• BMB Reports
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• 제50권1호
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• pp.43-48
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• 2017

Accumulation of tissue macrophages is a significant characteristic of disease-associated chronic inflammation, and facilitates the progression of disease pathology. However, the functional roles of these bone marrow-derived macrophages (BMDMs) in aging are unclear. Here, we identified age-dependent macrophage accumulation in the bone marrow, showing that aging significantly increases the number of M1 macrophages and impairs polarization of BMDMs. We found that age-related dysregulation of BMDMs is associated with abnormal overexpression of the anti-inflammatory interleukin-10. BMDM dysregulation in aging impairs the expression levels of pro-inflammatory cytokines and genes involved in B-cell maturation and activation. Phagocytosis of apoptotic Jurkat cells by BMDMs was reduced because of low expression of phagocytic receptor CD14, indicating that increased apoptotic cells may result from defective phagocytosis of apoptotic cells in the BM of aged mice. Therefore, CD14 may represent a promising target for preventing BMDM dysregulation, and macrophage accumulation may provide diagnostic and therapeutic clues.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2011년도 학술발표회
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• pp.269-273
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• 2011

본 연구는 도암댐 상류 고랭지 농업지역의 이른 봄철 융설에 의해 발생되는 비점오염 물질의 배출 특성을 규명하고자 수행하였다. 연구는 2010년 2월 중순부터 4월 말까지 수행하였다. 연구지역에서는 2009년 11월 2일부터 2010년 4월 29일까지 눈이 내렸으며, 일 최대 적설량은 2월 11일에 기록된 59.3 cm이고, 총 적설량은 372.1 cm로 나타났다. 연구결과 융설에 의해 발생되는 단위 면적당 유량은 $77.05\;m^3$/ha/day로서 겨울철 평시 유량 $26.99\;m^3$/ha/day에 비해 두배 가까이 증가하였다. 유량의 변화는 기온의 영향을 많이 받는 것으로 나타났으며, 유량의 변화는 탁도와 SS 그리고 $COD_{Mn}$의 농도 변화에 영향을 주는 것으로 조사되었다. 오염물질 항목 중 SS와 COD의 유량가중평균농도는 각각 986.0 mg/L와 16.3 mg/L로서 겨울철 평시 농도보다 크게 증가하였는데, 이는 융설시 발생한 유출수에 의해 미세한 토양입자의 유실과 함께 오염물질도 배출된 결과로 판단된다. 그러나 T-N과 T-P의 농도는 큰 변화가 없는 것으로 조사되었다. 본 연구결과에 기초할 때, 담수호 상류에 위치한 고랭지 지역에서는 겨울철 적설량이 많고 융설에 의한 수질오염 문제가 하는 것으로 판단된다. 따라서 해빙기 융설로 인해 발생되는 비점오염 물질의 정량화에 대한 연구가 체계적이고 지속적으로 수행될 필요가 있다. 특히 우리나라의 겨울철 적설량과 기온은 연도별로 많은 편차가 있고, 연구결과 다량의 오염물질이 배출되기 때문에 융설에 대한 연구는 반드시 수행되어야 할 것으로 판단된다.

• 한국식품과학회지
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• 제43권3호
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• pp.369-374
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• 2011

D. geothermalis의 dgeo_0475 유전자로부터 만들어지는 효소를 정제하여 그 특성을 확인하였다. DGMA는 분자량이 약 68 kDa 크기의 효소로서 ${\beta}$-CD, soluble starch 및 pullulan을 가수분해하는 CD 분해 효소임을 확인하였다. 효소의 최적 온도는 $40^{\circ}C$ 최적 pH 는 6.0이며 대부분의 기질들을 glucose와 maltose로 가수분해 하였고 pullulan 및 soluble starch로부터 미량의 panose를 생성하였다. ${\beta}$-CD를 가장 잘 가수분해하나 기질간 상대적 활성차이는 다른 CD 분해효소에 비하여 크지 않았다.

• Tuberculosis and Respiratory Diseases
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• 제63권6호
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• pp.511-514
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• 2007

Mycoplasma pneumoniae에 의한 폐렴의 임상양상은 다양하다고 알려져 있으며, 흉부 방사선 소견상 대부분 기관지 주위 폐렴이나 반점형 폐 침윤 양상을 보이고 폐허탈은 5% 정도로 매우 드물게 발생하는 것으로 되어 있다. 본 저자들은 미열, 두통, 건성 기침, 근육통 등 비정형적인 폐렴의 증상을 보이면서 대엽성 무기 폐로 발현한, 마이코플라즈마 폐렴을 경험하였기에 이를 보고하는 바이다.

• Journal of Information Display
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• 제5권1호
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• pp.28-33
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• 2004

A high voltage NMOSFET is proposed to drive top emission organic light emitting device (OLED) used in the organic electroluminescent (EL) display on the single crystal silicon substrate. The high voltage NMOSFET can be fabricated by utilizing a simple layout technique with a standard CMOS logic process. It is clearly shown that the maximum supply voltage ($V_{DD}$) required for the pixel-driving transistor could reach 45 V through analytic and experimental methods. The high voltage NMOSFET was fabricated by using a standard 1.5 ${\mu}m$, 5 V CMOS logic process. From the measurements, we confirmed that the high voltage NMOSFET could sustain the excellent saturation characteristic up to 50 V without breakdown phenomena.

• Bulletin of the Korean Chemical Society
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• 제31권11호
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• pp.3309-3312
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• 2010

D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU are F-18 labeled nucleoside analogue which have been efficiently synthesized in order to be a PET imaging probe. D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU were compared as PET imaging agents using HSV1-TK gene expressing tumor-bearing mice. Their cellular uptake profiles were also compared using MCA and MCA-TK cell lines. D-[$^{18}F$]FMAU demonstrated higher cellular uptake and higher accumulation in MCA-TK tumor regions than L-[$^{18}F$]FMAU. On the other hand, L-[$^{18}F$]FMAU showed higher MCA-TK/MCA ratio of %ID/g than that of D-[$^{18}F$]FMAU. L-[$^{18}F$]FMAU can be utilized as a good candidate for HSV1-TK PET imaging. It can be used for antiviral drug evaluation.

• Nuclear Engineering and Technology
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• 제20권4호
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• pp.253-264
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• 1988

본 논문에서는 불란서에서 건설한 900 MWe급 가압경수형 원자로의 중성자 잡음해석 결과를 제시하였다. 중성자 잡음해석이란 노심내의 반응도 변화 및 노심의 수평운동으로 인한 노외검출기 신호의 변화를 해석하는 기법을 의미한다 이러한 방법은 Deterministic Dynamic Testing 기법중에서도 발전소의 정상운전 조건을 유지시키며 기존의 발전소 계측설비를 이용할 수 있다는 장점을 지니고 있다. 본 논문에 사용된 잡음신호는 울진 1호기 원자로의 시운전 시험기간에 구하였으며 이를 통계적 기술함수인 에너지 밀도함수(PSD), 검출기간의 상관함수 (CF)및 위상차(Phase Difference)로 나타내었다. 실험결과, 원자로 용기내의 냉각수 흐름 및 압력맥동 등에 의해 유도되는 Core Support Barrel(CSB)의 진동 주파수가 8Hz 근처임을 규명하였다.

• 한국수산과학회지
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• 제51권4호
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• pp.411-419
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• 2018

This study investigated the survival rates and physiological responses of Korean rockfish, Sebastes schlegeli, in live fish containers ($8^{\circ}C$, 33 psu) for 18 days. The survival rate was 99% and 97% in the control and experimental groups, respectively. Hematocrit and hemoglobin did not differ significantly between the control and experimental groups. Glucose and cortisol rose immediately on the first day of containment, but both gradually normalized. Aspartate aminotransferase and alanine aminotransferase did not differ significantly between the two groups after recovery. $NH_3$ continued to rise after the first day, but decreased to a level not significantly different from that of the control group during the recovery period. Plasma ions and osmolality did not change abnormally. The hemocyte population was not significantly different from that of the control. The ratios of apoptotic and necrotic cells indicated no specific variation in hemocyte viability. The histological changes in the skin and gills were not significantly different from those seen in the control. The experimental data obtained in this study suggest that live fish containers may be used to transport Korean rockfish without significantly affecting their physiology or survival.

• 지역사회간호학회지
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• 제15권4호
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• pp.618-627
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• 2004

Purpose: To investigate the dental health status of kindergarten children according to their oral health behavior. Method: The subjects were 172 kindergarten children aged 5. A structured questionnaire was used for dental health behavior and oral health status were examined by dentist and bacteria in salivary. Result: 1. Mean score of oral health behavior of children was 4.69 points (SD1.65) with the highest score being 13. No significant differences were observed according to sex, except using tooth paste. A total 71.5% of subjects brushed their tooth twice a day, 9.9% of them once a day, 18.6% of them three times a day, 19.2% of children brushed their teeth after breakfast and lunch, 89.5% of then after dinner, 5.8% of them before going to bed, 18.6% of children brushed correctly, 79.7% of them used tooth paste with fluorine, 3.5% of them regularly examined oral cavity, 84.4% of them took cariogenic food without any restrain, 67.1% of them were observed with oral cavity by their mother. 2. Streptococcus mutans and lactobacilli in the saliva was $3.66({\times}106CFU/m{\ell})\;and\;1.05({\times}103CFU/m{\ell})$, respectively. No significant differences were observed according to sex, while lactobacilli were significantly lower in those children who had regular dental examinations. 3. The index of plaque was 1.56 and the boys were significantly higher than the girls. The mean dft was 4.99. No significant differences were observed according to sex, while the children whose oral cavity was observed regular were significantly lower than those who were not observed. Conclusion: As a whole the practice of oral health behavior of the kindergarten children was poor, and regular dental examinations and oral cavity observations affect their dental health status. These results suggest that intensive dental health education was needed not only for the pre-school children but also their parents and teachers.

• 한국환경과학회지
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• 제8권6호
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• pp.685-690
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• 1999

The pollution characteristics of groundwaters in Taegu City and correlation coefficients(r) between water pollution indicators were investigated for two years from January 1996 to December 1997. Volatile organic compounds such as TCE(tri-chloroethylene), PCE(tetrachloroethylene), l,l,l-trichloroethane, THM(trihalo-methane), dichloromethane, pesticides such as diazinon, parathion, malathion, and toxic inoganic matters such as As, Hg, Se, Pb, Cd, $Cr_6^+,$ CN were not detected in the groundwaters. Mean values of groundwater pollution indicators were below drinking-water standards, but hardness, $KMnO_4-C(potassium$ permanganate consumption), evaporate residues, $SO_4^{-2},\;Fe,\;NO_3^{-}-N,$ color and turbidity exceeded a little in some samples. As groundwater became deeper, hardness and evaporate residues remarkably increased, but $KMnO_4-C,\;NO_3^{-}-N,\;Cl-,$ color, turbity and bacteria decreased. $KMnO_4-C,$ evaporate residues, $Cl^-\;and\;SO_4^{-2}$ were very high at industrial and commercial areas, and $NO_3^--N$ and $NH_4^+-N$ were very high at agricultural and forest areas. It showed high positive significances in the relationships between hardness and each of evaporate residues, $SO_4^{-2}$, Zn and Mn, $KMnO_4-C$ and each of color, turbidity and Zn, color and each of turbidity, Cu, Zn and Mn, turbidity and each of Fe, Cu, Zn and Mn, and evaporate residues and each of $Cl^-,\;SO_4^{-2}$ and Zn.