• Structural Engineering and Mechanics
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• 제48권5호
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• pp.697-709
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• 2013

A simulation method called modified differential transform is studied to solve the free vibration problems of uniform Euler-Bernoulli beam. First of all, the modified differential transform method is derived. Secondly, the modified differential transformation is applied to uniform Euler-Bernoulli beam free-free vibration. And then a set of differential equations are established. Through algebraic operations on these equations, we can get any natural frequency and normalized mode shape. Thirdly, the FEM is applied to obtain the numerical solutions. Finally, mode experimental method (MEM) is conducted to obtain experimental data for analysis by signal processing with LMS Test.lab Vibration testing and analysis system. Experimental data and simulation results are illustrated to be in comparison with the analytical solutions. The results show that the modified differential transform method can achieve good results in predicting the solution of such problems.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1571-1576
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• 2016

Alteration of the acetylation status of chromatin and other non-histone proteins by HDAC inhibitors has evolved as an excellent epigenetic strategy in treatment of cancers. The present study was sought to identify compounds with positive pharmacological profiles targeting HDAC1. Analogues of Vorinostat synthesized by Cai et al, 2015 formed the test compounds for the present pharmacological evaluation. Hydroxamte analogue 6H showed superior pharmacological profile in comparison to all the compounds in the analogue dataset owing to its better electrostatic interactions and hydrogen bonding patterns. In order to identify compounds with even better high affinity and pharmacological profile than 6H and Vorinostat, virtual screening was performed. A total of 83 compounds similar to Vorinostat and 154 compounds akin to analogue 6H were retrieved. SCHEMBL15675695 (PubCid: 15739209) and AKOS019005527 (PubCid: 80442147) similar to Vorinostat and 6H, were the best docked compounds among the virtually screened compounds. However, in spite of having good affinity, none of the virtually screened compounds had better affinity than that of 6H. In addition SCHEMBL15675695 was predicted to be a carcinogen while AKOS019005527 is Ames toxic. From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report Vorinostat hydroxamate analogue 6H to be a potential candidate for HDAC inhibition in treatment of cancers through an epigenetic strategy.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4267-4271
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• 2013

Background: As natural medicines in Asia, curcumin and triptolide extracted from different drug plants have proven to possess anticancer potential and widely used for anti-cancer research. The present study attempted to clarify that curcumin and triptolide synergistically suppress ovarian cancer cell growth in vitro. Methods: To test synergic effects, cell viability and apoptosis were analyzed after curcumin and triptolide combination treatment on ovarian cancer cell lines. Synergistic effects on apoptosis induction were determined by lactate dehydrogenase (LDH) leakage assay, intracellular reactive oxygen species (ROS) assay, mitochondrial membrane potential (MMP) loss assay and flow cytometry analysis. Critical regulators of cell proliferation and apoptosis related were analyzed by qRT-PCR and Western blotting. Results: We showed that the combination of curcumin and triptolide could synergistically inhibit ovarian cancer cell growth, and induce apoptosis, which is accompanied by HSP27 and HSP70, indicating that HSP27 and HSP70 play the important role in the synergic effect. Conclusions: From the result present here, curcumin and triptolide combination with lower concentration have a synergistic anti-tumor effect on ovarian cancer and which will have a good potential in clinical applications.

• Journal of Electrical Engineering and Technology
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• 제8권3호
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• pp.446-452
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• 2013

Under frequency load shedding (UFLS) is an effective way to prevent system blackout after a serious disturbance occurs in a power system. A novel centralized adaptive under frequency load shedding (AUFLS) scheme using the synchronous phase measurement unit (PMU) is proposed in this paper. Two main stages are consisted of in the developed technique. In the first stage, the active power deficit is estimated by using the simplest expression of the generator swing equation and static load model since the frequency, voltages and their rate of change can be obtained by means of measurements in real-time from various devices such as phase measurement units. In the second stage, the UFLS schemes are adapted to the estimated magnitude based on the presented model. The effectiveness of the proposed AUFLS scheme is investigated simulating different disturbance in IEEE 10-generator 39-bus New England test system.

• 대한가정학회지
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• 제43권7호
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• pp.1-21
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• 2005

The purposes of this study were to investigate the actual condition and to deal with the psychological characteristics of computer addicted adolescent using the Minnesota Multiphasic Personality Inventory (MMPI). The subjects of this study were 407(male 185, female 222) 2nd grade students in senior high school in Daegu. All participant were evaluated on the basis of the Minnesota Multiphasic Personality Inventory (MMPI) and the upgraded Computer Addiction Inventory (CAI) scale which referred to the Young's Internet Addiction Self Diagnosis Scale and the Mind Test's Came Addiction. SPSS version 10.0 was used for data analysis. The scores of F, Hs, D, Pd, Pa, Pt, Sc of the MMPI scales showed that there were statistically significant differences between computer addicted adolescents and non-addicted adolescents. The rate of addicted adolescents was significantly higher than that of non-addicted adolescent in psychological problematic score ranges in the scales. The characteristics of the scores of computer addiction adolescents were similar to those of alcohol and drug addicts in the scales of D, Pd, and Pt. This survey revealed that the psychological disorders suffered by computer addiction adolescents may cause more serious social problems than alcohol and drug addicts.

• Steel and Composite Structures
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• 제27권6호
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• pp.747-759
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• 2018

This study proposed a new type of concrete column that was confined with both steel angles and spiral hoops, named angle-steel and spiral confined concrete (ASCC) column. A total of 22 ASCC stub columns were tested under axial compression to investigate their behavior. For a comparison, three angle-steel reinforced concrete (ARC) stub columns were also tested. The test results indicated that ASCC column had a superior mechanical performance. The strength, ductility and energy absorption were considerably increased due to the improvement of confinement from spiral hoops. The confinement behavior and failure mechanism of ASCC column were investigated by the analysis of failure mode, load-deformation curve and section-strain distribution. Parametric studies were carried out to examine the influences of different parameters on the axial compression behavior of ASCC columns. A calculation approach was developed to predict the ultimate load carrying capacity of ASCC columns under axial compression. It was validated that the predicted results were in well agreement with the experimental results.

• Steel and Composite Structures
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• 제25권6호
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• pp.727-734
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• 2017

This paper describes a quasi-static finite element analysis, which uses the explicit integration method, of the apex joint of a cold-formed steel portal frame. Such cold-formed steel joints are semi-rigid as a result of bolt-hole elongation. Furthermore, the channel-sections that are being connected have a reduced moment capacity as a result of a bimoment. In the finite element model described, the bolt-holes and bolt shanks are all physically modelled, with contact defined between them. The force-displacement curves obtained from the quasi-static analysis are shown to be similar to those of the experimental test results, both in terms of stiffness as well as failure load. It is demonstrated that quasi-static finite element analysis can be used to predict the behavior of cold-formed steel portal frame joints and overcome convergence issues experienced in static finite element analysis.

• Nuclear Engineering and Technology
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• 제53권7호
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• pp.2348-2356
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• 2021

As a relatively new radiation imaging method, the cosmic-ray muon scattering imaging technology can be used to prevent nuclear smuggling and is of considerable significance to nuclear safety. Proposed in this paper is a new reconstruction algorithm based on density clustering, aiming to improve inspection quality with better performance. Firstly, this new algorithm is introduced in detail. Then in order to eliminate the inequity of the density threshold caused by the heterogeneity of the muon flux in different positions, a new flux correction method is proposed. Finally, three groups of simulation experiments are carried out with the help of Geant4 toolkit to optimize the algorithm parameters, verify the correction method and test the inspection quality under shielded condition, and compare this algorithm with another common inspection algorithm under different conditions. The results show that this algorithm can effectively identify and locate nuclear material with low misjudging and missing rates even when there is shielding and momentum precision is low, and the threshold correcting method is universally effective for density clustering algorithms.

• Parasites, Hosts and Diseases
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• 제57권1호
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• pp.61-67
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• 2019

Cystic echinococcosis (CE) in sheep is a hazardous zoonotic parasitic disease that is caused by Echinococcus granulosus (Eg). At present, serological test is an important diagnostic method for Eg infection in domestic animals. Here, a fusion protein Eg mefAg-1 harboring 8 dominant B-cell epitopes of Eg such as antigen B, tetraspanin 1, tetraspanin 6, reticulon and Eg95 was produced in E. coli and evaluated for CE in sheep by indirect ELISA. Eg mefAg-1 showed in ELISA a high sensitivity (93.41%) and specificity (99.31%), with a coincidence rate of 97.02%. Overall, it is suggested that the Eg mefAg-1 could be a potential antigen candidate for CE serodiagnosis in sheep.

• Geomechanics and Engineering
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• 제27권6호
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• pp.595-604
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• 2021

With the advantages of high permeability and strength, pervious concrete piles can be suitable for ground improvement with high water content and low bearing capacity. By comparing the strength and permeability of pervious concrete with different aggregate sizes (3-5 mm and 4-6 mm) and porosities (20%, 25%, 30% and 35%), the recommended aggregate size (3-5 mm) and porosity (30%) can be achieved. The model tests of the pervious concrete piles in soft soil (silt and clay) foundations were conducted to evaluate the bearing characteristics, results show that, for the higher consolidation efficiency of the silty foundation, the bearing capacity of the silty foundation is 16% higher, and the pile-soil stress ratio is smaller. But when it is the ultimate load for the piles, they will penetrate into the underlying layer, which reduces the pile-soil stress ratios. With higher skin friction of the pile in the silty foundation, the pile penetration is smaller, so the decrease of the pile axial force can be less. For the difference in consolidation efficiency, the skin friction of pile in silt is more affected by the effective stress of soil, while the skin friction of pile in clay is more affected by the lateral stress. When the load reaches 4400 N, the skin friction of the pile in the silty foundation is about 35% higher than that of the clay foundation.