• Journal of the Korean Professional Engineers Association
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• v.16 no.1
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• pp.20-34
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• 1983

A phenomenon in the unplanned urban sprawl of Cheong-ju city has to be rest-rained from disposing and to develop, though progress in urbanization inevitably decreases rural area. So, this thesis aims at reviewing, revising and guiding toward the more effective land use planning practice and zoning mechanism and system of Cheong-ju city. I proposed that land use planning should be had several factors and thereupon that Korean zoning mechanism and system including Building Code should be amended because of inducing human activities in buildings and facilities not to demarcate and plan every one of them. First, the factors of urban planning are a rather diversified approach to it than a unified, supplementation of the applicable difference in time between preparing and appling it, a solid controlling system, a micro and macro planning theory and giving serious consideration for the inertia from the existing land use. Second, the applicable amendments for our zoning mechanism including Eluding Code are as follows; a need of reorganization for Zoning Ordinance appricated to different regulation concerning a scale and peculiarity of a oily, a decision of the different earmarked confinement in area to different zone ana from Zoning Ordinance in City Planning Law, a demarcated facilities and the more detailed land use concerning human activies than the exsisting and entrusting decision on the ways and processes of it to every rural city planning committee, a settlement of zone ana area considering for block-unit and Planned Unit Development(P. U. D.), and a need of security jurisprudence in order to solve the zoning regulation rather in City Planning Law than in Building Code that our zoning regulation and controlling system are depended on. According to these applicable amendments to Cheong-ju city, I proposed the conceptions of Cheong-ju city land use planning are as follows; a reinforcement with one cored pattern of urban land use, a selection of gradual urban sprawl by way of city development and renewal, a strengthening accessibility to the core of the city with Plurizing the system of arterial roads, a choice of priority to conservation at the core of tile city and security of open spaces and parking area at the area of the city, a harmonization between development and conservation at the inner ring area that is situated between the core and periphery reserved area in order to develop in the future, a buffered open space situated at the congested area with heterogenous functions, and a completion of urban open space system. The proposal made here so far is for the hope of the better structure of Cheong-ju city that should be granted to the peculiarity developed with educational, cultural, conservative and self-sufficient city functions.

• Interdisciplinary Bio Central
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• v.1 no.2
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• pp.7.1-7.7
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• 2009

"To be, or not to be?" This question is not only Hamlet's agony but also the dilemma of mitochondria in a cancer cell. Cancer cells have a high glycolysis rate even in the presence of oxygen. This feature of cancer cells is known as the Warburg effect, named for the first scientist to observe it, Otto Warburg, who assumed that because of mitochondrial malfunction, cancer cells had to depend on anaerobic glycolysis to generate ATP. It was demonstrated, however, that cancer cells with intact mitochondria also showed evidence of the Warburg effect. Thus, an alternative explanation was proposed: the Warburg effect helps cancer cells harness additional ATP to meet the high energy demand required for their extraordinary growth while providing a basic building block of metabolites for their proliferation. A third view suggests that the Warburg effect is a defense mechanism, protecting cancer cells from the higher than usual oxidative environment in which they survive. Interestingly, the latter view does not conflict with the high-energy production view, as increased glucose metabolism enables cancer cells to produce larger amounts of both antioxidants to fight oxidative stress and ATP and metabolites for growth. The combination of these two different hypotheses may explain the Warburg effect, but critical questions at the mechanistic level remain to be explored. Cancer shows complex and multi-faceted behaviors. Previously, there has been no overall plan or systematic approach to integrate and interpret the complex signaling in cancer cells. A new paradigm of collaboration and a well-designed systemic approach will supply answers to fill the gaps in current cancer knowledge and will accelerate the discovery of the connections behind the Warburg mystery. An integrated understanding of cancer complexity and tumorigenesis is necessary to expand the frontiers of cancer cell biology.

• The Transactions of the Korea Information Processing Society
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• v.4 no.12
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• pp.3159-3174
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• 1997

This paper reports a research to develop a methodology and a tool for understanding of very large and complex real-time software. The methodology and the tool mostly developed by the author are called the Architecture-based Real-time Software Understanding (ARSU) and the Software Re/reverse-engineering Environment (SRE) respectively. Due to size and complexity, it is commonly very hard to understand the software during reengineering process. However the research facilitates scalable re/reverse-engineering of such real-time software based on the architecture of the software in three-dimensional perspectives: structural, functional, and behavioral views. Firstly, the structural view reveals the overall architecture, specification (outline), and the algorithm (detail) views of the software, based on hierarchically organized parent-chi1d relationship. The basic building block of the architecture is a software Unit (SWU), generated by user-defined criteria. The architecture facilitates navigation of the software in top-down or bottom-up way. It captures the specification and algorithm views at different levels of abstraction. It also shows the functional and the behavioral information at these levels. Secondly, the functional view includes graphs of data/control flow, input/output, definition/use, variable/reference, etc. Each feature of the view contains different kind of functionality of the software. Thirdly, the behavioral view includes state diagrams, interleaved event lists, etc. This view shows the dynamic properties or the software at runtime. Beside these views, there are a number of other documents: capabilities, interfaces, comments, code, etc. One of the most powerful characteristics of this approach is the capability of abstracting and exploding these dimensional information in the architecture through navigation. These capabilities establish the foundation for scalable and modular understanding of the software. This approach allows engineers to extract reusable components from the software during reengineering process.