• 재활치료과학
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• 제1권1호
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• pp.57-70
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• 2012

목적 : 본 연구는 뇌졸중 환자를 대상으로 신경되먹임(Neurofeedback; NFB)을 통한 뇌파 훈련과 컴퓨터보조 인지 재활(Computer-Assisted Cognitive Rehabilitation; CACR) 훈련이 뇌졸중 환자의 인지, 상지기능에 미치는 영향을 알아보고자 한다. 연구방법 : 뇌졸중 후 3개월에서 1년 이내이며, 경기도 소재 병원에서 입원치료중인 환자 44명을 NFB군(14명)과 CACR군(14명), 대조군(16명)의 세 그룹으로 배치시켰다. NFB 훈련과 CACR 훈련은 6주간에 걸쳐 실시하였으며 사전, 사후 평가기간을 포함하여 총 9주간 연구를 진행하였다. 측정은 인지, 상지 기능을 측정하였으며 훈련 전후와 그룹간의 인지, 상지 기능의 변화를 분석하였다. 결과 : 연구대상자들의 훈련방법에 따른 인지기능의 차이를 알아보기 위해 한국형 간이정신상태 검사(Mini-Mental State Examination-Kore; MMSE-K) 총점의 변화를 분석한 결과 NFB군은 실험전 16.92 점에서 실험 후 20.50 점으로 유의한 차이를 보였고 CACR군은 실험 전 17.85 점에서 실험 후 22.14 점으로 유의한 차이를 보였으며 대조군도 실험 전 18.62 점에서 실험 후 19.25 점으로 유의한 차이를 보였다. 그러나 사후검정 결과 실험방법 간 차이는 보이지 않았다. 상지기능의 차이를 알아보기 위해 뇌졸중 상지 기능인 뇌졸중 상지 기능 검사(Manual Function Test; MFT) 총점을 분석한 결과 상지운동 영역에서 NFB군은 실험 전 4.64 점에서 실험 후 5.50 점으로 유의한 차이를 보였고 CACR군은 실험 전 3.92 점에서 실험 후 5.35 점으로 유의한 차이를 보였으며 대조군도 실험 전 3.68 점에서 실험 후 4.75 점으로 유의한 차이를 보였다. 그러나 사후검정 결과 실험방법 간 차이는 보이지 않았다. 결론 : 본 연구는 NFB 훈련과 CACR 훈련, 전통적 재활훈련 이후 인지기능과 상지 기능의 향상을 제시하였으며 앞으로 각 개인에게 적절한 훈련방법을 적용한 NFB 훈련과 CACR 훈련 프로그램 개발 및 프로토콜이 제시되어야 할 것이다.

• Journal of Korean Neurosurgical Society
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• 제54권6호
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• pp.484-488
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• 2013

Objective : To examine the synergistic effects of both computer-assisted cognitive rehabilitation (CACR) and transcranial direct current stimulation (tDCS) on cognitive function in patients with stroke. Methods : The current double-blind, sham-controlled study enrolled a total of 11 patients who were newly diagnosed with stroke. The patients of the tDCS group (n=6) completed sessions of the Korean computer-assisted cognitive rehabilitation program five times a week for 30 minutes a session during a mean period of 18.5 days concomitantly with the anodal tDCS over the bilateral prefrontal cortex combined with the CACR. The patients of the control group (n=5) also completed sessions of the sham stimulation during a mean period of 17.8 days. Anodal tDCS over bilateral prefrontal cortex (F3 and F4 in 10-20 EEG system) was delivered for 30 minutes at an intensity of 2 mA. Cathode electrodes were applied to the non-dominant arm. All the patients were evaluated using the Seoul Computerized Neuropsychological Test (SCNT) and the Korean Mini-Mental State Examination. Results : Mann-Whitney U test revealed a significant difference between the two groups. The patients of the tDCS group achieved a significant improvement in the post/pre ratio of auditory continuous performance test and visual continuous performance test on the SCNT items. Conclusion : Our results indicate that the concomitant use of the tDCS with CACR to the prefrontal cortex may provide additional beneficial effects in improving the cognitive dysfunction for patients with stroke.

• 대한통합의학회지
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• 제11권4호
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• pp.1-15
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• 2023

Purpose : This study investigates the effectiveness of digital therapy for stroke patients in Korea. Methods : A comprehensive database search was performed using KCI, Science on, e-article, RISS, KISS and Korea OpenMed databases for randomized controlled trials (RCTs) that studied the effects of digital therapy on patients who had a stroke. This study includes RCTs published from January 2000 to July 15, 2022, which fulfilled the inclusion and exclusion criteria. A total 697 studies were screened and 30 studies were included in the final analysis. Methodological quality was assessed with the Cochrane's RoB (risk of bias) tool. Meta-analysis was performed using CMA 4.0 software. Results : A total of 56 effect sizes were calculated from the 30 selected studies. As a result of the analysis, the overall effect size of digital therapy was .59 (95 % CI=.43-.74). When classified according to type of intervention, VR (virtual reality) (g=.58, 95 % CI=.40-.75), and CACR (computer assisted cognitive rehabilitation) (g=.62, 95 % CI=.30-.95) were statistically significant. VR showed medium to large effect sizes in cognitive function (g=.78, 95 % CI=.20-1.37), psychosocial function (g=.63, 95 % CI=.20-1.07), and physical function (g=.61, 95 % CI=.38-.83). In the CACR, there was a large effect size in cognitive function (g=.84, 95 % CI=.52-1.15), but there was no significant difference in psychosocial function. Also, there was no significant difference between the two interventions in activities of daily living and no significant difference in the effect size of both interventions according to the intervention session. Furthermore, medium to large effect sizes were found for subacute and chronic stroke patients according to the duration of disease. Conclusion : This study presents evidence that digital therapy has a positive effect on various functions of stroke patients in Korea. The researchers expect to actively accept the new paradigm of digital therapy and continue to apply digital therapy in clinical practice.