• 정보보호학회논문지
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• 제12권6호
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• pp.81-92
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• 2002

실제적인 환경에서는 서명자의 능력이 제한되어져야 하는 경우가 있다. 그룹 서명 스킴(Group Signature Scheme)에서 그룹의 구성원은 그룹 내에서 자신의 직위에 따라 정해진 횟수까지 서명을 생성하도록 허락되어 질 수 있다. 또는 대리 서명 스킴(proxy signature scheme)에서 본래의 서명자는 대리 서명자(proxy signer)에게 그 서명자를 대신하여 일정한 횟수까지만 서명을 생성하도록 서명능력을 제한하고 싶을 것이다. 본 논문에서는 전자서명 스킴 설정단계에서 미리 정해진 값 c에 대해 서명자의 서명횟수를 c번까지만 제한하는 서명 스킴(c-times 서명스킴)을 제안한다. 최초로 c-times 서명 스킴의 형식적인 정의를 기술하고 일반적인 서명 스킴을 c-times 서명 스킴으로 변환시키는 방법을 소개한다. 그리고 특정한 예로서 (t, n)-임계 기법(Threshold Technique)인 Feldman의 증명가능한 (t, n)-비밀분산 기법을 사용하여 DSA (Digital Signature Algorithm)에 기반한 c-times 서명 스킴인 $^c$DSA를 제시하고 이 스킴의 안전성을 증명한다. 여기에 적용된 변환방법은 다른 EIGamal형태의 전자서명 스킴에 적용되어질 수 있다.

• Journal of Pharmaceutical Investigation
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• 제33권1호
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• pp.51-53
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• 2003

This study was conducted to compare the bioavailability of a generic product of Sinil Atenolol Tablets (Sinil Pharmaceutical Co., Ltd., Korea) with the innovator product, $Tenormin^{\circledR}$ Tablets in 20 healthy Korean volunteers. The volunteers received a single 50 mg dose of each atenolol formulation according to a randomized, two-way crossover design. Plasma samples were obtained over a 24-hour interval, and atenolol concentrations were determined by HPLC with a fluorescence detector. From the plasma atenolol concentration vs time curves, the following parameters were compared: area under the plasma concentration-time curve (AUC), peak plasma concentration $(C_{max})$, time to reach peak plasma concentration $(T_{max})$, and terminal first order elimination half-life $(t_{1/2})$. No statistically significant difference was obtained between the $T_{max}$ values, and the logarithmic transformed AUC and $C_{max}$ values of the two products. The 90% confidence for the ratio of the logarithmically transformed AUC and $C_{max}$ values of Sinil Atenolol Tablets over those of $Tenormin^{\circledR}$ Tablets were calculated to be between 0.99 and 1.07, and 1.04 and 1.16, respectively; both were within the bioequivalence limit of 0.80-1.25. The mean of $T_{max}$ in $Tenormin^{\circledR}$ Tablet group was 3.68 hour, and that in Sinil Atenolol Tablet group was 3.65 hour. The values of $t_{1/2}$ between the two products were found comparable, and the mean $t_{1/2}$ values of $Tenormin^{\circledR}$ Tablets and Sinil Atenolol Tablets were 5.9 and 6.0 hour, respectively. Based on these results, it was concluded that Sinil Atenolol Tablets were comparable to $Tenormin^{\circledR}$ Tablets in both the rate and extent of absorption, indicating that Sinil Atenolol Tablets were bioequivalent to the reference product, $Tenormin^{\circledR}$ Tablets

• Biomolecules & Therapeutics
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• 제15권3호
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• pp.187-191
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• 2007

This study was conducted to compare the bioavailability of two brands of atenolol (50 mg) tablets, which are a generic product of $Ditent^{\circledR}$ (Daewon Pharmaceutical Co., Ltd., Korea) and an innovator product $Tenormin^{\circledR}$ (Hyundai Pharm. Ind. Co., Ltd., Korea), in 20 healthy Korean male volunteers. The volunteers received a single 50 mg dose of each atenolol formulation according to a randomized, two-way cross-over design. The washout period between treatments was 1 week. Plasma samples were obtained over a 24-hour interval, and atenolol concentrations were determined by HPLC with a fluorescence detector. From the plasma atenolol concentration vs. time curves, the following parameters were compared: area under the plasma concentration-time curve ($AUC_{0-24}$), peak plasma concentration ($C_{max}$), time to reach peak plasma concentration ($T_{max}$), and terminal first order elimination half-life ($t_{1/2}$). No statistically significant difference was obtained between the $T_{max}$ values, and the logarithmic transformed $AUC_{0-24}$ and $C_{max}$ values of the two products. The 90% confidence interval for the ratio of the logarithmically transformed AUC and $C_{max}$ values of $Ditent^{\circledR}$ over those of $Tenormin^{\circledR}$ were calculated to be between 0.85 and 1.04, and 0.89 and 1.07, respectively; both were within the bioequivalence limit of 0.80-1.25. The mean of $T_{max}$ in $Tenormin^{\circledR}$ group was 3.1 hour, and that in Ditent$^{\circledR}$ group was 3.2 hour. The values of $t_{1/2}$ between the two products were found comparable, and the mean values were 5.2 hour in the both products. Based on these results, it was concluded that $Ditent^{\circledR}$ was comparable to $Tenormin^{\circledR}$ in both the rate and extent of absorption, indicating that $Ditent^{\circledR}$ was bioequivalent to the reference product, $Tenormin^{\circledR}$.

• JSTS:Journal of Semiconductor Technology and Science
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• 제5권2호
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• pp.89-101
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• 2005

Research on highly abstracted system modeling and simulation has received a great deal of attention as of the concept of platform based design is becoming ubiquitous. From a practical design point of view, such modeling and simulation must consider the following: (i) fast simulation speed and cycle accuracy, (ii) early availability for early stage software development, (iii) inter-operability with external tools for software development, and (iv) reusability of the models. Unfortunately, however, all of the previous works only partially addresses the requirements, due to the inherent conflicts among the requirements. The objective of this study is to develop a new system design methodology to effectively address the requirements mentioned above. We propose a new transaction-level system modeling methodology, called ViP (Virtual Platform). We propose a two-step approach in the ViP method. In phase 1, we create a ViP for early stage software development (before RTL freeze). The ViP created in this step provides high speed simulation, lower cycle accuracy with only minor modeling effort.(satisfying (ii)). In phase 2, we refine the ViP to increase the cycle accuracy for system performance analysis and software optimization (satisfying (i)). We also propose a systematic ViP modeling flow and unified interface scheme based on utilities developed for maximizing reusability and productivity (satisfying (ii) and (iv)) and finally, we demonstrate VChannel, a generic scheme to provide a connection between the ViP and the host-resident application software (satisfying (iii)). ViP had been applied to several System-on-a-chip (SoC) designs including mobile applications, enabling engineers to improve performance while reducing the software development time by 30% compared to traditional methods.

• 소성∙가공
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• 제24권1호
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• pp.52-61
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• 2015

Evaluation of the elevated temperature flow stress for thermoplastic fiber metal laminates(TFMLs) sheet, comprised of two aluminum sheets in the exterior layers and a self-reinforced polypropylene(SRPP) in the interior layer, was conducted. The flow stress as a function of temperature should be evaluated prior to the actual forming of these materials. The flow stress can be obtained experimentally by uniaxial tensile tests or analytically by deriving a flow stress model. However, the flow stress curve of TFMLs cannot be predicted properly by existing flow stress models because the deformation with temperature of these types of materials is different from that of a generic pure metallic material. Therefore, the flow stress model, which includes the effect of the temperature, should be carefully identified. In the current study, the flow stress of TFMLs were first predicted by using existing flow stress models such as Hollomon, Ludwik, and Johnson-Cook models. It is noted that these existing models could not effectively predict the flow stress. Flow stress models such as the modified Hollomon and modified Ludwik model were proposed with respect to temperatures of $23^{\circ}C$, $60^{\circ}C$, $90^{\circ}C$, $120^{\circ}C$. Then the stress-strain curves, which were predicted using the proposed flow stress models, were compared to the stress-strain curves obtained from experiments. It is confirmed that the proposed flow stress models can predict properly the temperature dependent flow stress of TFMLs.

• 대한원격탐사학회지
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• 제37권5_1호
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• pp.1187-1198
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• 2021

해상풍 데이터는 최근 들어서 신재생 에너지 개발의 일환으로 해상 풍력발전 단지가 각광받으면서 더욱 중요성을 더하고 있다. 본 연구에서는 2015~2020년 부울경(부산, 울산, 경남) 연안해역을 촬영한 Sentinel-1 영상 368장과 저해상도 수치모델의 UV 컴포넌트를 이용한 DNN (Deep Neural Network) 모델을 개발하여 해상풍 데이터를 공간해상도 10 m 수준으로 정밀하게 생산하는 방법을 제시하였다. 이를 통해 기존의 CMOD (C-band Model) 함수에 비해 40% 정도 오차가 감소하였으며, U 컴포넌트와 V 컴포넌트는 각각 상관계수 0.901, 0.826의 비교적 높은 정확도를 나타냈다. 본 연구에서 부울경 해역(해안선으로부터 3 km 버퍼 영역)에 대해 산출한 10 m 해상도의 바람장 지도를 작성해 보면, 내륙에서 외해로 갈수록 풍속이 강해지는 일반적인 경향을 따르면서도 공간적으로 상세화된 바람 패턴을 잘 나타낼 수 있었다. 이러한 고해상도 해상풍 지도는 해상 풍력발전을 위한 상세조사뿐 아니라, SAR를 활용한 전천후 연안 방재 및 연안레저 정보 제공을 지원할 수 있을 것으로 기대한다.

• Structural Engineering and Mechanics
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• 제28권1호
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• pp.53-67
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• 2008

Anisotropic materials are increasingly required in modern technological applications. Certainly, civil, mechanical and naval engineers frequently deal with the situation of analyzing the dynamical behaviour of structural elements being composed of such materials. For example, panels of anisotropic materials must sometimes support electromechanical engines, and besides, holes are performed in them for operational reasons e.g., conduits, ducts or electrical connections. This study is concerned with the natural frequencies and normal modes of vibration of rectangular anisotropic plates supported by different combinations of the classical boundary conditions: clamped, simply - supported and free, and with additional complexities such holes of free boundaries and attached concentrated masses. A variational approach (the well known Ritz method) is used, where the displacement amplitude is approximated by a set of beam functions in each coordinate direction corresponding to the sides of the rectangular plate. Consequently each coordinate function satisfies the essential boundary conditions at the outer edge of the plate. The influence of the position and magnitude of both hole and mass, on the natural frequencies and modal shapes of vibration are studied for a generic anisotropic material. The classical Ritz method with beam functions as spatial approximation proved to be a suitable procedure to solve a problem of such analytical complexity.

• 한국통신학회논문지
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• 제27권5C호
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• pp.435-444
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• 2002

본 논문에서는, 세션별 결정적 지연품질의 보장이 주어짐과 동시에, 세션간 서비스품질의 안정성이 지원되는 패킷 스케쥴링 알고리즘인 "클래스별 서비스 차등제공" (CSL: Class level Service Lagging) 알고리즘[6]에 대하여, 시뮬레이션을 통한 기능 검증과, 실질적 구현에 관련된 이슈를 분석하였다. 서비스품질의 안정성 면에서 CSL알고리즘과 EDD(Earliest Due Date) 방식과의 차별성을 확인하였다. 구현의 복잡성에 대한 검토에서, CSL알고리즘은 sorting을 제외하고는, 0(1)의 복잡성을 갖도록 구현될 수 있음을 보였다. 공평큐잉의 기본 골격이 유지됨으로써, 다양한 형태의 공평큐잉 구현에 쉽게 적용될 수 있는 점은 CSL알고리즘이 갖는 주요 특징이다. TCP/IP 네트워크에서와 같이, 사용자의 의지에 의존하는 TCP 혼잡제어의 환경에서, 세션간 서비스품질의 안정성 보장은 필수적이며, 이러한 측면에서 CSL알고리즘이 갖는 적합성을 확인하였다.합성을 확인하였다.

• 한국임상약학회지
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• 제16권1호
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• pp.52-56
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• 2006

Aceclofenac, a nonsteroidal antiinflammatory agent of a phenylacetic acid type, has been used for rheumatoid arthritis and osteoarthrits. Although the metabolic pathway of aceclofenc is relatively well-known in vitro, pharmacokinetic profiles of its three major or metabolites are still unclear in human. The present study was designed to investigate pharmacokinetic profiles of the metabolites of aceclofenac, and to evaluate the bioequivalence of the generic preparation of aceclofenac 100 mg tablet. Blood samples were serially collected for a period of 12 hours following a single oral administration of 100 mg aceclofenac in 20 healthy human volunteers. A simple protein precipitation with acetonitrile was employed to purify those substances from plasma. Aceclofenac, diclofenac, 4'-hydroxyaceclofenac and 4'-hydroxy-diclofenac in heparinized plasma were simultaneously measured with flufenamic acid, an internal standard, using HPLC coupled to a tandem mass spectrometer. Time courses of 4'-hydroxydiclofenac, diclofenac and aceclofenac plasma concentrations were clearly revealed, and the pharmacokinetic properties were analyzed. The 90% confidence intervals for the ratios of test/reference for log-transformed AUC and $C_{max}$ lie within 0.80-1.25.

• JSTS:Journal of Semiconductor Technology and Science
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• 제16권6호
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• pp.781-792
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• 2016

This paper presents a new approach to enhance the data retention of logic-compatible embedded DRAMs. The memory bit-cell in this work consists of two logic transistors implemented in generic triple-well CMOS process. The key idea is to use the parasitic junction capacitance built between the common cell-body and the data storage node. For each write access, a voltage transition on the cell-body couples up the data storage levels. This technique enhances the data retention and the read performance without using additional cell devices. The technique also provides much strong immunity from the write disturbance in the nature. Measurement results from a 64-kbit eDRAM test chip implemented in a 130 nm logic CMOS technology demonstrate the effectiveness of the proposed circuit technique. The refresh period for 99.9% bit yield measures $600{\mu}s$ at 1.1 V and $85^{\circ}C$, enhancing by % over the conventional design approach.