• 한국식품위생안전성학회지
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• 제26권3호
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• pp.266-272
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• 2011

The safety of liquid-type herbal preparations (47 samples) and beverages containing herbal medicines (18 samples), which are distributed in Gyeonggi province was studied by analyzing heavy metals, benzo(a)pyrene, preservatives and sugar content and to explain the differences between medicine and food based on the labeling standards. The herbal preparation is regarded as medicine and can be differentiated from the beverages containing herbal medicine, which is food, based on the fact that the herbal preparation should be labeled with usage, dosage, efficiency and effect. The mean concentrations of Pb, As, Cd, Hg were found to be 0.014 mg/kg, 0.113 mg/kg, 0.004 mg/kg and 0.003 mg/kg in herbal preparation and 0.009 mg/kg, 0.122 mg/kg, 0.003 mg/kg and 0.002 mg/kg in beverages containing herbal medicines, respectively. In 10 cases of herbal preparations and 6 cases of beverages containing Rehmanniae Radix Preparata (Sukjihwang), benzo(a)pyrene was not found. According to preservative test on herbal medicine, dehydroacetic acid was found less than the indicated content in 6 cases out of 37 cases, which labeled with preservatives, and benzoic acid, dehydroacetic acid and methylparaben were contained with 164.0~198.0 mg/kg, 149.8~272.5 mg/kg and 88.4 mg/kg, respectively, in 3 cases out of 10 cases, which was not labeled with preservatives. Among 16 cases of beverages containing herbal medicines, 3 cases of preservative-labeled beverages had the preservatives, and the rest of all, which was not labeled with preservatives, did not show that they contain any preservative, therefore, it was suitable for the labeling standards. As a result of sugar content test, preservative-labeled products were not appreciably different from the others.

• Restorative Dentistry and Endodontics
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• 제16권2호
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• pp.155-164
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• 1991

The purpose of this study was to evaluate the effects of bleaching agent through the dentinal tubules of cervical area in the intracoronal bleaching of pulpless teeth on cutured fibroblast cells. Extracted human incisors were enlarged to # 40 K-file and obturated with gutta-perella and AH 26 sealer. The gutta-percha was removed to 2mm below the cementoenamel junction of the root The teeth were divided into 3 experimental and control groups. Experimental groups; Experimental group 1: Temporary inlay wax filld with 30% $H_2O_2$ in pulp cavity. Experimental group 2: Temporary inlay wax filld with 30% $H_2O_2$ in pulp cavity after placement of ZOE cement to cementoenamel junction. Experimental group 3: Temporary inlay wax filld with 30% $H_2O_2$ in pulp cavity after application of Copalite to cementoenamel junction. Control group: Temporary inlay wax filled without 30% $H_2O_2$ in pulp cavity under the same condition at each experimental group. Each tooth was immersed in well of multidish cultured fibroblast cell for 48 hours. The cellular multiplication and cell viability were calculated at the interval of 1, 3, 5. 7 hours and the morphological changes in well were observed and their photographs were taken with inverted microscope. The obtained results were as follows : CD The cellurar multiplicaton and cell viability decreased in all experimental groups at 1 hour after experiment and the morphology of fibroblast cell was changed from star shape to round (2) The cell viability was lowered to 34 % in experemental group 1, 44 % in experimental group 2, and 38 % in experemental group 3 at 3 hours after experiment (3) The cell multiplication was decreased to 54% in experemental group 1. 47% in experimental group 2, and 40% in experemental group 3 at 7 hours after experiment. (4) The decrease of cell number and morphological changes of fibroblast cell were remarkable in experimental group 1, group 3 and 2 in order. These results suggest that the fibroblast cells receive severe damage by 30% $H_2O_2$ solution leaked through the dentinal tubules and the dentinal tubules are able to be obturated better by ZOE cement than by Copalite.

• 한국산학기술학회논문지
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• 제18권8호
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• pp.41-47
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• 2017

새로운 기술의 도입과 정교함이 더해진 최근의 지상무기가 지능형 포탄의 발달로 이어졌으며 주요 선진국의 관심을 이끌었다. 본 연구에서는 회전운동을 하는 비행체에 대한 공력 데이터를 확보하기 위해 BLU-103 모델을 통한 전산유체역학해석을 수행하였다. 먼저 회전하는 비행체의 정상해석 기법을 모사하기 위해 동체는 고정시키고 주변의 공기를 회전시켜 동체가 회전 하는 것과 같은 원리를 이용하였다. 회전운동 하는 비행체의 공력 타당성을 검토하기 위해 단순형상에 대해 받음각 0도에서 90도, 옆 미끄럼각 0도에서 90도까지 각각 30도 간격으로 고려하여 해석을 수행하였다. Drag book에 제시되어 있는 항력 값을 통해 단순모델에 대한 항력계수가 1.0 ~ 1.2의 정량적 결과를 만족한다는 사실을 확인하였다. 단순형상에서의 해석조건을 통해 검증 된 유효한 입력 값을 동일하게 실제형상에 적용하여 회전 유무에 따른 공력데이터베이스를 구축하였고 경향성을 분석하였다. 분석 결과 단순모델 뿐 아니라 실제 모델의 회전 시 축력계수, 수직력 계수, 측력 계수가 증가한다는 사실을 확인 하였고 특히 수직력 계수의 영향이 크게 작용되어 비행에 유리할 것이라 판단하였다.

• 대한한방부인과학회지
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• 제24권3호
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• pp.28-47
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• 2011

Objectives: This study was performed to investigate the effects of Angelicae gigantis Radix (AGR) which is one of the most useful herbal-drug to treat patients with Polycystic Ovary Syndrome (PCOS) in Oriental medicine on gene expression of ovary tissue. Methods: The effects of AGR on gene expression of ovary tissue resected from PCOS induced rats using single injection of $\ss$-Estradiol 17-valerate (EV) was measured using microarray technique, and the functional analysis on these genes was conducted. Results: Total 2,812 genes were up-regulated or down-regulated, 1,421 genes were up-regulated, 1,391 genes were down-regulated by induction of PCOS. Up-regulated genes were mainly involved in biological function such as cell signalling pathways and inflammatory response. Expression levels of 1,442 genes were restored to those of naive animals by administration of AGR. 558 genes were restored to those of naive animals, which were lowered by induction of PCOS. 884 genes were lowered to naive levels, which were elevated by induction of PCOS. The functions of restored genes were partially involved in the restoration of expression levels, which were changed by induction of PCOS. Especially, up-regulated gene by induction of PCOS were mainly involved in these changes. These results mean restorative effects of AGR on damaged functions by induction of PCOS. The network of total protein interactions was measured using cytoscape program, and some key molecules, such as IRS2, MCM10, ORC2L related in up-regulated genes, CTBP2, CD44, RHOA, related in down-regulated genes that can be used for elucidation of therapeutical mechanism of medicine in future were identified. Conclusion: Restored genes by AGR were thought to have common pathways related in regulation of gene expressions. Especially, genes in restored expression levels by AGR, which were up-regulated by induction of PCOS, were regulated by 9 of common transcription factors, genes in restored expression levels by AGR, which were down-regulated by induction of PCOS, were involved in 25 of common transcription factors.

• Tuberculosis and Respiratory Diseases
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• 제47권5호
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• pp.691-696
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• 1999

건강검진시 촬영한 단순흉부사진에서 우연히 발견된 다발성 결절로 내원한 34세 여자 환자에서 개흉술을 통한 조직검사상 미분화 혈관분화를 보이고 면역조직 화학염색상 제 VIII 인자-관련인자, CD34 와 vimentin에 양성반응을 보여 EH로 확진 되었던 1예를 경험하였기에 보고하는 바이다.

• 한국수산과학회지
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• 제39권2호
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• pp.106-117
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• 2006

We measured the concentrations of organic matter and metallic elements (Al, Fe, Cr, Mn, Ni, Cu, Zn, As, Cd, Pb and Hg) in the surface sediments of Masan Harbor (in the southern sea, Korea) to evaluate the geochemical characters of sediment and the pollutions by organic matter and metallic elements. The mean grain size of the surface sediments in the study area ranged from $5.6{\phi}$ to $7.8{\phi}$, indicating silt sediment. The water content of the surface sediments exceeded 60% except at some stations. The contents of ignition loss (IL), total organic carbon (TOC) and total nitrogen (TN) ranged from 7.2-14.3%, 1.2-3.2%, and 0.10-0.28%, respectively. Based on the C/N ratios, the organic matter in the surface sediments of Masan Harbor may originate from terrigenous sources including fluvial inputs (mainly sewage in urban areas). The chemical oxygen demand (COD) and acid volatile sulfide (AVS) ranged from $11.3-29.9\;mgO_2/g\;dry$ and 0.20-4.47 mgS/g dry, respectively, and low concentrations were observed near a shipping route. In addition, the concentrations of metallic elements showed large spatial variations in Masan Harbor and the distributions of metallic elements were also comparable to those of organic matter. This implies that the distributions of organic matter and metallic elements in the surface sediments of Masan Harbor are mainly controlled by biogenic matter and artificial action (mainly dredging). In addition, we calculated the enrichment facto. (EF) and geoaccumulation index (Igeo) in order to evaluate pollution by metallic elements. The enrichment of metallic elements relative to Al was three to eighteen times higher at the study sites, compared to levels in the Earth's crust except for Fe, Ni and Mn. In addition, the Igeo class indicated that the surface sediments in the study area were moderately to strongly polluted in terms of metallic elements.

• 한국보건간호학회지
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• 제16권1호
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• pp.45-63
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• 2002

The purpose of this study is to understand the current status of high school students' exposure to pornographic materials as well as to provide basic data to develop sex education programs. This study was conducted through a self-administered questionnaire survey of 774 students of six high schools in Seoul, three boys' and three girls' respectively, from August 22 to August 25, 2000. This study shows that high school students' exposure to pornographic materials such as CD-ROMs, internet, video tapes and adult movies has become very serious. The results of this study are as follows. 1. Among the students surveyed, $23.5\%$ of them currently has opposite-sex friends, while $42.2\%$ used to have and $34.2\%$ has never had opposite-sex friends. 2. $55.3\%$ of the students pick up their sexual knowledge from their friends, followed by mass media $(47.5\%),\;school (21.1\%),\;adult\; magazines (17.1\%)\;, internet (14.1\%)$, pornography visual $materials (11.5\%),\; sexual\; books (3.6\%)$ and pornography printed $materials (2.4\%).$ 3. Regarding the frequency of sexual education taken in school, $54.2\%$ of the students answered 'often', while $37.6\%$ answered 'almost none', 'several times' $(4.4\%)$, 'never' $(2.9\%)$ and 'frequently' $(0.9\%)$, respectively. Regarding sexual education at home, $42.2\%$ answered 'almost none', followed by 'never' $(36.3\%)$, 'often' $(16.3\%)$, 'several times' $(3.3\%)$ and 'frequently' $(1.8\%)$, respectively. 4. $68.2\%$ of the students have been exposed to adult movies, followed by pornography videos $(60.1\%)$, internet chatting $(50.2\%)$ and pornography computer diskettes $(38.0\%)$. 5. The degree of exposure to pornographic materials of boy students is much higher than that of girl students. 6. It appears that there is an interrelation between the kind of schools and the degree of the students' exposure to pornographic materials. 7. The higher the students' grade is. the more they have been exposed to pornographic materials. 8. It shows that there is an interrelation between the students' academic performance and the degree of their exposure to pornographic materials. 9. There is also an interrelation between the amount of students' pocket money and the degree of their exposure to pornographic materials. 10. There is an interrelation between the degree of their adaptation to school life and the degree of their exposure to pornographic materials. 11. It appears that there is an interrelation between their parents' relations with them and the degree of the students' exposure to pornographic materials. 12. There is a significant difference in the degree of their exposure to pornographic materials in accordance with their residential area. 13. There is also a significant difference in the degree of their exposure to pornographic materials in accordance with the average income of their families. 14. There is also a significant difference in the degree of their exposure to pornographic materials in accordance with the mean sexual education at home.

• Journal of Gastric Cancer
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• 제6권1호
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• pp.47-51
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• 2006

위에서 생기는 점막하 종양은 내시경적 조직검사로는 그 기원을 알기 어려운 경우가 많다. 이러한 점막하 종양 중, 슈반 세포(Schwann cell)로부터 분화하여 생기는 종양을 신경초종(Schwannoma)이라고 하며, 위에서 생기는 전체 종양의 0.2%를 차지한다고 알려져 있다. 이 증례는 2개월 전부터 시작된 다량의 흑색변과 빈혈을 주소로 내원한 57세 여자 환자에 대한 보고이다. 복부 컴퓨터 단층 촬영 및 상부 위장관 내시경에서 위 분문에서 3 cm정도 아래부터 위각 직상부까지 위체부 소만을 대부분 차지하는 약 8 cm 이상의 돌출된 종양이 관찰되었고, 수 차례에 걸친 내시경적 조직검사를 시행하였으나 괴사조직과 육아종성 조직, 만성 위염 소견만 반복해서 나왔다. 출혈을 동반한 진행성 위암, 림프종 등을 생각하여 정확한 진단 및 출혈에 대한 치료를 위해 수술을 시행하였다. 술 후 조직검사에서 전반적으로 소엽상 형태(lobulating pattern)로 주변에 림프구 침윤(lymphocyte cuffing)이 있었고 책상핵(palisading nuclei), 방추세포(spindle-cell) 등이 보였다. C-kit, CD34, SMA 모두 음성이었으며 S-100 양성으로 신경초종으로 진단되었다.

• 한국토양비료학회지
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• 제43권3호
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• pp.268-274
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• 2010

전북지역 밭 토양의 화학적 특성은 150개 지점, 물리적 특성은 84개 지점에 대하여 토양의 물리화학적 특성을 조사하였다. 화학적 특성 조사지역의 지형분포는 곡간 및 선상지 (34.7%), 구릉 및 산악지 (18.7%), 산록경사지 (20.0%), 하성평탄지 (14.0%), 홍적대지 (8.0%) 및 하해혼성평탄지 (4.6%)로 나타났다. 물리적 특성인 토성은 사양토, 사질식양토, 식양토, 식토로 구성되어 있었고 사질식양토가 모든 지형에 고르게 분포하였고, 모든 조사지점의 경사도는 최적조건 (0~15%)을 보였다. 지형별 용적밀도는 1.19~1.24 Mg $m^{-3}$이었고, 경도는 12.1~13.9 mm이었다. 지형에 관계없이 밭 토양의 화학성인 pH는 37.3%, 유기물함량 42.7%, EC는 93.0%가 적정수준이었지만, 유효인산함량은 42.7%, 치환성 K는 64.0%, Ca은 47.3%, Mg은 48.7%가 적정수준 이상이었다. 토양 pH는 하해혼성평탄지를 제외하고 pH 5.9~6.1 수준이었고, 유기물함량은 산록경사지에서 20.6 g $kg^{-1}$로 가장 높았다. 유효인산은 하해혼성평탄지를 제외하고 534~739 mg $kg^{-1}$이었고, 치환성 K는 홍적대지에서 1.28 $cmol_c\;kg^{-1}$로 가장 높았고, Ca은 하해혼성평탄지와 홍적대지에서 각각 3.79와 4.9 $cmol_c\;kg^{-1}$로 낮았지만, Mg은 지형별로 차이가 없었다. 한편 CEC는 하해혼성평탄지를 제외하고 10.4~10.9 $cmol_c\;kg^{-1}$ 수준을 보였다. 지형별 중금속함량은 토양오염우려기준보다 훨씬 낮은 수준으로 전북지역 밭 토양은 안전한 것으로 조사되었다.

• 정신신체의학
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• 제28권1호
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• pp.20-28
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• 2020

연구목적 본 연구에서는 FGID 환자군, FGID양성군 및 정상대조군에서 정신사회적 특성을 비교하고, 기능성위장질환 환자의 삶의 질에 영향을 주는 요인을 알아보고자 하였다. 방 법 원광대학교병원 소화기 내과 전문의에 의해 기능성위장질환으로 진단받은 환자135명을 FGID 환자군으로 선정하였다. 167명의 일 도 지역 공무원을 대상으로 로마 III 진단 기준에 따라 기능성위장증상을 보이지 않는 79명을 정상대조군, 기능성위장증상을 나타내는 88명은 FGID 양성군으로 선별하였다. 인구통계학적 요인을 조사하였으며 정신사회적 요인을 평가하기 위해 Korean version of the Beck Depression Inventory-II (K-BDI-II), Korean version of the Beck Anxiety Inventory (K-BAI), Korean version of Childhood Trauma Questionnaire (CTQ-K), Multi-dimensional Scale of Perceived Social Support (MSPSS), Korean Version of Connor-Davidson Resilience Scale (K-CD-RISC), Patient Health Questionnaire-15 (PHQ-15), World Health Organization Quality of Life Assessment Instrument Brief Form (WHOQOL-BREF)를 사용하였다. 일원배치 분산분석(one-way ANOVA)을 사용하여 집단들 간의 차이를 비교하고 FGID 환자군의 삶의 질과 정신사회적 요인들의 상관관계를 분석하기 위해 Pearson correlation test를 시행하였다. FGID 환자군의 삶의 질에 영향을 미치는 요인들을 알아보기 위해 위계적 회귀분석(Hierarchical regression analysis)을 시행하였다. 결 과 우울 증상(F=48.75, p<0.001), 불안(F=14.48, p<0.001), 아동기 트라우마(F=12.71, p<0.001) 및 신체화(F=24.42, p<0.001)에서 FGID 환자군이 다른 두 그룹에 비해 유의하게 점수가 높았다. 사회적지지(F=39.95, p<0.001)와 회복탄력성(F=17.51, p<0.001) 및 삶의 질(F=52.14, p<0.001)에서 FGID 환자군이 다른 두 그룹에 비해 유의하게 점수가 낮았다. Model 2에서는 Model 1에 심리적 변인들을 추가했으며 회복탄력성(β=0.373, p<0.01)이 가장 중요한 설명 변인이었다. 최종 회귀 모델의 설명 변량은 47.2%였다. 결 론 FGID 환자군은 FGID 양성군 및 정상대조군에 비해 우울 증상, 불안과 아동기 트라우마, 신체화가 유의하게 높았으며 사회적지지 및 회복탄력성, 삶의 질이 낮았다. FGID 환자군의 삶의 질에 주요한 요인은 회복탄력성이었다.