• Journal of Korean Medicine Rehabilitation
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• v.30 no.2
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• pp.105-123
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• 2020

Objectives This study was conducted to verify the effectiveness of east-west integrative rehabilitation therapy on activity of daily living and cognitive functional recovery in stroke patients by comparing with integrative rehabilitation therapy group and conventional rehabilitation therapy group in a single institution. Methods The medical records of 106 stroke patients hospitalized in Department of Rehabilitation Medicine, Dongguk University Bundang Oriental Hospital from January 1, 2017 to February 28, 2019 were reviewed. After screening and dividing it into conventional rehabilitation (CR) group and integrative rehabilitation (IR) group, Korean version of Modified Barthel Index (K-MBI), functional independence measure (FIM), clinical dementia rating-sum of boxes (CDR-SB) were statistically analyzed. Results IR group showed significant improvement in K-MBI, FIM, and CDR-SB after treatment (p<0.001) and there was a statistically significant difference in K-MBI and CDR-SB score changes than CR group (p<0.05). And chronic patient of IR group showed significant improvement in K-MBI, FIM, and CDR-SB after treatment (p<0.01) and there was a statistically significant difference in CDR-SB score changes than CR group (p<0.05). In particular, the earlier the treatment initiation time, the more the improvement in function and when the treatment started within 2 years from the onset and patients took acupuncture and pulsed electromagnetic therapy, all scales significantly improved (p<0.001). Conclusions IR showed more improvement on activities of daily life and cognitive functional recovery than CR in this study.

• Journal of Oriental Neuropsychiatry
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• v.34 no.3
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• pp.141-150
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• 2023

Objectives: This study aimed to comprehend the characteristics of Korean medicine patterns in relation to varying degrees of cognitive impairment in an elderly population. Methods: The dataset included 127 elderly individuals with cognitive impairment obtained from three Korean medicine hospitals between 2018 and 2021. The participants were categorized into two groups based on Clinical Dementia Rating-Sum of Boxes (CDR-SB) scores: those with questionable impairment (QI) and those with very mild dementia (VMD). A diagnostic framework for Korean medicine patterns encompassing Qi deficiency, Yin deficiency, Phlegm dampness, and Heat-fire was employed. Liver blood markers, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the AST/ALT ratio, were also analyzed. Results: The scores of the cognitive assessment tools (MoCA-K, MMSE-DS, and K-IADL) of the QI group significantly differed from those of the VMD group. CDR-SB exhibited a positive correlation with the scores of each pattern of Qi deficiency, Yin deficiency, Phlegm dampness, and Heat-fire, whereas ALT and AST values displayed negative correlations. Binomial logistic analysis, controlling for potential confounders, such as age, education years, body mass index, the presence of chronic disease, and the presence of medication, verified that the VMD group showed higher pattern scores and lower ALT and AST values than the QI group. Conclusions: Increases in pattern scores along with decreased AST and ALT levels might be indicative of more severe cognitive impairment.

• Journal of KIISE:Databases
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• v.29 no.6
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• pp.429-440
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• 2002

Temporal databases manage time-evolving data. They provide built-in supports for efficient recording and querying of temporal data. The temporal aggregate in temporal databases is an extension of the conventional aggregate to include time concept on the domain and range of aggregation. This paper focuses on multidimensional temporal aggregation. In a multidimensional temporal aggregate, we use one or more general attributes as well as a time attribute on the range of aggregation, thus it is a useful operation for historical data warehouse, Call Data Records(CDR), etc. In this paper, we propose a structure for multidimensional temporal aggregation, called PTA-tree, and an aggregate processing method based on the PTA-tree. Through analyses and performance experiments, we also compare the PTA-tree with the simple extension of SB-tree that was proposed for temporal aggregation.

• Korean Journal of Biological Psychiatry
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• v.27 no.2
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• pp.94-100
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• 2020

Objectives Amyloid β positron emission tomography (Aβ PET) is widely used as a diagnostic tool in patients who have symptoms of cognitive impairment, however, this diagnostic examination is too expensive. Thus, predicting the positivity of Aβ PET before patients undergo the examination is essential. We aimed to analyze clinical predictors of patients who underwent Aβ PET retrospectively, and to develop a predicting model of Aβ PET positivity. Methods 468 patients who underwent Aβ PET with cognitive impairment were recruited and their clinical indicators were analyzed retrospectively. We specified the primary outcome as Aβ PET positivity, and included variables such as age, sex, body mass index, diastolic blood pressure, systolic blood pressure, education, dementia family history, Mini Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), Clinical Dementia Rating-Sum of Box (CDR-SB), hypertension (HTN), diabetes mellitus (DM) and presence of apolipoprotein E (ApoE) E4 as potential predictors. We developed three final models of amyloid positivity prediction for total subjects, mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia using a multivariate stepwise logistic regression analysis. Receiver operating characteristic (ROC) curve analysis was performed and the area under curve (AUC) value was calculated for the ROC curve. Results Aβ PET negative patients were 49.6% (n = 232), and Aβ PET positive patients were 50.4% (n = 236). In the final model of all subjects, older age, female sex, presence of ApoE E4 and lower MMSE are associated with Aβ PET positivity. The AUC value was 0.296. In the final model of MCI subjects (n = 244), older age and presence of ApoE E4 are associated with Aβ PET positivity. The AUC value was 0.725. In the final model of AD subjects (n = 173), lower MMSE scores, the presence of ApoE E4 and history of HTN are associated with Aβ PET positivity. The AUC value was 0.681. Conclusions The cerebral amyloid positivity model, which was based on commonly available clinical indicators, can be useful for prediction of amyloid PET positivity in MCI or AD patients.

• The Journal of the Korea Contents Association
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• v.16 no.6
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• pp.225-235
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• 2016

This study aims at developing Reminiscence Function Scale-Short Form(RFS-S) and verifying it as a supplemental diagnosis instrument to judge differences between normal and mild cognitive impairment and useful measure to rate effects of reminiscence therapy in the clinical field through internal consistency reliability and criterion validity. The study also aims at figuring out factors affection reminiscence function by figuring out demographic features of RFS-S. The research subjects were the control group of 60 normal people and experimental group of 58 people with mild cognitive impairment and both groups were over 65 years old. For internal consistency reliability(Cronbach's alpha) between questions was reliable with 0.63. Convergent validities of RFS-S with SRT and CDR-SB were 0.20(p<.05) and -0.25(p<.001), respectively, as both showed significant correlations. As a result of criterion validity to analyze AUROC, it was 0.68(p<.001) and less accurate. Its optimal cut-off points were 17 and sensitivity according to them was 0.59, and specificity was 0.72, respectively. However, reminiscence function according to demographic variables did not show any significant differences. Therefore, it is expected that RFS-S will be used as a supplemental diagnosis instrument with higher reliability and validity for discerning differences between normal and mild cognitive impairment and as a useful one to verify effects of reminiscence therapy.