to determine whether and when the prefetching is performed using the current available I/O bandwidth. Experimental results confirmed that the use of the proposed prefetching policy in a parallel file system produced a higher file system performance.

• Journal of Korea Multimedia Society
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• v.8 no.11
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• pp.1483-1495
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• 2005

TCP/IP is the most commonly used protocol to communicate among servers, and is used in a wide range of applications. Unfortunately, Data transmission through TCP/IP places a very heavy burden on host CPUs. And it hardly makes another job to be processed. So, TOE(TCP/IP Offload Engine) is considered in many servers. But, most of TOE modules tends to not support binary compatibility for standard socket interfaces. So, it has problems that existing applications should be modified and recompiled to get advantage of TOE device. In this paper, to resolve upper problems, we suppose design and implementation of TOE module supporting binary compatibility for standard socket interfaces. Also, it can make a usage of multiple TOEs and NICs simultaneously.

• Archives of Pharmacal Research
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• v.27 no.11
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• pp.1141-1146
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• 2004

Lonicera japonica Thunb.(Caprifoliaceae) has long been known as an anti-inflammatory. In the present study, the effect of water fraction of Lonicera japonica (LJ) on trypsin-induced mast cell activation was examined. HMC-1 cells were stimulated with trypsin (100 nM) in the presence or absence of LJ (10, 100, and 1000 $\mu$ g/mL). TNF-$\alpha$ and tryptase production were measured by enzyme-linked immunosorbent assay (ELISA) and reverse transcription-PCR. Extracellular signal-regulated kinase (ERK) phosphorylation was assessed by Western blot. Trypsin activity was measured by using Bz-DL-Arg-p-nitroanilide (BAPNA) as substrate. LJ (10, 100, and 1000 $\mu$g/mL) inhibited TNF-$\alpha$ secretion in a dose-dependent manner. LJ (10, 100, and 1000 $\mu$g/mL) also inhibited TNF-$\alpha$ and tryptase mRNA expression in trypsin-stimulated HMC-1. Furthermore, LJ inhibited trypsin-induced ERK phosphorylation. However, LJ did not affect the trypsin activity even 1000 $\mu$g/mL. These results indicate that LJ may inhibit trypsin-induced mast cell activation through the inhibition of ERK phosphorylation than the inhibition of trypsin activity.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2003.10b
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• pp.43-43
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• 2003

Multiple regression equations (Rehman et al. 2000) have been developed to predict the salinity tolerance of Acacia seeds, expressed as the I$\sub$50/ (the concentration of NaCl required to reduce final germination to 50% of the control value in DW). Accurate predictions can be made using one or more chemical and biological seed parameters. In this study the theoretical effect of varying final germination percentage in distilled water, germination rate in distilled water. (Rate), Ca$\^$2+/ or K$\^$+/ contents and their ratios, as independent factors or related factors, on the predicted salinity tolerance (I$\sub$50/) of Acacia species was investigated. Simulation of the effects of changing final germination, rate, calcium and potassium suggest the possibility of practical application of these results to modify the salinity tolerance of seeds. The predicted I$\sub$50/ increased with increasing final germination. Similarly, the higher the rate of germination, the higher the predicted salt tolerance of Acacia species. The Ca$\^$2+/ content of seeds was found to be positively correlated with I$\sub$50/. Species with higher Ca$\^$2+/ contents had a higher I$\sub$50/. This suggests that I$\sub$50/ might be increased by increasing the Ca$\^$2+/ contents of seeds by pretreatment with calcium salts or by supplying these to the mother plants.

• The Korean Journal of Emergency Medical Services
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• v.9 no.1
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• pp.5-13
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• 2005

Purpose : The purpose of this study was to investigate dual gender identity, masculine gender identity, feminine gender identity, undifferentiated gender identity with related to Sex, home environments, parental child-rearing attitude of warmth, parental child-rearing attitude of control, role division of parents and determine predictors for dual gender identity. Method : Study subjects were $6^{th}$ grade of primary students with 2,118. Data was collected from Oct to Nov 2003 by using structured questionnaire. Results : ${\cdot}$ Among the children, 345 had masculine gender identity, 529 had feminine gender identity, 526 had undifferentiated gender identity, and 718 had dual gender identity. ${\cdot}$ There were significant differences in the children's sex, mother's age, father's age, mother's educational level, father's educational level, existence of mother's job, father's job, social economic status, sex of siblings, mother's job satisfaction, family structure, family atmosphere, child-rearing attitude(warmth and control), role division of parents($p{\leq}0.001$) among 4 groups. ${\cdot}$ The significant predictors for dual gender identity were children's sex (OR = 0,196, P =0.001), father's age(OR = 31.053, p = 0.020), mother's educational level(OR = 43,980, p = 0.001), father's job(OR=27.465, p = 0.001), social economic status(OR=O.941, p=0.001), sex of siblings(OR = 0.329, p = 0.005), mother's job satisfaction(OR = 0.673, p =0.001), family structure(OR = 0.887, p = 0.001), family atmosphere(OR = 23.786, p = 0.001), parental Child-rearing attitude of warmth(OR = 8.043, p = 0.001) and child-rearing attitude of control(OR = 0.666, p = 0.005), role division of parents(OR = 3.009, p = 0.001). Conclusions : These findings suggest the necessity of broad understandings about factors which influence dual gender role, and construction of combinative model. Also they suggest parent education for establishment of children's dual gender identity.

• Parasites, Hosts and Diseases
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• v.37 no.3
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• pp.171-179
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• 1999

Non-biting midges are known to contain potent inhalant allergens. IgE antibody responses to the crude extract of Chironomus kiiensis adults, a dominant chironomid species in Korea, were examined. With the IgE-ELISA or passive cutaneous anaphylaxis reactions, increased levels of chironomid-specific IgE were detected in the skin test positived human sera, or immunized BALB/c mouse sera with the crude extract adsorbed to alum. IgE-immunoblot analysis showed mafor IgE-reacting protein band patterns, which reacted with more than 50% of the skin test positive human sera, at 110, 80, 46, 40, 37, 34 and 31 kDa. The reactive band patterns were larely similar between skin test positive humans and immune BALB/c mice. However, the bands of 55, 31, 27, 26, 24 and 23 kDa were found only in sensitized humans, but not in immunized mice.

• The Journal of Korean Medicine
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• v.19 no.2
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• pp.439-449
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• 1998

Anal Therapy is another way of taking medicine. It is a traditional pathway but not available in common situation. Nevertheless, It has many benifect and usefulness, it has not treated so much. Through Anal Therapy, the valid compound of Herb med can be reach to the desination in theory of the organism and loca1 medical action. The former is called Jung-Chei Theory(整體論), which is the one of the most important basements in building traditional Korean medicine. As there are many kinds of Anal therapy, this study use reservation type. Sosihotang(SSHT) is one of the well-known korean medicines for a long time. It is used for the treatment of such dieases as infectious diseases, hepatic diseases and gastroenteritis and so on. In this study, the author investigated the effect of an aqueous extract of SSHT by Anal therapy(Reservative Enema) in anaphylactic shock. The following results were obtained 1. SSHT inhibited anaphylactic shock 100% with a dose of 1.0 g/kg 1 hr before intraperitoneal injection of compound 48/80. SSHT significantly reduced serum histamine contents induced by compound 48/80. 2. SSHT (0.1 g/kg) also inhibited to 30.9% (P<0.05)) local cutaneous anaphylactic reaction activated by anti-dinitrophenyl (DNP) IgE. 3. The validity rate of reservative enema is as much as oral pathway. 4. In addition, SSHT dose-dependently inhibited the histamine release from the peritoneal mast cells by compound 48/80 or anti-DNP IgE. These results provide evidence that Anal Therapy(Reservative enema) of SSHT may be beneficial in the treatment of systemic and local anaphylactic reaction. Moreover, I wish another much sincere study of Anal Therapy (Reservative enema) would be obtained.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.267-273
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• 2020

Background: Continuous exposure to high temperatures can lead to heat stress. This stress response alters the expression of multiple genes and can contribute to the onset of various diseases. In particular, heat stress induces oxidative stress by increasing the production of reactive oxygen species. The liver is an essential organ that plays a variety of roles, such as detoxification and protein synthesis. Therefore, it is important to protect the liver from oxidative stress caused by heat stress. Korean ginseng has a variety of beneficial biological properties, and our previous studies showed that it provides an effective defense against heat stress. Methods: We investigated the ability of Korean Red Ginseng and Korean black ginseng extracts (JP5 and BG1) to protect against heat stress using a rat model. We then confirmed the active ingredients and mechanism of action using a cell-based model. Results: Heat stress significantly increased gene and protein expression of oxidative stress-related factors such as catalase and SOD2, but treatment with JP5 (Korean Red Ginseng extract) and BG1 (Korean black ginseng extract) abolished this response in both liver tissue and HepG2 cells. In addition, JP5 and BG1 inhibited the expression of inflammatory proteins such as p-NF-κB and tumor necrosis factor alpha-α. In particular, JP5 and BG1 decreased the expression of components of the NLRP3 inflammasome, a key inflammatory signaling factor. Thus, JP5 and BG1 inhibited both oxidative stress and inflammation. Conclusions: JP5 and BG1 protect against oxidative stress and inflammation induced by heat stress and help maintain liver function by preventing liver damage.