• Microbiology and Biotechnology Letters
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• v.41 no.4
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• pp.425-432
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• 2013

Typha orientalis, also known as bulrush or cattail, is a perennial herbaceous plant found in freshwater wetlands and has been widely used in constructed wetlands for wastewater treatment. Recent data has revealed that SH21B, a mixture composed of seven herbs including T. orientalis, exhibited an anti-adipogenic activity by the inhibition of the expression of adipogenic regulators. However, the anti-cancer effect of T. orientalis and its molecular mechanisms remain unclear. In this study, we evaluated the anti-cancer effect and its mechanism in the methanol extract of T. orientalis (METO) on human colon carcinoma HT29 cells. It was found that METO treatment showed cytotoxic activity in a dose-dependent manner, and induced G2/M cell cycle arrest and apoptosis in HT29 cells. The induction of G2/M arrest by METO was associated with the up-regulation of phospho-Cdc2 (Tyr15), an inactive form of Cdc2 and the down-regulation of Cdc25c phosphatase. METO also induced tumor suppressor p53 and cyclin-dependent kinase inhibitor p21 (WAF1/CIP1) expression. In addition, METO-induced apoptosis was characterized by the proteolytic activation of caspase-3, degradation of poly ADP ribose polymerase (PARP), and up-regulation of death receptor FAS and pro-apoptotic Bax expression. Collectively, these results indicate that the cell cycle inhibition and apoptosis induction of METO in HT29 cells allows for the possibility of its use in anti-cancer therapies.

• Proceedings of the Microbiological Society of Korea Conference
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• 2004.05a
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• pp.77-79
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• 2004

• 대한예방의학회:학술대회논문집
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• 2004.05a
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• pp.1-21
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• 2004

• Bulletin of the Korean Chemical Society
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• v.19 no.1
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• pp.29-31
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• 1998

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.1126-1131
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• 2007

This paper presents unified chassis control (UCC) to improve the vehicle lateral stability. The unified chassis control implies combined control of active front steering (AFS), electronic stability control (ESC) and continuous damping control (CDC). A direct yaw moment controller based on a 2-D bicycle model is designed by using sliding mode control law. A direct roll moment controller based on a 2-D roll model is designed. The computed direct yaw moment and the direct roll moment are generated by AFS, ESP and CDC control modules respectively. A control authority of the AFS and the ESC is determined by tire slip angle. Computer simulation is conducted to evaluate the proposed integrated chassis controller by using the Matlab, simulink and the validated vehicle simulator. From the simulation results, it is shown that the proposed unified chassis control can provide with improved performance over the modular chassis control.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.1132-1137
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• 2007

This paper describes a Unified Chassis Control (UCC) strategy to prevent vehicle rollover by integrating individual modular chassis control systems such as Electronic Stability Control (ESC) and Continuous Damping Control (CDC). The UCC threshold is determined from a rollover index computed by estimated roll angle, roll rate and measured lateral acceleration. A direct yaw moment control method is used to design the ESC based on a 2-D bicycle model. Similarly, the CDC is designed based on a 2-D roll model using a direct roll moment control method. The performance of the proposed UCC scheme is investigated and compared to that of modular chassis controllers through computer simulations using a validated vehicle simulator. It is shown that the proposed the UCC can lead to improvements in vehicle stability and efficient actuation of chassis control systems.

• Proceedings of the KIEE Conference
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• 2006.07a
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• pp.250-251
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• 2006

현대 전력산업은 IEC61850의 표준화작업이 한창 진행중이다. IEC61850-7-4는 전력설비 요소마다 Logical Node를 선언해 놓았다. 현재의 Logical Node는 보호, 제어, 인터페이스, 기록, 자동, 측정, 센서 & 모니터링, 변전기기 등의 그룹으로 나뉘어져 있다. 그러나 본 논문에서 대상으로 하는 GIS 예방진단 시스템에 관한 Logical Node와 공통 데이터 클레스(CDC: Common Data Class)가 명확히 선언되지 않았다. 1993년 IEC61850의 객체모델이 제안될 때부터 변전소의 다양한 설비를 완벽하게 객체화 할 수 있는가에 대한 의문이 있었으며 현재에서 이런 의문점을 개선하기 위하여 TC57위원회에서는 지속적인 모델 수정 및 정비 작업을 수행하였다. 실제로 현재에도 전력품질에 대한 logical node가 'Q'그룹으로 새롭게 제시되고 있고 풍력발전이나 분산전원에 대한 logical node가 추가되거나 기존의 IEC61850-7-4의 내용이 수정되고 있는 실정이다. 본 연구는 이와 같이 변전설비 자동화에 필요하지만 IEC TC57에서 표준화되지 않은 온라인 GIS 예방진단용 설비에 대한 표준모델을 제시하였고 모델에 대한 logical node나 CDC를 구성하였다.

• Journal of the Korea Safety Management & Science
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• v.3 no.3
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• pp.77-86
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• 2001

An operational strategy for inventory control on finished goods in the distribution system has been given attention to many enterprises and many studies regarding this field have been done and is also on-going currently. Many of these studies represented a large scale distribution network with a unified formulation by using defined symbols. These methods have provided the systematic approach of the distribution network but they are impossible to applying the reality system due to not considering the service rate of demand and treating the shortage of inventory. In order to overcome these unrealistic problems, the novel safety stock policy of responding to customers' inventory distribution network is suggested. this paper explores the transportation between Central Distribution Center(CDC) and Regional Distribution Center(RDC). Especially, the relation of transportation cost between CDC and RDC and cost of inventory control according to safety inventory with service level are emphasized. We could obtain the good results of this study by determining the optimal safety stock considering the various variables and constraints.

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.11
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• pp.1096-1103
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• 2010

This paper proposes CDC (Continuous Damping Control) algorithm and verifies in multi-body dynamic vehicle. In order to distinguish a road profile on driving, waviness calculated by the filtered vertical-accelerations of sprung and unsprung masses is introduced. Sky-hook control is used at a low waviness road and constant damping level control is used at a high waviness road, where the hard damping level is determined by waviness, roll rate, acceleration, and deceleration. The damping levels of ride, anti-roll, anti-squat, and anti-dive modules are calculated by tuning parameters which is dependent upon vehicle velocity. Therefore this high tunable algorithm is useful to improve the ride and handling performance under various driving conditions. In the simulations, tire and dampers are modelled by SWIFT (Short Wavelength Intermediate Frequency Tire) model and 1st order delay model, and results are compared with conventional damper's.

• Journal of Microbiology
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• v.44 no.4
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• pp.457-460
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• 2006

A suspicious meningococcal meningitis death case was reported to the Beijing CDC. The blood specimen was analyzed via multi-PCR and MLST. 6 isolates from close contacts were analyzed via PFGE and MLST. According to the results of the above analyses, the cause of this case was identified as a serogroup A Neisseria meningitidis, which, in terms of sequence typing, belonged the ST7 group.