• 제목/요약/키워드: CCR

검색결과 507건 처리시간 0.031초

CCD/CCR 중심의 표준진료문서 관리 도구의 개발 (Development of a Management Tool of CCD/CCR-centric Standard Clinical Document)

  • 이인근;조훈;김화선
    • 한국지능시스템학회논문지
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    • 제22권4호
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    • pp.507-514
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    • 2012
  • PHR(Personal Health Record)의 표현, 통합, 교류를 위해 CCD(Continuity of Care Document)와 CCR(Continuity of Care Record)과 같은 XML 기반의 표준들이 개발되었고, 이들 표준에 기반하여 PHR 교환을 위한 다양한 연구들이 수행되고 있다. 이들 연구에서는 각기 다른 방법으로 CCD/CCR 문서의 처리 도구를 개발하여 사용하고 있으나, 이들 표준이 구조적으로 복잡하여 도구의 개발 및 수정이 쉽지 않다. 또한 PHR 관련 의료정보시스템의 상호운용을 위해서는 CCD와 CCR 문서간의 상호 변환이 필요하다. 따라서 본 논문에서는 XML에 기반하여 작성된 CCD와 CCR과 같은 의료정보 표준 문서를 처리하고 관리하기 위한 프로그램 설계 방법을 제안하였다. 그리고 제안한 방법에 기반하여 CCD/CCR 처리 도구를 개발하고, 이 도구를 이용하여 CCD를 CCR로 변환하기 위한 변환기를 개발하였다. 개발한 도구의 효용성 확인을 위해 경북대학교병원에서 만성질환 입원자를 대상으로 수집한 개인건강정보를 이용하여 CCD 문서를 생성하고, CCD 문서를 CCR 문서로 변환하는 실험을 수행하였다.

일체형 CCR에 대한 동작 실험 사례 (Operation test case for integrated CCR)

  • 이기민
    • 한국항공운항학회:학술대회논문집
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    • 한국항공운항학회 2015년도 추계학술대회
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    • pp.175-178
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    • 2015
  • A-SMGCS(Advanced Surface Movement Guidance and Control system)의 ILCMS(Individual Light Control&Monitoring System) 고도화의 목표를 달성하기 위한 일체형 CCR(CONSTANT CURRENT REGULATOR)을 제작하고, 개발되어진 LCU(LOCAL CONTROL UNIT)모듈 및 LK CCR FILTER가 일체형 CCR의 실제 동작에 끼치는 영향과 일체형 CCR의 동작 상태를 실험을 통해 결과를 표현 하였다.

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Comparative Analysis of CCR2 and CCR5 Binding Sites to Facilitate the Development of Dual Antagonists: An in Silico Study

  • Kothandan, Gugan
    • 조선자연과학논문집
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    • 제5권1호
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    • pp.22-26
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    • 2012
  • Chemokine receptor antagonists have potential applications in field of drug discovery. Although the chemokine receptors are G-protein-coupled receptors, their cognate ligands are small proteins (8 to 12 kDa), and so inhibiting the ligand/receptor interaction has been challenging. In particular, CCR2 and CCR5 and their ligands have been implicated in the pathophysiology of a number of diseases, including rheumatoid arthritis and multiple sclerosis. Based on their roles in disease, they have been attractive targets for the pharmaceutical industry, targeting both CCR2 and CCR5 could be a useful strategy. Because of the importance of these receptors, providing information regarding the binding site is of prime importance. Herein, we report the comparison of CCR2 of CCR5 binding sites both sequentially as well as structurally. We also urged the importance of crucial residues in the binding site, to facilitate the development of dual antagonists targeting both the receptors. These results could also be useful for the design of novel and potent dual CCR2 and CCR5 antagonists using structure based drug design.

CCR5 Polymorphism as a Protective Factor for Hepatocellular Carcinoma in Hepatitis B Virus-Infected Iranian Patients

  • Abdolmohammadi, Reza;Azar, Saleh Shahbazi;Khosravi, Ayyoob;Shahbazi, Majid
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권10호
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    • pp.4643-4646
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    • 2016
  • The CC chemokine receptor 5 (CCR5) delta 32 allele results in a nonfunctional form of the chemokine receptor and has been implicated in a variety of immune-mediated diseases. $CCR5{\Delta}32$ may also predispose one to chronic liver disease or be linked with resistance to HBV infection. This study was undertaken to investigate any association between CCR5 polymorphism with resistance to hepatitis B or susceptibility to HBV infection. A total of 812 Iranian individuals were enrolled into two groups: HBV infected cases (n=357), who were HBsAg-positive, and healthy controls (n=455). We assessed polymorphisms in the CCR5 gene using specific CCR5 oligonucleotide primers surrounding the breakpoint deletion. Genotype distributions of the HBV infected cases and healthy controls were determined and compared. The CCR5/CCR5 (WW) and $CCR5/CCR5{\Delta}32$ (W/D) genotypes were found in (98%) and (2%) of HBV infected cases, respectively. The $CCR5{\Delta}32/{\Delta}32$genotype was not found in HBV infected cases. Genotype distributions of CCR5 in healthy controls were W/W genotype in (87.3%), W/D genotype in (11.2%) and D/D genotype in (1.5%). Heterozygosity for $CCR5/CCR5{\Delta}32$ (W/D) in healthy controls was greater than in HBV infected cases (11.2% vs 2%, p < 0.001). W/D and D/D genotypes were more prominent in healthy controls than in HBV infected cases. This study provides evidence that the $CCR5{\Delta}32$ polymorphism may have a protective effect in resistance to HBV infection at least in the Iranian population.

CCR : 트리패턴 기반의 코드클론 탐지기 (CCR : Tree-pattern based Code-clone Detector)

  • 이효섭;도경구
    • 한국소프트웨어감정평가학회 논문지
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    • 제8권2호
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    • pp.13-27
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    • 2012
  • 본 연구에서는 트리패턴 기반으로 코드클론을 탐지하는 도구인 CCR(Code Clone Ransacker)를 제안하고 구현하였다. CCR은 프로그램 트리의 모든 하위트리 쌍을 비교하여 중복된 부분인 트리패턴을 찾고 동일한 모양의 패턴들을 하나로 묶어 프로그램에 존재하는 클론들을 샅샅이 탐지한다. 이때 이미 찾은 패턴 내부의 클론 패턴을 비교대상에서 제외하여 중복계산을 하지 않아 불필요한 예산을 최대한 줄인다. 실험으로 CCR의 성능을 평가한 결과, CCR의 정확성과 탐지성은 높다. 프로그램의 구조를 비교하는 기존의 트리패턴 기반의 코드클론 탐지 도구들의 정확성과 탐지성은 이미 좋은 것으로 알려져 있지만, CCR은 높은 정확성을 유지하면서 탐지성은 기존의 Asta보다는 최대 5배, CloneDigger보다는 약 1.9배 높다. 그리고 CCR이 찾은 코드클론은 기존의 코드클론 표본 집합체의 클론을 대부분 포함한다.

Ets-1 enhances tumor migration through regulation of CCR7 expression

  • Fang, Li-Wen;Kao, Ying-Hsien;Chuang, Ya-Ting;Huang, Huey-Lan;Tai, Tzong-Shyuan
    • BMB Reports
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    • 제52권9호
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    • pp.548-553
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    • 2019
  • Ets-1 is a prototype of the ETS protein family. Members of the ETS protein family contain a unique ETS domain. Ets-1 is associated with cancer progression and metastasis in many types of cancer. Many studies have shown a link between elevated expression of Ets-1 in cancer biopsies and poor survival. CCR7 is a chemokine that binds to specific ligand CCL21/CCL19. CCR7 expression is associated with tumor metastasis and infiltration into lymph nodes. The objective of this study was to test whether Ets-1 could regulate CCR7 expression and enhance tumor metastasis. Our data showed that CCR7 expression was downregulated in Ets-1-deficient T cells upon T-cell stimulation. Overexpression of Ets-1 increased CCR7 expression in breast cancer cell lines. In contrast, knockdown of Ets-1 reduced CCR7 expression. Ets-1 could directly bind to CCR7 promoter and mediate CCR7 expression in luciferase reporter assays and chromatin immunoprecipitation assays. Transactivation activity of Ets-1 was independent of the Pointed domain of Ets-1. Ets-1 could also enhance $NF-{\kappa}B$ and CBP transactivation of CCR7 promoter. Our results also showed that Ets-1 could modulate cancer cell transmigration by altering CCR7 expression in transwell assay and wound healing assay. Taken together, our data suggest that Ets-1 can enhance CCR7 expression and contribute to tumor cell migration.

XML 기반 CCR 문서의 무선 데이터 방송을 위한 프레임워크의 설계와 구현 (Design and Development of Framework for Wireless Data Broadcast of XML-based CCR Documents)

  • 임석진;황희정
    • 한국인터넷방송통신학회논문지
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    • 제15권5호
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    • pp.169-175
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    • 2015
  • ICT 기술과 의료기술이 융합된 의료 정보기술에서 XML 기반의 CCR 문서는 환자 데이터의 연속성과 이동성을 확보해 준다. 대규모의 클라이언트들이 CCR 문서를 동시에 액세스할 때 클라이언트의 수에 상관없이 데이터 배표가 가능하게 해주는 확장성을 가진 무선 데이터 방송은 효율적인 정보 전달을 위한 하나의 대안이 된다. 본 논문은 무선데이터방송을 이용한 CCR 문서 전달을 위해 다양한 CCR 문서 스케줄링 기법과 인덱스 기법을 적용하여 최적의 클라이언트 성능을 낼 수 있도록 방송환경을 구축할 수 있는 무선 데이터 방송 시뮬레이션 프레임워크를 설계하고 구현한다. 구현된 프레임워크에 다양한 스케줄링 기법과 인덱스를 적용한 시뮬레이션을 통해 제안된 프레임워크의 효율성을 보였다.

In-silico Modeling of Chemokine Receptor CCR2 And CCR5 to Assist the Design of Effective and Selective Antagonists

  • Kothandan, Gugan;Cho, Seung Joo
    • 조선자연과학논문집
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    • 제5권1호
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    • pp.32-37
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    • 2012
  • Chemokine receptor antagonists have potential applications in field of drug discovery. Although the chemokine receptors are G-protein-coupled receptors, their cognate ligands are small proteins (8 to 12 kDa), and so inhibiting the ligand/receptor interaction has been challenging. The application of structure-based in-silico methods to drug discovery is still considered a major challenge, especially when the x-ray structure of the target protein is unknown. Such is the case with human CCR2 and CCR5, the most important members of the chemokine receptor family and also a potential drug target. Herein, we review the success stories of combined receptor modeling/mutagenesis approach to probe the allosteric nature of chemokine receptor binding by small molecule antagonists for CCR2 and CCR5 using Rhodopsin as template. We also urged the importance of recently available ${\beta}2$-andrenergic receptor as an alternate template to guide mutagenesis. The results demonstrate the usefulness and robustness of in-silico 3D models. These models could also be useful for the design of novel and potent CCR2 and CCR5 antagonists using structure based drug design.

Cloning and expression of cDNA for chemokine receptor 9 from Olive flounder, Paralichthys olivaceus

  • Kim, Mu-Chan;An, Geun-Hee;Park, Chan-Il
    • 한국어병학회지
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    • 제20권3호
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    • pp.299-306
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    • 2007
  • Cysteine-cysteine chemokine receptor 9 (CCR9) homologue cDNA was isolated from olive flounder leukocyte cDNA library. Olive flounder CCR9 homologue consisted of 1709 bp encoding 367amino acid residues. When compared with other known CCR peptide sequences, the most conserved region of the olive flounder CCR9 peptide is the seven transmembranes. A phylogenetic analysis based on the deduced amino acid sequence showed the homologous relationship between the olive flounder CCR9 sequence and that of Mouse CCR9. The olive flounder CCR9 gene was predominantly expressed in the Peripheral blood leukocytes (PBLs), kidney, spleen, and gills.

Molecular Cloning and Characterization of Soybean Cinnamoyl CoA Reductase Induced by Abiotic Stresses

  • So, Hyun-Ah;Chung, Eun-Sook;Cho, Chang-Woo;Kim, Kee-Young;Lee, Jai-Heon
    • The Plant Pathology Journal
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    • 제26권4호
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    • pp.380-385
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    • 2010
  • Suppression subtractive hybridization was used to isolate wound-induced genes from soybean. One of the wound-induced genes, gmwi143 designated as GmCCR, showed high homology with genes encoding cinnamoyl-CoA reductase (CCR; EC 1.2.1.44). Deduced amino acid sequences encoded by GmCCR showed the highest identity (77%) with those of Acacia CCR. There are 2 CCR genes highly homologous to GmCCR in soybean genome based on Phytozome DB analysis. RNA expression of GmCCR was specifically induced by local and systemic wounding, drought, high salinity or by ultraviolet stress. Our study suggests that GmCCR may be involved in resistance mechanism during abiotic stresses in plants.