• Biomolecules & Therapeutics
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• v.30 no.1
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• pp.19-27
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• 2022

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase widely expressed in many cancers such as non-small cell lung cancer (NSCLC), pancreatic cancer, breast cancer, and head and neck cancer. Mutations such as L858R in exon 21, exon 19 truncation (Del19), exon 20 insertions, and others are responsible for aberrant activation of EGFR in NSCLC. First-generation EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib and erlotinib have clinical benefits for EGFR-sensitive (L858R and Del19) NSCLC patients. However, after 10-12 months of treatment with these inhibitors, a secondary T790M mutation at the gatekeeper position in the kinase domain of EGFR was identified, which limited the clinical benefits. Second-generation EGFR irreversible inhibitors (afatinib and dacomitinib) were developed to overcome this T790M mutation. However, their lack of selectivity toward wild-type EGFR compromised their clinical benefits due to serious adverse events. Recently developed third-generation irreversible EGFR TKIs (osimertinib and lazertinib) are selective toward driving mutations and the T790M mutation, while sparing wild-type EGFR activity. The latest studies have concluded that their efficacy was also compromised by additional acquired mutations, including C797S, the key residue cysteine that forms covalent bonds with irreversible inhibitors. Because second- and third-generation EGFR TKIs are irreversible inhibitors, they are not effective against C797S containing EGFR triple mutations (Del19/T790M/C797S and L858R/T790M/C797S). Therefore, there is an urgent unmet medical need to develop next-generation EGFR TKIs that selectively inhibit EGFR triple mutations via a non-irreversible mechanism.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38C no.9
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• pp.797-801
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• 2013

Visible light communication (VLC) is a rapidly growing area of research and applications, due to the potential and predicted high efficiency of bandwidth. One of the key challenges in VLC technology is the choice of devices which are going to be deployed VLC features. Smartphone rationally uses the most widely deployed visible light sensor i.e. image sensor in camera, which could be used to receive the intensity modulated data. Image sensor based VLC system would be the most deployable scenario but initially the capacity was not much attractive compared with photodetector based VLC system. Here, the spatial multiplexing is proposed in MIMO based VLC system to increase the system capacity by utilizing the property of spatial separation of optical light sources in smartphone's camera module. The active pixels of imaging plane act as the multiple receivers which could be able to use on MIMO spatial multiplexing to enhance the system performance.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2013.05a
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• pp.797-798
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• 2013

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1993.06a
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• pp.793-797
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• 1993

• Bulletin of the Korean Chemical Society
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• v.14 no.6
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• pp.678-681
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• 1993

The new ternary phase $UP_2S_6$ has been prepared and structurally characterized. The compound is isostructural with $ZrP_2S_6$ and $ThP_2S_6$ but is different from $TiP_2S_6$. The structure has been determined by a single crystal X-ray diffraction technique. $UP_2S_6$ crystallizes in the the tetragonal system $({C^2}_{4h}-P4_2/m,\;a=6.797(7)\;{\AA},\;c=9.738(12)\;{\AA})$ with two formula units in the unit cell. The structure can be described in terms of $U^{4+}$ and ${P_2S_6}^{4-}$ ions. This hexathiohypodiphosphate anion $({P_2S_6}^{4-})$ has ideally staggered conformation. The $U^{4+}$ cation is coordinated by 8 sulfur atoms in a slightly distorted dodecahedral geometry (42m). The distribution of sulfur atoms is very well optimized for this geometry.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2012.05a
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• pp.797-798
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• 2012

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.792-797
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• 2007

This study investigates the change of the temperature and fatigue property of the braking disk (GC25-30 material) for the railway vehicle. The average temperature is measured about $100^{\circ}C$ and the maximum temperature is measured over $200^{\circ}C$ by non-contact sensor from Seoul to Chun-an. In the $20^{\circ}C-300^{\circ}C$. The Fatigue tests did for new and used disk specimens. The fatigue test results of new disk specimens were similar due to the temperature change. But the compare of specimens between new disk and old disk, The fatigue life of old disk specimens was smaller than new disk specimens about 10%.

• Journal of the Chungcheong Mathematical Society
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• v.22 no.4
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• pp.789-797
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• 2009

Invertible transformations over n-bit words are essential ingredients in many cryptographic constructions. When n is large (e.g., n = 64) such invertible transformations are usually represented as a composition of simpler operations such as linear functions, S-P networks, Feistel structures and T-functions. Among them we will study T-functions which are probably invertible transformation and are very useful in stream ciphers. In this paper we will show that $f(x)=x+(g(x)^2{\vee}C)$ mod $2^n$ is a permutation with a single cycle of length $2^n$ if both the least significant bit and the third significant bit in the constant C are 1, where g(x) is a T-function.

• Proceedings of the KIEE Conference
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• 1997.07c
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• pp.797-799
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• 1997

This paper presents an operation and planning model of integrated energy systems which consist of small scale cogeneration systems, thermal accumulator, ice storage and electrical energy storage systems. In the proposed planning model, an optimization of total cost which contains investment, operation, thermal shortage and salvage costs has carried out with the maximum principle based on the lifetime of each system component and unit price per capacity. From this model, optimal investment capacity per annum can be determined during the studied periods using the marginal costs according to the operation characteristics of each system component.

• Fashion & Textile Research Journal
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• v.13 no.5
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• pp.797-805
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• 2011

This study was carried out to investigate dyeing characteristics of CDP(cation dyeable polyester)/silk knitted fabrics with disperse type cation dyes/acid dyes by one bath dyeing method in comparison with two bath dyeing method in the interests for rationalization of the dyeing process. The apparent color depth(K/S) of the disperse type cation dyes with CDP and that of acid dyes with silk decreased slowly with increasing pH values of dyebath with the exception of sharp decrease at alkali region for CDP. The contamination behavior of CDP by the acid dyes and that of silk by the disperse type cation dyes decreased with progressing of dyeing. The migration ratio(%) of the disperse type cation dyes with CDP is low compared with that of acid dyes with silk. The sediment in mixed dying solution of disperse type cation dyes and acid dyes remarkably less compared with that of regular type cation dyes and acid dyes at $100^{\circ}C$ regardless applying of preventer agent of precipitation. When CDP/silk knitted fabrics was dyed with by with mixtures of disperse type cation dyes/acid dyes one bath or two bath dyeing method, the characteristic of reflectance spectra of CDP components were greatly influenced by disperse type cation dyes and that of silk components by acid dyes. It was confirmed that K/S values of each components of CDP/silk knitted fabrics dyed by one bath dyeing method decreased slightly compared with two bath dyeing method.