• 한국산학기술학회논문지
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• 제15권2호
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• pp.609-615
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• 2014

최근 글로벌 경기 침체로 인한 완성차 수요 급감으로 세계 자동차부품산업이 위기에 직면해 있다. 미국 자동차부품업체들은 2008년 4분기 이후 대규모 적자를 기록 중에 있으며, 고성장세를 유지하던 일본 및 유럽 부품업체들도 경영실적이 크게 악화되었다. 국내 자동차부품기업도 이러한 영향에서 벗어나기가 어려울 것으로 예상된다. 본 연구는 자동차부품 중소기업 중 상장된 25개의 업체를 대상으로 DEA분석기법을 활용하여 각 기업에 대한 상대적 효율성을 분석하였다. 효율성분석결과 CCR모델에서는 전체 25개 기업 중 6개 기업이 효율적인 것으로 나타났지만 기업의 규모를 고려한 효율성 분석인 BCC분석결과 12개 기업이 효율적으로 운영하는 것으로 나타났다. 그리고 25개의 자동차부품기업 중 효율성이 1인 기업이 DMU 1, 5, 7, 10, 18, 24로, 다른 자동차부품기업이 상대적으로 벤치마킹을 해야 할 대상은 DMU 1, 10, 24로 나타났다. 본 연구의 결과를 바탕으로 국내 자동차부품기업이 나가야 할 방향을 제시하고, 국내 자동차부품기업의 효율성을 실증적으로 분석하여 경영효율성을 제고함으로써 향후 자동차부품기업을 경영하는데 있어 매우 중요한 정보를 제공할 것으로 기대된다.

• 한국항만경제학회지
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• 제37권2호
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• pp.91-105
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• 2021

컨테이너선의 대형화 추이에 따라 일정 지역 내에 있는 항만 간에 컨테이너 화물을 유치하기 위한 경쟁이 치열해지고 있다. 결국, 컨테이너선의 기항 여부는 항만의 효율성과 직결되며, 항만의 효율성 분석은 항만 운영업자와 관리자의 의사결정에 영향을 미치는 강력한 경영 도구가 되며 항만 운영 계획을 수립하는데 유용한 정보를 제공한다. 본 연구는 지중해 지역에 있는 주요 컨테이너 항만들의 기술적 효율성을 조사하고 특정 요소가 컨테이너항만의 효율성에 어떤 영향을 미치는지 분석하는 데 목적이 있다. 비용 효율성은 CCR 모형과 BCC 모형을 사용하여 측정되었으며 주요 분석 대상은 지중해에 있는 7개국 12개 항만을 대상으로 하였다. 주요 항만은 발렌시아, 제노아, 암발리, 포트사이드, 알렉산드리아 등을 포함하고 있다. 본 연구는 지중해 지역에 있는 주요 항만의 효율성을 분석한 연구로써 의미가 있다. 또한, 연구 결과를 통해 어떤 변수에 주안점을 두어야 할지에 대한 기초 자료와 사전적 연구로서 의미가 있으며 또한 주요 해운항만 정책 입안자 또는 항만 운영업자 등의 효율적 의사결정에 유의미한 정보를 제공한다.

• 한국융합학회논문지
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• 제12권7호
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• pp.273-282
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• 2021

중국의 급속한 인구 고령화 상황에서 요양원은 노인요양을 제공하는 역할을 하고 있지만 요양원의 효율성에 대한 이해는 거의 없었다. 본 논문은 요양원의 효율성 향상전략을 제안할 목적으로 DEA 및 Malmquist 지수 분석을 활용하여 평가하였다. 효율성 평가지표는 병상의 수, 고정자산, 의료인원의 수를 투입변수로 하고, 자가간호 가능노인의 수, 부분간호 가능노인의 수, 와상노인의 수, 요양원의 수입을 산출변수로 하여, 계층화 분석결과 DEA-CCR에서는 베이징과 상하이가 조사기간 5개년동안 1.00의 결과를 나타냈고, DEA-BCC에서는 4개 지역(베이징, 장쑤, 산둥, 상하이)이 가장 높은 결과를 나타났다. Malmquist 지수(MPI)에서는 하이난이 가장 높은 것으로 나타났다. 효율성 평가 결과가 높은 성(省)의 요양원은 자원활용, 내부관리, 경영규모 등에서 효율적이고 기술 진보적인 반면, 효율성 평가가 낮은 지역의 요양원은 기술효율이 높아지는 특징을 보였다.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2008년도 International Meeting of the Microbiological Society of Korea
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• pp.62-64
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• 2008

A major hurdle to the development of RNA interference as therapy for HIV infection is the delivery of siRNA to T lymphocytes which are difficult cells to transfect even in vitro. We have employed a single chain antibody to the pan T cell surface antigen CD7 was conjugated to an oligo-9-arginine peptide (scFvCD7-9R) for T cell-specific siRNA delivery in NOD/SCIDIL2${\gamma}$-/- mice reconstituted with human peripheral blood lymphocytes (Hu-PBL). Using a novel delivery, we first show that scFvCD7-9R efficiently delivered CD4 siRNA into human T cells in vitro. In vivo administration to Hu-PBL mice resulted in reduced levels of surface CD4 expression on T cells. Mice infected with HIV-1 and treated on a weekly basis with scFvCD7-9R-siRNA complexes targeting a combination of viral genes and the host coreceptor molecule CCR5 successfully maintained CD4/CD3 T cell ratios up to 4 weeks after infection in contrast to control mice that displayed a marked reduction in CD4 T cell numbers. p24 antigen levels were undetectable in 3 of the 4 protected mice. scFvCD7-9R/antiviral siRNA treatment also helped maintain CD4 T cell numbers with reduced plasma viral loads in Hu-PBL mice reconstituted with PBMC from donors seropositive for HIV, indicating that this method can contain viral replication even in established HIV infections. Our results show that scFvCD7-9R could be further developed as a potential therapeutic for HIV-1 infection.

• 전기학회논문지
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• 제67권7호
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• pp.969-975
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• 2018

The purpose of this study is to develop a healthcare service based on standard protocol and information communication technology for mother's sustainable postpartum care. The developed service was consisted of a client area where mothers measure, manage and transmit their vital signs using their own smartphone and personal health devices, and a server area that manages and shares with the received mother's vital signs and the results of examination results and personal health records. The client area collects vital signs through the IEEE 11073 Personal Health Device (PHD) using the m-health application of the previous study and Continua Health alliance certified personal health devices and transfers to Health Level Seven (HL7) V2.4, Continuity of Care Record (CCR) and Continuity of Care Document (CCD). The server area consists of a mobile web that manages and shares the HL7 Fast Healthcare Interoperability Resources (FHIR)-compliant personal health records to ensure interoperability of examination results, and a mobile web where the postpartum caregiver enters and manages the results of the mother's examination results and provides it to the mother. In this way, the healthcare service of this study securing continued exchanges between the mother and postpartum caregiver improves the quality of life of the mother not only to satisfy the needs of the mother who was discharged but also through self-management and postpartum. In the future, we will conduct a study applying mothers and postpartum caregiver after approval of a clinical trail at a university hospital to evaluate developed healthcare services.

• 한방안이비인후피부과학회지
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• 제26권3호
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• pp.36-53
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• 2013

Objectives : The purpose of this study is to investigate the effects of DOGO phreatic water containing sulphur on Atopic Dermatitis in NC/Nga mouse. Methods : We made DOGO phreatic water removed sulphur using Twin Alternating Sulfate Eater. After making atopic dermatitis caused by sensitizing NC/Nga mouse to DNCB(dinitrochlorobenzene), we made mouse swim in tanks each filled with distilled water, tap water, DOGO phreatic water(contain sulphur), DOGO phreatic water(remove sulphur) for 30minutes everyday. 3weeks later, we analyzed skin clinical score, total IgE levels(by ELISA), WBC differential counting(Neutrophils, Monocytes), absolute cell number of $Neutrophil^+Gr-1^+$, CCR3 mRNA expressions(by Real-time PCR), IL-4, IFN-${\gamma}$ production levels(by ELISA), histologic test(by H&E staining, toluidine blue staining). Results : The results of making NC/Nga mouse induced atopic dermatitis swim in tanks filled with DOGO phreatic water(contain sulphur) are as follows. 1. Skin clinical scores were decreased significantly in comparison to control group. 2. Total IgG levels were decreased significantly in comparison to control group. 3. WBC differential counting(Neutrophils, Monocytes) were decreased significantly in c.mparison to control group. 4. Absolute cell number of $Neutrophil^+Gr-1^+$ were decreased significantly in comparison to control group. 5. CCR3 mRNA expressions were decreased significantly in comparison to control group. 6. IL-4, IFN-${\gamma}$ production levels were decreased significantly in comparison to control group. 7. The epithelial tissue thickness, leucocytes infiltration, erythema, edema, excoriation, scaling, mast cells infiltrations in dorsal skin were decreased in comparison to control group. Conclusions : These results indicate that DOGO phreatic water(contain sulphur) can be used for helping treat atopic dermatitis.

• Journal of Acupuncture Research
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• 제22권6호
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• pp.61-74
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• 2005

Objectives : The aim of this study was to investigate the effect of Asthma-depression and Immunoregulation with PR-HAS(Herbal-acupuncture with Platycodi Radix infusion solution) injection at Joksamni(St36) on ovalbumin-induced asthma in mice. Methods : C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week). The experimental group(OVA-PR-HA) wase treated with concentrations(1%) of PR-HAS at Joksamni(St36) for the later 8 weeks(3times/week). The second experimental group(OVA-Needle prick) was treated with Needle-Prick at Joksamni(St36) for the later 8 weeks(3times/week). Results : 1. The weight and total cells in the mice lung treated with PR-HA decreased significantly compared with that of control group. 2. Total leukocytes and eosinophils in BALF of the mice group treated with PR-HA decreased remarkably compared with those of control group. 3. The sticking of collagen on histological analysis of lung sections, the mice group treated with PR-HA decreased significantly compared with those of control group. 4. The concentrations of IL-4, IL-5, IgE in BALF, and IL-4, IL-5, IL-13 in serum of the mice group treated with PR-HA decreased significantly compared with those of control group. 5. The number of $Gr-1^+/CD11b^+\;and\;CD11b^+$ cells in the lungs of the mice group treated with PR-HA decreased significantly compared with that of control group. 6. The numbers of $CCR3^+\;cells,\;CD4^+\;cells\;and\;CD8^+\;cells$ in the lungs, and $CD3e^+/CD69^+$ in the lungs of the mice group treated with PR-HA decreased significantly compared with those of control group. 7. The mRNA expression of ${\beta}-actin,\;TNF-{\alpha}$, IL-4, IL-5,IL-13 in the mice group treated with PR-HA with RT-PCR decreased significantly compared with those of control group. Conclusion : The concentrations of IL-4, IL-5, IgE in BALF, and IL-4, IL-5, IL-13 in serum of the mice group treated with PR-HA decreased significantly compared with those of control group. The number of $Gr-1^+/CD11b^+\;and\;CD11b^+$ cells in the lungs of the mice group treated with PR-HA decreased significantly compared with that of control group. The numbers of $CCR3^+\;cells,\;CD4^+\;cells\;and\;CD8^+\;cells$ in the lungs, and $CD3e^+/CD69^+$ in the lungs of the mice group treated with PR-HA decreased significantly compared with those of control group. The mRNA expression of ${\beta}-actin,\;TNF-{\alpha}$, IL-4, IL-5, IL-13 in the mice group treated with PR-HA with RT-PCR decreased significantly compared with those of control group. These result suggests that Platycodi Radix Herbal-acupuncture at Joksamni(St36) in C57BL/6mice may be an effictive part to OVA-induced asthma in C57BL/6 mice.

• IMMUNE NETWORK
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• 제3권3호
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• pp.188-200
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• 2003

Background: Immunization of dendritic cells (DCs) pulsed with tumor antigen can activate tumor-specific cytotoxic T lymphocytes (CTL) that are responsible for protection and regression. In this study, we examined whether the uptake of necrotic tumor cells could modulate DC phenotypes and whether the immunization of necrotic tumor cell-loaded DCs could elicit efficient tumor specific immune responses followed by a regression of established tumor burdens. Methods: We prepared necrotic tumor cell-pulsed DCs for the therapeutic vaccination and investigated their phenotypic characteristics, the immune responses induced by these DCs, and therapeutic vaccine efficacy against colon carcinoma in vivo. Several parameters including phagocytosis of tumor cells, surface antigen expression, chemokine receptor expression, IL-12 production, and NK as well as CTL activation were assessed to characterize the immune response. Results: DCs derived from mouse bone marrow efficiently phagocytosed necrotic tumor cells and after the uptake, they produced remarkably increased levels of IL-12. A decreased CCR1 and increased CCR7 expression on DCs was also observed after the tumor uptake, suggesting that antigen uptake could induce DC maturation. Furthermore, co-culturing of DCs with NK cells in vitro enhanced IL-12 production in DCs and IFN-${\gamma}$ production in NK cells, which was significantly dependent on IL-12 production and cell-to-cell contact. Immunization of necrotic tumor cell-loaded DCs induced cytotoxic T lymphocytes as well as NK activation, and protected mice against subsequent tumor challenge. In addition, intratumoral or contra-lateral immunization of these DCs not only inhibited the growth of established tumors, but also eradicated tumors in more than 60% of tumor-bearing mice. Conclusion: Our data indicate that production of IL-12, chemokine receptor expression and NK as well as CTL activation may serve as major parameters in assessing the effect of tumor cell-pulsed DC vaccine. Therefore, DCs loaded with necrotic tumor cells offer a rational strategy to treat tumors and eventually lead to prolonged survival.

• Korean Journal of Acupuncture
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• 제22권2호
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• pp.107-125
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• 2005

Objectives : The aim of this study was to investigate the asthma-suppressive and immuno-regulatory effect of NR-HA(Notopterygii Rhizoma Herbal-acupuncture) at Pyesu(BL13) on OVA(ovalbumin)-induced asthma in mice. Methods : C57BL/6 mice out of all the experimental sloops, except the Normal group and the NR-HA group, were sensitized and challenged with OVA. The mice in the NR-HA group and the OVA-NR-HA group were treated with NR-HA(1%) at Pyesu(BL13). The mice in the OVA-Saline group were injected with saline at Pyesu(BL13). The mice in the OVA-Needle-prick group were treated with a single prick with an injection needle at Pyesu(BL13). NR-HA, saline injection and needle prick were administered for 8 weeks, three times a week Results : in vitro 1. The populations of granulocytes, $CD3e^-/CCR3^+$cells, $CD69^+/CD3e^+$ cells, $CD4^+\;cells\;and\;CD23^+/B220^+$ cells in the OVA-induced asthmatic mouse lungs decreased significantly by NR-HAS(Notopterygii Rhizoma Herbal-acupuncture solution). 2. The lung weight and total cells in lung of the OVA-NR-HA group decreased significantly compared with those of the OVA-Control group. 3. Total leukocytes and eosinophils in BALF of the OVA-NR-HA group decreas ed significantly compared with those of the OVA-Control group. 4. The collagen accumulation in the lung sections of the OVA-NR-HA group decreased significantly compared with that of the OVA-control group. 5. The concentrations of IL-4, IL-5, IL-13, IgE in BALF and serum of the OVA-NR-HA group decreased significantly compared with those of the OVA- Control group. 6. The numbers of $Gr-1^+/CD11b^+,\;CCR3^+,\;CD3e^+, \;CD19^+,\;CD3e^+/CD69^+$ cells in the OVA-NR-HA group decreased significantly compared with those of the OVA-Control group. 7. The mRNA expressions of $TNF-{\alpha}$, IL-5, IL-4 and IL-13 in lung of the OVA-NR-HA group decreased significantly compared with those of the OVA- Control group. 8. The NR-HA group did not show my considerable difference from the Normal group. The OVA-saline group and the OVA-Needle prick group showed suppressive effects on OVA-induced asthma however they were not statistically significant. Conclusion : These results suggest that NR-HA at Pyesu(BL13) is considered to be effective in treating asthma and to be put to practical use in the future asthma clinic.

• 한방안이비인후피부과학회지
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• 제27권4호
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• pp.141-157
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• 2014

Objectives : The purpose of this study is to investigate the effects of DOGO phreatic water containing germanium on Atopic Dermatitis in NC/Nga mouse. Methods : We made DOGO phreatic water added germanium. After making atopic dermatitis caused by sensitizing NC/Nga mouse to DNCB(dinitrochlorobenzene), we made mouse swim in tanks each filled with distilled water, tap water, DOGO phreatic water, DOGO phreatic water(added germanium) for 30minutes everyday. 3weeks later, we analyzed skin clinical score, total IgE levels(by ELISA), WBC differential counting(Neutrophils, Monocytes), absolute cell number of $Neutrophil^+Gr-1^+$, CCR3 mRNA expressions(by Real-time PCR), IL-4, IFN-${\gamma}$ production levels(by ELISA), histologic test(by H&E staining, toluidine blue staining). Results : The results of making NC/Nga mouse induced atopic dermatitis swim in tanks filled with DOGO phreatic water(contain germanium) are as follows. 1. Skin clinical scores were decreased significantly in comparison to control group. 2. Total IgG levels were decreased significantly in comparison to control group. 3. WBC differential counting(Neutrophils, Monocytes) were decreased significantly in comparison to control group. 4. Absolute cell number of $Neutrophil^+Gr-1^+$ were decreased significantly in comparison to control group. 5. CCR3 mRNA expressions were decreased significantly in comparison to control group. 6. IL-4, IFN-${\gamma}$ production levels were decreased significantly in comparison to control group. 7. The epithelial tissue thickness, leucocytes infiltration, erythema, edema, excoriation, scaling, mast cells infiltrations in dorsal skin were decreased in comparison to control group. Conclusions : These results indicate that DOGO phreatic water(contain germanium) can be used for helping treat atopic dermatitis.