• Title/Summary/Keyword: CD19+

Search Result 754, Processing Time 0.024 seconds

Predicting residual moment capacity of thermally insulated RC beams exposed to fire using artificial neural networks

  • Erdem, Hakan
    • Computers and Concrete
    • /
    • v.19 no.6
    • /
    • pp.711-716
    • /
    • 2017
  • This paper presents a method using artificial neural networks (ANNs) to predict the residual moment capacity of thermally insulated reinforced concrete (RC) beams exposed to fire. The use of heat resistant insulation material protects concrete beams against the harmful effects of fire. If it is desired to calculate the residual moment capacity of the beams in this state, the determination of the moment capacity of thermally insulated beams exposed to fire involves several consecutive calculations, which is significantly easier when ANNs are used. Beam width, beam effective depth, fire duration, concrete compressive and steel tensile strength, steel area, thermal conductivity of insulation material can influence behavior of RC beams exposed to high temperatures. In this study, a finite difference method was used to calculate the temperature distribution in a cross section of the beam, and temperature distribution, reduction mechanical properties of concrete and reinforcing steel and moment capacity were calculated using existing relations in literature. Data was generated for 336 beams with different beam width ($b_w$), beam account height (h), fire duration (t), mechanical properties of concrete ($f_{cd}$) and reinforcing steel ($f_{yd}$), steel area ($A_s$), insulation material thermal conductivity (kinsulation). Five input parameters ($b_w$, h, $f_{cd}$, $f_{yd}$, $A_s$ and $k_{insulation}$) were used in the ANN to estimate the moment capacity ($M_r$). The trained model allowed the investigation of the effects on the moment capacity of the insulation material and the results indicated that the use of insulation materials with the smallest value of the thermal conductivities used in calculations is effective in protecting the RC beam against fire.

Effects of Rituximab Including Long-term Maintenance Therapy in Children with Nephrotic Syndrome in a Single Center of Korea

  • Kim, Seong Heon;Lim, Taek Jin;Song, Ji Yeon;Kim, Su Young
    • Childhood Kidney Diseases
    • /
    • v.22 no.1
    • /
    • pp.1-6
    • /
    • 2018
  • Rituximab (RTX) is a chimeric monoclonal antibody that inhibits CD20-mediated B-cell proliferation and differentiation. Several studies have examined its use in intractable nephrotic syndrome (NS) with some positive results. However, those studies examined such effects for a short-term period of 1 year, and some patients continued to relapse after a lapse in RTX treatment. Our use of RTX as a maintenance therapy (RTX injection when the CD19 cell count exceeded $100-200/{\mu}L$ before relapse) showed some noticeable efficacy. We used RTX in 19 patients with steroid-dependent NS (SDNS). In 12 patients treated with RTX maintenance therapy, only one relapse occurred. The mean treatment period was $23.4{\pm}12.7months$, and the mean number of RTX administrations was $3.9{\pm}1.6$. The relapse rates were decreased (from 2.68/year to 0.04/year), and the drug-free period also increased (from 22.5 days/year to 357.1 days/year) during maintenance therapy. The other seven patients were treated with one cycle of RTX or additional cycles in case of relapse (non-maintenance therapy). Relapse rates were significantly decreased after RTX treatment (from 1.76/year to 0.96/year, P=0.017). The relapse-free period was $15.55{\pm}7.38$ (range, 5.3-30.7) months. No severe side effects of RTX were found except for a hypersensitivity reaction such as fever and chills during its infusion. In conclusion, RTX is considered an effective and safe option to reduce the relapse rate by a single- or maintenance-interval therapy in SDNS.

Analysis of mine tailings, soils, stream sediments and ground water around Imcheon disused mine (임천광산 광미와 주변 토양 및 지하수의 오염조사)

  • 김선태;윤양희;박제안;심의섭;박경수
    • Journal of Korea Soil Environment Society
    • /
    • v.3 no.3
    • /
    • pp.33-44
    • /
    • 1998
  • Mine tailings, soils, stream sediments, and ground water around Imcheon disused mine were analyzed in order to investigate their pollution levels of heavy metals and cyanide. The average contents of As, Cd, Cu, Hg, Pb, Zn, and CN ̄ in mine tailings were 366, 28.8, 202, 15.2, 1.97$\times$$10^3$, 3.85$\times$$10^3$, 90.6mg/kg respectively, The pollution indices that calculated by the tolerance level of Kloke were 8~19 and the pH values were acidic in mine tailngs. In the field and paddy soils of Imcheon disused mine area except for soils nearby mine tailngs, concentraitons of the heavy metals were less than standards of soil pollution of agricultral area in the environmental protection law. The nitrate contents In the ground water for drink were more than tolerance level of the drinking water of Ministry of Health and Social Affairs.

  • PDF

Socioeconomic Impacts of Gluten-Free Diet among Saudi Children with Celiac Disease

  • Sarkhy, Ahmed;El Mouzan, Mohammad I.;Saeed, Elshazaly;Alanazi, Aziz;Alghamdi, Sharifa;Anil, Shirin;Assiri, Asaad
    • Pediatric Gastroenterology, Hepatology & Nutrition
    • /
    • v.19 no.3
    • /
    • pp.162-167
    • /
    • 2016
  • Purpose: To determine the socio-economic impact of gluten free diet (GFD) on Saudi children and their families Methods: A cross-sectional study was conducted in which an online questionnaire was sent to all families registered in the Saudi celiac patients support group. We included only children (age 18 years of age and younger) with biopsy-confirmed celiac disease (CD). Results: A total of 113 children were included in the final analysis, the median age was 9.9 years; 62.8% were females. One hundred (88.5%) of the participating families reported that GFD food was not easily available in their areas, 17% of them reported that it was not available at all in their area. One hundred and six (93.8%) reported that the price of GFD food was very expensive and 70 (61.9%) families that the diet was heavily affecting their family budget. Significant social difficulties were reported among the participating families and their children including interference with the child's interaction with other children (49.6%), the families' ability to attend social gatherings (60.2%), the families' ability to eat in restaurants (73.5%), and the families' ability to travel (58.4%). Conclusion: There is significant negative socio-economic impact of GFD on children with CD & their families. Health care providers should be aware of these psycho-social difficulties and be well trained to provide a proper education and psychological support for these patients and their families.

A study on the identification of type IIa natural diamonds treated by the HPHT method (HPHT(고온고압)에 의해 처리된 type IIa 천연 다이아몬드의 감별에 관한 연구)

  • 김영출;최현민
    • Journal of the Korean Crystal Growth and Crystal Technology
    • /
    • v.14 no.1
    • /
    • pp.21-26
    • /
    • 2004
  • Results from PL and Raman spectroscopic analyses of HPHT (high-pressure high-temperature) treated type IIa diamonds are presented, and these spectral characteristics are compared with those of untreated diamonds of similar color and type. We identify a number of significant changes by 325 nm He/Cd laser excitation. Several peaks are removed completely, including H4, H3 system in HPHT treated diamond. The N3 system, however, increased in emission. Also we can find the behaviour of the nitrogen-vacancy related center N-V centers at 575 and 637.1 nm, as observed with 514 nm Ar ion laser excitation. When these centers are present, the FWHM (full width at half maximum) of 637.1 nm luminescence intensities offers a potential means of separating HPHT-treated from untreated type IIa diamonds. The width of 637.1 nm $(N-V)^-$line measured at the position oi half the peak's height are determine to range from 19.8 to $32.1cm^{-1}$ for HPHT treated diamonds.

Characteristics of Organic Electroluminescent Device Consisting of PDPMA LB Film as a Polymer Hole Transport Material and Alq$_3$ (고분자 정공 전달체로서 PDPMA LB 필름과 Alq$_3$로 구성되는 유기 발광소자의 특성)

  • 오세용;김형민;이창호;최정우;이희우
    • Polymer(Korea)
    • /
    • v.24 no.1
    • /
    • pp.90-96
    • /
    • 2000
  • Organic electroluminescent (EL) device was fabricated with Alq$_3$ as an emitting material and PDPMA ultra thin film prepared by Langmuir-Boldgett technique as a polymer hole transport layer. A stable condensed PDPMA monolayer was obtained using arachidic acid as a surface active material. The thickness and absorbance of PDPMA LB film increased line-arly with the layer numbers. The organic multilayered device consisted of ITO/PDPMA LB film (19 layers)/Alq$_3$/Al emitted green light with brightness of 2500 cd/m$^2$ at a DC 14 V Especially, the drive voltage of EL device having PDPMA LB film of 15 layers exhibited the value as low as 4 V. The effects of thickness control and molecular orientation in the PDPMA LB film on EL performance were discussed.

  • PDF

Comparison of Contrast Sensitivity Between Soft Contact Lens Wearers and Spectacle Wearers (콘택트렌즈와 안경 착용자의 대비감도 비교)

  • Kim, Jai-Min;Lee, Min-Ah
    • Journal of Korean Ophthalmic Optics Society
    • /
    • v.12 no.4
    • /
    • pp.119-125
    • /
    • 2007
  • The aim of the present study was to compare the contrast sensitivity of soft contact lens wearers, spectacle wearers or emmetropia. Seventy myopic eyes and thirty emmetropic eyes aged 19 to 26 years were collected. The myopic group included 48 eyes corrected with spectacle lenses and 22 eyes of them corrected with contact lenses, too: all had corrected vision acuity of 20/20 or better. Spatial contrast sensitivity was measured using the OPTEC 6500 contrast sensitivity view-in tester included the EyeView  Functional Vision Analysis software at photopic or mesoopic condition. There was no significant difference in contrast sensitivity between spectacle lenses and emmetropes. Myopes corrected with soft contact lenses showed statistical sensitivity losses at 1.5, 12 cycle/degree spatial frequencies. In conclusion, our findings suggest that loss of contrast sensitivity in soft contact lens wearers might be interpreted as evidence for corneal disruption before corneal pathological events occur in contact lens wearers. Contrast sensitivity testing appears to be a useful method for evaluating soft contact lenses.

  • PDF

Heavy Metal Contents In Tissues of Carassius auratus In Andong and Imha Reservoir (안동.임하호에 서식하는 붕어(Carassius auratus) 조직 내 중금속 함량)

  • Kim, Jeong-Sook;Shin, Myung-Ja;Lee, Jong-Eun;Seo, Eul-Won
    • Journal of Life Science
    • /
    • v.19 no.11
    • /
    • pp.1562-1567
    • /
    • 2009
  • Heavy metal contamination levels in Andong reservoir and Imha reservoir were measured with heavy metal contents in both water and sediment, and analyzed with heavy metal accumulation level in inhabitant fish, Carassius auratus, using an inductively coupled plasma spectrometer and an atomic absorption spectrometer. High levels of heavy metal contents in water, sediment and the tissues of C. auratus were detected. Likewise, relatively high levels of As were detected in water and sediment from Andong reservoir. In addition, higher levels of Cr, Cu, Cd and As content were detected in muscle and bone tissues of fish from Andong reservoir than those from Imha reservoir. As a result, the heavy metal content of water, sediment and inhabitant fish, C. auratus, in Andong reservoir was higher than Imha reservoir. We proposed that heavy metal contamination in water and inhabitant fish is attributed to various metals derived from abandoned mines and farmlands that are upstream of Andong reservoir.

Synthesis of New Nitrogen-Oxygen(N3O2) Pentadentate Ligands and the Substituent Effect on the Stability Constants of the Heavy(II) Metal Complexes (새로운 질소-산소(N3O2)계 다섯 자리 리간드의 합성과 중금속(II) 이온들의 착물 안정도상수에 대한 치환기효과)

  • Kim, Sun-Deuk;Lee, Hye-Won;Seol, Jong-Min
    • Journal of Environmental Science International
    • /
    • v.19 no.7
    • /
    • pp.849-860
    • /
    • 2010
  • A new $N_3O_2$ pentadentate ligand, N,N'-Bis(2-hydroxybenzyl)-ethylenetriamine(H-BHET 3HCl) was synthesized. The hydrochloric acid salts of Br-BHET 3HCl, Cl-BHET 3HCl, $CH_3O$-BHET 3HCl and $CH_3$-BHET 3HCl containing Br-, Cl-, H-, $CH_3O-$ and $CH_3-$ groups at the para-site of the phenol group of the H-BHEP were synthesized. The structures of the ligands were confirmed by C. H. N. atomic analysis and $^1H$ NMR, $^{13}C$ NMR, UV-visible and mass spectra. The calculated stepwise protonation constants(${\logK_n}^H$) of the synthesized $N_3O_2$ ligands showed six steps of the proton dissociation. The orders of the overall protonation constants($\log{\beta}_p$) of the ligands were Br-BHET < Cl-BHET < H-BHET < $CH_3O$-BHET < $CH_3$-BHET. The orders agreed well with that of para Hammett substituent constants(${\delta}_p$). The calculated stability constants($\logK_{ML}$) between the ligands and heavy metal ions (Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Pb(II)) agreed well with the order of the overall proton dissociation constants of the ligands but they showed a reverse order in para Hammestt substituent constants(${\delta}_p$). The order of the stability constants between the heavy metal ions with the synthesized ligands were Co(II) < Ni(II) < Cu(II) > Zn(II) > Cd(II) > Pb(II).

Residues of Heavy Metals and Organochlorine Pesticides in Ginseng at Environment of North Gyeongbuk (경북북부 인삼 재배환경 중 중금속과 유기염소계 농약의 잔류)

  • Park, Soo-Woon;Kim, Jung-Ho
    • Journal of Environmental Science International
    • /
    • v.19 no.10
    • /
    • pp.1203-1210
    • /
    • 2010
  • To obtain the risk assessment of hazardous materials in ginseng, the residues of heavy metals and organochlorine pesticides in samples on the Yeungju and Sangju are surveyed. Cd and Hg in ginseng on Yeungju and Sangju is not detected. 0.21 mg/kg of As, 0.39 mg/kg of Cr, 0.14 mg/kg of Pb, 1.83 mg/kg of Cu, 3.93 mg/kg of Zn and 0.43 mg/kg of Ni in ginseng on Sangju are shown. 0.25 mg/kg of Cr, 0.08 mg/kg of Pb, 1.11 mg/kg of Cu, 8.99 mg/kg of Zn and 1.15 mg/kg of Ni in ginseng on Yeungju are detected. As and Pb in ginseng on Sangju are 7.0% and 2.8% for Korea Food & Drug Administration(KFDA) advisory level, respectively. Pb in ginseng on Yeongju are 1.6% for Korea Food & Drug Administration(KFDA) advisory level. The heavy metals such as AS, Cr, Cd, Pb, Cu, Zn, Hg, Ni in soil on Yeongju and Sangju are range of 0-20% for with Korea Food & Drug Administration (KFDA) level. BHC isomer, DDT isomer and endosulfan isomer are not detected in ginseng and soil on Yeongju and Sangju, respectively. Finally, the assessment of hazardous materials of the heavy metals and organochlorine pesticides in ginseng on the Youngju and Sangju are verified the safety the level compare with tolerances level for Korea.