• International Journal of Stem Cells
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• 제15권2호
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• pp.164-172
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• 2022

Background and Objectives: Despite advances in wound treatments, chronic diabetic wounds remain a significant medical challenge. Exosomes from mesenchymal stem cells (MSCs) and small molecule activators of nuclear factor erythroid 2-related factor 2 (Nrf2) have emerged as potential therapies for nonhealing diabetic wounds. This study aimed to evaluate the effects of exosomes from bone marrow-derived MSCs (BMSCs) alone, or in combination with a small molecule activator of Nrf2 on diabetic wound healing. Methods and Results: BMSCs and endothelial progenitor cells (EPCs) were isolated from the femur and tibia bone marrow of Sprague-Dawley (SD) rats and culture-expanded. Exosomes were harvested from the BMSC culture supernatants through ultracentrifugation. The effects of the exosomes and Nrf2 knockdown, alone or in combination, on EPC tube formation were evaluated. Streptozotocin-induced diabetic rats bearing a fresh full-thickness round wound were treated with the exosomes alone, or in combination with a lentiviral shRNA targeting Nrf2 (Lenti-sh-Nrf2) or tert-butylhydroquinone (tBHQ), a small molecule activator of Nrf2. Two weeks later, wound closure, re-epithelization, collagen deposition, neovascularization, and local inflammation were evaluated. BMSC exosomes promoted while Nrf2 knockdown inhibited EPC tube formation. BMSC exosomes accelerated wound closure, re-epithelization, collagen deposition, and neovascularization, and reduced wound inflammation in diabetic rats. These regenerative and anti-inflammatory effects of the exosomes were inhibited by Lenti-sh-Nrf2 but enhanced by tBHQ administration. Conclusions: BMSC exosomes in combination with a small molecule Nrf2 activator hold promise as a new therapeutic option for chronic diabetic wounds.

• 한국해양공학회지
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• 제16권2호
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• pp.53-59
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• 2002

This paper shows the experimental results controlling the height of surface and back bead in GMAW by analyzing the unexpected gaps between base metals produced in welding and by controlling welding velocity due to the variation of the gap between base metals in thin-plate welding. The back bead behavior and burn-through in I-type butt joint $CO_2$ welding of thin mild steel are analyzed in the views of short circuit time ratio and short circuit frequency. It is shown through experimental consideration that the short circuit time ratio method is more reasonable than the short circuit frequency method in analyzing the formulation of back bead under changing the gap between base metals. Based on the these results, welding manipulator is designed so as to satisfy the bead height control in real time by measuring the short circuit time ratio. To show the effectiveness of the developed bead formulation control system, the experiment is implemented under two welding conditions such as increasing gap from 0mm to 0.8mm and gradually increasing gap from 0mm to 1.2mm. The experimental results show that the bead formulation can be controlled uniformly in spite of the variation of the gap between base metals.

• Child Health Nursing Research
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• 제4권1호
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• pp.97-104
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• 1998

Burns in children result in the loss of precious life, or if the child survives, in much suffering from physical, emotional, social, and economic problems. These burn accidents to children happen in the bustle of family life and frequently without any warning. With this background information, this study was designed to identity types of burns in children and mothers' attitudes towards, and knowledge of burn prevention, in order, to not only, in still a safety consciousness regarding the seriousness of burn accidents and the strengthening prevention, but also as basic data towards the development of an educational program aimed at prevention. From May 1 to May 25 in 1997, data were collected from the mothers of children attending five day care centers and kindergartens located in Seoul, which had been selected for the study. The tools used for the study, which were developed by the researchers, surveyed the type of burns suffered by children, mothers' knowledge of burns and attitudes toward burn accidents. The data were analyzed through real numbers percentages and analysis was done using SPSS computer programs. The results of the study show that the most frequent type of burn accidents were those caused by hot water(55.4%) and these were frequently related to everyday habits that easily lead to danger. Further, the first aid treatment following a burn was weak. The majority of the mothers had not instructed their children on who to contact in the case of a fire, first aid for burns, or how to take escape in the case of a fire. This left the children in a defenseless position in case of a fire. The mothers showed a lack knowledge, on what to do when a blaze is discovered, how to put out a fire, first aid for burns, escaping from a fire and appropriate water temperature, in that 50% of the time they answered incorrectly. From this study a prevention program, HIPP (Home Injury Prevention Program) could be developed that includes fire prevention habits and first aid for burns. This program can be used with kindergarten and elementary school children for group education on fire prevention and can be used as a foundation for construction of a system of facilities and equipment to prevent fires and also prevent injury from fires.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제36권3호
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• pp.111-115
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• 2014

Purpose: This study evaluated powdered burn wound dressing materials from wild silkworm fibroin in an animal model. Methods: Fifteen rats were used in this experiment. Full-thickness $2{\times}2cm$ burn wounds were created on the back of rats under anesthesia. In the two experimental groups, the wounds were treated with two different dressing materials made from silkworm fibroin. In the Control Group, natural healing without any dressing material was set as control. The wound surface area was measured at five days, seven days and 14 days. Wound healing was evaluated by histologic analysis. Results: By gross observation, there were no infections or severe inflammations through 14 days post-injury. The differences among groups were statistically significant at seven days and 14 days, postoperatively (P<0.037 and 0.001, respectively). By post hoc test, the defect size was significantly smaller in experimental Group 1 compared with the Control Group and experimental Group 2 at seven days postoperatively (P=0.022 and 0.029, respectively). The difference between Group 1 and Group 2 was statistically significant at 14 days postoperatively (P<0.001). Group 1 and control also differed significantly (P=0.002). Group 1 showed a smaller residual scar than the Control Group and Group 2 at 14 days post-injury. Histologic analysis showed more re-epithelization in Groups 1 and 2 than in the Control Groups. Conclusion: Burn wound healing was accelerated with silk fibroin spun by wild silkworm Antheraea pernyi. There was no atypical inflammation with silk dressing materials. In conclusion, silk dressing materials can be used for treatment of burn wound.

• 대한예방한의학회지
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• 제17권2호
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• pp.105-127
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• 2013

Objectives : We examined the use of the moxibustion through survey on Korean Medicine Doctors (KMDs) on preparation of universal moxa product standard by fully reflecting opinions of practitioners and the industry. Methods : The questionnaire is composed of 25 questions including use of indirect moxa, side effects, complaints and improvements, general characteristics and so on, and were responded by 1,588 KMDs. For statistics, frequency analysis, chi-square analysis, T-test and ANOVA were conducted using SPSS 12.0 for windows, and the significance level was 0.05. Results : In this research, 91% of the responded KMDs was using moxibustion, and the proportion of using mediate moxibustion was shown as 63.2%. They used mediate moxibustion for side effects of direct moxa method such as risk of burn, ease of use, control of stimulation and so on. And it was mostly being conducted to women and 40 ages. Most respondents gave moxibustion treatments for the purpose of thermal stimulation on acupoint to musculoskeletal diseases. Most respondents were treating 1~2 pieces of moxibustion to patients by moxibustion points to those of 1~2 regions every time within 10 minutes. Regarding the frequency of side effects of mediate moxibustion, within 3% of respondents had experienced side effects, and the types were burn, flare and itchiness, odor and smoke. The dissatisfaction of mediate moxibustion products was moderate(2.00 out of 5 point scale), and went up public health doctors, the younger ages and the shorter clinical experience. Complaints on mediate moxibustion products were serious odor, poor attachment, risk of burn etc. Regarding ways to improve mediate moxibustion, the expansion of moxibustion's insurance cost carne out highest, followed by preparation of manual on efficacy, strengthening of training, acquiring evidence on efficacy, diversification of specifications, safety improvement, quality improvement of mediate moxibustion products. Conclusions: Many KMDs use for ease of use and give moxibustion treatments for thermal stimulation but they complain about safety, efficacy and quality of mediate moxibustion. After this it is considered that we have to elevate therapeutic effect through the improvement of mediate moxibustion products.

• 한국측량학회지
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• 제22권3호
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• pp.261-268
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• 2004

위성영상자료를 통해 각 파장대별로 기록된 지표면에 대한 반사특성정보로 정규산화율지수(NBR)나 정규식생지수(NDVI)를 구하여 산림에 대한 분석을 할 수 있다. 따라서 본 연구에서는 산불이 발생한 강릉시 사천면 지역을 중심으로 산불 발생이전 산림이 온전하였던 시기의 영상과 산불 발생 직 후, 발생 1년 후 그리고 2년 후의 영상으로 정규산화율지수와 정규식생지수를 각각 구하여 이 지수를 비교 분석함으로써 정규산화율지수의 효용성을 강조하였다. 그 결과 NBR영상간 차이가 NDVI영상간 차이보다 큰 범위의 동적변화를 보이고 있으므로 산불 피해강도나 식생회복상태 분석 시 NBR영상을 사용하는 것이 좋을 것으로 판단되며, 산불피해 지역에서도 NBR 영상이 NDVI영상보다 산림피해강도나 회복상태를 더욱 뚜렷하게 보여주고 있다.

• Transactions on Electrical and Electronic Materials
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• 제5권4호
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• pp.138-142
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• 2004

This paper presents the improved bum-in method for the reliability of SRAM in Multi Chip Package (MCP). Semiconductor reliability is commonly improved through the bum-in process. Reliability problem is more significant in MCP that includes over two chips in a package, because the failure of one chip (SRAM) has a large influence on the yield and quality of the other chips - Flash Memory, DRAM, etc. Therefore, the quality of SRAM must be guaranteed. To improve the quality of SRAM, we applied the improved wafer level bum-in process using multi cells selection method in addition to the previously used methods. That method is effective in detecting special failure. Finally, with the composition of some kind of methods, we could achieve the high quality of SRAM in Multi Chip Package.

• 한국염색가공학회지
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• 제33권4호
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• pp.338-347
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• 2021

In the case of occlusive dressings currently used in dressings for burn treatment, it is impossible to confirm the replacement time, so replacement is delayed, resulting in additional infection. To solve this problem, liposomes capable of bacterial sensing were prepared using 5(6)-Carboxyfluorescein, Phosphatidylcholine, 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine, Cholesterol, and 10,12-Tricosadiynoic acid. In this study, evaluation of changes in drug encapsulation rate in liposomes according to changes in three types of phosphatidylcholine phospholipids during liposome production, high-performance phosphatidylcholine phospholipids selected through vesicle size analysis, low and high temperature stability evaluation, bacterial sensitization ability evaluation, animals cell responses were assessed.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 2001년도 추계학술발표대회 개요집
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• pp.15-18
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• 2001

• Journal of Welding and Joining
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• 제13권4호
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• pp.75-84
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• 1995

In GMA welding of sheet metal, the short circuit metal transfer mdoe is preferred because of its low heat input and capability of bridging the root gap. The molten electrode is transferred to the workpiece during repectitive short circuit in the model. The waveform of welding current or voltage and the frequency of short circuiting are affected by a number of factors including: magnitude of welding current and voltage, root gap, electrode extension, power supply characteristics, and so on. In this study experimental models were proposed, which are able to determine the relationship between the root gap and short circuit frequency and the relationship between the root gap and appropriate welding speed that produces the good quality of back bead without burn through. Using the experimental models, the root gap can be obtained from measuring the short circuit frequency, and then the appropriate weldig speed to the root gap can be determined. Thus a back bead control system was constructed by controlling the welding speed for maintaining the quality of back bead. The developed system has shown the successful capability of back bead control.