• 대한한의학회지
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• 제29권2호
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• pp.47-59
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• 2008

Object: Reactive gliosis that is induced by central nervous system (CNS) injury is involved with up-regulation of CD81 and GFAP. The present study was to examine the effect of the Salvia miltiorrhiza on CD81 and GFAP regulation following brain injury. Methods: Immunoblot and ELISA methods were used to define the level of CD81 and GFAP in the astrocyte cultured from rat brain. Then immunohistochemistry was used to detect CD81 and GFAP in the injured rat brain. Results: The following results were obtained. 1. We did western blot and ELISA to detect the protein isolated from the whole cell and they showed that CD81 and GFAP decreased. 2. We injected Salvia miltiorrhiza extract intravenously to brain-injured rats for 7 days and 30 days, and the immunohistochemistry analyses showed that CD81 and GFAP decreased significantly. Conclusion: These results indicate that Salvia miltiorrhiza could suppress the reactive gliosis, which disturbs the neural regeneration following CNS injury, by controlling the expression of CD81 and GFAP.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2221-2224
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• 2014

Objective: To explore the relationship between expressions of cell adhesion molecules CD44 v6 and E-cadherin (E-cad) and lymphatic metastasis in non-small cell lung cancer (NSCLC). Materials and Methods: Eightyseven tissue samples obtained from patients with primary NSCLC were collected in our hospital from Dec., 2007 to Dec., 2012, and the expressions of CD44 v6 and E-cad gene proteins in these samples were detected by immunohistochemical method. Results: In the tissue without lymphatic metastasis, the positive expression rate of CD44 v6 was significantly lower, whereas the normal expression rate of E-cad was notably higher than that with lymphatic metastasis (55.6% vs. 78.4%, 47.2% vs. 21.6%), and both differences had statistical significance (P<0.05). Besides, CD44 v6 and E-cad expressions had a significant correlation in the NSCLC tissue with lymphatic metastasis (P<0.05). Conclusions: The positive expression of CD44 v6 and abnormal expression of E-cad may play a very important role in promoting lymphatic metastasis of NSCLC, with synergistic effect. Hence, detection of CD44 v6 and E-cad expressions is conductive to judging the lymphatic metastasis in NSCLC.

• 대한수의학회지
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• 제36권3호
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• pp.635-646
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• 1996

To establish the effective ways to prevent bovine mastitis, the study has been performed to investigate the attributable factors causing down-regulation of immune responses in mammary gland of non-lactating cows. Lymphocytes from peripheral blood and mammary gland secretions(MGS) were obtained from normal healthy cows and mastitic cows, respectively. Cellular immune responses were examined by comparison of proportion of lymphocyte subpopulations using a set of monoclonal antibodies and flow cytometry. The results obtained are as follows. 1. Proportions of peripheral blood lymphocyte subpopulations expressing BoCD2 and BoCD4 molecules were 32.9%, 15.4% in mastitic cows and 43.3%, 28.3% in normal healthy cows, respectively. The ratios of BoCD4 to BoCD8 were 0.76 and 1.47, respectively. 2. Proportions of mammary gland lymphocyte subpopulations expressing BoCD2 and BoCD4 molecules were 18.5%, 8.3% in mastitic cows and 38.2%, 14.2% in normal healthy cows, respectively. The ratios of BoCD4 to BoCD8 were 0.6 and 2.0, respectively. 3. Proportions of T lymphocyte subpopulations from MGS were significantly lower than those from peripheral blood both in mastitic cows and normal healthy cows. However, lymphocyte subpopulations expressing ACT2 and ACT3, which represent activated T suppressor cells, were significantly higher in MGS than those in peripheral blood.

• 한국환경농학회지
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• 제12권2호
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• pp.105-111
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• 1993

경상북도 울진군 북면 덕구동과 칠곡군 동명면 덕명동에 소재한 2개 아연광산 인근 지역에서 채취한 토양과 야생식물체중의 Cd, Cu, Zn의 함량을 조사한 결과는 다음과 같다. 1. 생육기간에 따른 야생식물체중 중금속함량은 Cd는 다년생, 월년생, 1년생의 순위로, Cu는 1년생, 다년생, 월년생의 순위로 낮았으며, Zn은 다년생, 월년생, 1년생 모두 비슷하였다. 2. 중금속함량이 가장 높은 야생식물은 Cd의 경우 고비(다년생)였으며, Cu의 경우는 쇠뜨기(월년생), Zn의 경우는 고마리(1년생)이었지만, 조사된 식물체중 Cd, Cu, Zn 각 함량이 다 높았던 것은 고마리였다. 3. 야생식물의 과별 중금속함량은 Cd는 고사리과에서, Cu는 속새과에서, Zn는 마디풀과에서 가장 높았다. 4. 고마리와 망초의 식물체 부위별로 Cd 와 Zn의 함량은 잎, 줄기, 뿌리의 순위로 낮았는데 반하여, Cu는 뿌리, 잎, 줄기의 순위로 낮았다. 5. 토양중 Cd, Cu, Zn의 평균함량(범위)은 칠곡지역에선 1.27($0.45{\sim}2.75$)ppm, 12.04($3.00{\sim}33.20$)ppm, 64.28($8.14{\sim}209.79$)ppm 이었으며, 울진지역에선 3.30($0.50{\sim}9.52$)ppm, 72.93($47.75{\sim}118.35$)ppm, 194.04($41.37{\sim}520.96$)ppm이었다. 6. 토양중의 중금속(Cd, Cu, Zn 등) 함량과 식물체중 중금속 함량간에는 유의성은 없었으나, 정의 상관관계를 보였다. 7. 고비, 고마리, 쇠뜨기 등은 중금속(Cd, Cu, Zn)의 흡수력이 큰 야생식물로서 중금속 및 Zn 오염토양에서 중금속 제거에 효과가 클 것으로 사료된다.

• 제어로봇시스템학회논문지
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• 제5권1호
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• pp.47-53
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• 1999

CD-ROM(Compact Disk-Read Only Memory) is very attractive storage media because it has much storage space but is small size and portable. Optical pickup, one of the most important parts for reading data on a CD-ROM, is not produced tuned up. For the use of goods, we must tune up the optical pickup by adjusting the screw for adjustment. First, we developed analog servo system for optical pickup tuners. For eliminating some problems in analog servo system, this paper designed the modeling of digital servo system for optical pickup tuner. Though the characteristics of optical pickup are changed, the digital servo system for optical pickup tuner can easily apply to all pickup, and can reduce the measurement error among the optical pickup tuners. For the purpose of confirming the designed digital servo system, we produced data that specify the disk vibration and the disk eccentricity, and simulated servo system with MATLAB.

• 한국환경과학회지
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• 제7권1호
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• pp.46-51
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• 1998

The effects of aloe on the MDA(malondialdehyde) and the blood biochemical components of heavy metal poisoning in SD rat were examined and the following results were obtained. In rat liver homogenate intoxicated with $CdCl_2$, lipidperoxide was increased each 2.37times(24h), 3.31times(72h) but lipidperoxide In aloe administration groups was lower each 47% , 64% than in heavy metal group. In rat kidney homo- genate intoxicated with $CdCl_2$, lipidperoxide was increased 1.85times(24h), 1.33times(72h) but lipidperoxide in groups was almost the same as that of normal group. Lipidperoxide of kidney homogenate was slightly decreased as time passed. Also heavy metal poisoning rats showed high levels(1.38-2.50times) of serum AST, ALT and BUN. However. the administration of aloe significantly inhibited the reduction of them. These results suggest that Cd-induced hepatic and renal injury, via increase llpidpero)Ode and release of AST, ALT and BUN. Aloe may be used to inhibit or prevent the hepatic and renal toxicity which results from the heavy metal.

• 약학회지
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• 제47권4호
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• pp.200-205
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• 2003

The stability constants for the inclusion complexes between carboxymethyl-$\beta$-cyclodextrin (CM-$\beta$-CD) and five $\beta$-blockers, such as atenolol (ATE), bisoprolol (BIS), metoprolol (MET), pindolol (PIN) and propranolol (PRO) were determined by capillary electrophoresis. The magnitude of stability was decreased as following order; PRO＞MET＞BIS＞ATE＞PIN. Among them PRO showed the highest affinity towards CM-$\beta$-CD with stability constants of 383 and 371 $M^{-l}$ for (R)- and (S)-enantiomer, respectively. PIN enantiomers showed the lowest stability towards CM-$\beta$-CD, while the selectivity between (R)- and (S)-enantiomer was higher than any other tested $\beta$-blocker.r.

• Nuclear Engineering and Technology
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• 제54권11호
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• pp.4215-4219
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• 2022

The Cd_0.95Mn_0.05Te_0.98Se_0.02 (CMTS) ingot was grown by the vertical Bridgman technique at low pressure. All wafers showed high resistivity, which suggests potential as a room-temperature semiconductor detector. The resistivity of the CMTS planar detector was 1.47 × 10¹⁰ Ω·cm and mobility lifetime product of electrons was 1.29 × 10^-3 cm²/V. The spectroscopic property with Am-241 and Co-57 was evaluated. The energy resolution about 59.5 keV gamma-ray of Am-241 was 11% and the photo-peak of 122 keV gamma-ray from Co-57 was clearly distinguished. The result shows the first detector-grade CMTS in the world and proves CMTS's potential as a radiation detector operating at room temperature.

• 자원환경지질
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• 제47권4호
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• pp.405-420
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• 2014

도심환경의 인위적 오염원에 의한 토양오염과 대기오염의 특성을 파악하기 위하여 서울지역 가로수의 플라타너스 잎과 토양을 격자형으로 52개의 지역에서 시료채취 및 중금속원소 함량을 측정하였다. 비교 대조를 위하여 비교적 오염이 적을 것으로 예상되는 충청남도 예산에 전원지역에서 2개 지점의 시료를 분석하였다. 서울시 토양 내 중금속 함량을 지역별로 측정한 결과, Cd, Co, Cr, Ni은 산업지역에서, Cu, Zn, Pb는 교통량 밀집지역에서 높았고, 도심 내 전원지역은 비교 대조지역보다 높은 중금속 함량을 보였다. 플라타너스 잎의 세척 전과 후의 차이는 Cd, Cu, Pb, Zn가 교통량 밀집지역에서 높았다. 토양은 Cd-Co, Cr-Ni, Cu-Zn, Pb-Zn는 상관계수 값이 0.8이상으로 양의 상관성을 보여 이들 원소간의 배출원은 유사하고, 플라타너스 잎은 Pb-Cu, Cu-Zn 원소간 상관성이 높았다. 플라타너스 잎의 중금속 조성이 토양으로부터 기인되는지를 확인하기 위해 토양과 세척한 잎과의 관계를 분석한 결과, Cr, Cu, Pb, Zn는 양의 상관성을 보였고, 반면 Cd, Co, Fe, Mn, Ni은 이들의 상관성이 낮은 것으로 보여 이들 원소들은 대기로부터 기인된 것으로 생각된다. 서울지역의 중금속 원소 분산을 등함량도의 원소별 패턴을 분석한 결과, 토양은 산업지역에서 Ni, Cr원소와 교통량 밀집지역에서 Cd, Cu, Zn원소의 오염도가 크고, 세척하지 않은 잎에 대한 Cd-Pb, Cu-Zn의 오염양상이 유사한 것으로 나타났다. 대기 중 부유된 원소별 부화지수 값을 예측을 위해 가로수 잎의 원소별 부화지수 값을 분석한 결과, Cu, Zn, Pb, Mn, Co, Ni, Cd, Cr 순으로 높았으며, 특히 서울지역에서는 Cu, Zn, Pb, Mn 으로 인한 오염이 심각한 것으로 판단된다.

• 한국지하수토양환경학회지:지하수토양환경
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• 제17권2호
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• pp.47-53
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• 2012

In this study, the adsorption of $Cu^{2+}$ and $Cd^{2+}$ from aqueous solution on the biochar derived from used coffee grounds at different pyrolysis temperatures has been investigated as a potential low-cost treatment method for heavy metal-containing waters. Three biochar samples prepared by heating coffee sludge at temperature of $300^{\circ}C$ (B300), $500^{\circ}C$ (B500), and $700^{\circ}C$ (B700) were tested for the adsorption capacity and kinetics of Cd and Cu. Also the influencing factor of heavy metal removal by ion exchange in terms of cation exchange capacity (CEC) of each biochar was measured. Adsorption of Ca and Cu by biochar produced at higher pyrolysis temperature showed higher adsorption capacity but the optimal pyrolysis temperature based on performance and economy was known as $500^{\circ}C$. Sorption of Cu and Cd by biochar followed a Langmuir model at pH 6~6.5, attributing mainly to surface sorption. The biochar was more effective in Cu and Cd sorption than activated carbon (AC), with BC 500 being the most effective, which indicates that sorption of Cd and Cu by coffee sludge biochar is partly influenced by chemical sorption on surface functional group as well as physical sorption.