• 한국가스학회지
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• 제14권4호
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• pp.24-30
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• 2010

최소자연발화온도(AIT, autoignition temperature)의 정확한 정보는 산업화재를 예방하고 제어하는데 중요하다. 본 연구에서는 ASTM E659-78 장치를 이용하여 트리클로로실란 순수물질 그리고 디클로로실란(DCS)과 트리클로로실란(TCS) 혼합물의 AIT를 측정하였다. 트리클로로실란의 AIT는 $225^{\circ}C$로 측정되었으며, TCS(90wt%)-DCS(10wt%) 혼합물은 $250^{\circ}C$, TCS(70wt%)-DCS(30wt%) 혼합물은 각각 $236^{\circ}C$에서 발화가 발생하였다.

• Journal of Microbiology and Biotechnology
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• 제22권2호
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• pp.176-183
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• 2012

Eukaryotic translation termination is governed by eRF1 and eRF3. eRF1 recognizes the stop codons and then hydrolyzes peptidyl-tRNA. eRF3, which facilitates the termination process, belongs to the GTPase superfamily. In this study, the effect of the MC domain of eRF1a (eRF1aMC) on the GTPase activity of eRF3 was analyzed using fluorescence spectra and high-performance liquid chromatography. The results indicated eRF1aMC promotes the GTPase activity of eRF3, which is similar to the role of eRF1a. Furthermore, the increased affinity of eRF3 for GTP induced by eRF1aMC was dependent on the concentration of $Mg^{2+}$. Changes in the secondary structure of eRF3C after binding GTP/GDP were detected by CD spectroscopy. The results revealed changes of conformation during formation of the eRF3C GTP complex that were detected in the presence of eRF1a or eRF1aMC. The conformations of the eRF3C eRF1a GTP and eRF3C eRF1aMC GTP complexes were further altered upon the addition of $Mg^{2+}$. By contrast, there was no change in the conformation of GTP bound to free eRF3C or the eRF3C eRF1aN complex. These results suggest that alterations in the conformation of GTP bound to eRF3 is dependent on eRF1a and $Mg^{2+}$, whereas the MC domain of eRF1a is responsible for the change in the conformation of GTP bound to eRF3 in Euplotes octocarinatus.

• Toxicological Research
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• 제17권
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• pp.145-155
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• 2001

Cytochrome P4502C19 (CYP2C19) is one of human polymorphic xenobiotic-metabolizing enzymes. The enzyme has been reported to catalyze more than 70 substrates, involving more than 100 reactions. These include several classes of therapeutic agents (e.g. anti-microbial. cardiovascular, psycho-active, etc.), sex hormones and insecticides. Associations of the CYP2C19 genotype/phenotype with individual differences in drug efficacy (e.g. diazepam, omeprazole, proguanil) and toxicity (e.g. mephenytoin, barbiturates) have been documented by many investigators. At least 11 allelic variants of CYP2C19 gene were reported to date. Most of the mutant alleles found in the poor metabolizer (PM) led to the production of truncated and/or inactive proteins. Except for the exon 6, single-nucleotide mutations were reported in all nine exons of the gene. Genetic polymorphism of CYP2C19 shows marked interethnic variation with the population frequencies of PM phenotype ranging from 1∼2% up to more than 50%. The prevalence of CYP2C19 PM tends to be higher in Asian and certain Pacific Islanders than other race or ethnic specificity. Genotyping results of CYP2C19 also revealed that there are different proportions of individual mutant alleles among ethnic populations. This may, in part, explains the interethnic difference in the metabolism of certain drugs (i.e. diazepam), though they were from the same CYP2C19 phenotype. Recently, our research group has studied the genotype and phenotype of CYP2C19 and found that the PM frequency (7∼8%) in Thais is lower than other Asian populations. Molecular and clinical impacts of this finding warrant to further investigation.

• Asian-Australasian Journal of Animal Sciences
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• 제20권3호
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• pp.328-333
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• 2007

Carboxypeptidase E (CPE) plays an important role in the regulation of the body fat content. Therefore, it has been suggested as candidate gene for traits related to meat quality in beef cattle. This study was conducted to identify single nucleotide polymorphisms (SNPs) in the CPE gene and to investigate association of SNP marker with carcass and meat quality traits in Korean cattle. Three SNPs were identified in the intron 4 (A309G SNP and C445T SNP) and exon 5 (C601T SNP) of the CPE gene by sequence analyses of CPE cDNA and genomic DNA samples. The sequences have been deposited in GenBank database with accession numbers AY970664 and AY970663. Genotyping of the gene-specific SNP marker was carried out using the PCR-RFLP with restriction enzymes DdeI for C445T SNP and NlaIII for C601T SNP. The frequencies of C and T alleles were 0.43 and 0.57 for C445T SNP and 0.42 and 0.58 for C601T SNP, respectively. Statistical analysis indicated that the C445T SNP showed a significant effect (p<0.05) on marbling score (MS) and breeding value of backfat thickness (BF-EBV), respectively. Animals with the CT genotype showed higher marbling score and backfat thickness than those with the TT genotype. This marker also showed a significant dominance effect for the MS and BF-EBV (p<0.05). However, no significant associations were observed between C601T SNP genotypes and all traits examined. The results suggest that the CPE gene may be used as a marker for carcass traits in Korean cattle.

• 열처리공학회지
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• 제22권2호
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• pp.67-74
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• 2009

440A martensitic stainless steels which were modified with reduced carbon content (${\sim}$0.5%) and addition of small amount of nickel, vanadium, tungsten and molybdenum were manufactured. Effects of alloying elements and heat treatment on the pitting corrosion in 3.5% NaCl were investigated through the electrochemical polarization tests. The lowest pitting potential, $E_p$, was obtained when austenitizing temperature was $1250^{\circ}C$ and this is because of the grain coarsening. When austenitized at $1050^{\circ}C$ and tempered at $350{\sim}750^{\circ}C$, the highest $E_p$ was obtained at $350^{\circ}C$, while the lowest at $450^{\circ}C$ and $550^{\circ}C$ regardless of alloying elements added. But $E_p$ was increased a little at the tempering temperature of $450^{\circ}C$ and $550^{\circ}C$ when 0.4 wt.% of tungsten was added. More pitting was observed at $450{\sim}550^{\circ}C$, and pitting was formed at regions where Cr concentration is low or grain boundaries are intersecting and showed irregular shape.

• 무역상무연구
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• 제22권
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• pp.71-106
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• 2004

Todays, L/C transactions in international trade are governed by UCP 500 and eUCP. But UCP 500 and eUCP do not cover all legal problem of L/C transactions. Therefore choice of laws in international L/C transactions are occurred. U.S.A. has an enacted law (UCC ${\S}5-Letter$ of Credit) to govern L/C transaction. But other countries has no special enacted law to govern L/C transaction. The reason is that there are difference between legal attitude of U.S.A. and other countries. American law considers L/C as a special device made by merchants. Therefore U.S.A. applies UCC ${\S}5-Letter$ of Credit instead of general contract law. UCC ${\S}5-Letter$ of Credit includes provisions of warranties, remedies, and so on that UCP 500 and eUCP do not include. But the liabilities of the Issuing Bank on the wrongful dishonor in L/C transaction is very important legal problem. First, this study is to justify concepts of honor and dishonor, and sufficient conditions for dishonor of the issuing bank. in UCC. Second, this study is to examine closely the liabilities of the Issuing Bank on the wrongful dishonor in L/C transaction. Third, this study is suggest distinctive features on the Liabilities to wrongful dishonor of the issuing bank in UCC ${\S}5-Letter$ of Credit and our trader's matters to be attended to L/C transactions governed by UCC.

• 대한수학회논문집
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• 제33권2호
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• pp.561-569
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• 2018

In this paper, we introduce some notions of orthogonality in the setting of Finsler $C^*$-modules and investigate their relations with the Birkhoff-James orthogonality. Suppose that ($E,{\rho}$) and ($F,{\rho}^{\prime}$) are Finsler modules over $C^*$-algebras $\mathcal{A}$ and $\mathcal{B}$, respectively, and ${\varphi}:{\mathcal{A}}{\rightarrow}{\mathcal{B}}$ is a *-homomorphism. A map ${\Psi}:E{\rightarrow}F$ is said to be a ${\varphi}$-morphism of Finsler modules if ${\rho}^{\prime}({\Psi}(x))={\varphi}({\rho}(x))$ and ${\Psi}(ax)={\varphi}(a){\Psi}(x)$ for all $a{\in}{\mathcal{A}}$ and all $x{\in}E$. We show that each ${\varphi}$-morphism of Finsler $C^*$-modules preserves the Birkhoff-James orthogonality and conversely, each surjective linear map between Finsler $C^*$-modules preserving the Birkhoff-James orthogonality is a ${\varphi}$-morphism under certain conditions. In fact, we state a version of Wigner's theorem in the framework of Finsler $C^*$-modules.

• 대한간호
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• 제23권4호통권127호
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• pp.49-51
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• 1984

• 건축사
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• 통권455호
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• pp.14-15
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• 2007

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2018년도 추계학술논문요약집
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• pp.498-499
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• 2018