• Bulletin of the Korean Chemical Society
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• 제31권3호
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• pp.624-629
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• 2010

The synthesis and evaluation of a novel calix[4]arene-based fluorescent chemosensor 1 for the detection of I. is described. The fluorescent changes observed upon addition of various anions show that 1 is selective for I. over other anions. Addition of I. results in ratiometric measurements with 1 : 1 complex ratio.

• 천문학회보
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• 제35권1호
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• pp.75.1-75.1
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• 2010

The first near-infrared (NIR) spectroscopic survey of SDSS-selected blue early-type galaxies (BEGs) has been conducted using the AKARI/IRC. The NIR spectra of 36 BEGs are successfully secured, which are well balanced in their SF/Seyfert/LINER type composition. For high signal-to-noise ratio, we stack the BEG spectra all and in bins of several properties: color, specific star formation rate and optically-determined spectral type. We estimate the NIR continuum slope and the 3.3 micron PAH emission equivalent width in the stacked BEG spectra, and compare them with those of SSP model galaxies and known ULIRGs. We first report the NIR spectral features of BEGs and discuss the nature of BEGs based on the comparison with other objects.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1995년도 추계학술발표회논문집(2)
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• pp.544-549
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• 1995

An analysis for Steam Line Break (SLB) events which result in a return-to-power conditions after reactor trip was performed for a postulated Yonggwang Nuclear Power Plant Unit 3 cycle 8. Analysis methodology for post-trip return-to-power SLB is quite different from that of a no return-to-power SLB and is more complicated. Therefore, it is necessary to develop an methodology to analyze the response of the NSSS parameter and the fuel performance for the post-trip return-to-power SLB events. In this analysis, the cases with and without offsite power were simulated by crediting 3-D reactivity feedback effect due to local heatup around stuck CEA and compared with the cases without 3-D reactivity feedback with respect to fuel performance, departure from nucleate boiling ratio (DNBR) and linear heat generation rate (LHGR).

• 핵의학기술
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• 제27권1호
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• pp.55-61
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• 2023

Purpose In this study, the monthly population distribution was calculated for statistical verification of 10 tests (CA19-9, CA15-3, testosterone, PTH, calcitonin, AFP, CEA, CA72-4, PSA, estradiol) with changed reagents, and the trend of change By comparing and analyzing the results, we want to verify the accuracy of the results and improve the reliability of the test. Materials and Methods From June 2021 to February 2023, for the 10 items in which the reagent was changed, the monthly percentage and standard deviation index before and after the reagent change were compared, respectively. At this time, the reference value was arbitrarily set for the comparison group in consideration of the reference value of the test item, and the groups were subdivided and compared, and the standard deviation index allowed range was -2.0 or more and 2.0 or less. Results For CA19-9, CA15-3, AFP, CEA, and calcitonin 5 test items, the change in monthly ratio in all test sections before and after the reagent change was kept constant. On the other hand, for CA72-4, PSA, testosterone, PTH, and estradiol items, the standard deviation index exceeded the acceptable standard after changing the reagent. CA72-4 test items showed an increasing trend in standard deviation index in the test section exceeding the reference value. In the case of the PSA test item, the maintenance ratio of 0.04 ng/mL was significantly decreased after changing the reagent. The testosterone test item had a standard deviation index of -2.5 in the test section exceeding 10.1 ng/mL after changing the reagent, and the standard deviation index of the PTH test item was out of the acceptable range in all test sections. It was confirmed that the estradiol test item showed an overall increase in the result value. Conclusion Through this study, the continuity and accuracy of the test results could be verified. It is considered that the stability of the test can be secured by analyzing the factors affecting the test result and solving the cause for the test item whose standard deviation index is out of the acceptable standard.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.1003-1007
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• 2013

Objective: This work aimed to investigate the correlations of tumor-associated macrophages (TAMs) and their subtypes M1 and M2 with liver metastasis of colorectal cancer, and provide useful references for seeking predictors of liver metastasis and studying mechanisms. Methods: 120 patients with colorectal cancer from 2000 to 2009 were divided into low, middle and high liver metastasis groups (group A, B and C, respectively). S-P immunohistochemical staining and microscopic observation were conducted to compare expression in CD68-positive cells (TAMs), CD80-positive cells (M1) and CD163-positive cells (M2) in three groups. Correlations of TAMs, M1, M2, and M2/M1 ratio with clinical and pathological parameters were analyzed. Results: With increase of liver metastatic ability, the number of TAMs decreased gradually, with no significant difference between any two of the three groups (P > 0.05), while the numbers of M1 and M2 were significantly decreased and increased, respectively, with significant difference between any two of three groups (P < 0.05 or P < 0.01). In addition, the M2/M1 ratio increased with increase of liver metastatic ability (P < 0.01). There was no statistical significance of correlation of TAMs with each clinical and pathological parameter. M1 was negatively related with lymphatic metastasis and liver metastatic ability. M2 was positively correlated with preoperative CEA level, lymphatic metastasis, tumor differentiation degree and liver metastatic ability. The same was the case for the M2/M1 ratio. Conclusions: Effects of TAMs on liver metastasis of colorectal cancer do not depend on the total number of TAMs, but on the number and proportion of functional subtypes M1 and M2. M2 number and M2/M1 ratio are more accurate predictors for liver metastasis of colorectal cancer.

• 시스템엔지니어링학술지
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• 제17권2호
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• pp.49-60
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• 2021

The Core Protection Calculator System (CPCS) is vital for plant safety as it ensures the required Specified Acceptance Fuel Design Limit (SAFDL) are not exceeded. The CPCS generates trip signals when Departure from Nucleate Boiling Ratio (DNBR) and Local Power Density (LPD) exceeds their predetermined setpoints. These setpoints are established based on the operating margin from the analysis that produces the SAFDL values. The goal of this research is to create a simplified CPCS that optimizes operating margin for I-SMRs. Because the I-SMR is compact in design, instrumentation placement is a challenge, as it is with Ex-core detectors and RCP instrumentation. The proposed CPCS addresses the issue of power flux measurement with In-Core Instrumentation (ICI), while flow measurement is handled with differential pressure transmitters between Steam Generators (SG). Simplification of CPCS is based on a Look-Up-Table (LUT) for determining the CEA groups' position. However, simplification brings approximations that result in a loss of operational margin, which necessitates compensation. Appropriate compensation is performed based on the result of analysis. FPGAs (Field Programmable Gate Arrays) are presented as a way to compensate for the inadequacies of current systems by providing faster execution speeds and a lower Common Cause Failure rate (CCF).

• 한국임상약학회지
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• 제19권2호
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• pp.96-104
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• 2009

배경: 당뇨병 환자에게 관상동맥심질환은 생존률, 건강 상태 유지 및 삶의 질에 주요한 영향을 미치는 합병증이며 적극적인 당뇨병 치료는 이러한 심혈관 합병증을 예방할 수 있으나 당뇨병의 적극적 치료와 관리에는 많은 비용이 소요된다. 목적: 제2형 당뇨병 환자를 대상으로 메트포르민과 글리메피리드 병합요법과 메트포르민과 피오글리타존 병합요법의 비용-효과성을 비교하고자 하였다. 연구방법: 마르코프 코호트 프로세스(Markov Cohort Process Model) 모형을 이용하여 비용-효과분석을 실시하였다. 연장된 수명 (life years gained, LYG)과 삶의 질(quality)을 보정하여 증가된 QALYs를 주요 효과 지표로 측정하였고, 총비용으로는 직접의료비용과, 환자와 가족의 교통비를 직접비의료비용으로 고려하였고 환자와 가족의 시간비용을 간접비용으로 포함하였다. 연구결과: 비용-효과분석 결과, 메트포르민과 글리메피리드 병합요법의 경우 총 비용은 5,962,288원, 효과는 7.94LYG, 6.43QALY이었다. 반면 메트포르민과 피오글리타존 병합요법은 총 비용 10,982,243원, 효과 8.62LYG, 6.99QALY으로, 점증적 비용-효과비(ICER)는 7,402,663원/LYG과 8,934,546원/QALY 이었다. 결론: 우리 사회의 연장된 수명(LYG)에 따른 지불의사가 700만원 이하인 경우는 메트포르민과 글리메피리드 병합요법이 비용-효과적인 대안이며 700만원 이상인 경우에는 메트포르민과 피오글리타존 병합요법이 비용-효과적인 대안이 될 수 있다.

• 천문학회보
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• 제36권2호
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• pp.75.1-75.1
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• 2011

We investigate the connection between the presence of bars and AGN activity, using a volume-limited sample of ~6,000 late-type galaxies with axis ratio b/a > 0.6 and $M_r=-19.5+5logh$ at low redshift (0.02 < z ${\leq}$ 0.055), selected from Sloan Digital Sky Survey Data Release 7. Although bars are believed to play an important role in fueling AGNs, it is still an open question whether AGN activity is connected with the presence of bars. We find that the bar fraction in AGN-host galaxies (44.1%) is 2.5 times higher than in non-AGN galaxies (17.6%), implying an AGN-bar connection. However, this trend is simply caused by the fact that AGN-host galaxies are on average more massive and redder than non-AGN galaxies since the bar fraction increases with u-r color and velocity dispersion. When AGN-host and non-AGN galaxies with fixed u-r color and velocity dispersion are compared, the excess of bar fraction in AGN-host galaxies disappears. Among AGN-host galaxies we find no strong difference of the Eddington ratio distributions between barred and non-barred systems. These results indicate that AGN activity is not directly connected with the presence of bars.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2237-2243
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• 2015

Background: Adjuvant chemotherapy improves survival in Dukes C colon cancers post-curative resection. However, the evidence for a role with Dukes B lesions remains unproven despite frequent use for disease characterized by poor prognostic features. In view of limited Asia-specific data, this study aimed to determine survival outcomes and identify prognostic factors in a tertiary teaching hospital in Malaysia. Materials and Methods: A total of 116 subjects who underwent curative surgery with and without adjuvant chemotherapy for Duke B and C primary colon adenocarcinomas diagnosed from 2004-2009 were recruited and data were collected retrospectively. Five-year overall survival (OS) and disease free survival (DFS) were analysed using Kaplan-Meier survival analysis and log-rank (Mantel-Cox) test. Prognostic factors were determined using Cox proportional hazards regression with both univariate and multivariate analyses. Results: The survival analysis demonstrated a 5-year OS of 74.0% for all patients, with 74.9% for Dukes C subjects receiving chemotherapy compared to 28.6% in those not receiving chemotherapy (p=0.001). For Dukes B disease, the 5-year survival rate was 82.6% compared to 75.0% for subjects receiving and not receiving chemotherapy, respectively (p=0.17). Independent prognostic factors identified included a CEA level more than 3.5 ng/ml (hazard ratio (HR)=4.78; p=0.008), serosal involvement (HR=3.75; p=0.028) and completion of chemotherapy (HR= 0.20; p=0.007). Conclusions: In a regional context, this study supports current evidence from the West that adjuvant chemotherapy improves survival in Dukes C colon cancers post curative surgery. However, although a clear benefit has yet to be proven for Dukes B disease, our results suggest survival improvement in selected cases.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1485-1488
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• 2016

Background: Chile is one of the countries with the highest prevalence of cholelithiasis worldwide, considering the Mapuche ethnicity as a risk factor for developing this pathology. Moreover, cholelithiasis is the main risk factor for developing gallbladder cancer, being the fifth cause of cancer death in Chile. The purpose of this study was to compare the frequency of cholelithiasis and biliary pathology among the population belonging to Rapanui ethnicity and non-Rapanui population living on Easter Island. Materials and Methods: In this retrospective case-control study, a total of 609 abdominal ultrasonographs performed consecutively in Hanga Roa Hospital during the period August 2012 to January 2015 were analyzed. Multiple logistic regression was used to obtain odds ratio (OR) and 95% confidence intervals (95% CI) of cholelithiasis and biliary pathology, adjusting for age, gender and referral diagnostic hypothesis. Results: In the Rapanui population the frequency for cholelithiasis and biliary pathology was 6.4% and 13%, meanwhile for the non-Rapanui population it was 13% and 22% respectively. Compared to the non-Rapanui Chilean population, the Rapanui ethnicity presented an OR of 0.53 (95% CI: 0.29-0.95) for cholelithiasis and OR of 0.52 (95% CI: 0.33-0.82) for biliary pathology. Conclusions: We found statistically significant ethnic differences in the frequency of cholelithiasis and biliary disease among the population of Rapanui and non-Rapanui ethnicity, so that this could be a protective factor for the development of biliary pathology, given the Chilean population context. Other studies including community population to determine the real prevalence of cholelithiasis and analyze the protective role of Rapanui ethnicity on this disease are necessary.