• Title/Summary/Keyword: CD structure

Search Result 785, Processing Time 0.036 seconds

Ig G fusion 단백질을 사용한 리간드-수용체의 상호작용

  • 천혜경
    • Proceedings of the Korean Society of Applied Pharmacology
    • /
    • 1994.11a
    • /
    • pp.143-145
    • /
    • 1994
  • Chimeric fusion proteins involving IgG have proven valuable in studying protein-protein interactions and may possess therapeutic applications as well. For example, three receptor subtypes for the natriuretic peptides, when fused to the Fc portion of human IgG ${\gamma}$ chain, were quantitatively and qualitatively indistinguishable from the native receptor, thus allowing detailed structure-function studies of the receptor. In an attempt to block human immunodeficiency virus infectivity with soluble derivatives of CD4, a CD4/IgG Fc chimeric molecule was shown to increase the plasma half life of soluble CD4 and possessed the added advantage of IgG Fc-mediated placental transfer. In the case of the KGFR, this approach provided a framework for dissection of its ligand binding domains and made it possible to demonstrate that high affinity binding sites for two ligands, aFGF and KGF, reside within different receptor Ig-like domains. Chimeric molecules fused to immunoglobulins would have the advantages of secretion from transfected cells as well as detection and purification from medium utilizing Staphylococcus aureus Protein A. In addition, where highly related receptors make their discrimination very hard due to the difficulties in generating specific immunochemical probes, IgG fusion protein with tailor-made specificities confers particular advantages to elucidate patterns of receptor distribution and expression. The approach described here may have general applications in defining ligand-receptor interactions as well as searching for specific agonists and antagonists of receptor function.

  • PDF

Study of Deep Blue Organic Light-Emitting Diodes Using Doped BCzVBi with Various Blue Host Materials

  • Kim, Tae-Gu;Oh, Hwan-Sool;Kim, You-Hyun;Kim, Woo-Young
    • Transactions on Electrical and Electronic Materials
    • /
    • v.11 no.2
    • /
    • pp.85-88
    • /
    • 2010
  • Deep blue organic light emitting diodes (OLEDs) were fabricated using 5 wt.% doped BCzVBi with various blue host materials such as NPB, DPVBi, MADN and TPBi. A blue OLED device, using DPVBi as host material, was constructed via NPB ($500\;{\AA}$) / DPVBi:BCzVBi ($200\;{\AA}$) / Bphen ($300\;{\AA}$) / LiF ($20\;{\AA}$) / Al ($1,000\;{\AA}$) and it shows a maximum luminescence of $4,838\;cd/m^2$, a current density of $32.7\;mA/cm^2$, a luminous efficiency of 3.3 cd/A and CIExy coordinates of (0.19, 0.15) at 4.5 V whereas the luminous efficiencies and CIExy coordinates of other blue OLEDs using NPB, MADN and TPBi as host materials have 1.1, 2.6 and 2.0 cd/A and (0.15, 0.11), (0.15, 0.10) and (0.15, 0.10), respectively. Energy transfer mechanisms between BCzVBi and its host materials were discussed with an energy band structure of host materials.

Polyplex Formation of Calf Thymus DNA with Branched and Linear Polyethyleneimine

  • Han, Jung-Ho;Kim, Seog K.;Cho, Tae-Sub;Lee, Jae-Cheol;Joung, Hyun-Sook
    • Macromolecular Research
    • /
    • v.12 no.5
    • /
    • pp.501-506
    • /
    • 2004
  • We have investigated the spectral properties of DNA, including its electric absorption, circular and linear dichroism (CD and LD), and fluorescence emission, in the DNA-linear polyethyleneimine (LPEI) and DNA-branched polyethyleneimine (BPEI) complexes at various polymer concentrations. The spectral properties of both complexes are similar. We observed a relatively moderate change in the absorption and CD spectra at low amine/DNA phosphate (NIP) ratios (< 0.5), followed by a drastic collapse within the N/P range from 0.8 and 1.0. The absorption and CD spectra recovered as the N/P ratio increased to ca. 1.2. In contrast, the LD and emission of ethidium intercalated between the DNA bases decreased almost linearly at N/P ratios between 0.0 and 1.0. These spectra never recovered at higher N/P ratios. We believe that the moderate changes in the spectrum at low N/P ratios occurred because of electrostatic interactions between DNA and BPEI, while the collapsed spectra at N/P ratios between 0.5 and 1.5 occurred because of condensation/aggregation of the DNA. Considering the structure of the polymers, we suggest that the secondary amino group of LPEI and all three amino groups of BPEI are equally involved in DNA condensation.

Investigation of Photocatalytic Activity with a Metal Doped TiO2 Nanotubular Electrode for Hydrogen Production (금속담지 된 수소제조용 TiO2 나노튜브 전극의 광활성 연구)

  • Lee, Jae-Min;Lee, Chang-Ha;Yoon, Jae-Kyung;Joo, Hyun-Ku
    • Transactions of the Korean hydrogen and new energy society
    • /
    • v.22 no.5
    • /
    • pp.656-662
    • /
    • 2011
  • The purpose of this study was to correlate between photoelectrochemcial hydrogen production rate and electron transfer with various types of metal doped $TiO_2$ nanotubes as photoanodes. In order to fabricate light sensitized photoanode, CdS, $WO_3$, and Pt were doped by electrodeposition method. As the results of experiments, the electron transfer was favorable from higher position to lower position of conduction band (CB). In consequence, the higher hydrogen production rate was as follows, CdS/$TiO_2$ (100 $umol/hr-cm^2$) > $WO_3/TiO_2$ (20 $umol/hr-cm^2$) > Pt/$TiO_2$ (10 $umol/hr-cm^2$). The surface characterizations exhibited that crystal structure, morphological and electrical properties of various metal depoed $TiO_2$ nanotubes by the results of SEM, TEM, XPS, and photocurrent measurements.

Structural, Optical, and Chemical Properties of Cadmium Phosphate Glasses

  • Chung, Jae-Yeop;Kim, Jong-Hwan;Choi, Su-Yeon;Park, Hyun-Joon;Hwang, Moon-Kyung;Jeong, Yoon-Ki;Ryu, Bong-Ki
    • Journal of the Korean Ceramic Society
    • /
    • v.52 no.2
    • /
    • pp.128-132
    • /
    • 2015
  • In this study, we prepared cadmium phosphate glasses with various compositions, given by $xCdO-(100-x)P_2O_5$ (x = 10-55 mol%), and analyzed their Fourier transform infrared spectra, dissolution rate, thermal expansion coefficient, glass transition temperature, glass softening temperature, and optical band gap. We found that the thermal expansion coefficient and dissolution rate increased while the glass transition temperature and glass softening temperature decreased with increasing CdO content. These results suggest that CdO acts as a network modifier in binary phosphate glass and weakens its structure.

A Study on the Injection Molding Technology by Micro Multi-Square Strucrure Mold (다중 미세 각주 구조물의 사출성형기술 연구)

  • 제태진;신보성;박순섭
    • Proceedings of the Korean Society of Precision Engineering Conference
    • /
    • 1997.10a
    • /
    • pp.1061-1064
    • /
    • 1997
  • Micro injection molding technology is very important fiw mass product of micro structures or micro parts. And, it is so difficult that the molding technology of micro pole or thin wall(barrier rib) structures with high aspect ratio. In this stud). \vc intend to research on the basic technology of micro wall structure part:< with high aspect ratio by the inject~on moldins method. The mold for esperimenrs with micro multi-square structures was made by L, I(;A process. One square polc's size is 157 157pm. height 50011111. And the distance of each poles is 5011n1. 7'hus. molding products will be for~nctl like as the net structure with thin wall of about 50pn thickness.(aspect ratio 10) Ihrough the e~lxriment. \be obtained the prociuctr of micro multi-square slructure with bout 37.000 cell per a piece. 'Ihe micro injection molding process technolog for thin wall by multi-square structure mold was analy~cd.

  • PDF

Structure of an Antimicrobial Peptide Buforin II

  • Yi, Gwan-Su;Park, Chan-Bae;Kim, Sun-Chang;Chaejoon Cheong
    • Proceedings of the Korean Biophysical Society Conference
    • /
    • 1996.07a
    • /
    • pp.29-29
    • /
    • 1996
  • The structure of an antimicrobial peptide buforin II has been studied by $^1$H NMR and CD spectroscopy. Buforin II is flexible and random structure in H$_2$O but the parts of buforin II become helical structure in trifluoroethanol (TFE)/H$_2$O (1:1, v/v) solution. From the restrained molecular dynamics calculation using NMR data, we obtained the possible conformation of buforin II in TFE/H$_2$O solution. (omitted)

  • PDF

EFFECT OF METAL CONTACT ON THE CZT DETECTOR PERFORMANCE

  • Park, Se-Hwan;Park, Hyung-Sik;Lee, Jae-Hyung;Kin, Han-Soo;Ha, Jang-Ho
    • Journal of Radiation Protection and Research
    • /
    • v.34 no.2
    • /
    • pp.65-68
    • /
    • 2009
  • Metal-semiconductor contact is very important for the operating property of semiconductor detector. $Cd_{0.96}$ $Zn_{0.04}$ Te semiconductor crystal was grown with Bridgman method, and the crystal was cut and polished. EPMA (Electron Probe Micro Analyzer) and ICP-MS (Inductively Coupled Plasma Mass Spectrometry) analysis were done to obtain the chemical composition and impurity of the crystal. Metal contact was deposited with thermal evaporator on both sides of the crystal. Detectors with Au/CZT/Au and In/CZT/Au structure were made, and I-V curve and the energy spectrum were measured with the detectors. It could be seen that the detector with the In/CZT/Au structure has superior property than the detector with Au/CZT/Au structure when the crystal resistivity was low. However, the metal contact structure effect becomes low when the crystal resistivity was high.

A Study on Powder Electroluminescent Device through Structure and Thickness Variation (구조 및 두께 변화에 따른 후막 전계 발광소자에 관한 연구)

  • 오주열;정병선;이종찬;박대희
    • Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
    • /
    • 1998.11a
    • /
    • pp.9-11
    • /
    • 1998
  • A phenomenon of electroluminescent radiate as electric field applied in the phosphor, in this paper, we produced the Powder Electroluminescent Device(PELD) which was changing the structure and the thickness of phosphor and insulator for realization of the PELD with high brightness. We made PELD with structure that is WK-1(ITO film/Phosphor/Insulator/Electrode), WK-2(ITO film/Phosphor/Insulator/Electro de), WK-3(ITO film/Phosphor/Insulator/Electrode), WK-4(ITO film/Phosphor+Insulator/ Electrode). The property of the produced PELD are analyzed by measuring the spectrum which electrical and optical property, the brightness and the transferred charge density. In this result, the structure of WK-4 have good luminescence property than others, it's effective thickness is 60${\mu}{\textrm}{m}$. At 100V 400Hz, High brightness of 2700cd/m2 was performed.

  • PDF

High Efficiency Red PHOLEDs with Organic Single Layer Structure

  • Jeon, Woo-Sik;Park, Tae-Jin;Yu, Jae-Hyung;Pode, Ramchandra;Jang, Jin;Kwon, Jang-Hyuk
    • 한국정보디스플레이학회:학술대회논문집
    • /
    • 2009.10a
    • /
    • pp.42-45
    • /
    • 2009
  • We report simple structure red phosphorescent devices comprising only single organic layer structure. Maximum current efficiency of 9.44 cd/A and the driving voltage of 5.4 V are obtained in this single layer structure PHOLEDs, respectively. The mixed host system using electron transporting and hole transporting materials doped with $Ir(piq)_3$ provides such high efficiency and reasonable driving voltage. The principal to simplification is the direct charges injection from the metallic electrodes into mixed host materials.

  • PDF